Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.

Papetti et al. discuss recent advances in understanding human neural development, aging, and disease uncovered through human-rodent chimeric brain models and examine their potential to drive progress ...

The NIH has recently called for expanding use of new approach methodologies (NAMs) to reduce use of animals in research. Arany discusses the need not to forget the irreplaceable aspects of animal rese...

Jin et al. develop chimeric mouse brains containing human microglia, astroglia, oligodendroglia, and neurons, enabling direct interrogation of human neuron-glia interactions in vivo. These models reca...

Nature Neuroscience - Engineering human microglia with a Down-syndrome-linked myeloid gene variant resists tau-induced dysfunction and protects neurons in chimeric brains, offering proof of concept...

Microglia are immune cells of the central nervous system, playing a vital role in brain development, homeostasis, and disease. When these cells become…

Guiqin Chen, Mengmeng Wang, et al. demonstrate that ApoE3 R136S inhibits AEP-mediated Tau cleavage and neuroinflammation by binding more tightly to Tau, preventing its propagation, and thereby slowing the progression of Alzheimer’s disease in mice.

Graham et al. show that Alzheimer's disease-associated genetic variants are enriched in gene networks expressed by microglia and oligodendrocytes during ag

This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several strategies are pr...