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Peng Jiang Lab@Rutgers

@jianglab.bsky.social

188 followers 207 following 25 posts

We use brain organoid and chimeric-brain platforms to uncover disease mechanisms and engineer human microglia for brain repair. cbn.rutgers.edu/peng-jiang-lab/339-…

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Peng Jiang Lab@Rutgers @jianglab.bsky.social · 02/07/2026

Well said on the role of somatic mutations in myeloid cells in Alzheimer's disease! (www.cell.com/trends/molec... The CSF2RB A455D variant from our study is also a promising example. More studies using chimeric brain models with human microglia carrying somatic mutations are needed.

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Peng Jiang Lab@Rutgers @jianglab.bsky.social · 24/11/2025

An idea we started in 2019 is now published in @natneuro.nature.com! Excited to share our new study: rdcu.be/eRvdA Congrats to Mengmeng Jin and our team! Heartfelt thanks to all collaborators for their support, and to the reviewers for their insightful comments!

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Peng Jiang Lab@Rutgers @jianglab.bsky.social · 28/04/2025

This review was actually written once before (the section on methodological considerations for creating chimeric models is shown in the image below), but it didn’t make it to publication at the time.

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Peng Jiang Lab@Rutgers @jianglab.bsky.social · 28/04/2025

I was inspired by Dr. Suchun Zhang’s work on differentiating human PSCs + transplanting them into mice, and Dr. Steven Goldman’s work on human oligodendroglia taking over mouse brains. We discussed the idea of chimeric models in our 2014 Nat Commun paper 👇

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Peng Jiang Lab@Rutgers @jianglab.bsky.social · 28/04/2025

Thrilled to share our review just published in @cp-neuron.bsky.social ! 🎉 Big shoutout to Ava, Mengmeng, and our entire team! authors.elsevier.com/a/1k-uh3BtfH...

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