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Joe Hamley

@jhamley98.bsky.social

63 followers 128 following 5 posts

Postdoc @ The Crick | Interested in the 3D genome + enhancers

Posts Replies Media

Reposted by Joe Hamley

MRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 08/10/2026

#WIMMReads🧪 Milne, Hughes and Davies Groups have developed a technology that helps reveal how genetic variants linked to disease affect our genes. 👉https://www.imm.ox.ac.uk/news/nat-gen-mapping-variants #AcademicSky @rdm.ox.ac.uk @medsci.ox.ac.uk

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Reposted by Joe Hamley

Bora Ozcan @boraaozcan.bsky.social · 07/10/2026

Very happy to have helped with this project led by Joe!

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Reposted by Joe Hamley

Roman Doll @romanmdoll.bsky.social · 07/10/2026

Check out this new work from the lab, led by Joe! It’s been really impressive seeing this project develop — huge congrats to everyone!

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Reposted by Joe Hamley

James Davies @jojdavies.bsky.social · 07/10/2026

Delighted to see our latest paper out in @natgenet.nature.com ! The brilliant @jhamley98.bsky.social developed MCCv, allowing chromatin architecture to be visualised at base-pair resolution for each allele—a powerful way to identify functional genetic variants. www.nature.com/articles/s41... 🧵

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Joe Hamley @jhamley98.bsky.social · 07/10/2026

4/4 This project was a team effort and I’m incredibly grateful to @jojdavies.bsky.social, Jim Hughes and Tom Milne for their supervision. I would also like to thank all co-authors for their contributions. bsky.app/profile/jojd...

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Joe Hamley @jhamley98.bsky.social · 07/10/2026

3/4 We applied the platform to autoimmune genetics in human CD4 T cells. One key variant created a new CTCF binding site, blocked super-enhancer–promoter contacts and reduced SESN3 expression. We then showed how SESN3 may contribute to autoimmunity through tryptophan dependent mTOR signaling.

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Joe Hamley @jhamley98.bsky.social · 07/10/2026

2/4 Most variants associated with common disease lie in noncoding regulatory elements, making it challenging to identify which variants are functional and which genes they dysregulate. By mapping chromatin contacts between alleles, MCCv helps assign variant function and nominate target genes.

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Joe Hamley @jhamley98.bsky.social · 07/10/2026

1/4🧵 Really excited to see that a major part of my PhD work has now been published in Nature Genetics! 🎉 In this study, we developed Micro Capture-C variant-to-function (MCCv): a method to map how genetic variants alter gene regulation at single-allele resolution. www.nature.com/articles/s41...

nature.com

Single-allele nanoscale mapping of regulatory variants - Nature Genetics

This study uses high-resolution, allele-specific chromatin architecture to identify causal gene-regulatory mechanisms in inflammatory diseases and uncovers a mechanism by which a neo-CTCF site promote...

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Roman Doll @romanmdoll.bsky.social · 20/12/2025

Excited to share that a part of my PhD work is online now on BioRxiv! www.biorxiv.org/content/10.6... We developed a genome editing approach to target the JAK2 V617F mutation and demonstrate its potential to alleviate MPN hallmarks in primary patient cells. Thread 👇

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The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · 05/11/2025

Not from Tron or a psychedelic wallpaper. This exquisite pic reveals chromatin at base-pair resolution, captured by #ListerFellow James Davies and collaborators🤩 "For the first time, we can see how the genome's control switches are physically arranged inside cells." @jojdavies.bsky.social

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Joe Hamley @jhamley98.bsky.social · 05/11/2025

So exciting to see this finally out! Incredible work by Hangpeng pushing the resolution of MCC even further.

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Reposted by Joe Hamley

Davies Lab @davieslab.bsky.social · 27/08/2025

We’re really excited to see Hangpeng Li present our latest work at the CSH Mechanisms of Eukaryotic Transcription meeting.

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