iiinova — where your digital self keeps evolving

Jean lab @jeanlab-uds.bsky.social · 09/09/2026

We wanted an easy way to map precisely CRISPR edits. Through a fun collaboration with the Choquet’s lab and the RNomics Core, we developed a tool for analyzing genome editing using nanopore sequencing. Here is our preprint. We hope it will be useful to many labs! www.biorxiv.org/content/10.6...

biorxiv.org

NANOCUTSIGHT: A NANOPORE-SEQUENCING APPROACH AND ANALYSIS PIPELINE TO ASSESS GENOME EDITING EFFICACY IN VARIOUS CELL POPULATIONS

Genome editing has revolutionized biomedical sciences and is now an essential tool to define molecular pathways through genetic interaction and loss-of-function studies. Through its diverse variations...

020

Reposted by Jean lab

Daniel MacPhee 🇨🇦 @d-macphee.bsky.social · 05/05/2026

“A country that under-invests in basic research does not stop benefiting from science. It becomes more reliant on other systems to take the early risks, generate the foundational knowledge and shape the next generation of…advances.” Over reliance is bad #Canada 🧪 theconversation.com/to-lead-in-g...

theconversation.com

To lead in global innovation, Canada must prioritize basic science

Canada must decide what kind of country it wants to be: One that generates new scientific knowledge, or one that waits for other nations’ discoveries.

0105

Reposted by Jean lab

Alejandro Montenegro @aemonten.bsky.social · 27/04/2026

"In this study, we present a genome-scale map of genetic interactions in the human haploid cell line HAP1, based on CRISPR-based perturbation of ∼4 million gene pairs. The resulting network comprises ∼89,000 high-confidence gene-gene interactions" doi.org/10.1016/j.ce...

0299

Reposted by Jean lab

T. Ryan Gregory 🇨🇦 @tryangregory.bsky.social · 11/12/2025

Scientists at Canadian institutions have long punched well above our weight despite low and stagnant funding. Spending a billion dollars on external recruitment while science here is starving is exactly what Harper got wrong about supporting research excellence in Canada.

1220670

Reposted by Jean lab

Mathieu Ferron @mathieuferron.bsky.social · 02/04/2025

Fantastic opportunity if you are interested in moving your lab to Montreal, Canada! Through this program, Chairholders will be awarded up to $1 million per year for a period of 8 years. Contact me if you are interested. www.nature.com/naturecareer...

nature.com

Canada Excellence Research Chairs (CERC) - Montréal, Quebec (CA) job with University of Montreal (UdeM) | 12838461

Canada Excellence Research Chairs (CERC)

3172117

Reposted by Jean lab

Francis Lynn 🇨🇦 @nictitate.bsky.social · 10/03/2025

We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...

nature.com

Postdoctoral Research Fellow - Vancouver, British Columbia (CA) job with University of British Columbia Department of Surgery | 12837375

The successful candidate will work on a project developing cell-based therapies for those living with type 1 diabetes (T1D).

02023

Reposted by Jean lab

The Freeman Lab @spencerfreeman.bsky.social · 27/02/2025

We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....

06243

Reposted by Jean lab

Peter Cullen @peterjcullen1.bsky.social · 04/02/2025

Two new lab manuscripts describing new insight into VPS29’s role in Retromer vs Retriever, and the identification of a non-classical Commander pathway in melanosome biogenesis. Both with @BrettCollins.bsky.social lab. www.biorxiv.org/content/10.1... and www.biorxiv.org/content/10.1...

biorxiv.org

Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through auto-inhibition.

The endosomal-lysosomal network is a hub of organelles that orchestrate the dynamic sorting of hundreds of integral membrane proteins to maintain cellular homeostasis. VPS29 is a central conductor of ...

1259

Reposted by Jean lab

Mathieu Quesnel-Vallières @rna-ken.bsky.social · 04/02/2025

Postdoc opening in my lab, joint with Prof Lee-Hwa Tai, to develop genomics, transcriptomcis and immunology pipelines for cancer immunotherapy. Details here or DM me: mqvlab.com/positions/

Panoramic view of research buildings and hospital surrounded by trees with small mountains in the background.

034

Reposted by Jean lab

Andrew Simmonds 🇨🇦 @simmondlab.bsky.social · 03/02/2025

Looking for a high qualtiy scientific meeting being held in Canada this year? The 12th Canadian Developmental Biology Meeting (Regional SDB @socdevbio.bsky.social meeting) is happening May 25-28 in Kelowna BC. Registration is now open! www.sdbonline.org/meeting?Reso...

sdbonline.org

Society for Developmental Biology | Meeting

01818

Reposted by Jean lab

Marco Hein @marco.heinlab.org · 14/01/2025

Time to share our organelle proteome paper out in @cellcellpress.bsky.social: doi.org/nzwz We created a spatial map of human cells using organelle immunoprecipitation at scale. Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/ 1/3 🧪

Graphical abstract of the Organelle Profiling paper, showing the workflow:
Endogenously tagged organelle library;
Native IP proteomics;
Data-driven graph clustering;
resulting in a subcellular proteome map with
more than 7,600 proteins localized across 19 subcellular compartments.

719860

Reposted by Jean lab

Mathieu Quesnel-Vallières @rna-ken.bsky.social · 14/11/2024

Now that science bsky is a thing, I would like to remind you that my Department has two faculty openings in cancer biology/-omics/immunology. Come work with me - We have a very supportive environment, big dreams, and life in Sherbrooke is so good! shorturl.at/EcnMZ @futurepislack.bsky.social

24826

Reposted by Jean lab

Luciano A. Masullo @lumasullo.bsky.social · 27/11/2024

We developed #RESI (Resolution Enhancement by Sequential Imaging), a #DNAPAINT based single-molecule method that achieves 1-2 Å localization precision and sub-nm resolution using a conventional fluorescence microscope and standard reagents. 1/13

1249

Jean lab @jeanlab-uds.bsky.social · 21/11/2024

For my first post on Bluesky, here is our BioID map of RAB GTPases! It was a collective effort from many in the lab initiated by Benoît, Raphaëlle, and Dominique and followed up extensively by Véronique! I'll happily share the associated data if anyone is interested. www.biorxiv.org/content/10.1...

biorxiv.org

A Proximity MAP of RAB GTPases

RAB GTPases are the most abundant family of small GTPases and regulate multiple aspects of membrane trafficking events, from cargo sorting to vesicle budding, transport, docking, and fusion. To regula...

3309