iiinova — where your digital self keeps evolving

Reposted by José Carlos Souto (@jcsouto)

Eric Topol @erictopol.bsky.social · 11/08/2026

Stop the hype on anti-aging treatments such as NAD+ and peptides. Get the evidence. Editorial @naturemedicine.bsky.social nature.com/articles/s41...

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 24/07/2026

A ilusão de segurança - por que exames demais pode não ser uma boa ideia substack.com/@jcsouto/not...

substack.com

A ilusão de segurança

Quando se trata de exames, mais nem sempre é melhor.

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Reposted by José Carlos Souto (@jcsouto)

Tamar Haspel @tamarhaspel.bsky.social · 10/02/2026

You know that coffee & dementia study that's going around? It's hogwash. For starters, it's not pre-registered (that I could find), which means it may have been the product of a fishing expedition looking for dementia associations. But even if it's not ... www.nytimes.com/2026/02/09/h...

nytimes.com

2 to 3 Cups of Coffee a Day May Reduce Dementia Risk. But Not if It’s Decaf.

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Reposted by José Carlos Souto (@jcsouto)

Eric Topol @erictopol.bsky.social · 16/01/2026

Tylenol during pregnancy is safe without increased risk of autism, ADHD, or intellectual disability of offspring A new review of the evidence just out www.thelancet.com/journals/lan...

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Reposted by José Carlos Souto (@jcsouto)

F. Perry Wilson, MD @fperrywilson.bsky.social · 24/11/2025

I’ve called GLP-1 agents like Ozempic and Mounjaro "miracle drugs." But a new study forces me to re-evaluate that moniker. The miracle has a problem: It ends when the prescription runs out. Let's look at the data on the "Rebound Effect." 🧵

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Reposted by José Carlos Souto (@jcsouto)

Eric Topol @erictopol.bsky.social · 24/11/2025

Semaglutide (Ozempic) failed to have clinical impact for slowing progression in people with mild Alzheimer’s disease in 2 large, placebo-controlled trials novonordisk.com/content/nnco...

novonordisk.com

News Details

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Reposted by José Carlos Souto (@jcsouto)

Elisa Brietzke MD, PhD @ebrietzke.bsky.social · 18/11/2025

Eu gostaria de lembrar aos colegas anti-vacina que estão apagando suas postagens às pressas da seguinte máxima de Hipócrates: “O print é eterno.”

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Reposted by José Carlos Souto (@jcsouto)

Eric Topol @erictopol.bsky.social · 09/11/2025

visual abstract of the trial and results

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Reposted by José Carlos Souto (@jcsouto)

Elisa Brietzke MD, PhD @ebrietzke.bsky.social · 06/11/2025

Quero falar sobre a meta-análise de Dieta Cetogênica na Depressão e na Ansiedade que saiu no @JAMAPsych porque sei que amanhã a PICARETOSFERA inteira vai repercutir e vocês precisam saber o significado desses achados. Segue o fio 🧵. jamanetwork.com/journals/jam...

jamanetwork.com

Ketogenic Diets and Depression and Anxiety

This systematic review and meta-analysis assesses the associations between ketogenic diets and mental health outcomes in adults, with a focus on depressive and anxiety symptoms.

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 29/09/2025

This is a fascinating story. A Lebanese team published a study showing massive benefits for apple cider vinegar in 2024. People immediately noticed it was problematic, and complained. BMJ asked the authors for the data, and they sent it through. The study has just been retracted and WOW 1/n

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 26/09/2025

New piece out - do soft drinks give you depression? Probably not. The evidence is SUPER weak. gidmk.substack.com/p/soft-drink...

gidmk.substack.com

Soft Drinks Probably Aren't Making You Depressed

Why soda/pop/soft drinks probably aren't causing depression.

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 26/09/2025

10/n Regardless, all of this fuss and noise about soft drinks and depression comes from a cross-sectional study that only assessed soft drink consumption at one time point and did not follow-up patients at all. Which is absurd.

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 26/09/2025

4/n This is straightforwardly meaningless scientifically. It was a cross-sectional survey of food consumption with some gut microbiome assessment thrown in. According to their methods, the only covariates included in the logistic model here were age and sex.

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 26/09/2025

Science can be such a headache sometimes. This study has hit the headlines because the authors claim that it shows that soft drinks cause people to be depressed by negatively impacting their gut microbiome. Several BIG issues with this 1/n

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 19/09/2025

Como escrevi na semana passada, esse estudo altamente problemático jamais permitiria sugerir que adoçantes em geral sejam deletérios para o cérebro, muito menos adoçantes específicos. A reprodução totalmente acrítica pela mídia é algo que precisa ser repensado

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Reposted by José Carlos Souto (@jcsouto)

Sophie E. Hill @sophieehill.bsky.social · 19/09/2025

Groundbreaking! @gidmk.bsky.social and @slate.com prove that you can cover an academic study by actually *reading* it, not just regurgitating every breathless bullet point from the press release... This is what science journalism should look like 👇 slate.com/technology/2...

slate.com

Scientists Tested the Link Between Artificial Sweetener and Cognitive Decline. Here’s What You Need to Know.

Scientists tested for links between artificial sweeteners and cognitive decline.

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Reposted by José Carlos Souto (@jcsouto)

F. Perry Wilson, MD @fperrywilson.bsky.social · 09/09/2025

We've all had this conversation before: "Dude, we both agree this is red... but how do I know what I see as red is what you see as red? Maybe you see red as I see blue." Mind blown lol. But we finally have some research that sheds light (and color) on the issue. (Thread)

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 08/09/2025

O artigo sobre adoçantes e declínio cognitivo, além dos problemas que já citei ontem aqui e no último episódio do podcast Comida sem Filtro, está repleto de erros estatísticos, se vê nesse fio

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Reposted by José Carlos Souto (@jcsouto)

Carl Müller-Crepon @carlmc.bsky.social · 06/09/2025

It’s really worrying that it takes a political scientist to point out all these irregularities in a paper that is picked up to such an extent by the press — reviewers, science editors, anyone listening? Anyone bothered to ask for the underlying data & code?

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 08/09/2025

Man, I should really stop opening cans of Pepsi Max by slamming them into my forehead

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 07/09/2025

1/ 👉 Proliferam manchetes sobre um novo estudo (neurology.org/doi/10.1212/...) que alega que 7 adoçantes artificiais estão associados com declínio cognitivo acelerado. 📰 Quase todas usam linguagem causal e números assustadores. Mas o estudo é BEM problemático. 🧵

neurology.org

Association Between Consumption of Low- and No-Calorie Artificial Sweeteners and Cognitive Decline | Neurology

Background and ObjectivesConsumption of low- and no-calorie sweeteners (LNCSs) has been associated with adverse health outcomes. However, little is known about the association between consumption of L...

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 25/08/2025

A new expression of concern was published on this randomized clinical trial of cinnamon for diabetes. The study itself has been cited, according to Google, 1,700 times. I first complained about it in 2023, so let me tell you the story of one of the most problematic papers I've come across 1/n

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 21/08/2025

Querem apostar que o Tarcísio vai continuar se humilhando? g1.globo.com/politica/blo...

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 13/08/2025

Editorial do Estadão de hoje. Lembrando que trata-se de um jornal *conservador*. O conservadorismo precisa se distanciar do golpismo e do entreguismo. Ainda há tempo

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Reposted by José Carlos Souto (@jcsouto)

Kevin Hall @kevinh-phd.bsky.social · 16/07/2025

Excited to announce my new book FOOD INTELLIGENCE coauthored with brilliant journalist @juliabelluz.bsky.social‬! Cutting through the confusion about diet & health, #FoodIntelligence describes the fascinating science of how food both nourishes & harms us. www.penguinrandomhouse.com/books/671334...

penguinrandomhouse.com

Food Intelligence by Julia Belluz, Kevin Hall, PhD: 9780593332306 | PenguinRandomHouse.com: Books

The essential guide for understanding what you’re eating, and the forces that are driving you to eat it. Nutrition isn’t rocket science; it’s harder. There are new diet fads, bold...

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 15/07/2025

A direita brasileira tem agora uma oportunidade *única* de imitar a direita europeia e criar um CORDÃO SANITÁRIO para isolar o extremismo golpista. Não precisa ser petista nem esquerdista. Mas não pode vender o país e rastejar pra salvar Grande Líder. Editorial do Estadão:

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 13/07/2025

Excelente novamente. O Estadão (insuspeito de ser "comunista") sacou que não haverá outra chance melhor de a direita se descolar de vez do bolsonarismo. Vestir-se de verde e amarelo não torna ninguém patriota, como ficou claro nos últimos dias.

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 10/07/2025

Editorial do Estadão de hoje 👏👏👏👏

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Reposted by José Carlos Souto (@jcsouto)

Eric Topol @erictopol.bsky.social · 03/07/2025

Some ultraprocessed foods and sugar-sweetened beverages labeled “Not Recommended for Human Consumption” in one state/US for the first time) long after action taken by Australia, Canada, the European Union, and the United Kingdom. katiecouric.com/health/nutri... @katiecouric.bsky.social

katiecouric.com

These Foods Will Be Labeled “Not Recommended for Human Consumption” in Texas

A look at the new law in the Lone Star State.

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Reposted by José Carlos Souto (@jcsouto)

Sleeping Giants Brasil @sleepinggiantsbr.bsky.social · 30/06/2025

📢 Paloma Shemirani, uma jovem de 23 anos, morreu de um tipo de câncer altamente tratável após rejeitar a quimioterapia e seguir um tratamento ineficaz baseado em enemas e sucos de vegetais, defendido por sua mãe negacionista, Kate Shemirani. [+]

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 28/05/2025

The key issue with putting contrarians in power is that their platform is entirely based on arguing against the mainstream. Mainstream public health makes mistakes, but on the aggregate it's pretty solid and evidence-based. If you throw out everything mainstream, you're left with a lot of nonsense.

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Reposted by José Carlos Souto (@jcsouto)

Eric Topol @erictopol.bsky.social · 27/05/2025

2 new studies on weight loss 1. Sustained reduction during midlife improved survival and reduced chronic diseases jamanetwork.com/journals/jam... 2. A randomized trial found patient-to-patient care was more effective than professional for weight loss and less CV risk jamanetwork.com/journals/jam...

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Reposted by José Carlos Souto (@jcsouto)

Frankito, o Curioso @weisefranklin.bsky.social · 27/05/2025

12. Fica a lição: por enquanto, Grok e outras IAs, quando usados para data scraping, tem fornecido dados bem pouco confiáveis e justificativas que não condizem com os fatos. IA deveria ser usada como muleta, jamais como perna.

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Reposted by José Carlos Souto (@jcsouto)

Frankito, o Curioso @weisefranklin.bsky.social · 27/05/2025

Nos últimos meses, o uso de IA para corroborar a veracidade de alguma informação ou solicitado dados quantitativos aumentou de forma impressionante em mídias sociais – o que pode parecer bom, mas é preocupante, como vou mostrar com exemplos reais. 🧵

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Reposted by José Carlos Souto (@jcsouto)

Spencer Nadolsky DO @drnadolsky.bsky.social · 23/05/2025

5 truths about losing a lot of weight 1. You need to get into a calorie deficit 2. Lift weights to not lose muscle 3. You don’t need to do cardio, but it may help keep the weight off 4. It’s not going to be easy and you may need medicine to help 5. Food choice matters

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 22/05/2025

E eis que, finalmente, o veranico de maio se foi. Espero por esse dia ❄️ que nem criança espera pelo Natal

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 22/05/2025

The chances that a viral health trend is at least two of: 1. Ineffective 2. Harmful 3. Expensive Is close to 100%. The worst reason to do something for your health is that it's briefly popular on Instagram/Tiktok.

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 19/05/2025

As outras estações que me perdoem, mas o outono é fundamental

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 14/05/2025

I have no interest in defending Prasad, but I think it's worth noting that the U.S.'s position on childhood immunization against COVID-19 is out of step with international guidelines. In Australia, children under 18 are only eligible for COVID-19 vaccines if they are seriously immunocompromised.

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