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Reposted by José Carlos Souto (@jcsouto)

Eric Topol @erictopol.bsky.social · 11/08/2026

Stop the hype on anti-aging treatments such as NAD+ and peptides. Get the evidence. Editorial @naturemedicine.bsky.social nature.com/articles/s41...

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 24/07/2026

A ilusão de segurança - por que exames demais pode não ser uma boa ideia substack.com/@jcsouto/not...

substack.com

A ilusão de segurança

Quando se trata de exames, mais nem sempre é melhor.

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Reposted by José Carlos Souto (@jcsouto)

Tamar Haspel @tamarhaspel.bsky.social · 10/02/2026

You know that coffee & dementia study that's going around? It's hogwash. For starters, it's not pre-registered (that I could find), which means it may have been the product of a fishing expedition looking for dementia associations. But even if it's not ... www.nytimes.com/2026/02/09/h...

nytimes.com

2 to 3 Cups of Coffee a Day May Reduce Dementia Risk. But Not if It’s Decaf.

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Reposted by José Carlos Souto (@jcsouto)

Eric Topol @erictopol.bsky.social · 16/01/2026

Tylenol during pregnancy is safe without increased risk of autism, ADHD, or intellectual disability of offspring A new review of the evidence just out www.thelancet.com/journals/lan...

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 22/12/2025

Sugiro a eles trocar por ferraduras. Que além de tudo trazem sorte 🤞

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 06/12/2025

Valeu. Eu comecei com o Duolingo por diversão enquanto estava em Viena. Mas atualmente, pago uma professora de carne e osso mesmo 😉

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 03/12/2025

Só quando eu dominar o alemão, o que me dá ainda muitos anos pela frente 😉

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Reposted by José Carlos Souto (@jcsouto)

F. Perry Wilson, MD @fperrywilson.bsky.social · 24/11/2025

I’ve called GLP-1 agents like Ozempic and Mounjaro "miracle drugs." But a new study forces me to re-evaluate that moniker. The miracle has a problem: It ends when the prescription runs out. Let's look at the data on the "Rebound Effect." 🧵

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Reposted by José Carlos Souto (@jcsouto)

Eric Topol @erictopol.bsky.social · 24/11/2025

Semaglutide (Ozempic) failed to have clinical impact for slowing progression in people with mild Alzheimer’s disease in 2 large, placebo-controlled trials novonordisk.com/content/nnco...

novonordisk.com

News Details

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 22/11/2025

A tranquilidade de quem sabe que não será acordado às 6:30 com batidas na porta 😁

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Reposted by José Carlos Souto (@jcsouto)

Elisa Brietzke MD, PhD @ebrietzke.bsky.social · 18/11/2025

Eu gostaria de lembrar aos colegas anti-vacina que estão apagando suas postagens às pressas da seguinte máxima de Hipócrates: “O print é eterno.”

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Reposted by José Carlos Souto (@jcsouto)

Eric Topol @erictopol.bsky.social · 09/11/2025

visual abstract of the trial and results

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Reposted by José Carlos Souto (@jcsouto)

Elisa Brietzke MD, PhD @ebrietzke.bsky.social · 06/11/2025

Quero falar sobre a meta-análise de Dieta Cetogênica na Depressão e na Ansiedade que saiu no @JAMAPsych porque sei que amanhã a PICARETOSFERA inteira vai repercutir e vocês precisam saber o significado desses achados. Segue o fio 🧵. jamanetwork.com/journals/jam...

jamanetwork.com

Ketogenic Diets and Depression and Anxiety

This systematic review and meta-analysis assesses the associations between ketogenic diets and mental health outcomes in adults, with a focus on depressive and anxiety symptoms.

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 06/11/2025

Já tem MUITO mais evidências do que outras coisas que, lamentavelmente, foram incluídas no SUS (homeopatia e outras bruxarias do gênero). Não estou sugerindo a inclusão precoce, mas era só pra não deixar passar isso...

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 21/10/2025

Tive que comprar às pressas NO MESMO DIA um voo de Oslo para Bergen. Custou 200 dólares *com direito a mala despachada* (empresa Norwegian). Tá bem que Porto Alegre é mais legal 😂

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 29/09/2025

This is a fascinating story. A Lebanese team published a study showing massive benefits for apple cider vinegar in 2024. People immediately noticed it was problematic, and complained. BMJ asked the authors for the data, and they sent it through. The study has just been retracted and WOW 1/n

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 26/09/2025

New piece out - do soft drinks give you depression? Probably not. The evidence is SUPER weak. gidmk.substack.com/p/soft-drink...

gidmk.substack.com

Soft Drinks Probably Aren't Making You Depressed

Why soda/pop/soft drinks probably aren't causing depression.

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 26/09/2025

10/n Regardless, all of this fuss and noise about soft drinks and depression comes from a cross-sectional study that only assessed soft drink consumption at one time point and did not follow-up patients at all. Which is absurd.

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 26/09/2025

4/n This is straightforwardly meaningless scientifically. It was a cross-sectional survey of food consumption with some gut microbiome assessment thrown in. According to their methods, the only covariates included in the logistic model here were age and sex.

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Reposted by José Carlos Souto (@jcsouto)

Health Nerd @gidmk.bsky.social · 26/09/2025

Science can be such a headache sometimes. This study has hit the headlines because the authors claim that it shows that soft drinks cause people to be depressed by negatively impacting their gut microbiome. Several BIG issues with this 1/n

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 19/09/2025

Como escrevi na semana passada, esse estudo altamente problemático jamais permitiria sugerir que adoçantes em geral sejam deletérios para o cérebro, muito menos adoçantes específicos. A reprodução totalmente acrítica pela mídia é algo que precisa ser repensado

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Reposted by José Carlos Souto (@jcsouto)

Sophie E. Hill @sophieehill.bsky.social · 19/09/2025

Groundbreaking! @gidmk.bsky.social and @slate.com prove that you can cover an academic study by actually *reading* it, not just regurgitating every breathless bullet point from the press release... This is what science journalism should look like 👇 slate.com/technology/2...

slate.com

Scientists Tested the Link Between Artificial Sweetener and Cognitive Decline. Here’s What You Need to Know.

Scientists tested for links between artificial sweeteners and cognitive decline.

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 11/09/2025

O Fux está inocentando o Paulo Sérgio porque o Paulo Sérgio tentou demover Jair de dar um golpe. Mas ele acabou de inocentar o Jair de golpe 🤷 É o golpe de Schrödinger

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Reposted by José Carlos Souto (@jcsouto)

F. Perry Wilson, MD @fperrywilson.bsky.social · 09/09/2025

We've all had this conversation before: "Dude, we both agree this is red... but how do I know what I see as red is what you see as red? Maybe you see red as I see blue." Mind blown lol. But we finally have some research that sheds light (and color) on the issue. (Thread)

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 08/09/2025

O artigo sobre adoçantes e declínio cognitivo, além dos problemas que já citei ontem aqui e no último episódio do podcast Comida sem Filtro, está repleto de erros estatísticos, se vê nesse fio

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Reposted by José Carlos Souto (@jcsouto)

Carl Müller-Crepon @carlmc.bsky.social · 06/09/2025

It’s really worrying that it takes a political scientist to point out all these irregularities in a paper that is picked up to such an extent by the press — reviewers, science editors, anyone listening? Anyone bothered to ask for the underlying data & code?

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 08/09/2025

Smarter people than me found worrisome mistakes: bsky.app/profile/soph...

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 08/09/2025

14/ 👉 Conclusion:📌 It makes no sense to claim that 7 different molecules all cause the same brain damage just because they’re sweet. The study does not show causality, nor clinical relevance. The tagatose debacle shows the findings are just statistical noise and confounding by indication

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 08/09/2025

13/ 👉 In the end, the study proves only one thing: When you cross FFQs with food composition tables and dozens of unadjusted tests, you can “find” an association between any molecule and any outcome.🤯 Even a molecule that nobody actually consumed. Tooth Fairy science + Schrödinger's sweetener

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José Carlos Souto (@jcsouto) @jcsouto.bsky.social · 08/09/2025

12/ 👉 Eighth: biological implausibility. It’s impossible that 7 COMPLETELY different molecules (saccharin, erythritol, etc.) all cause the same brain damage 🧠. What do they have in common? They’re used by people already at higher risk (diabetics, obese, hypertensive). Tagatose wasn't even used!

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