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Journal of Clinical Investigation @jci.org · 8h

In this working model inhibition of LSD1 by its specific inhibitor ORY- 1001 could reduce LSD1 expression, and treatment with senolytic drugs (Dasatinib and Quercetin) could ameliorate cellular senescence and organ aging.

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Journal of Clinical Investigation @jci.org · 8h

Could targeting LSD1 be a novel strategy to decrease senescence, organ aging, and hair graying? doi.org/10.1172/JCI1... Zhang et al. demonstrate LSD1 as a key regulator of DNA damage-induced senescence and organ aging and highlights it as a promising therapeutic target.

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Journal of Clinical Investigation @jci.org · 29/09/2026

Casalino-Matsuda et al. analyzed serially collected alveolar samples from unvaccinated patients with severe #SARSCoV2 pneumonia treated with Auxora vs placebo & find Auxora reprograms pathogenic alveolar macrophage–T cell circuits in viral pneumonia: doi.org/10.1172/JCI2... catgaohow.bsky.social

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Journal of Clinical Investigation @jci.org · 28/09/2026

For the first time, gene therapy successfully treats Cockayne Syndrome in mice: doi.org/10.1172/JCI1... Batista et al. show the AAV-mediated gene therapy corrected the DNA damage hypersensitivity of CSA-deficient human cells extended lifespan safely in mice.

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Journal of Clinical Investigation @jci.org · 28/09/2026

DEG-77 in combination with ribociclib improves progression-free survival in a CDK4/6i-refractory preclinical model of ER+/Her2– breast cancer: doi.org/10.1172/JCI1...

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Journal of Clinical Investigation @jci.org · 28/09/2026

Presenting phosphorylated FADD as a novel driver of resistance in breast cancer: doi.org/10.1172/JCI1... Awadia et al. find that blocking FADD phosphorylation restored CDK4/6 inhibitor sensitivity and improved tumor control in resistant ER+ breast cancer models.

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Journal of Clinical Investigation @jci.org · 27/09/2026

Sunday Read💫: The difference between cysts & no cysts in polycystic kidney disease. Li et al. @yalenephrology.bsky.social show that upstream protein translation on the PKD1 transcript blunts PC1 expression & can be blocked to therapeutically increase expression in PKD: doi.org/10.1172/JCI2...

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Journal of Clinical Investigation @jci.org · 26/09/2026

Weekend highlight💫: Targeting ferroptosis in heart and kidney disease: doi.org/10.1172/JCI2... In this Review, Hossein Ardehali @hosseinardehali.bsky.social & colleagues describe the diverse physiological and pathological roles of ferroptosis and its potential as a therapeutic target.

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Journal of Clinical Investigation @jci.org · 25/09/2026

TGF-β serves as a critical signaling determinant of liver progenitor cell activation and function: doi.org/10.1172/JCI1...

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Journal of Clinical Investigation @jci.org · 25/09/2026

A potential therapeutic target for liver failure. Tong et al. @uniheidelberg.bsky.social explore the repair process in liver failure using several models, reporting that TGF-β serves as a critical signaling determinant of liver progenitor cell activation & function: doi.org/10.1172/JCI1...

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Journal of Clinical Investigation @jci.org · 24/09/2026

Could excess complement activation lead to more thrombosis and miscarriages? doi.org/10.1172/JCI2... Using mouse models, Smid et al. reveal cooperation between platelets, coagulation, and complement in establishing maternal blood flow to the placenta.

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Journal of Clinical Investigation @jci.org · 23/09/2026

From silos to synergy: The interdisciplinary discovery potential in redefining polyendocrine metabolic ovarian syndrome: doi.org/10.1172/JCI2... Morhaus et al. provide a Commentary on Morhaus et al.: doi.org/10.1172/JCI1... #PMOS #PCOS

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Journal of Clinical Investigation @jci.org · 23/09/2026

Here is a sneak peek at the Commentary highlight by Morhaus et al.: doi.org/10.1172/JCI2...

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Journal of Clinical Investigation @jci.org · 23/09/2026

Highlighting the genetic architecture bridging ovarian and metabolic mechanisms in PMOS doi.org/10.1172/JCI1... Nguyen et al. integrate human and mouse genetic data to reveal connections between reproductive, endocrine, and cardiometabolic aspects of PMOS/PCOS.

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Journal of Clinical Investigation @jci.org · 22/09/2026

The difference between cysts & no cysts in polycystic kidney disease: doi.org/10.1172/JCI2... Li et al. @yalenephrology.bsky.social show that upstream protein translation on the PKD1 transcript blunts Polycystin-1 expression & can be blocked to therapeutically increase expression in PKD

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Journal of Clinical Investigation @jci.org · 21/09/2026

Going to the source: pancreatic lymph nodes maintain stem-like CD8+ T cells in human type 1 diabetes: doi.org/10.1172/JCI2... Fatoumata Samassa, Sylvaine You, & Roberto Mallone @institutcochin.bsky.social write a Commentary on Peters et al.: doi.org/10.1172/JCI1...

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Reposted by Journal of Clinical Investigation

Elizabeth Thompson @e-thompson-lab.bsky.social · 18/09/2026

I’m very happy to share that our work looking at the role of B cell lipid metabolism in driving response to vaccination during immunosuppression is now (finally!) out online and published as an in press preview at JCI - www.jci.org/articles/vie...

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Journal of Clinical Investigation @jci.org · 21/09/2026

Pancreatic lymph nodes house T1D-like CD8 T cells with self-renewing features doi.org/10.1172/JCI1... Todd M Brusko @bruskolab.bsky.social & team profiled T cells in T1D, highlighting a stem-like population in lymph nodes as a potential source for pancreatic autoreactive T cells.

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Journal of Clinical Investigation @jci.org · 20/09/2026

2/ Cilia–to–basement membrane signaling initiates cystogenesis in the #kidney doi.org/10.1172/JCI1... Mazloum et al. @inem-necker.bsky.social link polycystin-1 loss in ADPKD to tubule basement membrane remodeling in a model that implicates both luminal and basolateral mechanisms in cyst formation.

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Journal of Clinical Investigation @jci.org · 20/09/2026

1/ Highlighting authors behind the Cover💫: Coauthors (from left to right), Manal Mazloum, Frank Bienaimé, Vicky Scata, & Rushdi Alghamdi are featured here working @inem-necker.bsky.social in Paris, France with one of the TEM microscopes used to demonstrate basement membrane thinning in #ADPKD

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Journal of Clinical Investigation @jci.org · 19/09/2026

Obesity enhances HO formation and impairs functional recovery after injury: doi.org/10.1172/JCI2...

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Journal of Clinical Investigation @jci.org · 19/09/2026

Saturday spotlight💫: Dietary omega-6 lipids drive aberrant tissue repair in #obesity: doi.org/10.1172/JCI2... Obesity is linked to impaired healing, including #HeterotopicOssification (HO) at the injury site. Benjamin Levi & team implicate dietary #Omega6 lipids in this elevated risk for HO.

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Journal of Clinical Investigation @jci.org · 18/09/2026

Targeting ferroptosis in heart and kidney disease: doi.org/10.1172/JCI2... In this Review, Hossein Ardehali @hosseinardehali.bsky.social & colleagues describe the diverse physiological and pathological roles of ferroptosis and its potential as a therapeutic target.

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Journal of Clinical Investigation @jci.org · 17/09/2026

Commentary: Imaging B-Cell Maturation Antigen in Multiple Myeloma: doi.org/10.1172/JCI2... Yangmeihui Song, Wenyu Song, & Weibo Cai discuss Gu et al.: doi.org/10.1172/JCI2...

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Reposted by Journal of Clinical Investigation

Ashish Kumar @iamashish008.bsky.social · 16/09/2026

Excited to share my first paper as a co-first author, now published in the Journal of Clinical Investigation! 🎉 📄 J Clin Invest. 2026 🔗 doi.org/10.1172/JCI2... #Diabetes #BetaCells #CellSignaling #BiomedicalResearch #JCI #PhDResearchhttps://www.jci.org/articles/view/202344

jci.org

JCI - Acute activation of Gq-signaling in pancreatic islet macrophages inhibits insulin secretion through AMPK-sphingolipid axis

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Reposted by Journal of Clinical Investigation

Mriganka Sarkar @mriganka8016.bsky.social · 16/09/2026

I am grateful to have contributed to this work as the 2nd author, particularly through my involvement in Lipidomics and scRNA-seq analysis, alongside my M.Tech project during my time at BSBE, IIT Kanpur.🎉🎉

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Journal of Clinical Investigation @jci.org · 17/09/2026

Here is a peek at the Commentary by Song et al.: doi.org/10.1172/JCI2...

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Journal of Clinical Investigation @jci.org · 17/09/2026

BCMA imaging enables a more complete picture of multiple myeloma doi.org/10.1172/JCI2... Gu et al. show that a BCMA-targeted PET tracer measures both tumor burden and disease activity in multiple myeloma with superior sensitivity and selectivity to metabolic imaging.

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Journal of Clinical Investigation @jci.org · 16/09/2026

Nominating CARD8 and Caspase-1 as therapeutic targets for patients with Hatipoglu syndrome: doi.org/10.1172/JCI2... Xiao et al. @yaleschoolofmed.bsky.social develop a new way to model this human genetic disease and discover why patients with DPP9 deficiency have loss of blood cells.

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Journal of Clinical Investigation @jci.org · 16/09/2026

This year’s theme for #PeerReviewWeek is Peer Review Capacity: Volume, Speed, and Quality. In today's changing publishing landscape, we commend our reviewers for meeting the demands, maintaining the highest standards, and staying true to the peer review process. Thank you Reviewers! #PRW #PRW2026

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Journal of Clinical Investigation @jci.org · 16/09/2026

Understanding migraine mechanisms: doi.org/10.1172/JCI2... Hemiplegic migraine involves headache preceded by motor weakness. In this Review, Daniela Pietrobon discuss the genetics of this condition, and potential approaches to treat the pain and motor symptoms.

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Journal of Clinical Investigation @jci.org · 15/09/2026

Evidence for a tubular basement membrane-cilia connection in autosomal dominant #PolycysticKidneyDisease pathogenesis: doi.org/10.1172/JCI2... Caroline R Sussman & Peter C Harris @mayoclinic.org comment on Mazloum et al.: doi.org/10.1172/JCI1... #PKD #KidneyResearch

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Journal of Clinical Investigation @jci.org · 15/09/2026

Cilia–to–basement membrane signaling is a biomechanical driver in models of autosomal dominant polycystic kidney disease: doi.org/10.1172/JCI1...

doi.org

JCI - Cilia to basement membrane signaling is a biomechanical driver in models of autosomal dominant polycystic kidney disease

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Journal of Clinical Investigation @jci.org · 15/09/2026

Behind the Scenes: Coauthors (from left to right), Manal Mazloum, Frank Bienaimé, Vicky Scata, & Rushdi Alghamdi working @inem-necker.bsky.social in Paris, France with one of the TEM microscopes used to demonstrate basement membrane thinning in ADPKD

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Journal of Clinical Investigation @jci.org · 15/09/2026

Cilia–to–basement membrane signaling initiates cystogenesis in the kidney doi.org/10.1172/JCI1... The Cover features work by Mazloum et al. @inem-necker.bsky.social showing basement membrane remodeling drives cyst formation in autosomal dominant kidney disease

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Journal of Clinical Investigation @jci.org · 14/09/2026

Sensory Neuron BRAF Mediates Opioid-Induced Hyperalgesia and Tolerance via Presynaptic NMDA Receptor Hyperactivity: doi.org/10.1172/JCI2...

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Journal of Clinical Investigation @jci.org · 14/09/2026

Opioid use can worsen pain over time by increasing pain sensitivity while decreasing its relief Here, Hui-Lin Pan & team report that opioids activate the cancer-related protein kinase BRAF in sensory neurons to increase pain signaling: doi.org/10.1172/JCI2...

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Journal of Clinical Investigation @jci.org · 14/09/2026

GLP-1–targeted therapies for alcohol and other substance use disorders: a new era on the horizon? doi.org/10.1172/JCI2... A Viewpoint by Lorenzo Leggio & W. Kyle Simmons

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Journal of Clinical Investigation @jci.org · 13/09/2026

Sunday Spotlight💫: Proposing a combination treatment for reducing death from cerebral malaria: doi.org/10.1172/JCI2... Alvin H. Schmaier & team report on a role for bradykinin in cerebral malaria and find plasma kallkrein inhibitors target host-mediated vascular dysfunction.

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Journal of Clinical Investigation @jci.org · 13/09/2026

Read the author’s response✏️: Jay D. Horton & colleagues reply to Making sense of cardiomyopathy caused by deletion of acetyl-CoA carboxylase 1 and 2: doi.org/10.1172/JCI2...

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Journal of Clinical Investigation @jci.org · 13/09/2026

We previously posted about Kim et al. as a landmark in cardiac metabolism. In a recent Letter to the Editor✏️ Rong Tian & E. Douglas Lewandowski present Making sense of cardiomyopathy caused by deletion of acetyl-CoA carboxylase 1 and 2: doi.org/10.1172/JCI2... @the-asci.org

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Journal of Clinical Investigation @jci.org · 12/09/2026

Distinct parafascicular neuronal ensembles mediate the sensory and affective dimensions of trigeminal neuralgia: doi.org/10.1172/JCI2...

doi.org

JCI - Distinct parafascicular neuronal ensembles mediate the sensory and affective dimensions of trigeminal neuralgia

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Journal of Clinical Investigation @jci.org · 12/09/2026

Revealing how chronic pain and emotional distress become linked: doi.org/10.1172/JCI2... Lu et al. find distinct brain circuits in the parafascicular nucleus independently drive facial pain and anxiety in trigeminal neuralgia.

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Journal of Clinical Investigation @jci.org · 12/09/2026

Saturday Spotlight💫: As part of JCI’s review series on neurodegeneration, Erika Holzbaur & colleagues present: Mitophagy in neuronal health and disease: from mechanisms to neurodegeneration: doi.org/10.1172/JCI1...

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Journal of Clinical Investigation @jci.org · 11/09/2026

The alpha and the omega (6 lipids): discovering dietary drivers of heterotopic ossification: doi.org/10.1172/JCI2... Peyton L. Carpen & Matthew B. Greenblatt provide a Commentary on Moye et al.: doi.org/10.1172/JCI2...

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Journal of Clinical Investigation @jci.org · 11/09/2026

See the Commentary by Peyton L. Carpen & Matthew B. Greenblatt: doi.org/10.1172/JCI2...

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Journal of Clinical Investigation @jci.org · 11/09/2026

Dietary omega-6 lipids promote post-injury aberrant bone formation in obesity: doi.org/10.1172/JCI2...

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Journal of Clinical Investigation @jci.org · 11/09/2026

Dietary fats drive aberrant tissue repair in obesity: doi.org/10.1172/JCI2... Obesity is linked to impaired healing, including heterotopic ossification (HO) at the injury site. Benjamin Levi & team implicate dietary omega-6 lipids in this elevated risk for HO. @mathews-tom.bsky.social @the-asci.org

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