iiinova — where your digital self keeps evolving

Jorge Castorena @jcastorena.bsky.social · 05/06/2026

A lot remains to be uncovered about the underlying signaling in lymphatic GLP-1Rs, but this is the first of hopefully many studies on this newish project from our lab. Congrats to @maryschulz.bsky.social on her second first author publication with our lab during her PhD.

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Jorge Castorena @jcastorena.bsky.social · 13/02/2026

We had a very productive day at the lab today, testing yet-another antibody for GLP-1R and a potential new marker for lymphatic endothelial cells… we also had our last King Cake of the season as a lab. We are on home stretch for Mardi Gras 2026!

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Jorge Castorena @jcastorena.bsky.social · 05/02/2026

We decided to start keeping track of the number of isolated lymphatics we successfully study. A strong 138 vessels in January… and not too shabby for a PI to run 52. @maryschulz.bsky.social is killing it, her and I hogged our 2 systems. I’m sure @keithkeane.bsky.social will have a strong February.

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Jorge Castorena @jcastorena.bsky.social · 27/12/2025

Our new preprint led by @maryschulz.bsky.social is now up. We show that semaglutide enhances the pumping capacity of collecting lymphatics. Our results support recent case reports suggesting beneficial effects of GLP-1R agonists in secondary lymphedema patients. www.biorxiv.org/content/10.6...

biorxiv.org

GLP-1R Agonism Directly Improves the Pumping Capacity of Murine Collecting Lymphatic Vessels

Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists have recently been suggested as effective therapies to treat or reduce the risk of developing secondary lymphedema in patients with obesi...

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Jorge Castorena @jcastorena.bsky.social · 17/08/2025

Happy Birthday, next time have them include Cookie Monster!

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Jorge Castorena @jcastorena.bsky.social · 13/08/2025

Very proud of my student @maryschulz.bsky.social, who just received a NOA for her NIH-F31 project to study obesity-induced lymphatic dysfunction and explore novel therapeutics. Also, her recent paper (www.ahajournals.org/doi/10.1161/...), has been highlighted by an Editorial at ATVB. Congrats, Mary!

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Reposted by Jorge Castorena

Hans schoofs @hansschoofs.bsky.social · 15/07/2025

This beautiful work from the lab in Uppsala @taijamakinenlab.bs made it to the cover ! Happy to be part of it ! Congrats again to the first author Marle Kraft ! Stunning images

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Jorge Castorena @jcastorena.bsky.social · 20/06/2025

Thank you very much for the nice review and highlight of our work.

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Reposted by Jorge Castorena

Hao Yin @haoyin.bsky.social · 19/06/2025

scRNAseq of🐭collecting lymphatic vessels😎 Cell type-specific #LymphaticEndothelialCell vs peri-lymphatic myeloid cell contributions of TRPV4 in distinct stages of lymphatic contractile activity @maryschulz.bsky.social @jcastorena.bsky.social #ATVB 2025 www.ahajournals.org/doi/full/10....

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Jorge Castorena @jcastorena.bsky.social · 15/06/2025

Our lab had a great time learning and catching up with friends and colleagues at the Lymphatic Forum 2025. Congrats to @maryschulz.bsky.social and @keithkeane.bsky.social for receiving Travel Awards! Thank you @navbo.bsky.social, LE&RN, and @mcsociety.bsky.social for your support.

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Jorge Castorena @jcastorena.bsky.social · 01/05/2025

It looks like a huge vessel, based on lumen size… maybe a pig, horse, or monkey?

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Jorge Castorena @jcastorena.bsky.social · 01/05/2025

Our study with Mike Davis showing that a component of the lymphatic contractile impairment in db/db mice is mediated by the activation of KATP channels in lymphatic muscle cells, in part due to chronic metabolic stress associated with elevated glucose, is now out. www.frontiersin.org/journals/phy...

frontiersin.org

Frontiers | Chronic metabolic stress impairs lymphatic contractility via activation of KATP channels in a mouse model of Type-2 diabetes

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Jorge Castorena @jcastorena.bsky.social · 28/04/2025

Congrats, Manuel! This is a very well deserved recognition of your impactful work.

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Reposted by Jorge Castorena

Vincenza Cifarelli, PhD @cifarelliv.bsky.social · 12/03/2025

Our latest publication investigating the role of #palmitoylation in #lymphatic endothelial integrity. Big shoutout to Silvia Gonzalez-Nieves, Simon GUIGNARD and Thi Nguyen for their incredible work and dedication. 👏👏 www.sciencedirect.com/science/arti...

sciencedirect.com

Insulin regulates lymphatic endothelial integrity via palmitoylation

Lipid metabolism plays a critical role in lymphatic endothelial cell (LEC) development and vessel maintenance. Altered lipid metabolism is associated …

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Jorge Castorena @jcastorena.bsky.social · 12/03/2025

Congrats to you, Silvia, and the entire team!

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Reposted by Jorge Castorena

Kalev Freeman @uvmtraumalab.bsky.social · 04/02/2025

We are studying the biology of wound healing, using the smallest possible acute vascular injury we can imagine—a 5 um micropoint pulsed laser deformation of the endothelial cell plasma membrane. 🧪 #MedSky #EMSky #EMedSky #immunosky

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Jorge Castorena @jcastorena.bsky.social · 23/01/2025

Many saw this coming, unfortunately not enough. We’ll have to work through the new extra barriers they’ll put in front of us, and continue to do what we love doing.

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Reposted by Jorge Castorena

Brant Isakson @brantisakson.bsky.social · 07/01/2025

🦕🦕 I’m happy this fun little book is finally out exploring how the physiology of the sauropod dino helped contribute to its dominance on earth for so long. However, I think I’ll stick to my day job 😁 🦕🦕

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