Reposted by Jay RosheARPA-H @arpa-h.bsky.social · 30/09/2026What if clinical trials could run start to finish in under 4 years? ARPA-H’s SURPASS program is taking on that challenge. We’re calling on top minds in AI, biostatistics, clinical operations, and regulatory science to join us. Learn more ➡️ arpa-h.gov/explore-fund... 021
Reposted by Jay RosheThe Longevity Initiative @thelongevityinitiative.org · 30/09/2026The longevity science community is converging on Boston for ARDD and Biomarkers of Aging… and The Longevity Initiative will be there! We’re fundraising, and looking for collaborators to bring regulation and public understanding up to speed with the latest breakthroughs in longevity science. 114
Jay Roshe @jayroshe.bsky.social · 24/09/2026Yikes, I forgot to get that done! Thanks for the reminder. 010
Jay Roshe @jayroshe.bsky.social · 20/09/2026I'd be curious to know your take on other XPrize Healthspan finalists. At the bottom of this article is a table of the 10 finalists (and 10 honorable mentions) with a description of their intervention. thelongevityinitiative.org/2026/08/xpri... 010
Jay Roshe @jayroshe.bsky.social · 01/09/2026I'm confident I'd be one of those people who is just fine with only hobby hobbies instead of a job hobby. 010
Jay Roshe @jayroshe.bsky.social · 15/07/2026If this passes the Senate and if history is any guide, people will realize how terrible this is in the winter (especially in Massachusetts), and the public will demand it be reversed within a year. This is exactly what happened in the 1970s when Congress made this mistake. 070
Reposted by Jay RosheEric Topol @erictopol.bsky.social · 02/06/2026"new ways to circumvent the will of Congress and starve American science" www.science.org/doi/10.1126/... @science.org @holdenthorp.bsky.socialscience.orgAnother red alert for American scienceAlthough research has bipartisan support in the US Congress, and trust in science is above 75% across the country, the Trump administration seems as determined as ever to mortally wound the nation’s s... 411854
Reposted by Jay RosheRep. Scott Peters @repscottpeters.bsky.social · 29/05/2026Emerald from Rancho Bernardo needed help with a delayed grant that threatened layoffs at UCSD’s Biodynamics Lab. My staff worked with Emerald and the NIH to determine the cause of the grant’s delay and within a month, the lab received their full grant funding! 061
Jay Roshe @jayroshe.bsky.social · 26/05/2026In addition to coverage, protecting funding for mental health research breakthroughs is also critical. ARPA-H funding must be protected in 2027, so that research programs like EVIDENT can realize their full potential. arpa-h.gov/explore-fund...arpa-h.govEvidence-Based Validation & Innovation for Rapid Therapeutics in Behavioral Health (EVIDENT)The Advanced Research Projects Agency for Health (ARPA-H) supports transformative research ranging in scale from molecular to societal to deliver health breakthroughs in years, not decades. 0210
Jay Roshe @jayroshe.bsky.social · 26/05/2026Absolutely. Anything to increase housing supply is highly impactful. 0140
Reposted by Jay RosheAmerican Aging Association @americanaging.bsky.social · 18/05/2026Every $1B cut to NIH = ~8 fewer approved drugs over a decade. Proposed $18B NIH cuts = risk of 144 fewer treatments reaching patients. The #geroscience pipeline is in the line of fire. www.brookings.edu/articles/the... #NIH #AgingResearch #ResearchFunding 032
Jay Roshe @jayroshe.bsky.social · 14/05/2026"...and a high-quality study could take many years, or even decades." A primary objective of ARPA-H's PROSPR program is to create surrogate biomarkers of aging to determine in much less time if an intervention is working or not, rather than running incredibly long trials. 120
Reposted by Jay RosheThe Jackson Laboratory @jax.org · 05/05/2026Now hiring in NYC: Senior Director of Research Programs at The Jackson Laboratory. Define and drive the strategic vision for the research programs portfolio, lead project teams and partner with industry to advance translational models: go.jax.org/08aetr 🧪 💼 go.jax.orgSenior Director, Research ProgramsThe Senior Director of Research Programs is responsible for the project management team and for overseeing project monitoring, reporting, and delivery in alignment with research strategy goals and tactics. The role provides strategic guidance to senior ... 011
Jay Roshe @jayroshe.bsky.social · 02/05/2026Very well-written article. Calorie-restriction interventions (or those that imitate them genetically like Kenyon's IGF-1 signaling) have much larger effects as a percentage on lifespan of short-lived species. Nematode worm lifespan has been increased up to 5x, while mice have come nowhere near that. 020
Reposted by Jay RosheRoss Andersen @rossandersen.bsky.social · 02/05/2026This is a story about life extension for dogs, in which my own pup makes several appearances www.theatlantic.com/science/2026...theatlantic.comYour Next Dog May Live LongerA new pill could soon extend dogs’ lives. How will that change our relationship with our pets? 1112
Jay Roshe @jayroshe.bsky.social · 01/05/2026Christin Glorioso writes about BioAge Labs' NLRP3 inhibitor which cleared a Phase 1 clinical trial: drglorioso.substack.com/p/bioages-lo...drglorioso.substack.comBioAge’s Longevity Drug Cleared Phase 1 with an 86% Drop in InflammationInflammaging, CRP, and the longevity drugs coming to reduce them 000
Jay Roshe @jayroshe.bsky.social · 30/04/2026Read up about the course ARPA-H programs take from beginning to end: arpa-h.gov/news-and-eve...arpa-h.govARPA-H 101: The lifecycle of an ARPA-H programThe Advanced Research Projects Agency for Health (ARPA-H) supports transformative research ranging in scale from molecular to societal to deliver health breakthroughs in years, not decades. 000
Jay Roshe @jayroshe.bsky.social · 20/04/2026Seems like ARPA-H STOMP's mission is important: '"What if we could detect, understand the health impacts of, and remove toxic microplastics from the body?" arpa-h.gov/explore-fund...arpa-h.govSTOMPThe Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs ranging from molecular to societal to provide transformative hea... 120
Jay Roshe @jayroshe.bsky.social · 18/04/2026Biomarkers of Aging Consortium has started uploading recordings from the Oct. 2025 conference: www.youtube.com/@Biomarkerso...youtube.comBiomarkers of Aging ConsortiumEstablishing Reliable Biomarkers of Aging for Longevity Interventions. 000
Reposted by Jay RosheThe Jackson Laboratory @jax.org · 16/04/2026Registration is now open for the 2026 JAX–NYSCF Conference. 🧬 Marking the anniversary of iPSC discovery, this year’s meeting brings together global leaders in stem cell science to share breakthroughs and shape what’s next in translational research. Join us: go.jax.org/jax-nyscf-conf 021
Jay Roshe @jayroshe.bsky.social · 13/04/2026You're right that age-related diseases are projected to increase dramatically with an increasingly older population. That's why Congress has to protect and increase funding for geroscience research across NIA, NIH, and ARPA-H to make strides against age-related illnesses. 000
Jay Roshe @jayroshe.bsky.social · 03/04/2026ARPA-H has announced a new program that aims to detect, understand the health impacts of, and remove microplastics from the body: arpa-h.gov/explore-fund...arpa-h.govSTOMPThe Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs ranging from molecular to societal to provide transformative hea... 000
Jay Roshe @jayroshe.bsky.social · 01/04/2026Here's an example of a research paper that examines the question of increasing healthy life expectancy: www.nature.com/articles/s43... For additional reading, there have been various papers on something called the "longevity dividend".nature.comThe economic value of targeting aging - Nature AgingAn economic analysis suggests that targeting aging offers potentially larger economic gains than eradicating individual diseases. Slowing aging to increase life expectancy by 1 year is worth US$38 tri... 030
Reposted by Jay RosheOklahoma Nathan Shock Center @oknathanshock.bsky.social · 30/03/2026The Oklahoma Nathan Shock Center Translational Pilot Awards open this Wednesday, April 1! 🔗 For more information: oklahomanathanshockcenteronaging.org/translationa... #Geroscience 011
Reposted by Jay RosheOklahoma Nathan Shock Center @oknathanshock.bsky.social · 01/04/2026Submissions for the OKNSC Translational Pilot Awards are now open! 011
Jay Roshe @jayroshe.bsky.social · 19/03/2026There is scant evidence to justify claims made by promoters behind the peptide craze. People should also know there are risks to taking these injections. Thankfully Nevada regulators helped hold some of these promoters accountable for violating state law: www.propublica.org/article/raad...propublica.orgNevada Regulators Fine Peptide Providers at Anti-Aging Festival Where Two Women Became Critically IllThree individuals, along with the group accused of supplying the peptides, were fined between $5,000 and $10,000 for their involvement in an incident at the Revolution Against Aging and Death Festival... 011
Jay Roshe @jayroshe.bsky.social · 14/03/2026@trahan.house.gov Your support for ARPA-H is commendable, and I urge you also to act to protect researchers supported by NIA grants. Even if Congress restores funding levels, research can be sabotaged by low grant approval rates. Your support for NIA research is urgently needed. 000
Jay Roshe @jayroshe.bsky.social · 14/03/2026Thank you for your support of ARPA-H and for your participation in the Longevity Science Caucus. The PROSPR and FRONT programs in ARPA-H are especially inspiring and great examples of bold research within geroscience. 000
Reposted by Jay RosheScience Magazine @science.org · 09/03/2026ARPA-H will “build the train tracks” for the first large clinical studies of aging interventions. scim.ag/4dcPEJj scim.agU.S. agency will devote $144 million to studies that slow aging, extend quality of lifeARPA-H will “build the train tracks” for first large clinical studies of aging interventions 1204
Jay Roshe @jayroshe.bsky.social · 08/03/2026An informative overview on research and trials of mTOR-targeting interventions by Nicolas di Leo with a mention of @lamminglab.bsky.social, @arpa-h.bsky.social, and many others : norngroup.substack.com/p/advancing-...norngroup.substack.comAdvancing Longevity Trials: Lessons from mTOR-Targeting InterventionsWhat two decades of trials can teach us about translating rapamycin to human aging. 010
Reposted by Jay RosheJoao Pedro Magalhaes @jpsenescence.bsky.social · 03/03/2026🚨 The Human Ageing Genomic Resources Are at Risk For over 20 years, our Human Ageing Genomic Resources (HAGR) have supported ageing and longevity research. We are raising funds to secure their continuity while we pursue long-term funding. www.justgiving.com/page/human-a...justgiving.comSupport the Human Ageing Genomic ResourcesHelp Joao Pedro Magalhaes raise money to support University of Birmingham 055
Jay Roshe @jayroshe.bsky.social · 02/03/2026Nir Barzilai was elected to the Association of American Physicians: www.afar.org/news/afar-bo...afar.orgAFAR Board Member in the News: Nir Barzilai, MD, elected to the Association of American Physicians (AAP) - American Federation for Aging ResearchAFAR is pleased to announce that Board Member Nir Barzilai, MD, has been elected to the Association of American Physicians (AAP), one of the most 010
Jay Roshe @jayroshe.bsky.social · 26/02/2026@liccardo.house.gov Congratulations to Stanford University in your district! They are one of the awardees in the @arpa-h.bsky.social PROSPR program. This is an important development for the Longevity Science Caucus. Thanks for being a member and supporting geroscience. arpa-h.gov/news-and-eve...arpa-h.govResearch teams to add more healthy years to Americans’ lives as they ageThe Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs ranging from molecular to societal to provide transformative hea... 000
Jay Roshe @jayroshe.bsky.social · 25/02/2026Christin Glorioso also wrote her thoughts on the trial, and she mentions you too: drglorioso.substack.com/p/the-new-yo... 100
Reposted by Jay RosheARPA-H @arpa-h.bsky.social · 24/02/2026Most of us don’t just want longer lives, but more years of good health. PROSPR awardees are spotting early signs that health is slipping, building systems for aging clinical trials & testing new drugs that could be the 1st gen drugs to extend healthy years. Meet the teams: arpa-h.gov/news-and-eve... 011
Jay Roshe @jayroshe.bsky.social · 11/02/2026You might be interested in following Loyal's clinical trial to increase canine healthy lifespan: www.fastcompany.com/91490365/loy... Their blog is also interesting reading: loyal.com/blogfastcompany.comThis startup raised $250 million to help dogs live longerLongevity Fund-backed Loyal is working toward FDA approval of a drug that could help dogs live longer, healthier lives. 130
Reposted by Jay RosheARPA-H @arpa-h.bsky.social · 11/02/2026🚨 BIOGAMI Proposers' Day Registration is closing soon – sign up by Feb. 18 at 5pm ET for in-person attendance, or by Feb. 19 at noon ET for virtual attendance. arpa-h.gov/explore-fund... 011
Jay Roshe @jayroshe.bsky.social · 04/02/2026I wonder if the term "geroscience" would be better than "longevity." "Longevity" has been adopted by quacks and grifters and is also used in many different ways. "Geroscience" might be reserved for more narrow use of research on aging biology and associated clinical trials. 100
Jay Roshe @jayroshe.bsky.social · 30/01/2026This is encouraging and shows why medical research targeting aging biology to impact age-related health decline is only growing in importance. Tyler Cowen, Richard Evans, and other economists recently helped produced this interactive on ROI of R&D in Geroscience: silverlinings.bio?chapter=abou...silverlinings.bioSilver LiningsGenerated by create next app 000
Reposted by Jay RosheMichael Ringel | Chief Operating Officer, Life Biosciences @michaelringel.bsky.social · 28/01/2026@lifebiosciences.bsky.social, founded by @davidsinclairphd.bsky.social & Tristan Edwards, helmed by CEO Jerry McLaughlin, has received @fda.gov IND clearance for cellular rejuvenation using partial epigenetic reprogramming in optic neuropathies. I'm so proud: www.lifebiosciences.com/life-bioscie...lifebiosciences.comLife Biosciences Announces FDA Clearance of IND Application for ER-100 in Optic NeuropathiesIND clearance marks the first ever cellular rejuvenation therapy using partial epigenetic reprogramming to reach human clinical trials BOSTON, January 28, 2026 – Life Biosciences, Inc., (“Life Bio”) a... 011
Jay Roshe @jayroshe.bsky.social · 22/01/2026Program Manager Andrew Brack also ran his lab at UCSF! 000
Jay Roshe @jayroshe.bsky.social · 21/01/2026Aging Research and Drug Discovery (ARDD) has begun uploading video lectures from its Aug 2025 conference: www.youtube.com/@ardd3628/vi...youtube.comARDDThis is the channel for the Aging Research and Drug Discovery meeting (www.agingpharma.org). We reserve the right to remove derogatory, personal and/or non-scientific comments. 010
Jay Roshe @jayroshe.bsky.social · 21/01/2026BioAge Labs provides on update on its 2026 clinical plans for oral NLRP3 inhibitor: ir.bioagelabs.com/news-release...ir.bioagelabs.comBioAge Announces Indication Expansion for Oral NLRP3 Inhibitor BGE-102, with Plans to Initiate Phase 1b/2a Proof-of-Concept Clinical Trial in Patients with Diabetic Macular Edema in Mid-2026 | Tue, 01...BGE-102 has the potential for therapeutic retinal exposure with oral delivery, reducing treatment burden in ocular indications currently treated with intravitreal therapies Growing preclinical and cli... 010
Jay Roshe @jayroshe.bsky.social · 21/01/2026Too true. HHS is the largest health organization in the world and should be headed by someone who adheres to science-based medicine rather than quackery and conspiracy-theory thinking. 010
Jay Roshe @jayroshe.bsky.social · 20/01/2026PA indeed has an impressive biotech/pharma scene. There are high-profile startups/firms with a focus on age-related illness, like LyGenesis aiming for organ regeneration and Annovis Bio targeting neurodegeneration. Both are running clinical trials. Fostering these ecosystems is critically important. 000
Reposted by Jay RosheSarah Tishkoff, PhD @sarahtishkoff.bsky.social · 18/01/2026Call on your house representatives to support a FY2026 budget bill that would preserve funding for NIH at the Senate Appropriations Committee approved level of $48.7B and adopt Senate language prohibiting a cap on indirect costs and limiting multi-year funded grants to levels consistent with FY2024 085
Jay Roshe @jayroshe.bsky.social · 16/01/2026FYI - Kelsey Piper describes around the middle of her section "Doing the math" what she believes are two math errors in your article: www.theargumentmag.com/p/we-absolut...theargumentmag.comWe absolutely do know that Waymos are safer than human driversWhat Bloomberg got very wrong about self-driving cars 130
Jay Roshe @jayroshe.bsky.social · 14/01/2026Loyal has achieved two of three components needed for FDA expanded conditional approval of its canine longevity drug: loyal.com/posts/loy-00...loyal.comOne step closer to a dog longevity drug: What LOY-002’s safety milestone means to a practicing vetThe FDA recently accepted the Target Animal Safety (TAS) submission for LOY-002, our drug in development for senior dog lifespan extension. Our Director of Veterinmary Medicine, Brennen McKenzie, expl... 010
Jay Roshe @jayroshe.bsky.social · 10/01/2026Thank you for trying to positively influence HHS. Relatedly, funding for geroscience within NIH and NIA is critical to make progress against Parkinson's and other age-related diseases by researching aspects of aging biology that contribute to their development: www.nia.nih.gov/gsignia.nih.govTrans-NIH Geroscience Interest Group (GSIG)GSIG is a collaborative framework to enhance opportunities to explore the intersection between aging biology and the biology of diseases. 000
Jay Roshe @jayroshe.bsky.social · 05/01/2026Section five by Hannah Ritchie touches on this issue: hannahritchie.substack.com/p/venezuelan...hannahritchie.substack.comFive(ish) charts that give some context to Venezuelan oilIt has the world's largest reserves, produces comparatively little, and has a type of oil that the US needs. 000