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Jay Roshe

@jayroshe.bsky.social
1.3K followers 1.5K following 291 posts

Interested in treating/preventing age-related ill health (dementia, cardiovascular disease, cancer, frailty, etc.) by targeting aspects of the biology of aging. Learn more: www.afar.org/what-is-geroscience-2

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Reposted by Jay Roshe
ARPA-H @arpa-h.bsky.social · 30/09/2026
What if clinical trials could run start to finish in under 4 years? ARPA-H’s SURPASS program is taking on that challenge. We’re calling on top minds in AI, biostatistics, clinical operations, and regulatory science to join us. Learn more ➡️ arpa-h.gov/explore-fund...
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Reposted by Jay Roshe
The Longevity Initiative @thelongevityinitiative.org · 30/09/2026
The longevity science community is converging on Boston for ARDD and Biomarkers of Aging… and The Longevity Initiative will be there! We’re fundraising, and looking for collaborators to bring regulation and public understanding up to speed with the latest breakthroughs in longevity science.
The Boston skyline
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Jay Roshe @jayroshe.bsky.social · 24/09/2026
Yikes, I forgot to get that done! Thanks for the reminder.
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Jay Roshe @jayroshe.bsky.social · 20/09/2026
I'd be curious to know your take on other XPrize Healthspan finalists. At the bottom of this article is a table of the 10 finalists (and 10 honorable mentions) with a description of their intervention. thelongevityinitiative.org/2026/08/xpri...
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Jay Roshe @jayroshe.bsky.social · 01/09/2026
I'm confident I'd be one of those people who is just fine with only hobby hobbies instead of a job hobby.
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Jay Roshe @jayroshe.bsky.social · 15/07/2026
If this passes the Senate and if history is any guide, people will realize how terrible this is in the winter (especially in Massachusetts), and the public will demand it be reversed within a year. This is exactly what happened in the 1970s when Congress made this mistake.
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Reposted by Jay Roshe
Eric Topol @erictopol.bsky.social · 02/06/2026
"new ways to circumvent the will of Congress and starve American science" www.science.org/doi/10.1126/... @science.org @holdenthorp.bsky.social
science.org
Another red alert for American science
Although research has bipartisan support in the US Congress, and trust in science is above 75% across the country, the Trump administration seems as determined as ever to mortally wound the nation’s s...
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Reposted by Jay Roshe
Rep. Scott Peters @repscottpeters.bsky.social · 29/05/2026
Emerald from Rancho Bernardo needed help with a delayed grant that threatened layoffs at UCSD’s Biodynamics Lab. My staff worked with Emerald and the NIH to determine the cause of the grant’s delay and within a month, the lab received their full grant funding!
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Jay Roshe @jayroshe.bsky.social · 26/05/2026
In addition to coverage, protecting funding for mental health research breakthroughs is also critical. ARPA-H funding must be protected in 2027, so that research programs like EVIDENT can realize their full potential. arpa-h.gov/explore-fund...
arpa-h.gov
Evidence-Based Validation & Innovation for Rapid Therapeutics in Behavioral Health (EVIDENT)
The Advanced Research Projects Agency for Health (ARPA-H) supports transformative research ranging in scale from molecular to societal to deliver health breakthroughs in years, not decades.
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Jay Roshe @jayroshe.bsky.social · 26/05/2026
Absolutely. Anything to increase housing supply is highly impactful.
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Reposted by Jay Roshe
American Aging Association @americanaging.bsky.social · 18/05/2026
Every $1B cut to NIH = ~8 fewer approved drugs over a decade. Proposed $18B NIH cuts = risk of 144 fewer treatments reaching patients. The #geroscience pipeline is in the line of fire. www.brookings.edu/articles/the... #NIH #AgingResearch #ResearchFunding
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Jay Roshe @jayroshe.bsky.social · 14/05/2026
"...and a high-quality study could take many years, or even decades." A primary objective of ARPA-H's PROSPR program is to create surrogate biomarkers of aging to determine in much less time if an intervention is working or not, rather than running incredibly long trials.
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Reposted by Jay Roshe
The Jackson Laboratory @jax.org · 05/05/2026
Now hiring in NYC: Senior Director of Research Programs at The Jackson Laboratory. Define and drive the strategic vision for the research programs portfolio, lead project teams and partner with industry to advance translational models: go.jax.org/08aetr 🧪 💼
go.jax.org
Senior Director, Research Programs
The Senior Director of Research Programs is responsible for the project management team and for overseeing project monitoring, reporting, and delivery in alignment with research strategy goals and tactics. The role provides strategic guidance to senior ...
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Jay Roshe @jayroshe.bsky.social · 02/05/2026
Very well-written article. Calorie-restriction interventions (or those that imitate them genetically like Kenyon's IGF-1 signaling) have much larger effects as a percentage on lifespan of short-lived species. Nematode worm lifespan has been increased up to 5x, while mice have come nowhere near that.
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Reposted by Jay Roshe
Ross Andersen @rossandersen.bsky.social · 02/05/2026
This is a story about life extension for dogs, in which my own pup makes several appearances www.theatlantic.com/science/2026...
theatlantic.com
Your Next Dog May Live Longer
A new pill could soon extend dogs’ lives. How will that change our relationship with our pets?
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Jay Roshe @jayroshe.bsky.social · 01/05/2026
Christin Glorioso writes about BioAge Labs' NLRP3 inhibitor which cleared a Phase 1 clinical trial: drglorioso.substack.com/p/bioages-lo...
drglorioso.substack.com
BioAge’s Longevity Drug Cleared Phase 1 with an 86% Drop in Inflammation
Inflammaging, CRP, and the longevity drugs coming to reduce them
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Jay Roshe @jayroshe.bsky.social · 30/04/2026
Read up about the course ARPA-H programs take from beginning to end: arpa-h.gov/news-and-eve...
arpa-h.gov
ARPA-H 101: The lifecycle of an ARPA-H program
The Advanced Research Projects Agency for Health (ARPA-H) supports transformative research ranging in scale from molecular to societal to deliver health breakthroughs in years, not decades.
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Jay Roshe @jayroshe.bsky.social · 20/04/2026
Seems like ARPA-H STOMP's mission is important: '"What if we could detect, understand the health impacts of, and remove toxic microplastics from the body?" arpa-h.gov/explore-fund...
arpa-h.gov
STOMP
The Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs ranging from molecular to societal to provide transformative hea...
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Jay Roshe @jayroshe.bsky.social · 18/04/2026
Biomarkers of Aging Consortium has started uploading recordings from the Oct. 2025 conference: www.youtube.com/@Biomarkerso...
youtube.com
Biomarkers of Aging Consortium
Establishing Reliable Biomarkers of Aging for Longevity Interventions.
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Reposted by Jay Roshe
The Jackson Laboratory @jax.org · 16/04/2026
Registration is now open for the 2026 JAX–NYSCF Conference. 🧬 Marking the anniversary of iPSC discovery, this year’s meeting brings together global leaders in stem cell science to share breakthroughs and shape what’s next in translational research. Join us: go.jax.org/jax-nyscf-conf
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Jay Roshe @jayroshe.bsky.social · 13/04/2026
You're right that age-related diseases are projected to increase dramatically with an increasingly older population. That's why Congress has to protect and increase funding for geroscience research across NIA, NIH, and ARPA-H to make strides against age-related illnesses.
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Jay Roshe @jayroshe.bsky.social · 03/04/2026
ARPA-H has announced a new program that aims to detect, understand the health impacts of, and remove microplastics from the body: arpa-h.gov/explore-fund...
arpa-h.gov
STOMP
The Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs ranging from molecular to societal to provide transformative hea...
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Jay Roshe @jayroshe.bsky.social · 01/04/2026
Here's an example of a research paper that examines the question of increasing healthy life expectancy: www.nature.com/articles/s43... For additional reading, there have been various papers on something called the "longevity dividend".
nature.com
The economic value of targeting aging - Nature Aging
An economic analysis suggests that targeting aging offers potentially larger economic gains than eradicating individual diseases. Slowing aging to increase life expectancy by 1 year is worth US$38 tri...
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Reposted by Jay Roshe
Oklahoma Nathan Shock Center @oknathanshock.bsky.social · 30/03/2026
The Oklahoma Nathan Shock Center Translational Pilot Awards open this Wednesday, April 1! 🔗 For more information: oklahomanathanshockcenteronaging.org/translationa... #Geroscience
Flyer for the Oklahoma Nathan Shock Center of Excellence in Aging Research announcing “Translational Pilot Awards.” The flyer explains that the awards support translational studies using human biosamples or animal models relevant to age-related disease. It lists available cores (CRISPR Whole-Genome Screening, Genomic Sciences, Geroscience Redox Biology, and Multiplexing Protein Analysis), includes a link to apply, and notes funding amounts of $5,000–$20,000. It highlights that awards support early-stage and senior investigators starting aging or geroscience research. Key dates: submission deadline June 1, 2026, and funding period July 1, 2026 to June 30, 2027. A QR code is shown for more information.
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Reposted by Jay Roshe
Oklahoma Nathan Shock Center @oknathanshock.bsky.social · 01/04/2026
Submissions for the OKNSC Translational Pilot Awards are now open!
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Jay Roshe @jayroshe.bsky.social · 19/03/2026
There is scant evidence to justify claims made by promoters behind the peptide craze. People should also know there are risks to taking these injections. Thankfully Nevada regulators helped hold some of these promoters accountable for violating state law: www.propublica.org/article/raad...
propublica.org
Nevada Regulators Fine Peptide Providers at Anti-Aging Festival Where Two Women Became Critically Ill
Three individuals, along with the group accused of supplying the peptides, were fined between $5,000 and $10,000 for their involvement in an incident at the Revolution Against Aging and Death Festival...
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Jay Roshe @jayroshe.bsky.social · 14/03/2026
@trahan.house.gov Your support for ARPA-H is commendable, and I urge you also to act to protect researchers supported by NIA grants. Even if Congress restores funding levels, research can be sabotaged by low grant approval rates. Your support for NIA research is urgently needed.
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Jay Roshe @jayroshe.bsky.social · 14/03/2026
Thank you for your support of ARPA-H and for your participation in the Longevity Science Caucus. The PROSPR and FRONT programs in ARPA-H are especially inspiring and great examples of bold research within geroscience.
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Reposted by Jay Roshe
Science Magazine @science.org · 09/03/2026
ARPA-H will “build the train tracks” for the first large clinical studies of aging interventions. scim.ag/4dcPEJj
scim.ag
U.S. agency will devote $144 million to studies that slow aging, extend quality of life
ARPA-H will “build the train tracks” for first large clinical studies of aging interventions
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Jay Roshe @jayroshe.bsky.social · 08/03/2026
An informative overview on research and trials of mTOR-targeting interventions by Nicolas di Leo with a mention of @lamminglab.bsky.social, @arpa-h.bsky.social, and many others : norngroup.substack.com/p/advancing-...
norngroup.substack.com
Advancing Longevity Trials: Lessons from mTOR-Targeting Interventions
What two decades of trials can teach us about translating rapamycin to human aging.
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Reposted by Jay Roshe
Joao Pedro Magalhaes @jpsenescence.bsky.social · 03/03/2026
🚨 The Human Ageing Genomic Resources Are at Risk For over 20 years, our Human Ageing Genomic Resources (HAGR) have supported ageing and longevity research. We are raising funds to secure their continuity while we pursue long-term funding. www.justgiving.com/page/human-a...
justgiving.com
Support the Human Ageing Genomic Resources
Help Joao Pedro Magalhaes raise money to support University of Birmingham
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Jay Roshe @jayroshe.bsky.social · 02/03/2026
Nir Barzilai was elected to the Association of American Physicians: www.afar.org/news/afar-bo...
afar.org
AFAR Board Member in the News: Nir Barzilai, MD, elected to the Association of American Physicians (AAP) - American Federation for Aging Research
AFAR is pleased to announce that Board Member Nir Barzilai, MD, has been elected to the Association of American Physicians (AAP), one of the most
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Jay Roshe @jayroshe.bsky.social · 26/02/2026
@liccardo.house.gov Congratulations to Stanford University in your district! They are one of the awardees in the @arpa-h.bsky.social PROSPR program. This is an important development for the Longevity Science Caucus. Thanks for being a member and supporting geroscience. arpa-h.gov/news-and-eve...
arpa-h.gov
Research teams to add more healthy years to Americans’ lives as they age
The Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs ranging from molecular to societal to provide transformative hea...
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Jay Roshe @jayroshe.bsky.social · 25/02/2026
Christin Glorioso also wrote her thoughts on the trial, and she mentions you too: drglorioso.substack.com/p/the-new-yo...
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Reposted by Jay Roshe
ARPA-H @arpa-h.bsky.social · 24/02/2026
Most of us don’t just want longer lives, but more years of good health. PROSPR awardees are spotting early signs that health is slipping, building systems for aging clinical trials & testing new drugs that could be the 1st gen drugs to extend healthy years. Meet the teams: arpa-h.gov/news-and-eve...
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Jay Roshe @jayroshe.bsky.social · 11/02/2026
You might be interested in following Loyal's clinical trial to increase canine healthy lifespan: www.fastcompany.com/91490365/loy... Their blog is also interesting reading: loyal.com/blog
fastcompany.com
This startup raised $250 million to help dogs live longer
Longevity Fund-backed Loyal is working toward FDA approval of a drug that could help dogs live longer, healthier lives.
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Reposted by Jay Roshe
ARPA-H @arpa-h.bsky.social · 11/02/2026
🚨 BIOGAMI Proposers' Day Registration is closing soon – sign up by Feb. 18 at 5pm ET for in-person attendance, or by Feb. 19 at noon ET for virtual attendance. arpa-h.gov/explore-fund...
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Jay Roshe @jayroshe.bsky.social · 04/02/2026
I wonder if the term "geroscience" would be better than "longevity." "Longevity" has been adopted by quacks and grifters and is also used in many different ways. "Geroscience" might be reserved for more narrow use of research on aging biology and associated clinical trials.
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Jay Roshe @jayroshe.bsky.social · 30/01/2026
This is encouraging and shows why medical research targeting aging biology to impact age-related health decline is only growing in importance. Tyler Cowen, Richard Evans, and other economists recently helped produced this interactive on ROI of R&D in Geroscience: silverlinings.bio?chapter=abou...
silverlinings.bio
Silver Linings
Generated by create next app
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Reposted by Jay Roshe
Michael Ringel | Chief Operating Officer, Life Biosciences @michaelringel.bsky.social · 28/01/2026
@lifebiosciences.bsky.social, founded by @davidsinclairphd.bsky.social & Tristan Edwards, helmed by CEO Jerry McLaughlin, has received @fda.gov IND clearance for cellular rejuvenation using partial epigenetic reprogramming in optic neuropathies. I'm so proud: www.lifebiosciences.com/life-bioscie...
lifebiosciences.com
Life Biosciences Announces FDA Clearance of IND Application for ER-100 in Optic Neuropathies
IND clearance marks the first ever cellular rejuvenation therapy using partial epigenetic reprogramming to reach human clinical trials BOSTON, January 28, 2026 – Life Biosciences, Inc., (“Life Bio”) a...
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Jay Roshe @jayroshe.bsky.social · 22/01/2026
Program Manager Andrew Brack also ran his lab at UCSF!
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Jay Roshe @jayroshe.bsky.social · 21/01/2026
Aging Research and Drug Discovery (ARDD) has begun uploading video lectures from its Aug 2025 conference: www.youtube.com/@ardd3628/vi...
youtube.com
ARDD
This is the channel for the Aging Research and Drug Discovery meeting (www.agingpharma.org). We reserve the right to remove derogatory, personal and/or non-scientific comments.
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Jay Roshe @jayroshe.bsky.social · 21/01/2026
BioAge Labs provides on update on its 2026 clinical plans for oral NLRP3 inhibitor: ir.bioagelabs.com/news-release...
ir.bioagelabs.com
BioAge Announces Indication Expansion for Oral NLRP3 Inhibitor BGE-102, with Plans to Initiate Phase 1b/2a Proof-of-Concept Clinical Trial in Patients with Diabetic Macular Edema in Mid-2026 | Tue, 01...
BGE-102 has the potential for therapeutic retinal exposure with oral delivery, reducing treatment burden in ocular indications currently treated with intravitreal therapies Growing preclinical and cli...
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Jay Roshe @jayroshe.bsky.social · 21/01/2026
Too true. HHS is the largest health organization in the world and should be headed by someone who adheres to science-based medicine rather than quackery and conspiracy-theory thinking.
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Jay Roshe @jayroshe.bsky.social · 20/01/2026
PA indeed has an impressive biotech/pharma scene. There are high-profile startups/firms with a focus on age-related illness, like LyGenesis aiming for organ regeneration and Annovis Bio targeting neurodegeneration. Both are running clinical trials. Fostering these ecosystems is critically important.
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Reposted by Jay Roshe
Sarah Tishkoff, PhD @sarahtishkoff.bsky.social · 18/01/2026
Call on your house representatives to support a FY2026 budget bill that would preserve funding for NIH at the Senate Appropriations Committee approved level of $48.7B and adopt Senate language prohibiting a cap on indirect costs and limiting multi-year funded grants to levels consistent with FY2024
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Jay Roshe @jayroshe.bsky.social · 16/01/2026
FYI - Kelsey Piper describes around the middle of her section "Doing the math" what she believes are two math errors in your article: www.theargumentmag.com/p/we-absolut...
theargumentmag.com
We absolutely do know that Waymos are safer than human drivers
What Bloomberg got very wrong about self-driving cars
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Jay Roshe @jayroshe.bsky.social · 14/01/2026
Loyal has achieved two of three components needed for FDA expanded conditional approval of its canine longevity drug: loyal.com/posts/loy-00...
loyal.com
One step closer to a dog longevity drug: What LOY-002’s safety milestone means to a practicing vet
The FDA recently accepted the Target Animal Safety (TAS) submission for LOY-002, our drug in development for senior dog lifespan extension. Our Director of Veterinmary Medicine, Brennen McKenzie, expl...
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Jay Roshe @jayroshe.bsky.social · 10/01/2026
Thank you for trying to positively influence HHS. Relatedly, funding for geroscience within NIH and NIA is critical to make progress against Parkinson's and other age-related diseases by researching aspects of aging biology that contribute to their development: www.nia.nih.gov/gsig
nia.nih.gov
Trans-NIH Geroscience Interest Group (GSIG)
GSIG is a collaborative framework to enhance opportunities to explore the intersection between aging biology and the biology of diseases.
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Jay Roshe @jayroshe.bsky.social · 05/01/2026
Section five by Hannah Ritchie touches on this issue: hannahritchie.substack.com/p/venezuelan...
hannahritchie.substack.com
Five(ish) charts that give some context to Venezuelan oil
It has the world's largest reserves, produces comparatively little, and has a type of oil that the US needs.
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