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Jim Janetka

@janetka20.bsky.social
729 followers 965 following 54 posts

Medicinal chemist interested in cancer and infectious disease (Fimbrion and WashU). Kinase, protease, GPCR, PDE and lectin inhibitor drug discovery. Antibacterial, antiviral, anthelmintic, anti-parasitic. Small molecule, peptide and carbohydrate.

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Reposted by Jim Janetka
AW Sylwester @aw-sylwester.bsky.social · 30/09/2026
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Alt National Park Service @altnps.bsky.social · 05/09/2026
The title really says it all.
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Jon Cooper @joncooper-us.bsky.social · 04/09/2026
👇👇
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Max Kozlov @maxkozlov.bsky.social · 04/09/2026
🚨 The NIH is moving to transfer hundreds of millions of dollars in infectious-disease research projects to the DOD under a secret 10-year pact. Here’s what’s happening inside “Operation Prevailing Edge” 🧵👇 www.nature.com/articles/d41...
nature.com
Revealed: inside the US military's plan to tap huge sums from the NIH
An agreement paves the way for hundreds of millions of dollars’ worth of projects to be transferred from the NIH’s institute for infectious diseases to the Department of Defense.
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Ray @raymolson22.bsky.social · 01/09/2026
The same corruption that produced krasnov will protect him....unless the revolution happens very soon.
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Steven Goldsmith 🦋 @stevengoldsmith.bsky.social · 31/08/2026
I truly believe that everyone gets what they deserve. I really hope that Trump gets exactly what he deserves.
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Jim Janetka @janetka20.bsky.social · 28/08/2026
cen.acs.org/pharmaceutic...
cen.acs.org
13 clinical candidates revealed in Chicago
First-time disclosures session at ACS Fall 2026 debuted compounds designed to treat cancer, acne, urinary tract infections, and more
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Jim Janetka @janetka20.bsky.social · 28/08/2026
drughunter.com/articles/acs...
drughunter.com
ACS Fall 2026 First Time Disclosures
The First Time Disclosures at the ACS Fall 2026 meeting in Chicago featured 13 small molecule compounds across two sessions, offering a first look at the next wave of clinical candidates. Organized by...
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Jim Janetka @janetka20.bsky.social · 28/08/2026
lnkd.in/p/gRjb6fmK
lnkd.in
#acsfall2026 #medicinalchemistry #firsttimedisclosures #drugdiscovery #clinicaldevelopment #medchem | Drug Hunter
ACS Fall 2026 – First Time Disclosures | Open Access Article | https://lnkd.in/evDWdzgc The structures are here. The First Time Disclosures sessions at ACS Fall 2026 in Chicago unveiled 13 small mol...
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AltYellostoneNatPar @altyellonatpark.org · 25/08/2026
70 days and we vote
Podium reads 
one of ours 
all of yours

Is a line from Nazi Germany. It was coined when an SS officer was killed in a Czech Village and the Nazis killed every single ressident of that village in response. This very line appeared on a US federal government podium. Let that sink in.
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Hoodlum 🇺🇸 @nothoodlum.bsky.social · 20/08/2026
Just posting this because, as of yesterday, the US national debt surpassed $40 trillion for the first time. The GOP: the party of fiscal responsibility. 🥴
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Hart Cunningham @hart28.bsky.social · 18/08/2026
Dead Internet: our entire system-culture, economy, politics is a pyramid of lies. from aipac to grokipedia, bibi/putin to murdoch. fewer humans read or grasp the centuries-long fight against authoritarian rule built on religion. we’re not in the 1930s..we are back in the 1780s🇺🇸 Hart28.com
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Edward Elderman @elderman.bsky.social · 14/08/2026
Climate change recognized in 1912
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Joe Roberts 🔥💙🔥🐸 @robbyjoe.bsky.social · 14/08/2026
He didn’t change. They did.
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chwnp.bsky.social @chwnp.bsky.social · 14/08/2026
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Liberals🇨🇦🇺🇦 @saynotobs.bsky.social · 14/08/2026
Dear #merica, this is what happens when the #PedophileInTheWH destroys your intelligence agencies.
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call634-5789 @call634-5789.bsky.social · 11/08/2026
TMYK: Epstein would bring in little girls, Fat Donnie would auction them off...with proof. My thanks to Greg T. Read entire .pdf of events here: www.justice.gov/epstein/file... Ask your self how the hell is it possible fat Donnie is NOT in the deepest hole in a windowless prison. Makes me sick.
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tomwellborn3rd @wellborn.net · 04/08/2026
A 60 Minutes probe into Epstein's banking, with Wyden already interviewed, vanished right after Sharyn Alfonsi got pushed out under Bari Weiss. Same editor who stalled the CECOT migrant story until Stephen Miller got a say. CBS keeps calling it timing. Sure looks like a pattern.
mediaite.com
60 Minutes Epstein Banking Story Vanished After CBS Ousted Sharyn Alfonsi, Dem Senator Reveals
Wyden revealed he was interviewed for the show in a Senate report alleging the country's largest banks turned “a blind eye” to Epstein's financial activity
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Jenna Norton @jenna-m-norton.bsky.social · 04/08/2026
RFK jr overrode the NIH recommendation for NIAID Director to appoint his own preferred candidate (who applied, but NIH declined to interview), per @politico.com. Institute directors have final say on funding decisions and are critical to the integrity of NIH. 🧵 www.politico.com/news/2026/08...
politico.com
A lab-leak proponent is in line for Fauci’s old job
Steven Quay is in final vetting to run the National Institute of Allergy and Infectious Diseases.
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Scott Horton @robertscotthorton.bsky.social · 25/07/2026
This really is a perfect measure of the putrefaction of corporate media in the US, now heavily under the control of the tech bros.
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Brant Reeves @bireeves95.bsky.social · 25/07/2026
Looks Like Cheating to Win an Election…..
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Paul Bleicher @pbleic.bsky.social · 24/07/2026
Astonishing. RFK Jr. adds 8 members to a 6 member FDA advisory panel. 6 of them were sellers of peptides, and the 7th a compounding pharmacist. In an 8-6 vote with all 8 votes coming from these new panel members, the panel approved 4 peptides against the objections of FDA scientists.
nytimes.com
FDA Panel Supports Lifting Restrictions on Four Peptides (Gift Article)
In an all-day hearing, the agency’s scientists argued against allowing broad access to unproven drugs that the agency had banned three years ago.
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Robert Reich @rbreich.bsky.social · 22/07/2026
Investigations are ongoing but just four corporations control 54% of the fresh-cut salad industry, including Taylor Fresh Foods. Market concentration —> more pricing power —> higher profits —> more spending on lobbying and campaign donations —> more deregulation See the dangers of monopolization?
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Jenna Norton @jenna-m-norton.bsky.social · 22/07/2026
Remember when NIH Director Jay Bhattacharya said there were no banned words and NIH Program Officers were making them up? Here’s the proof he lied: apnews.com/article/cali... I know, Jay Bhattacharya lying is not news. But it’s still really validating to have the admission.
apnews.com
White House admits it used keywords to kill billions worth of California research grants
Federal agencies that terminated more than a thousand research grants at the University of California last year admitted that they used keywords related to diversity, gender, vaccine hesitancy and COV...
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God @thegodshow.com · 21/07/2026
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Jim Janetka @janetka20.bsky.social · 21/07/2026
Our new paper on new anthelmintics Discovery of GPCR Antagonists with Potent In Vitro and In Vivo Macrofilaricidal Activity | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...
pubs.acs.org
Discovery of GPCR Antagonists with Potent In Vitro and In Vivo Macrofilaricidal Activity
Chronic filarial infections remain a global health burden, with limited adulticidal therapies highlighting the need for new drugs. We explored repurposing human GPCR antagonists, including clemizole, ...
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Christopher Webb @cwebbonline.com · 19/07/2026
PURE EVIL Stephen Miller’s worldview in one video clip. "I think the ideal solution would be to cut off their fingers. I don't think it's necessary to kill them entirely. We're not a barbaric people. We respect life. Therefore, torture is the way to go. Because tortured people can live.”
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Just Another Mike @mwmarshall.bsky.social · 19/07/2026
It’s your right and your obligation to call out corruption and abuse.
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Acyn @acyn.bsky.social · 14/07/2026
Schiff: The judge, in that decision on Monday, referred Blanche, basically, to the New York Bar Association because of his conduct. How is it possible that after being referred to the bar association for potential discipline on Monday, we’re contemplating this guy for attorney general on Wednesday?
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Making Molecules @makingmolecules.com · 14/07/2026
This #ChemEd #Chemistry #ChemSky summary introduces 1,3-dipolar cycloadditions. It builds on the Diels-Alder 1 pagers & is another [4+2] cycloaddition but gives 5-membered rings. It is only an intro. More details will be on makingmolecules.com as soon as I've typed up my notes. Enjoy!
A one page summary of 1,3-dipolar cycloadditions. It starts with an introduction covering the general reaction and classifying 1,3-dipoles as either linear or bent. There are then four examples; nitrile oxide-alkene cycloadditions, nitrone-alkene cycloadditions, azide-alkyne cycloadditions and azomethine ylide cycloadditions (my favourite). The discussion of the azide reaction mentions the original pericyclic reaction and the catalysed variant that won the Nobel Prize.
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 13/07/2026
There are only a few hours left to comment on the proposed OMB rule that would eviscerate American science. This is the single best summary, and guidance for how to write a comment, that I have seen. PLEASE submit something, even if it is only 2 or 3 paragraphs.
elizabethginexi.substack.com
What We Need to do NEXT: OMB’s Proposed Federal Financial Assistance Rule (OMB-2026-0034)
What OMB’s Proposed Federal Financial Assistance Rule Means in Practice
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Jim Janetka @janetka20.bsky.social · 11/07/2026
Lead Optimization of TgCDPK1 Inhibitors for the Treatment of Toxoplasmosis | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/...
pubs.acs.org
Lead Optimization of TgCDPK1 Inhibitors for the Treatment of Toxoplasmosis
Toxoplasma gondii is an important opportunistic pathogen that infects many individuals and threatens the health of those with compromised immunity. Current therapies are unable to eradicate chronic in...
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Jim Janetka @janetka20.bsky.social · 11/07/2026
Reappraising Dichloromethane: Uncovering a Hidden Coupling Reagent for Activating Carboxylic Acids in Direct Amide Synthesis | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...
pubs.acs.org
Reappraising Dichloromethane: Uncovering a Hidden Coupling Reagent for Activating Carboxylic Acids in Direct Amide Synthesis
Amide bonds are essential in biology and chemistry, yet their synthesis often requires expensive reagents or harsh conditions. We report that dichloromethane (CH2Cl2), a commonly used solvent, can fun...
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Iain Wilson @iainwilsonwien.bsky.social · 09/07/2026
Congratulations to Prof. Geert-Jan Boons, who has been awarded the 2026 RSC Carbohydrate Group Haworth Memorial Lectureship #glycotime
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Brant Reeves @bireeves95.bsky.social · 27/06/2026
I still think this is one of the most egregious acts of Treason ever committed….
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Jeremy Berg @jeremymberg.bsky.social · 25/06/2026
Foundational! "The scientist doing basic research may not be at all interested in the practical applications of his work, yet the further progress of industrial development would eventually stagnate if basic scientific research were long neglected." From Science: The Endless Frontier, Bush, 1945
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RandyLand @randyland65.bsky.social · 24/06/2026
Global warming is real .... just slow
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Climate Dad @climatedad.bsky.social · 25/06/2026
“We’ve only had 114 years to do something, let our kids sort it out!”
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Scott Dworkin @dworkin.bsky.social · 19/06/2026
2020 FAKE ELECTORS CASE MOVES FORWARD: Three Trump allies in Wisconsin face eleven felony counts each, carrying up to six years apiece. Trump pardoned them federally—but he can’t pardon them for the state charges. They now head to trial. Full story here: www.dworkinsubstack.com/p/raskin-exp...
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Ariaa® @ariaa.bsky.social · 18/06/2026
THIS is HUGE! Researchers at Mie University in Japan have successfully used CRISPR Cas9 gene editing to remove the extra chromosome 21 responsible for Down syndrome from human cells for the first time. The team is led by Dr. Ryotaro Hashizume. Published in PNAS Nexus
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Robert Reich @rbreich.bsky.social · 17/06/2026
Trump’s DOJ has charged 15 anti-ICE protesters in Minnesota. The charges are based on his national security memo that categorized “anti-capitalism,” “anti-Americanism,” and “extremism on migration” as domestic terrorism. This is what tyranny looks like.
commondreams.org
'Major Escalation': Trump Prosecutor Invokes NSPM-7 While Unveiling Charges Against 15 ICE Protesters | Common Dreams
Federal prosecutors in Minnesota are targeting anti-ICE protesters with charges linked to Trump's crackdown on left-wing
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Jenna Norton @jenna-m-norton.bsky.social · 16/06/2026
“A deliberate crippling” is a very accurate description of what Russell Vought and Jay Bhattacharya are doing to NIH. cssh.northeastern.edu/a-deliberate...
cssh.northeastern.edu
‘A deliberate crippling’: NIH researchers, Mass. scientists sound alarm over new funding rules
One year after hundreds of National Institutes of Health employees publicly accused the Trump administration of politicizing biomedical research in what they called the “Bethesda Declaration,” staff m...
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Mark Hamill @markhamillofficial.bsky.social · 14/06/2026
TOMORROW!!! #NoKingsDay 🇺🇸
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Robert Reich @rbreich.bsky.social · 13/06/2026
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Peter Kenny @pwk2024.bsky.social · 10/06/2026
Opportunity for computational chemist at Vertex (Oxford UK) ref: REQ-29266 | closing: 19-Jun-2026 #CompChem #cheminformatics #ML #AI #UKChemJobs #ChemJobs #chemsky 🧪 vrtx.wd501.myworkdayjobs.com/Vertex_Caree...
vrtx.wd501.myworkdayjobs.com
Senior Scientist, Computational Chemistry
Job Description We are seeking a highly motivated and experienced Senior Scientist in Computational Chemistry to join our Computational Drug Design group in Oxford. The successful candidate will play ...
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Prof Gavin Yamey MD MPH @gavinyamey.bsky.social · 09/06/2026
In this piece, @gretchentg.bsky.social @ucs.org praises the collective response from scientists to the proposed OMB rule—but says we’d “do well to apply this same level of activation to the larger assaults on science & democracy that are harming communities” 👏👏👏 blog.ucs.org/gretchen-gol...
blog.ucs.org
The Science Community Is Stepping Up. Let’s Go Bigger.
The scientific community is fighting a proposed change to research funding. Let's keep this momentum going to take on more attacks on science.
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STAT @statnews.com · 09/06/2026
In a report published on the first anniversary of the Bethesda Declaration, 71 staffers write that they feel NIH leadership “largely ignored" their concerns www.statnews.com/2026/06/09/n...
statnews.com
NIH staffers published a letter of dissent a year ago. They feel it’s been ignored
In a report published on the first anniversary of the Bethesda Declaration, 71 staffers write that they feel NIH leadership “largely ignored" their concerns.
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Christopher Webb @cwebbonline.com · 09/06/2026
In case you forgot what it looks like when a real president gets the love at a game. You know, when the crowd actually wants the president there.
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The Lincoln Project @lincolnproject.us · 09/06/2026
The most expensive taxpayer funded nap #NBAFinals
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Robert Reich @rbreich.bsky.social · 09/06/2026
Trump’s power depends on maintaining the illusion that he’s all-powerful, and that most Americans adore him. But that illusion is harder to maintain when you're booed by thousands of fans at a basketball game in your hometown. The Emperor has no clothes. He is not all powerful. Remember this.
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