The mechanism by which phenotypic heterogeneity is generated within a bacterial population and leads to colistin heteroresistance has been unclear. Heteroresistance is a form of antibiotic resistance ...

Choby et al. show an antibiotic-resistant subpopulation is generated by heterogeneity in expression of an antibiotic importer repressed by environmental glucose, suggesting diabetes-related infection ...

Asymptomatic gut colonization is a reservoir for antimicrobial resistance (AMR) such as by the bacterium Acinetobacter baumannii. Geary and Ren, et al., report that A. baumannii evolved a regulator that helps sense competition from the gut microbiota.

Broad-spectrum antibiotics are frequently administered to intensive care unit patients as part of empiric care. This treatment has been associated ...

Recent studies link gut dysbiosis to neurological disease, but the underlying mechanisms remain unclear. This study shows that a high-fat diet increases gut permeability and enables bacterial transloc...

Liver abscesses caused by hypervirulent Klebsiella pneumoniae (hvKp) can lead to severe metastatic complications, with mortality rates ranging from...

The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.

Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular...

Chemical genomics reveals the fitness cost of bacterial metallo-β-lactamase in zinc-deplete environments, with implications for treatment options.

Nature Microbiology - Chemical genomics reveals the fitness cost of bacterial metallo-β-lactamase in zinc-deplete environments, with implications for treatment options.

Enteropathogenic E. coli (EPEC) belongs to a group of bacterial pathogens that induce epithelial cell actin rearrangements resulting in pedestal formation beneath adherent bacteria. This requires the secretion of specific virulence proteins needed for signal transduction and intimate adherence. EPEC interaction induces tyrosine phosphorylation of a protein in the host membrane, Hp90, which is the receptor for the EPEC outer membrane protein, intimin. Hp90–intimin interaction is essential for intimate attachment and pedestal formation.