Reposted by @tozturk90.bsky.social
We show how bacteria can adapt to B-lactam stress by increasing the copy number of "wimpy" beta-lactamases to overcome new drugs/B-lactamase inhibitors, without de novo evolution. This threatens the beta-lactam dominated antibiotic pipeline.
Congrats @jakechoby.bsky.social and team!
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Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline
Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular...