Applications are now open for the role of Laboratory Manager here at the Circadian Rhythms and Ageing laboratory! We are searching for an experienced researcher who will help to ensure a seamless da...

Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non...

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The authors uncover a mechano-metabolic adaptation where confinement induces rapid mitochondrial relocalization to the nuclear periphery, generating localized nuclear ATP surges that support chromatin...

Cancer-induced liver changes promote body wasting through secreted factors, with circadian regulators and hepatokines being important contributors to cancer cachexia.

Facing an extreme budget, the National Academies hosted an event that ignored it.

Nature Reviews Molecular Cell Biology - Communication between the circadian clocks of different cell and tissue types supports the daily rhythms of homeostatic processes that maintain bodily...

Smith et al. rescued circadian clock function in liver and muscle in otherwise clock-less mice, finding that glucose tolerance is achieved only when feeding rhythms and Bmal1 function in liver and mus...

Mitochondria are able to maintain two competing metabolic pathways—oxidative phosphorylation and the reductive synthesis of proline and ornithine—by generating two mitochondrial subpopulations that ar...