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Andrea Manrique Rincón

@itreg.bsky.social
33 followers 41 following 0 posts

Scientist working with cancer immunotherapy, interested on metastasis, T cells and Tregs!

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Reposted by Andrea Manrique Rincón
Open Targets @opentargets.org · 01/07/2025
Out now in iScience! @itreg.bsky.social in Annie Speak's lab created an in vitro model of T cell exhaustion to help identify and target new genes relevant to improving the immune response against cancer cells www.cell.com/iscience/ful...
Graphical abstract for the publication. The top section illustrates the in vitro model of T cell exhaustion, in which naive CD8 T cells OT-I are chronically stimulated with their cognate antigen— OVA peptide. This is followed by temporal phenotypic characterisation. This model recapitulates many critical hallmarks of exhaustion, including expression of canonical surface markers—ROS, PD1, CD39, 2B4 and LAG3— impaired proliferation, reduced cytokine production, decreased cytotoxic granule release, and metabolic alterations. The second section shows the identification of a gene signature of exhaustion between in vitro, mouse, and human TILs. Two in vivo models validate these results and establish a gene signature shared by in vitro and in vivo exhausted states. Critically, this signature is observed in tumour infiltrating T cells from multiple human tumour types, validating the translational potential of this model for discovering therapies.
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Reposted by Andrea Manrique Rincón
Nick Reeves #FBPE #NAFO @nickreeves.bsky.social · 27/04/2025
This petition deserves a lot more publicity. Please share it. Given its aim of growing the UK economy, we think the Government needs to quantify the effects of Brexit as soon as possible by setting up an inquiry. petition.parliament.uk/petitions/70...
petition.parliament.uk
Petition: Commission a public inquiry into the impact of the UK exiting the European Union
Given that it has stated its aim of growing the UK economy, we think the Government needs to quantify the effects of exiting the European Union as soon as possible by setting up an inquiry.
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Reposted by Andrea Manrique Rincón
Open Targets @opentargets.org · 24/04/2025
Introducing The T Cell Show! 📺👩‍🔬 Follow along as a T cell interviews the immune system while a B cell undertakes a journey through the body, highlighting the specific immune functions of various organs.
Comic illustration of the T Cell Show, overlayed with a play button
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Reposted by Andrea Manrique Rincón
Nick Reeves #FBPE #NAFO @nickreeves.bsky.social · 22/04/2025
Local elections have low turnouts. We can swing the results against Farage by getting good people off their sofas and into the polling stations. If you're angry with Labour, then there are the LibDems and Greens. Abstaining helps the fascists. Fight Fascism #Vote4Democracy
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Reposted by Andrea Manrique Rincón
Eric Topol @erictopol.bsky.social · 19/04/2025
We've made remarkable progress in the science of aging (geroscience) with readiness to apply this for "precision geromedicine." A brilliant new review @cellpress.bsky.social www.cell.com/cell/fulltex...
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Reposted by Andrea Manrique Rincón
Medical Art & Knowledge @medicalart.bsky.social · 04/03/2025
Synthetic Spore Husk-Encased Lipid bilayer (SSHELs) mimic bacterial spores and deliver peptides to dendritic cells, showing efficient tumor regression and improved survival in mice. SSHELs require complex synthesis but avoid cell culture use, unlike VLPs. #MedSky #MedEd #medschoolsky #immunosky
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Reposted by Andrea Manrique Rincón
Medicine at Cambridge @medcambridge.bsky.social · 20/02/2025
For the first time ever, we’re sitting down with the immune system itself! 🧪🎬 The T Cell Show is an animated talk show that explores how our bodies fight off infections and diseases. Watch the first episode now: buff.ly/4hKClz8 @itreg.bsky.social #ImmunoSky
buff.ly
The T cell show
Chapter oneWhat is it, and how does the immune system work? For the first time ever, we will interview the famous immune system. It will tell us about its jo...
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Reposted by Andrea Manrique Rincón
Waggoner Lab @labwaggoner.bsky.social · 02/12/2024
Concurrent intratumoural Treg cell depletion and CD8+ T cell expansion via a cleavable anti-4-1BB–interleukin-15 fusion protein www.nature.com/articles/s41...
nature.com
Concurrent intratumoural Treg cell depletion and CD8+ T cell expansion via a cleavable anti-4-1BB–interleukin-15 fusion protein - Nature Biomedical Engineering
An anti-4-1BB antibody fused to interleukin-15 via a peptide sensitive to tumour proteases augments tumour inhibition without increasing systemic toxicity by concurrently depleting regulatory T cells ...
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