The Affect Score is a powerful predictor of depression and anxiety in college freshmen. The combination of Affect Score and TSST is strongly predictive of anxiety in females.

Neurobiological mechanisms of resilience interact with stress biology in a dynamic process that simultaneously shapes responsiveness to specific stressors and modifies an individual’s lifelong traject...

Chronic stress is linked to many human psychiatric disorders involving the prefrontal cortex (PFC). We performed a meta-analysis of public transcriptional profiling data that showed that chronically ...

Habener led research that discovered the GLP-1 hormone, a key ingredient in Ozempic and Mounjaro.

Primary Work Address: 4000 Jones Bridge Road, Chevy Chase, MD, 20815 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the disco...

Background: Chronic stress increases risk for neuropsychiatric disorders in humans. By modeling stress-induced changes in animals, we may improve diagnosis or treatment of these disorders. Successful ...

Sleep deprivation (SD) causes large disturbances in mood and cognition. The molecular basis for these effects can be explored using transcriptional profiling to quantify brain gene expression. In the ...

Background: Major depressive disorder (MDD) is characterised by persistent depressed mood and loss of interest and pleasure in life, known as anhedonia. The first line of treatment for MDD is antidepr...