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Lena Palaniyappan

@lenapl.bsky.social
324 followers 616 following 48 posts

Psychiatric researcher

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Reposted by Lena Palaniyappan
Journal of Psychiatry & Neuroscience @jpnjournal.bsky.social · 15/01/2026
Our most read 2025 article explores AI-generated teaching signals in psychiatry, helping clinicians sharpen clinical sense-making. Read it now ▶️ ow.ly/I57u50XWp65 👥 Lena Palaniyappan, Priyadharshini Sabesan #BestofCSP
Cover of the Journal of Psychiatry and Neuroscience featuring a glowing brain scan highlighting neural pathways in red and white.
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Reposted by Lena Palaniyappan
Mach-Gaensslen Foundation of Canada @mach-gaensslenfdn.bsky.social · 18/12/2025
The Mach-Gaensslen Foundation of Canada is happy to announce the 2025 winner of the Royal-Mach-Gaensslen Prize for Mental Health Research. This year's recipient is Dr. Lena Palaniyappan with the Douglas Mental Health University Institute in Montreal. www.theroyal.ca/news/dr-lena...
Screen shot from webpage showing Dr. Palaniyappan with title "A Canadian scientist is shaking up the way we think about mental illness"
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Reposted by Lena Palaniyappan
Healthy Brains, Healthy Lives @hbhlmcgill.bsky.social · 15/12/2025
Kick off the new year with the Neurogenesis Speaker Series! 🎤🧠 Join Manuela Ferrari & @lenapl.bsky.social at @theneuro.bsky.social on Jan. 21, 2026, for two exciting talks on their research in mental health, followed by a meet-and-greet reception. 🧀 🫵 Register now: mcgill.ca/x/5kz @mcgill.ca
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Lena Palaniyappan @lenapl.bsky.social · 25/10/2025
Quantitative semiology: harnessing AI-generated teaching signals in psychiatry cdnsciencepub.com/doi/10.1139/...
cdnsciencepub.com
Quantitative semiology: harnessing AI-generated teaching signals in psychiatry
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Reposted by Lena Palaniyappan
Debra Titone @dtitone.bsky.social · 28/07/2025
New review paper on theory of mind/mentalizing and spontaneous speech/language. Led by Chaimaa El Mouslih, and co-authored with @vegashodgins.bsky.social and @lenapl.bsky.social www.mdpi.com/2076-328X/15...
mdpi.com
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Reposted by Lena Palaniyappan
NPP-Digital Psychiatry and Neuroscience (DPN) @dpn-journal.bsky.social · 09/07/2025
Check out this 🆕 paper form @lenapl.bsky.social et al showing that speech spectrograms can track negative symptom severity in schizophrenia www.nature.com/articles/s44...
nature.com
Taking a look at your speech: identifying diagnostic status and negative symptoms of psychosis using convolutional neural networks - NPP—Digital Psychiatry and Neuroscience
Short snippets of everyday speech hold medical clues. Using computer vision techniques on sound pictures (“spectrograms”) from short speech fragments, researchers trained a neural network on recording...
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Reposted by Lena Palaniyappan
Communications Medicine @commsmed.nature.com · 23/06/2025
🚨 NEW RESEARCH! ⚕️ 🩺 🧠 Elleuch et al. explore the association of grammatical challenges in people with Schizophrenia in a systematic review and meta-analysis of 45 studies. bit.ly/4kZnq66 @lenapl.bsky.social
bit.ly
Relationship between grammar and schizophrenia: a systematic review and meta-analysis - Communications Medicine
Elleuch et al, perform a systematic review and meta-analysis to evaluate the association between grammatical impairments and schizophrenia. Large effect size deficits in grammatical comprehension and production occur in this illness, highlighting the need for targeted interventions to address language use in people with psychotic disorders.
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Lena Palaniyappan @lenapl.bsky.social · 17/06/2025
One of the largest longitudinal study of computational speech and language features and psychosis from @stanglab.bsky.social Tang & colleagues! www.nature.com/articles/s44...
nature.com
Automated speech and language markers of longitudinal changes in psychosis symptoms - NPP—Digital Psychiatry and Neuroscience
We used acoustic analysis and Natural Language Processing (NLP) to evaluate speech data from 66 individuals with psychosis, over time. The study identified specific language features that correlate wi...
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Lena Palaniyappan @lenapl.bsky.social · 11/06/2025
www.sciencedirect.com/science/arti...
sciencedirect.com
Neurite Density and Kurtosis in the Gray Matter of People with Early Schizophrenia
Classical models of diffusion weighted imaging, especially diffusion tensor imaging, are unsuited for application to the cortical gray matter, given t…
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Reposted by Lena Palaniyappan
Neuropsychopharmacology @npp-journal.bsky.social · 03/06/2025
#ThisWeekInNPP This study identified a prefrontal-limbic structural covariance network with ⬇️ gray matter volume specific to treatment-resistant schizophrenia, linked to serotonergic, glutamatergic, histaminergic, & opioid receptor distributions 🧠 www.nature.com/articles/s41...
nature.com
Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis - Neuropsychopharmacology
Neuropsychopharmacology - Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis
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Lena Palaniyappan @lenapl.bsky.social · 28/05/2025
www.nature.com/articles/s41... People with schizophrenia that is resistant to treatment may have specific prefrontal-limbic brain deficits linked to non-dopaminergic neurotransmitter systems—highlighting the need for therapies beyond antipsychotics. #schizophrenia #neuroscience #mentalhealth
nature.com
Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis - Neuropsychopharmacology
Neuropsychopharmacology - Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis
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Reposted by Lena Palaniyappan
Timothy Caulfield @caulfieldtim.bsky.social · 24/05/2025
Very, very obviously we need to emphasize science-informed preventative strategies. Public health experts – myself included – have focused on this for decades! But phrase "root causes" long ago morphed into a red flag for bunk. 🚩 news.immunologic.org/p/real-root-... @drandrealove.bsky.social‬👇
news.immunologic.org
Real root cause medicine is based on science, not wellness disinformation.
RFK Jr, Marty Makary, and MAHA allies are lying to you. Biomedical research is BASED ON identifying and treating underlying causes of illness.
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Reposted by Lena Palaniyappan
CRBLM @crblm.bsky.social · 20/05/2025
Congratulations to @lenapl.bsky.social, @sylvainbaillet.bsky.social and the whole team on the boost from the @wellcometrust.bsky.social for the DIALOG initiative douglas.research.mcgill.ca/news/underst...
douglas.research.mcgill.ca
Understanding Psychiatric Disorders Through Language: $9.8M from The Wellcome Trust for DIALOG Initiative - The Douglas Research Centre
Montreal, April 23, 2025   The Douglas Mental Health University Institute is proud to announce that the Wellcome Trust has awarded $9.8 million to Dr. Lena Palaniyappan in support of ... Read more
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Reposted by Lena Palaniyappan
PSI Foundation @psifoundation.bsky.social · 23/05/2025
Drs. Peter Van Dyken and Lena Palaniyappan (@lenapl.bsky.social) (‪@schulichmeddent.bsky.social‬)'s research trainee study on graph theory and U-fibre network in people with #Schizophrenia: www.psifoundation.org/funded-resea... #SchizophreniaResearch
psifoundation.org
Funded Research - PSI Foundation
List of projects funded by PSI Foundation.
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Lena Palaniyappan @lenapl.bsky.social · 06/05/2025
Excellent synergy here, looking forward to it @sylvainbaillet.bsky.social !
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Reposted by Lena Palaniyappan
Ravi Menon @northernthrux.bsky.social · 05/05/2025
Western University is seeking applications for Canada Excellence Research Chairs. Please reach out if you are interested in Theme 2: Neuroscience. Western has extraordinary strengths in cognitive, molecular and systems neuroscience across species (rodents, NHPs, humans) uwo.ca/research/cer...
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Reposted by Lena Palaniyappan
Journal of Psychiatry & Neuroscience @jpnjournal.bsky.social · 25/04/2025
Greening the lab: Researchers are a group that can take concrete steps to reduce the environmental footprint associated with their activities. ➡️ www.jpn.ca/lookup/doi/1...
Researchers are a group that can take concrete steps to reduce the environmental footprint associated with their activities while continuing to improve human health outcomes through their research.

Editorial:
Greening the lab: fighting climate change to enhance mental health.
Albert et al.
J Psychiatry Neurosci April 23, 2025 50 (2) E142-E144; DOI: https://doi.org/10.1503/jpn.250040
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Reposted by Lena Palaniyappan
Journal of Psychiatry & Neuroscience @jpnjournal.bsky.social · 28/04/2025
Topiramate for treatment of behavioural disorders in Prader–Willi syndrome: Topiramate is effective in treating compulsive behaviours associated with PWS, but requires monitoring. ➡️ www.jpn.ca/lookup/doi/1...
Topiramate is effective in treating compulsive behaviours associated with PWS, but requires  monitoring for hyperammonemia and psychiatric comorbidities.

Psychopharmacology for the Clinician: 
Effectiveness of topiramate in the treatment of behavioural disorders in Prader–Willi syndrome.
Louveau et al.
J Psychiatry Neurosci April 23, 2025 50 (2) E145-E146; DOI: https://doi.org/10.1503/jpn.240107
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Lena Palaniyappan @lenapl.bsky.social · 26/04/2025
www.medscape.com/viewarticle/...
medscape.com
Substance-Induced vs Primary Psychosis: Are They Different?
Are substance-induced psychosis and primary psychosis fundamentally different? And if they are, does it matter?
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Reposted by Lena Palaniyappan
Douglas Research Centre @douglasresearch.bsky.social · 24/04/2025
📣 We are proud to announce that the Wellcome Trust has awarded Dr. Palaniyappan! 📣 Nous sommes fiers d’annoncer l'obtention d'une subvention de la Fondation Wellcome Trust à Dr Palaniyappan pour soutenir le projet DIALOG! More infos / plus d'infos : douglas.research.mcgill.ca/news/underst...
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Lena Palaniyappan @lenapl.bsky.social · 09/04/2025
We show cannabis use disorder is associated with higher midbrain neuromelanin, where such an increase is associated with #psychosis severity. The higher the use, the greater the putative dopamine turnover. Led by Jessica Ahrens @healthsciences.mcgill.ca IPN jamanetwork.com/journals/jam...
jamanetwork.com
Convergence of Cannabis and Psychosis on the Dopamine System
This cohort study investigates the association between cannabis and the midbrain dopamine pathway involved in psychosis.
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Lena Palaniyappan @lenapl.bsky.social · 03/04/2025
When we are depressed, we not only have negative thoughts but also experience a muddled, disorganized thinking process. We propose some steps to make progress in understanding and reducing the burden of disorganization in #Depression link.springer.com/article/10.1...
link.springer.com
Disorganisation and depression: a re-examination of how we think and speak when depressed - European Archives of Psychiatry and Clinical Neuroscience
Disorganised thinking in severe mental illness seriously cripples social functions. Historically, the study of disorganisation has primarily concentrated on schizophrenia, utilizing tools designed to ...
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Lena Palaniyappan @lenapl.bsky.social · 28/03/2025
ceymh-cesmj.ca/psychosis-my...
ceymh-cesmj.ca
Psychosis: My Journey to Recovery – CEYMH
Psychosis is often described as losing touch with reality, but for me, I never truly realized I had lost it. I ignored the signs, convinced myself I was okay—even when I wasn’t. In doing so, I only ma...
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Lena Palaniyappan @lenapl.bsky.social · 28/03/2025
www.sciencedirect.com/science/arti... We see a prominent excess of first-person pronouns in #schizophrenia, with no excessive inter-individual variability. While not a direct comparison, this effect (d=0.89) is >> than striatal dopamine excess or prefrontal glutamate reduction reported to date.
sciencedirect.com
Speaking of yourself: A meta-analysis of 80 years of research on pronoun use in schizophrenia
People with schizophrenia experience significant language disturbances that profoundly affect their everyday social interactions. Given its relevance …
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Lena Palaniyappan @lenapl.bsky.social · 23/03/2025
Dog person open.substack.com/pub/lenapl/p... #poetry
open.substack.com
Dog person
On what the RCMP allegedly did to thousands of sled dogs
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Lena Palaniyappan @lenapl.bsky.social · 07/03/2025
www.cambridge.org/core/journal...
cambridge.org
Seminal contributions of Timothy J. Crow | Psychological Medicine | Cambridge Core
Seminal contributions of Timothy J. Crow - Volume 55
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Lena Palaniyappan @lenapl.bsky.social · 06/03/2025
Transcriptional substrates of cortical thickness alterations in anhedonia of #depression ... www.sciencedirect.com/science/arti...
sciencedirect.com
Transcriptional substrates of cortical thickness alterations in anhedonia of major depressive disorder
Anhedonia is a core symptom of major depressive disorder (MDD), which has been shown to be associated with abnormalities in cortical morphology. Howev…
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Lena Palaniyappan @lenapl.bsky.social · 03/03/2025
academic.oup.com/schizophreni...
academic.oup.com
Default Mode Network, Disorganization, and Treatment-Resistant Schizophrenia
AbstractBackground and Hypothesis. Disorganized thinking is a prominent feature of schizophrenia that becomes persistent in the presence of treatment resis
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Lena Palaniyappan @lenapl.bsky.social · 02/03/2025
#Pubmed is down again. #NIH It has never been down like this for more than 20 years that I have been using it. They are likely cleaning up all mentions of gender, race, diversity, ethnicity, humanity, etc. I am confident they will not touch the keyword - 'stupidity'.
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Lena Palaniyappan @lenapl.bsky.social · 26/02/2025
www.sciencedirect.com/science/arti... Are hallucinations a result of pathological geenration of words? An experiential account argues so. A commentary with @olidn.bsky.social
sciencedirect.com
Commentary: Examining language and selfhood in hallucinations
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Lena Palaniyappan @lenapl.bsky.social · 25/02/2025
ceymh-cesmj.ca/five-ways-to...
ceymh-cesmj.ca
Five Ways to Support Students with Mental Health CrisisElementor – CEYMH
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Reposted by Lena Palaniyappan
Riccardo Fusaroli @fusaroli.eurosky.social · 24/02/2025
Our Ready to Connect (eigsti.psy.uconn.edu/home-2/ready...) project is hiring a postdoc (at UConn): eigsti.psy.uconn.edu/open-postdoc... We investigate conversational success in autistic and non-autistic teenagers during realistic social interactions. Ideal start date: May 15, 2025
psy.uconn.edu
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Lena Palaniyappan @lenapl.bsky.social · 21/02/2025
www.sciencedirect.com/science/arti... Impoverished articulation of perceptual processes in #schizophrenia is linked to the structure of #cerebellum For a special issue in Neuropsychologia edited by @valentinabambini.bsky.social & team!
sciencedirect.com
Cerebellum as a neural substrate for impoverishment in early psychosis
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Lena Palaniyappan @lenapl.bsky.social · 21/02/2025
www.bpsgos.org/article/S266... White matter does not seem to deteriorate in the first few years of #psychosis in patients receiving treatment.But negative symptoms consistently track white matter integrity.
bpsgos.org
Stable White Matter Structure in the First Three Years after Psychosis Onset
White matter alterations observed using diffusion weighted imaging have become a hallmark of chronic schizophrenia, but it is unclear when these changes arise over the course of the disease. Nearly al...
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Lena Palaniyappan @lenapl.bsky.social · 17/02/2025
How do stimulants, MDMA, #cannabis, #ketamine and #psychedelics affect speech & language? Can we use these behavioral effects to test for intoxication? Our new pre-registered systematic review journals.sagepub.com/doi/10.1177/...
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Lena Palaniyappan @lenapl.bsky.social · 11/02/2025
If you are in Montreal, apply!
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Lena Palaniyappan @lenapl.bsky.social · 07/02/2025
#psychiatry #computational #LLMs jpn.ca/content/50/1... Is pragmatism antithetical to computational psychiatry?
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Reposted by Lena Palaniyappan
Kate Clancy @kateclancy.bsky.social · 04/02/2025
Well just received this email regarding a paper under review:
Screenshot of an email that reads: "Dear Authors, 

As you may know, the new presidential administration in the United States has issued Executive Orders, including one that impacts foreign aid.  

As part of these Executive Orders, USAID-funded projects have received stop work orders. Given the circumstance, we must stop all work on Global Health: Science and Practice. As such, I regret that we will have to postpone processing submitted papers. We know that a lot of work has gone into preparing your paper. Please feel free to take your manuscript elsewhere.  

Thank you for your understanding and cooperation during this challenging time.   

Sincerely,

Natalie Culbertson
Managing Editor
Global Health: Science and Practice Journal"
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Lena Palaniyappan @lenapl.bsky.social · 05/02/2025
How long before we lose #pubmed ? I see a weird 'high traffic' notice on the site!
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Joseph Yaroch @jcyaroch.bsky.social · 02/02/2025
Today is Retraction Day, when we observe the anniversary of the retraction (Feb. 2, 2010) of the fraudulent paper that purported to show a link between vaccines and autism. 🧪#medsky
This is the front page of a fraudulent research article that purported to show a link between vaccines and autism. The word "RETRACTED" is written across it in large red letters. 

Wikipedia: On 28th February 1998, a fraudulent research paper by physician Andrew Wakefield and twelve coauthors, titled "Ileal-Lymphoid-Nodular Hyperplasia, Non-Specific Colitis, and Pervasive Developmental Disorder in Children", was published in the British medical journal The Lancet.[1] The paper falsely claimed causative links between the measles, mumps, and rubella (MMR) vaccine and colitis and between colitis and autism. The fraud involved data selection, data manipulation, and two undisclosed conflicts of interest.
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Lena Palaniyappan @lenapl.bsky.social · 01/02/2025
Congrats all! A proud moment for ceymh-cesmj.ca/youth-family... who shaped 2 of the 4 funded grants this time!
ceymh-cesmj.ca
Youth & Family Councils – CEYMH
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Lena Palaniyappan @lenapl.bsky.social · 01/02/2025
Well done, Tiana! douglas.research.mcgill.ca/news/hsi-wei.... Thanks to @sylvainbaillet.bsky.social & @magnetokrishio.bsky.social 's awesome groups - we are getting full-time into the oscillatory dynamics of psychosis.
douglas.research.mcgill.ca
Postdoctoral student Hsi Wei receives Mitacs Elevate scholarship - The Douglas Research Centre
Postdoctoral student Hsi Wei has been awarded a Mitacs Elevate grant to support her research project entitled: « Speech markers reveal brain oscillatory patterns reflecting thought disorder inPsychosi...
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Reposted by Lena Palaniyappan
Dominic Boutet @dominic-boutet.bsky.social · 27/01/2025
I've been working with the Wilson-Cowan neural mass model for a while now and, over time, I've accumulated a bunch of tools to explore/visualize it. I recently decided to collect it all into a github repository available here if anyone is interested: github.com/NeuroLife77/...
github.com
GitHub - NeuroLife77/Wilson_Cowan_analysis: Analytical derivations and numerical analyses associated with the Wilson-Cowan model
Analytical derivations and numerical analyses associated with the Wilson-Cowan model - NeuroLife77/Wilson_Cowan_analysis
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Department of Imaging Neuroscience @imagingneuroucl.bsky.social · 24/01/2025
Happy 30th birthday year to SPM!! 🎈🍰 To get the party started, we are delighted to announce SPM 25.01, a major new version of the open-source neuroimaging software. Read the preprint to discover what's new arxiv.org/pdf/2501.12081 and download SPM for free from Github github.com/spm/spm/rele...
arxiv.org
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Sunny X. Tang, M.D. @stanglab.bsky.social · 27/01/2025
Reminder! Submit your abstracts for poster and oral presentations for our DISCOURSE Satellite Meeting by 2/14/25! forms.gle/nW5K9MGtBkqQ...
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Lena Palaniyappan @lenapl.bsky.social · 27/01/2025
douglas.research.mcgill.ca/offres_d_emp... With ~C$9.5M+ investment from @wellcometrust.bsky.social, we are setting out to study why disorganized speech/behaviour occur in #psychosis #bipolar & how to reverse it. Join us for this 7-country study with MEG+PET+MRI & communication remediation.
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Matthew B @matthewbroome.bsky.social · 23/01/2025
wellcome.org/grant-fundin...
wellcome.org
Longitudinal studies | Grant funding | Wellcome
Wellcome are funding research teams to analyse longitudinal data to help identify mental health conditions early. See eligibility information and find out how to apply.
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Lena Palaniyappan @lenapl.bsky.social · 23/01/2025
www.nature.com/articles/s41.... Both childhood and adult trauma converge on caudate volume. Oxidative stress and glutamate transmission may have an influence on this convergence. With Qiang Luo & team at Fudan.
nature.com
Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia - Translational Psychiatry
Translational Psychiatry - Neuroimaging stratification reveals the striatal vulnerability to stress as a risk for schizophrenia
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Kylie Maidment @kyliemaidment.bsky.social · 15/01/2025
Great paper on the challenges of precision psychiatry, in particular modelling/predictions re complex causal/risk factors www.cambridge.org/core/journal...
cambridge.org
Precision psychiatry: thinking beyond simple prediction models – enhancing causal predictions | The British Journal of Psychiatry | Cambridge Core
Precision psychiatry: thinking beyond simple prediction models – enhancing causal predictions
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