CellWhisperer uses multimodal learning of transcriptomes and text to answer questions about single-cell RNA-sequencing data.

IntroductionThe cerebellar cortex is now recognized as a functionally heterogeneous brain region involved not only in traditional motor functioning but also ...

Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

Neuropsychopharmacology - Early-life adversity alters adult nucleus incertus neurons: implications for neuronal mechanisms of increased stress and compulsive behavior vulnerability

Nature Neuroscience - Challenges of the inconsistent neurorights framework in Latin America

This cohort study investigates the developmental pathways to suicidal ideation from teenage years to young adulthood.

This case-control study investigates if a regional homogeneity–magnetic resonance imaging cortical deficit pattern provides a more robust biomarker for major depressive disorder (MDD) than its structu...

Neuropsychopharmacology - Pharmacological reduction of reverse-translated hippocampal hyperactivity in mouse: relevance for psychosis

Schizophrenia - Cardiovascular protein profiling in patients with first-episode psychosis

Mazes are a fundamental and widespread tool in behavior and systems neuroscience research in rodents, especially in spatial navigation and spatial memory investigations in freely behaving animals. How...

Neuropsychopharmacology - Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD

Translational Psychiatry - Sex and regional differences in gene expression across the striatum in psychosis

Sleep loss is associated with a potential risk of using drugs such as cocaine, methamphetamines, and alcohol. Recently, our group showed that chronic …

GluA2-containing AMPA receptors (AMPARs) are not Ca2+ impermeable, and their ability to transport Ca2+ is shaped by the subunit composition of AMPAR tetramers as well as the orientation of transm...

This cohort study evaluates whether maternal inflammatory proteins during pregnancy are associated with the risk of neurodevelopmental disorders and executive functions in middle childhood.

Higginbotham et al. show that inflammatory pain increases opioid-evoked dopamine neuron activity to promote fentanyl use selectively in males. Ovarian hormones offer females protection, but estradiol’...

Microglial Gi signaling inhibits process dynamics, reduces microglia-neuron soma interactions, and decreases neuronal activity.

Molecular Psychiatry - Aging disrupts the coordination between mRNA and protein expression in mouse and human midbrain

This cross-sectional study compares positron emission tomography data for patients with first-episode psychosis and clinical high risk with those of healthy controls to gauge whether synaptic density ...

Tripotential intermediate progenitor cells are responsible for the local production of GABAergic neurons, oligodendrocyte precursor cells and astrocytes in the human neocortex.

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Cocaine and amphetamine stimulates astrocytes and downregulates the GLT-1. The dysfunction in GLT-1 modify EPSP kinetics and modulate STDP, switching LTP to LTD in psychostimulant-treated mice. These...

Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...

Leveraging data from the Adolescent Brain Cognitive Development (ABCD) Study, the largest (to date) study of adolescent brain and behavioral development, Miller et al1 examined associations between ne...

Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...

In astrocytes, there exists an intrinsic spatial threshold of subcellular calcium levels that triggers an astrocyte calcium surge throughout the cell, demonstrating cellular astrocyte calcium integrat...

In 1904, Richard Semon introduced the term “engram” to describe the neural substrate responsible for (or at least important in) storing and recalling memories (i.e., a memory trace). The recent introd...

Intestinal permeability biomarkers in patients with schizophrenia: Additional support for the impact of lifestyle habits - Volume 67 Issue 1

We demonstrate here that astrocytes in the striatum interact with striatal dopamine in bidirectional

Studies of the composition of the gut microbiome have consistently shown that psychiatric disorders such as schizophrenia are associated with gut dysbiosis. However, research focusing on adolescents w...

Analysis of nearly 2,000 people living in remote villages in Honduras reveals who’s spreading gut microorganisms to whom.