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Speech analysis could be a simple, noninvasive way to monitor Huntington’s disease progression remotely, so HD researchers developed an AI-powered tool that analyzes a short counting task. #hdresearch Read all about it → en.hdbuzz.net/584-your-voi...

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HDBuzz @hdbuzzfeed.bsky.social · 05/10/2026

Getting “stuck” on a thought, action or conversation may not be stubbornness; it can be a symptom of Huntington’s disease (HD) called *perseveration*. Recognising perseveration as an HD symptom can improve understanding, support and care for affected families. en.hdbuzz.net/cant-get-you...

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HDBuzz @hdbuzzfeed.bsky.social · 30/09/2026

uniQure reports that after 4 years, people given high-dose AMT-130 continue to show signs of slower HD progression, providing hope for their recent regulatory submission. But the new analyses are nuanced. We unpack the hopeful but complex results in this article → en.hdbuzz.net/amt-130-at-f...

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HDBuzz @hdbuzzfeed.bsky.social · 28/09/2026

September brought progress across the Huntington’s disease research landscape. From brain waves and visual thinking to DNA repeats, nutrition, inclusive care, new technologies, and encouraging SKY-0515 data, we round up a busy month in HD research. Full article here → en.hdbuzz.net/september-20...

Picture of a toolbox with title, “September 2026: This month in Huntington’s disease research

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HDBuzz @hdbuzzfeed.bsky.social · 24/09/2026

The CAG repeat that causes Huntington’s disease (HD) has a tendency to grow with age. New research on over 900,000 people uncovers parallel patterns and finds CAG growth can happen in many other parts of the genome. #hdresearch Read the full article → en.hdbuzz.net/studying-stu...

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HDBuzz @hdbuzzfeed.bsky.social · 21/09/2026

Unique research highlights an overlooked mental health disparity among Indigenous North American people with Huntington’s disease (HD) - and the need for care grounded in trust, community partnership, and cultural understanding. Read more here: en.hdbuzz.net/highlighting...

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HDBuzz @hdbuzzfeed.bsky.social · 16/09/2026

Skyhawk Therapeutics shared data for SKY-0515, an experimental once-daily pill that targets both huntingtin and somatic instability, making it a possible “two-for-one” drug to treat HD. Read more about this exciting news on HDBuzz → en.hdbuzz.net/encouraging-...

Graphic of a megaphone with the words, "Encouraging news from Skyhawk Therapeutics!" above.

Picture of pills from a pill bottle with words on text boxes: "A potential 2-for-1 approach to treat HD is safe and shows potential! SKY-0515 is an experimental once-daily pill that aims to lower huntingtin AND target somatic instability."

Close up photo of a doctor checking lab results. Words in text boxes read, "In the Phase 1/2 study, SKY0515 did just that, and showed positive changes in tests of movement & thinking." But will that add up to a treatment that slows HD?"

Text box: "Skyhawk's Phase 2/3 study, FALCON-HD, will tell us whether the Phase 1/2 study's promising signs hold up in a larger, placebo-controlled trial."

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HDBuzz @hdbuzzfeed.bsky.social · 14/09/2026

What if nutrition is one of the warning lights we should be checking earlier in Huntington’s disease? New research suggests simple nutrition measures may help identify when people with HD need extra support. en.hdbuzz.net/food-for-tho...

Photo of puzzle pieces on a dinner plate. Title reads, "Food for Thought: The Importance of Nutrition in Huntington's Disease".

Graphic of a wind cloud blowing at a woman holding onto an umbrella. Text reads, "Living with HD can be like walking into a strong headwind..."

Text continues, "... you're still moving forward, but it takes more energy. So a new study on nutrition in people with HD set out to discover if..."

Text continues, "1. malnutrition is more common in HD,
2. malnutrition is linked with symptoms such as movement and thinking changes, and
3. simple nutrition checks might help care teams spot when extra support is needed."

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HDBuzz @hdbuzzfeed.bsky.social · 10/09/2026

A review of 23 studies suggests that EEG could offer a non-invasive way to track brain changes across the course of Huntington’s disease (HD). #hdresearch Read all about it → en.hdbuzz.net/could-brain-...

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HDBuzz @hdbuzzfeed.bsky.social · 07/09/2026

Five Huntington’s disease (HD) researchers discuss the cutting-edge techniques driving their work, accelerating discovery and guiding development of treatments. #hdresearch Read all about it → en.hdbuzz.net/hot-techniqu...

Five research scientists compare notes. Title reads "Hot Techniques in HD Research: Five HD researches discuss the cutting-edge techniques driving their work."

Scientist looks in a microscope. "From reading DNA molecule by molecule..."

"... to visualizing proteins and neurons in remarkable detail,"

Man with a camera over the words, "these technologies are giving scientists an increasingly complete picture of how HD begins and progresses."

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HDBuzz @hdbuzzfeed.bsky.social · 03/09/2026

What if Huntington’s disease (HD) changes how we “see” the world before we even notice symptoms? New research suggests visual thinking skills may help track HD progression. en.hdbuzz.net/keeping-an-e...

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HDBuzz @hdbuzzfeed.bsky.social · 02/09/2026

NEWS! uniQure has submitted AMT-130 for regulatory approval in the US and UK. This drug is NOT yet approved; regulators must now review the evidence. Read more about this milestone here -> uniqure.gcs-web.com/node/12991/pdf and on HDBuzz here -> en.hdbuzz.net/the-other-sh...

Graphics of a megaphone and arrow pointing to words: "Press Release: uniQure has submitted AMT-130 for regulatory approval in the US & UK"

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HDBuzz @hdbuzzfeed.bsky.social · 31/08/2026

August was a busy month for Huntington’s disease (HD) research! Setbacks, new trials, a conference, and the HDBuzz Prize for Young Science Writers! Catch up on everything in our monthly roundup: en.hdbuzz.net/august-2026-...

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HDBuzz @hdbuzzfeed.bsky.social · 27/08/2026

A new Huntington's disease (HD) clinical trial has officially begun! It will test whether the drug pridopidine can slow the progression of HD. For more details, read our article: en.hdbuzz.net/first-partic...

Over a photo of medication pills is the text: "Analysis of a previous trial’s data suggested that people who were not taking antidopaminergic medications (ADMs) appeared to have greater benefit from pridopidine than those who were."

Over a photo of medication pills is the text "PRECISE-HD is a new confirmatory trial specifically designed to test that hypothesis."

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HDBuzz @hdbuzzfeed.bsky.social · 24/08/2026

New research points to HTT1a, a toxic shortened form of huntingtin (HTT), as a key driver of disease and a promising therapeutic target in Huntington’s disease (HD). Read the full article here: en.hdbuzz.net/taking-a-sho...

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HDBuzz @hdbuzzfeed.bsky.social · 20/08/2026

New Huntington’s disease (HD) trial begins! A Phase 1 study is testing SRP-1005, a huntingtin-lowering therapy given by injection under the skin. It’s early days, but this approach could add an important new arrow to the HD drug development quiver. More details here -> en.hdbuzz.net/a-shot-in-th...

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HDBuzz @hdbuzzfeed.bsky.social · 17/08/2026

Announcing the 2026 HDBuzz Prize for Young Science Writers – sponsored by the Hereditary Disease Foundation! Submission details here: en.hdbuzz.net/the-2026-hdb...

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HDBuzz @hdbuzzfeed.bsky.social · 14/08/2026

Day 3 of #HD2026 put the huntingtin protein (HTT) under the microscope. Researchers shared new insights into HTT1a, next-generation HTT-lowering approaches, somatic expansion, brain circuitry, and why boosting healthy HTT might help. Read our roundup here: en.hdbuzz.net/hd2026-milto...

The final day of HD2026 put the huntingtin protein (HTT) under the microscope.

Researchers shared:

- new insights into HTT1a
- next-generation HTT-lowering approaches
- why boosting healthy HTT might help

And lots more!

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HDBuzz @hdbuzzfeed.bsky.social · 13/08/2026

Neurons communicate via electrical impulses, and electrophysiologists can measure this activity in cells and mice. #HD2026

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HDBuzz @hdbuzzfeed.bsky.social · 13/08/2026

Day 2 #HD2026 - insights into the mechanics of somatic instability, new ways we can track Huntington’s disease (HD) in people over time, how AI can help us drive research forward, and new developments in our understanding of the HTT protein. Catch up on everything we learned on HDBuzz.net

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HDBuzz @hdbuzzfeed.bsky.social · 13/08/2026

Check out these fancy scopes that help Sonia and her team to study HD brain tissue to its full potential! #HD2026

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HDBuzz @hdbuzzfeed.bsky.social · 12/08/2026

Which HTT should we target? Human trials may give us an answer before laboratory experiments!

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HDBuzz @hdbuzzfeed.bsky.social · 12/08/2026

When scientists test a new method, they ask questions about whether it’s working as expected, and how well it might work in animal models (and eventually in people). #HD2026

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HDBuzz @hdbuzzfeed.bsky.social · 12/08/2026

Day 1 of #HD2026 - From what human brains can teach us about HD, to HTT1a, somatic CAG expansion and the normal biology of HTT, today’s talks spanned the spectrum from fundamental biology to potential treatments. Catch up on everything we learned right here. en.hdbuzz.net/hd-2026-milt...

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HDBuzz @hdbuzzfeed.bsky.social · 12/08/2026

Jim Gusella describes two interacting wheels that drive HD, expanded huntingtin and somatic instability, and a third wheel of additional genetic modifiers that we don’t yet understand. #HD2026

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HDBuzz @hdbuzzfeed.bsky.social · 12/08/2026

Ideally, everything scientists learn, from the level of DNA all the way up to populations of humans who are monitored over time, can be combined to contribute to our understanding of HD. #HD2026

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HDBuzz @hdbuzzfeed.bsky.social · 12/08/2026

Vanessa Wheeler reminds us that the study of somatic instability has a long history in HD research.

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HDBuzz @hdbuzzfeed.bsky.social · 11/08/2026

Anne's slide covering current and potential HD therapies in development - lots of shots on goal! #HD2026

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HDBuzz @hdbuzzfeed.bsky.social · 06/08/2026

Prilenia Therapeutics has donated data from two of its Huntington’s Disease (HD) clinical trials to CHDI Foundation, creating a valuable resource that researchers can use to better understand placebo effects, disease progression and future trial design. en.hdbuzz.net/prilenia-sha...

Text reads: Although data sharing has become increasingly common across biomedical research, it has not always been routine, so this is an important step forward for the field.

Text reads: Researchers will use the data to better understand placebo effects, disease progression and how to improve the design and interpretation of future clinical trials.

Text reads: In a disease where every participant and every dataset is precious, this an important investment in the future of HD research.

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HDBuzz @hdbuzzfeed.bsky.social · 03/08/2026

Roche's decision to stop development of two huntingtin-lowering programmes is disappointing, but the story doesn't end there. Years of research have answered some key questions, raised many new ones, and will inform the next generation of HD trials. Read about it here: en.hdbuzz.net/looking-back...

A road with arrows, one pointing forward and one back. Title words on screen: "Looking Back & Moving Forward - Four weeks after Roche announced two Huntington's disease programs were closing, questions remain..."

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HDBuzz @hdbuzzfeed.bsky.social · 30/07/2026

July was a hard month for Huntington’s disease research, with Roche ending two HD programs. But the month also brought promising new tools to visualize and track huntingtin, and important studies on eating and self-awareness in HD. Read the full recap: en.hdbuzz.net/july-2026-th...

Sketch of someone reading a newspaper that's on fire. On the firey side is "HARD NEWS" and the fire's out smoking side is "CONTINUING PROGRESS".

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HDBuzz @hdbuzzfeed.bsky.social · 27/07/2026

Published ANX005 trial results show the drug is safe, works as designed and may help people with Huntington’s disease - so what’s the holdup? en.hdbuzz.net/putting-it-i...

Trial drug to rein in runaway pruning is safe, so what’s next? HD can affect how well the immune system works within brain cells. Immune support cells called microglia “prune” unnecessary or damaged brain cell connections. But in people with HD, microglia can become overactive and “prune” (eliminate) useful connections. ANX005 (tanruprubart) aims to correct that immune system imbalance. The study showed the drug works as designed, has potential for benefit, and is safe. So what now?

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HDBuzz @hdbuzzfeed.bsky.social · 14/07/2026

Skyhawk Therapeutics have received the regulatory approval needed to broaden its FALCON-HD trial to include the United States, Canada, and the UK. The expanded trial will enroll up to 400 more people with Stage 2 and early Stage 3 HD across more than 40 sites worldwide.

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HDBuzz @hdbuzzfeed.bsky.social · 09/07/2026

Roche announced it is stopping development of two of its huntingtin-lowering ASO drugs, tominersen and RG6496. This marks a disappointing end to an important chapter in HD clinical research. en.hdbuzz.net/roche-ends-t...

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HDBuzz @hdbuzzfeed.bsky.social · 18/03/2026

Novartis has confirmed that the first clinical sites for INVEST-HD, the Phase 3 trial of votoplam, are now open. The study plans to recruit around 770 participants across 30+ countries, marking a major step forward in advancing potential treatments for Huntington’s disease.

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HDBuzz @hdbuzzfeed.bsky.social · 26/02/2026

To check that these 3D cell clumps actually mimic the human brain, Alice and her team visualize all of the different cell types in globe-shaped maps to see exactly where they all are in the structure and how well they are all working together. #HDTC2026

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HDBuzz @hdbuzzfeed.bsky.social · 25/02/2026

Gene’s lab uses cool tools that allow them to understand what proteins bind the HTT RNA message, in very specific locations within the cell. He thinks that the expanded huntingtin RNA is acting to reorganize its environment - pulling in extra proteins and making a mess! #HDTC2026

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HDBuzz @hdbuzzfeed.bsky.social · 25/02/2026

The final talk before we break for coffee is from Bogdan Bintu from the University of California San Diego. Bogdan starts by telling the audience how much he loves building microscopes! #HDTC2026

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HDBuzz @hdbuzzfeed.bsky.social · 25/02/2026

In this model, Steve’s team define different phases of HD which they think best explain the data and observations they have made from studying HD brains. They think expansions start slow at first, and rapidly increase as more CAG repeats are added. #HDTC2026

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HDBuzz @hdbuzzfeed.bsky.social · 25/02/2026

Another key focus for his team is on understanding why making the expanded HTT protein is toxic in some parts of the brain, but not so much for other tissues or organs. #HDTC2026

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HDBuzz @hdbuzzfeed.bsky.social · 25/02/2026

Latus is using computer modeling to build predictive models about how much their therapeutic could improve HD progression. #HDTC2026

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HDBuzz @hdbuzzfeed.bsky.social · 24/02/2026

Elena shows us super cool images of the brain-like cell systems her team uses - awesome!

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HDBuzz @hdbuzzfeed.bsky.social · 11/11/2025

To close out 2025, we're celebrating those who move Huntington's disease research forward, from scientists to families, closing this year with the gratitude we feel for the HD community.