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Broder Schmidt

@hbschmidt.bsky.social
216 followers 41 following 11 posts

Practitioner of the dark art of biochemistry 🧙‍♂️ In vivo | in vitro | in silico broderschmidt.com

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Broder Schmidt @hbschmidt.bsky.social · 25/02/2025
Ever wondered how mammalian cells sense osmotic stress? There's gotta be a signaling pathway, right? We propose a *one-component system*: NFAT5, the transcription factor that executes the osmoprotective response, is also the stress sensor! www.science.org/doi/full/10....
science.org
Direct ionic stress sensing and mitigation by the transcription factor NFAT5
Intracellular ionic strength is sensed and regulated by a prion-like domain in a transcription factor.
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Reposted by Broder Schmidt
Sri Kosuri @srikosuri.bsky.social · 08/02/2025
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
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Broder Schmidt @hbschmidt.bsky.social · 07/02/2025
Quick poll: what year is the below abstract from? „Our results indicate that protein sequences contain not only a folding code, but also a previously unrecognized code governing their distribution to diverse subcellular compartments.“
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Reposted by Broder Schmidt
Bede Portz @ysptsps.bsky.social · 23/01/2025
Dunno what they have planned, but a devastated NIH will destroy universities and academic science (on the heels of significant COVID impacts) but will also destroy biotech and cede US leadership in this sector to China and elsewhere very very quickly.
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Reposted by Broder Schmidt
Alex Holehouse @alexholehouse.bsky.social · 13/01/2025
The Dept. of Biochem. & Biophys. @ WashU is running its summer undergrad research program! Rising seniors who have not had the opportunity to do bona fide research but are interested in this are strongly encouraged to apply Deadline: Jan 31st Details: biochem.wustl.edu/resources/in... Pls share!
biochem.wustl.edu
Summer Undergraduate Research Group Experience Program (SURGE) – Department of Biochemistry and Molecular Biophysics
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Reposted by Broder Schmidt
David Mick @mick-lab.bsky.social · 11/01/2025
Proud to share our work spear-headed by PhD student Tommy Sroka with major contributions by #xenopus expert Kerstin Feistel. Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
biorxiv.org
iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade
Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide and background la...
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Broder Schmidt @hbschmidt.bsky.social · 02/01/2025
Congrats, Alex & team! You are a force and inspiration.
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Broder Schmidt @hbschmidt.bsky.social · 14/12/2024
True! Plus it provides an interesting new rationale to drug IDRs “across the stereochemical trees of life”
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Broder Schmidt @hbschmidt.bsky.social · 14/12/2024
Maybe not the ‘chiral’ response you were expecting? www.nytimes.com/2024/12/12/s...
nytimes.com
A ‘Second Tree of Life’ Could Wreak Havoc, Scientists Warn
Research on so-called mirror cells, which defy fundamental properties of living organisms, should be prohibited as too dangerous, biologists said.
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Broder Schmidt @hbschmidt.bsky.social · 13/12/2024
I recall that dissecting and drawing this parasitic worm took everything I got. Couldn’t even finish the gut epithelium…
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Broder Schmidt @hbschmidt.bsky.social · 13/12/2024
Personally, I’m still most drawn to the protist world.
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Broder Schmidt @hbschmidt.bsky.social · 13/12/2024
Found some old drawings I had to do for my undergrad in Molecular & Cellular Biology. @dadrummond.bsky.social may particularly appreciate this one, although I’m not nearly the artist he is.
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Broder Schmidt @hbschmidt.bsky.social · 13/12/2024
Lol, now we know your stance on the great olive oil rivalry between Italy and Spain.
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Broder Schmidt @hbschmidt.bsky.social · 28/11/2024
Old-y but gold-y: www.sciencedirect.com/science/arti...
sciencedirect.com
Chapter 2 Strategies and Considerations for Protein Purifications
Prior to embarking upon the purification of a protein, one should begin by considering what the protein is to be used for. In particular, how much of …
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Broder Schmidt @hbschmidt.bsky.social · 28/11/2024
@boeynaemssteven.bsky.social New night science project?
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