Reposted by hatzakislabAchilles Kapanidis @achilleskap.bsky.social · 16/09/2025What controls how/when growing RNA unblocks the "door" to exit RNA polymerase? Brilliant duo Anna Wang and Abhishek Majumder led a study in my lab - now out in NAR - on this. *Sequence* matters a lot! Read on... Super smFRET/dynamics work as well. Excited! academic.oup.com/nar/article/...academic.oup.comThe displacement of the σ70 finger in initial transcription is highly heterogeneous and promoter-dependentAbstract. Most bacterial sigma factors (σ) contain a highly conserved structural module, the ‘σ-finger’, which forms a loop that protrudes towards the RNA 0175
Reposted by hatzakislabDrLachie @drlachie.bsky.social · 17/09/2025Check out the PyCon Au talk from my team member: @ishratz25.bsky.social on the challenges and solutions(?) of cell counting in whole-brain light sheet images! Also give her a follow, she's new here. www.youtube.com/watch?v=ccLn...youtube.com"Big Brains, Small Targets: Whole-Brain Image Analysis with Python" - Ishrat Zaman (PyCon AU 2025)YouTube video by PyCon AU 1146
hatzakislab @hatzakislab.bsky.social · 12/06/2025Yes indeed. That is exactly the feedback i got. So happy you could join us 010
Reposted by hatzakislabGerti Beliu @beliulab.bsky.social · 12/06/2025Now it’s my turn! Excited to share our latest on GCE & click chemistry for live-cell and super-resolution microscopy 🧬🔬 From precise labeling to functional imaging — come by, join in, and let’s talk science! #CSSB25 #ClickChemistry #Bioimaging @uniregensburg.bsky.social @uni-wuerzburg.de 1112
hatzakislab @hatzakislab.bsky.social · 12/06/2025What a fantastic (TED ) talk by @krishnanyamuna.bsky.social explain her trifecta of dna nanotech, chemistry and electrophysiology for ion transport in organelles You know a conference discussion is excellent when #keynote speaker actually uses the white board to explain . @isbuc.bsky.social 1120
hatzakislab @hatzakislab.bsky.social · 12/06/20251st keynote talk of chemical solution to structural biology by #Nobel laureate Brian Kobilka. Fantastic conference organised by @isbuc.bsky.social and department of chemistry UCPH 091
hatzakislab @hatzakislab.bsky.social · 12/06/2025Chemical solutions to structural biology kick off by #Nobel laureate Morten Meldal . So happy to organise and attend such a event Check the amazing line up of speakers isbuc.ku.dk/documents/CS... 031
hatzakislab @hatzakislab.bsky.social · 11/06/2025Looking forward to have you here Sonja. Thank you for accepting our invitation 110
hatzakislab @hatzakislab.bsky.social · 10/06/2025Very excited to attend the Mediterranean neuroscience meeting in chania, and present in the special event what we do in my lab in the #COE center of @novo-nordisk.bsky.social and the #nanopans project funded by @lundbeckfonden.bsky.social #hatzakislab #machinelearning #singlemolecule 030
hatzakislab @hatzakislab.bsky.social · 02/06/2025Very excited to attend the #embo #febs lecture course and have a plenary on 4D microscopy and machine learning analysis of delivery of biologicals. A central part of the @coecenter.bsky.social funded by @novo-nordisk.bsky.social . meetings.embo.org/event/25-phy...meetings.embo.orgPhysical Virology: across length scales!! Spam/phishing e-mails have been reported from some FEBS Advanced lecture courses. Please be alert and watch out for fraudulent emails offering to arrange registration, accommodation, or other ser… 040
Reposted by hatzakislabCOE - Center for Optimized Oligo Escape and Control of Disease @coecenter.bsky.social · 28/05/2025One more monthly COE meeting funded by the NNF Challenge Programme was held. We discussed how material synthesized by KJJ lab are evaluated by all 3 groups and how #MachineLearning analysis by Hatzakis lab can propel #cardiomyocyte research of Carmos-Fonseca lab. 021
hatzakislab @hatzakislab.bsky.social · 26/05/2025a fanstistc and long lasting collaboration with @kirchhausenlab.bsky.social spearheaded by @jacobkaestelhansen.bsky.social . the wok is funded by @novo-nordisk.bsky.social as well @villumfonden.bsky.social 000
hatzakislab @hatzakislab.bsky.social · 26/05/2025See our recent article in @natmethods.nature.com on a machine learning model #DeepSPT to rapidly precisely and automatically analyze anomalous diffusion. The model predicted biological identity from diffusion alone indicating that motion beside structure defines function. 1122
Reposted by hatzakislabNature Reviews Drug Discovery @natrevdrugdiscov.nature.com · 21/03/2025For readers interested in siRNA drugs such as Alnylam's just-approved ATTR therapy vutrisiran, here's a comprehensive review www.nature.com/articles/s41... rdcu.be/eewvj 042
Reposted by hatzakislabSteve Quinn @steve-quinn-lab.bsky.social · 19/03/2025Blood biomarkers are beginning to revolutionize #Alzheimers diagnosis and have potential to offer early detection. Could emerging blood test technologies transform patiet care? Check out my editorial, out now in @jprecmed.bsky.social 👇👇 tinyurl.com/nwk34t7k #Biomarkers #Dementia #Diagnosticstinyurl.comThe Urgent and Global Need for Democratized Blood-Based Biomarker Diagnostics in Alzheimer’s DiseaseAlzheimer’s disease (AD) represents one of the most pressing healthcare challenges of the 21st century. As a leading cause of dementia, AD impacts over 55 million people worldwide, with this number pr... 012
hatzakislab @hatzakislab.bsky.social · 21/02/2025Happy to see the great progress you guys are making 010
hatzakislab @hatzakislab.bsky.social · 20/02/2025What a great few days in #bps2025. New interactions new collaborations and great times with a few of my group members 130
hatzakislab @hatzakislab.bsky.social · 15/02/2025Excited to attend #bps2025 with multiple of my group members. Interested in #machinelearning single particle tracking ? Quantification of lipid nanoparticles heterogeneity in dimensions and mRNA loading ? Direct observation of #lnp entering cell ? Or single enzyme activity ? Just reach out 060
hatzakislab @hatzakislab.bsky.social · 12/02/2025The registration Chemical solutions to structural biology symposium . Join us for 2 days and 30 speakers exploring state of the art science at the intersection of chemical and structural biology 030
Reposted by hatzakislabNynke Dekker Lab @nynkedekkerlab.bsky.social · 12/12/2024Opening for a senior postdoc in our single-molecule DNA replication lab! Deadline January 15, 2025! 189
hatzakislab @hatzakislab.bsky.social · 10/12/2024So sorry to see this ! My sincere condolences to you and your family 010
Reposted by hatzakislabSteve Quinn @steve-quinn-lab.bsky.social · 02/12/2024We have 4 fully funded #PhD positions available in York! Interested in single molecule biophysics, structural biology, biochemistry and/or physical chemistry? Get in touch! We have state-of-the-art labs in a fun-filled city! Come join us! DM for more or check out: sites.google.com/york.ac.uk/q... 062
hatzakislab @hatzakislab.bsky.social · 28/11/2024Sorry to see this Rita ! Hope everything turns out well 010
Reposted by hatzakislabJohannes Hohlbein @hohlbeinlab.bsky.social · 13/11/2024First attempt in a (loosely defined) Single-Molecule Biophysics starter pack. Please share and (self-) nominate. go.bsky.app/CteFZM5 6510760