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Sudarshan A Shetty

@gutmicrobe.bsky.social
262 followers 518 following 20 posts

Senior Team Lead Microbiome @ Danone Research & Innovation | Gut Microbiome | Nutrition | Computational Biology | Academic in previous life | Scientist forever | 🇮🇳 🇳🇱 | Opinions on bsky are mine not of my employer 🕊

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Sudarshan A Shetty @gutmicrobe.bsky.social · 29/09/2026
We are hiring! careers.danone.com/benelux/en/j...
careers.danone.com
Scientist - Bioinformatics
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Leo Lahti @antagomir.bsky.social · 06/02/2026
A Bayesian approach to differential prevalence analysis with applications in microbiome studies ("DiPPER") arxiv.org/abs/2602.05938
arxiv.org
A Bayesian approach to differential prevalence analysis with applications in microbiome studies
Recent evidence suggests that analyzing the presence/absence of taxonomic features can offer a compelling alternative to differential abundance analysis in microbiome studies. However, standard approa...
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bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 05/01/2026
BiomeGPT: A foundation model for the human gut microbiome www.biorxiv.org/content/10.64898/20…
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Stephen Turner @stephenturner.us · 12/11/2025
How I recovered from a collaboration gone wrong www.science.org/content/arti...
science.org
How I recovered from a collaboration gone wrong
After learning “how quickly ‘we’ can turn wicked,” this researcher reshaped his approach
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Sudarshan A Shetty @gutmicrobe.bsky.social · 31/10/2025
@antagomir.bsky.social 🙌
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Sudarshan A Shetty @gutmicrobe.bsky.social · 27/02/2025
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Sudarshan A Shetty @gutmicrobe.bsky.social · 19/01/2025
With a huge inflow of tweeps to the skies, let us hope the skies will continue to support a spectrum of opinions rather than the division by extremes 🕊
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Hall Lab @halllab.bsky.social · 11/01/2025
1/ 🚨 New preprint alert! 🚨 We’re thrilled to share our latest work exploring microbiome & genomic #Bifidobacterium co-evolutionary & functional signatures across diverse animal hosts. This has been a long time coming, & huge credit to Magda for her incredible hard work as first author! 🐾✨👇
doi.org
Host-specific microbiome and genomic signatures in Bifidobacterium reveal co-evolutionary and functional adaptations across diverse animal hosts
Animal hosts harbour divergent microbiota, including various Bifidobacterium species and strains, yet their evolutionary relationships, and functional adaptions remain understudied. By integrating tax...
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Sudarshan A Shetty @gutmicrobe.bsky.social · 05/01/2025
Fascinating Insights here 👇 50% of all bacteriology papers focus on just 10 species, a disproportionate emphasis on pathogens. Narrow focus hinders the development of novel health promoting microbes. #microbiome www.biorxiv.org/content/10.1...
biorxiv.org
Ten species comprise half of the bacteriology literature, leaving most species unstudied
Microbiology research has historically focused on a few species of model organisms. Our bibliographic analysis finds extreme bias in the distribution of bacteriology research across species, with half...
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Raymond Kiu @raymondkiu.bsky.social · 03/01/2025
Starting the new year with a new pre-print from the Hall Lab @halllab.bsky.social looking at the impact of empirical antibiotics on gut microbiome and resistome of both probiotic and non-probiotic supplemented VLBW preterm infants: www.biorxiv.org/content/10.1... #resistome #amr #microbiome #preterm
biorxiv.org
Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants
Preterm infants (<37 weeks’ gestation) are often administered broad-spectrum antibiotics in hospitals due to their vulnerability to severe morbidity, including necrotising enterocolitis and sepsis. Ho...
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Sudarshan A Shetty @gutmicrobe.bsky.social · 03/01/2025
If you are a microbial ecologist, add this to your must-read library
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 29/12/2024
Spatial heterogeneity influences phage-host co-existence dynamics and phage resistance development in Vibrio anguillarum www.biorxiv.org/content/10.1101/202…
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Bork Group at EMBL Heidelberg @borklab.bsky.social · 17/12/2024
"Functional and evolutionary significance of unknown genes from uncultivated taxa", a publication from the lab of @jhcepas.bsky.social (2023), highlights what can be achieved by integrating GMGC and other gene catalogs to hunt for novel gene families in 150k genomes www.nature.com/artic...
nature.com
Functional and evolutionary significance of unknown genes from uncultivated taxa
Nature - We analysed 149,842 environmental genomes from multiple habitats and compiled a curated catalogue of 404,085 functionally and evolutionarily significant novel gene families exclusive to...
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Stephen Turner @stephenturner.us · 17/12/2024
SCARAP: scalable cross-species comparative genomics of prokaryotes academic.oup.com/bioinformatics/adv… 🧬🖥️🧪 github.com/swittouck/scarap
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 22/08/2024
Ecological factors that drive microbial communities in culturally diverse fermented foods www.biorxiv.org/content/10.1101/202…
biorxiv.org
Ecological factors that drive microbial communities in culturally diverse fermented foods https://www.biorxiv.org/content/10.1101/2024.08.20.608727v1
Fermented foods are increasingly recognized for their health benefits. Historically, cultures worldw
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Segata Lab @cibiocm.bsky.social · 12/06/2024
NEW from Willem M. De Vos's lab, HELMi team and our lab: longitudinal metagenomic analyses on infant gut microbiota seeding dynamics just published! 👏 THANKS to Leonard Dubois, Mireia Valles Colomer and all co-authors, the study participants, and the funding agencies! www.cell.com/cell-host-mi...
cell.com
Paternal and induced gut microbiota seeding complement mother-to-infant transmission
Assembly of the gut microbiome is disrupted in cesarean deliveries. Dubois, Valles-Colomer, et al. assessed the role of both parents and of maternal fecal microbiota transplantation (FMT) in shaping t...
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Sudarshan A Shetty @gutmicrobe.bsky.social · 11/05/2024
The dysbiosisR package is a collection of functions to calculate six dysbiosis measures from microbiota profiling data. microsud.github.io/dysbiosisR/a...
microsud.github.io
Introduction
dysbiosisR
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 07/01/2024
Quantifying the daily harvest of fermentation products from the human gut microbiota www.biorxiv.org/content/10.1101/202…
biorxiv.org
Quantifying the daily harvest of fermentation products from the human gut microbiota https://www.biorxiv.org/content/10.1101/2024.01.05.573977v1
Fermentation products released by the gut microbiota provide energy and important regulatory functio
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Sudarshan A Shetty @gutmicrobe.bsky.social · 07/01/2024
Prof. Marten Scheffer explains the concept of 'sickness of rarity' in ecosystems. We had an opportunity to collaborate & demonstrate its presence in human gut microbiota(HGM). This has implications for understanding occasional pathobiont blooms in HGM. www.wur.nl/en/research-...
wur.nl
'Stickiness' of rarity and the universal dance of dominance
In a revelatory exploration of biodiversity, a recent study has exposed the universal principles governing the dominance and rarity of species across ecosystems. The researchers unveil that a mere few...
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Sudarshan A Shetty @gutmicrobe.bsky.social · 03/01/2024
A tiny fraction of all species forms most of nature: Rarity as a sticky state doi.org/10.1073/pnas...
doi.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 31/12/2023
Vaginal Lactobacillus fatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment www.biorxiv.org/content/10.1101/202…
biorxiv.org
Vaginal Lactobacillus fatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment https://www.biorxiv.org/content/10.1101/2023.12.30.573720v1
Bacterial vaginosis (BV), a common syndrome characterized by Lactobacillus-deficient vaginal microbi
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 31/12/2023
Exposure and resistance to lantibiotics impact microbiota composition and function www.biorxiv.org/content/10.1101/202…
biorxiv.org
Exposure and resistance to lantibiotics impact microbiota composition and function https://www.biorxiv.org/content/10.1101/2023.12.30.573728v1
The intestinal microbiota is composed of hundreds of distinct microbial species that interact with e
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Sudarshan A Shetty @gutmicrobe.bsky.social · 29/12/2023
Automate Microbiome Analysis Using Quarto At the beginning of 2023, I created a blog post on how to automate basic and routine microbiome data analysis tasks in R using Quarto. Here is a tutorial for #Microbiome #blueskiers microsud.github.io/quarto_micro...
microsud.github.io
Automate microbiome analysis - Automate Microbiome Analysis Using Quarto
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Sudarshan A Shetty @gutmicrobe.bsky.social · 28/12/2023
Our recent paper is out now in Aging Cell. pre-vaccination immune sytem configuration associate with antibody responses to influenza vaccination and contain signatures that improve our understanding of immune aging and post-vaccination immune subset kinetics. onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
Pre‐vaccination immunotypes reveal weak and robust antibody responders to influenza vaccination
Aging Cell is an open access geroscience journal addressing the biology of aging, from molecular mechanisms of aging to age-related disease.
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Cameron Thrash @jcamthrash.bsky.social · 28/12/2023
Metabolic profiling of petroleum-degrading microbial communities incubated under high-pressure conditions www.frontiersin.org/articles/10.... #jcampubs
frontiersin.org
Metabolic profiling of petroleum-degrading microbial communities incubated under high-pressure condi...
While pressure is a significant characteristic of petroleum reservoirs, it is often overlooked in laboratory studies. To clarify the composition and metabolic properties of microbial communities under...
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bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 28/12/2023
A catalogue of small proteins from the global microbiome www.biorxiv.org/content/10.1101/202…
biorxiv.org
A catalogue of small proteins from the global microbiome https://www.biorxiv.org/content/10.1101/2023.12.27.573469v1
Small open reading frames (smORFs) shorter than 100 codons are widespread and perform essential role
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Victor J. Torres @torreslab.bsky.social · 27/12/2023
Job Alert! We are looking for a Principal Bioinformatics Research Scientist with extensive experience in large-scale microbial genomics to create and direct our new Microbial Computational Genomics and Bioinformatics Lab @StJudeResearch stjude.wd1.myworkdayjobs.com/stjude/job/M...
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 28/12/2023
Benchmarking A Novel Quantitative PCR-based Microbiome Profiling Platform Against Sequencing-based Methods www.biorxiv.org/content/10.1101/202…
biorxiv.org
Benchmarking A Novel Quantitative PCR-based Microbiome Profiling Platform Against Sequencing-based Methods https://www.biorxiv.org/content/10.1101/2023.12.27.573468v1
Background. PCR-based diagnostics, predominantly utilized for pathogen detection, have faced chal- l
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Meike Wortel @meikewortel.bsky.social · 23/12/2023
I'm happy 😀 to announce I have a PhD position on the mathematical 🧮 modelling 💻 of microbial 🦠 evolution! I'm looking forward to working with an enthousiastic candidate on this project, please contact me with any questions! #JobAlert Please retweet! vacatures.uva.nl/UvA/job/PhD-...
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 24/12/2023
Bacteroidia and Clostridia perform a progressive cascade of polysaccharide degradation along the hindgut of the herbivorous fish Kyphosus sydneyanus www.biorxiv.org/content/10.1101/202…
biorxiv.org
Bacteroidia and Clostridia perform a progressive cascade of polysaccharide degradation along the hindgut of the herbivorous fish Kyphosus sydneyanus https://www.biorxiv.org/content/10.1101/2023.12.23.570891v1
The gut microbiota of the marine herbivorous fish Kyphosus sydneyanus are thought to play an importa
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Bluesky @bsky.app · 22/12/2023
📢 App Version 1.60 is rolling out now (1/5) We have a new logo! 🦋  Bluesky is emerging from its cocoon of clouds to transform into a social butterfly. Read more about why we chose this logo here: blueskyweb.xyz/blog/12-21-2...
The bluesky logo with the blue butterfly
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 04/12/2023
This is a super cool piece of work - Olivia Kosterlitz & Benjamin Kerr et al Evolutionary “Crowdsourcing”: Alignment of Fitness Landscapes Allows for Cross-species Adaptation of a Horizontally Transferred Gene academic.oup.com/mbe/article/... #MicroSky #EvoSky
academic.oup.com
Evolutionary “Crowdsourcing”: Alignment of Fitness Landscapes Allows for Cross-species Adaptatio...
Abstract. Genes that undergo horizontal gene transfer (HGT) evolve in different genomic backgrounds. Despite the ubiquity of cross-species HGT, the effects of s
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Eiko Fried @eikofried.bsky.social · 04/12/2023
New paper: of 5000 PhDs awarded at large Dutch uni, men were about twice as likely to receive a cum laude degree even if they had same supervisor. Difference most severe with all male PhD committees & reduces with more female members. www.nature.com/articles/s41...
nature.com
Gender inequality in cum laude distinctions for PhD students - Scientific Reports
Scientific Reports - Gender inequality in cum laude distinctions for PhD students
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Anne Kupczok @annecmg.bsky.social · 04/12/2023
We are looking for a colleague! Assistant/associate professor machine learning in bioinformatics at Wageningen University www.wur.nl/en/vacancy/a...
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Luis Pedro Coelho @luispedrocoelho.bsky.social · 17/11/2023
If you are applying for a PhD in the US, can I suggest you consider Australia🦘? Great science and many of the advantages of the US: English-speaking, easy-going, multi-cultural But the coffee is better, no school shootings, and if—God forbid—you ever need an ambulance, that won't bankrupt you
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Ákos T Kovács @evolvedbiofilm.bsky.social · 12/11/2023
Reactivity of complex communities can be more important than stability @NatureComms by Yuguang Yang, @coytelab.bsky.social, Kevin R. Foster & Aming Li www.nature.com/articles/s41...
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Sudarshan A Shetty @gutmicrobe.bsky.social · 11/11/2023
Wishing everyone a Happy and prosperous Diwali! Let us celebrate our cultural identities, spread peace and love 🕊 ❤️
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Elin Videvall @elinvidevall.bsky.social · 06/11/2023
A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity. #microbiome #preprint www.biorxiv.org/content/10.1...
biorxiv.org
A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Sudarshan A Shetty @gutmicrobe.bsky.social · 24/10/2023
Tidyverse has really disappointed with lack of stability 😞
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 24/10/2023
Phylogenetic diversity of the carbon monoxide-utilizing prokaryotes and their divergent carbon monoxide metabolisms in the human gut microbiome www.biorxiv.org/content/10.1101/202…
biorxiv.org
Phylogenetic diversity of the carbon monoxide-utilizing prokaryotes and their divergent carbon monoxide metabolisms in the human gut microbiome https://www.biorxiv.org/content/10.1101/2023.10.23.563559v1
Although the production of toxic CO within the human body has been detected, only a few CO-utilizing
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Jonathan Eisen @phylogenomics.bsky.social · 24/10/2023
Reading: www.biorxiv.org/content/10.1...
biorxiv.org
nf-core/taxprofiler: highly parallelised and flexible pipeline for metagenomic taxonomic classificat...
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Sudarshan A Shetty @gutmicrobe.bsky.social · 21/10/2023
𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗖𝗼𝗻𝗳𝗶𝗴𝘂𝗿𝗮𝘁𝗶𝗼𝗻𝘀 𝗼𝗳 𝘁𝗵𝗲 𝗚𝘂𝘁 𝗠𝗶𝗰𝗿𝗼𝗯𝗶𝗼𝗺𝗲 𝗹𝗶𝗻𝗸𝗲𝗱 𝘁𝗼 𝗗𝗶𝗲𝘁, 𝗗𝘆𝘀𝗯𝗶𝗼𝘀𝗶𝘀, 𝗮𝗻𝗱 𝗛𝗲𝗮𝗹𝘁𝗵 Authors use meta-omics data to identify four distinct functional configurations of the gut microbiome. microbiomejournal.biomedcentral.com/articles/10....
microbiomejournal.biomedcentral.com
Four functional profiles for fibre and mucin metabolism in the human gut microbiome - Microbiome
Background With the emergence of metagenomic data, multiple links between the gut microbiome and the host health have been shown. Deciphering these complex interactions require evolved analysis method...
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 20/10/2023
Diurnal rhythmicity of fecal microbiota and metabolite profiles in the first year of life: a randomized controlled interventional trial with infant formula www.biorxiv.org/content/10.1101/202…
biorxiv.org
Diurnal rhythmicity of fecal microbiota and metabolite profiles in the first year of life: a randomized controlled interventional trial with infant formula https://www.biorxiv.org/content/10.1101/2023.10.19.563092v1
Microbiota assembly in the infant gut is influenced by time and duration of dietary exposure to brea
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Segata Lab @cibiocm.bsky.social · 19/10/2023
JOIN our lab in a nice little city –Trento🇮🇹– surrounded by mountains & lakes. Are you a COMPUTATIONAL BIOLOGIST and interested in doing microbiome science with a supportive team of dry-lab & wet-lab scientists? Feel free to contact nicola.segata@unitn.it 1/3
alps mountains snow ski
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Ran Blekhman @blekhman.bsky.social · 17/10/2023
Happy to share our latest preprint -- we built an integrated compendium of all publicly available human gut microbiome 16S data (~168,000 samples) and used it to explore patterns of microbiome variation around the world www.biorxiv.org/content/10.1...
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 18/10/2023
Mechanism of 2-Fucosyllactose degradation by Human-Associated Akkermansia www.biorxiv.org/content/10.1101/202…
biorxiv.org
Mechanism of 2-Fucosyllactose degradation by Human-Associated Akkermansia https://www.biorxiv.org/content/10.1101/2023.10.17.562767v1
Among the first microorganisms to colonize the human gut of breastfed infants are bacteria capable o
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Sudarshan A Shetty @gutmicrobe.bsky.social · 07/10/2023
A microbiologist and this museum ❤️ 📍Amsterdam
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Susan Holmes🎲🖥️🧬 @sherlockpholmes.bsky.social · 04/10/2023
Extensions of Survey for another few days so we can include the Bluesky and mastodon participants that were not polled earlier.
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Sudarshan A Shetty @gutmicrobe.bsky.social · 03/10/2023
Nobel prize in physiology or medicine awarded to Katalin Karikó and Drew Weissman! 🥳
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David Coil @davidacoil.bsky.social · 03/10/2023
Clinical Lab Scientist (CLS) position open at Student Health at @ucdavis. Come work in a fancy lab with a great student population! careerspub.universityofcalifornia.edu/psp/ucdavis/...
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