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GcL

@grosscol.bsky.social
443 followers 152 following 267 posts

Programming and human genetics. Working with TOPMED data and providing a view into human variation via BRAVO (bravo.sph.umich.edu)

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GcL @grosscol.bsky.social · 16/06/2026
Before engaging with anyone on the internet, remember, "𝐭𝐡𝐞𝐫𝐞 𝐢𝐬 𝐧𝐨 𝐢𝐝𝐞𝐚 𝐭𝐨𝐨 𝐬𝐭𝐮𝐩𝐢𝐝 𝐟𝐨𝐫 𝐚 𝐩𝐞𝐫𝐬𝐨𝐧 𝐭𝐨 𝐡𝐚𝐯𝐞."
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GcL @grosscol.bsky.social · 03/06/2026
Skipped writing the edge case handling, and now I have to break out one of my command lines of shame to mop up: 𝚙𝚜 –𝚞 𝚐𝚛𝚘𝚜𝚜𝚌𝚘𝚕 | 𝚐𝚛𝚎𝚙 𝚜𝚊𝚖𝚝𝚘𝚘𝚕𝚜 |\  𝚌𝚞𝚝 –𝚍 ' ' –𝚏𝟷 | 𝚡𝚊𝚛𝚐𝚜 𝚔𝚒𝚕𝚕 "This will be the last time I neglect handling nfs shares becoming inaccessible" and other lies I tell myself.
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GcL @grosscol.bsky.social · 26/05/2026
Logged into post a quick story about a bash script. Was presented with a story of an 8th grader going off script after being given a microphone.
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GcL @grosscol.bsky.social · 12/05/2026
I love this choppy little dude
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GcL @grosscol.bsky.social · 06/05/2026
#!/usr/bin/env bash⁣ # Generate $1 number of unique ids⁣ # Expected use: rnd_ids 200 > new_ids.txt⁣ N_IDS=${1:–10}⁣ LC_ALL=C⁣ 𝚌𝚊𝚝 /𝚍𝚎𝚟/𝚛𝚊𝚗𝚍𝚘𝚖 |\⁣   𝚝𝚛 –𝚍𝚌 '𝙰–𝚉𝟶–𝟿' |\⁣   𝚏𝚘𝚕𝚍 –𝚠 𝟷𝟶 |\⁣   𝚊𝚠𝚔 '!𝚡[$𝟶]++' |\⁣   𝚑𝚎𝚊𝚍 –𝚗 ${𝙽_𝙸𝙳𝚂}
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Catalin Cimpanu @campuscodi.risky.biz · 09/04/2026
The Claude[.]md file can be abused for malicious operations layerxsecurity.com/blog/vibe-ha...
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GcL @grosscol.bsky.social · 09/04/2026
A family member sent a Christian apologist book. I'm reading it cover to cover only because it is important to them. I'm impressed at the army of straw men the authors burn to illuminate their points. The tl;dr is that unless you're already an evangelical Christian, this book is not for you.
Photo of cover of the book, I Don't Have Enough Faith to Be an Atheist.
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The Ghost of Mark Twain @ghostofmarktwain.bsky.social · 23/03/2026
I apologize in advance No, I don't .... 🤣
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GcL @grosscol.bsky.social · 05/11/2025
@leftistlawyer.com you changed your profile picture. This new one is great too.
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GcL @grosscol.bsky.social · 04/11/2025
𝚜𝚊𝚖𝚝𝚘𝚘𝚕𝚜 𝚖𝚎𝚛𝚐𝚎 doesn't have an option to write to stdout.  It just has a –𝚘 arg to specify output file. Named pipes to the rescue. 𝚖𝚔𝚏𝚒𝚏𝚘 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍 𝚋𝚊𝚖𝚜𝚊𝚖𝚝𝚘𝚘𝚕𝚜 𝚖𝚎𝚛𝚐𝚎 –𝚏 \ –𝚘 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍.𝚋𝚊𝚖 "${𝙸𝙽𝙿𝚄𝚃_𝙿𝙸𝙿𝙴𝚂[@]}" & 𝚌𝚛𝚊𝚖_𝚜𝚞𝚖𝚖𝚊𝚛𝚒𝚣𝚎𝚛 𝚙𝚒𝚙𝚎_𝚖𝚎𝚛𝚐𝚎𝚍.𝚋𝚊𝚖 > \ 𝚜𝚟_𝚜𝚞𝚖𝚖𝚊𝚛𝚢.𝚓𝚜𝚘𝚗
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GcL @grosscol.bsky.social · 30/10/2025
For the first time, I'm glad I don't work with the Ruby ecosystem anymore.
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GcL @grosscol.bsky.social · 20/10/2025
This was a useful list. Nice that this platform facilitates blocking lists of bad actors.
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GcL @grosscol.bsky.social · 16/10/2025
If you rip off my post without liking it, you owe me two dollars.
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GcL @grosscol.bsky.social · 04/10/2025
@katmabu.bsky.social keep it up. Good luck!
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GcL @grosscol.bsky.social · 04/10/2025
@bcdreyer.social how do you edit copy? I thought paste took care of that?! /S
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GcL @grosscol.bsky.social · 03/10/2025
@@cherylrofer.bsky.social I came across a post of yours, checked your profile, and found that I liked both. I have heard a lot about thorium reactors in recent years. What are your thoughts on thorium and thorium reactors?
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GcL @grosscol.bsky.social · 20/09/2025
Those that know history are done to watch everyone else repeat it.
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Michael Pollard @kmichaelpollard.bsky.social · 13/09/2025
If you want something written about the human genome that is not complex science, then this is a good place to start. 🧪
Photo of the cover of the book "The Mysterious World of the Human Genome" by Frank Ryan.
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Leah @leah.myatproto.social · 13/09/2025
#ScienceSky 🧪
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Electronic Frontier Foundation @eff.org · 04/09/2025
"The unsettling feeling that your device is spying on you is real — but the culprit isn't a secret microphone. It's the data broker industry," EFF’s @evacide.bsky.social tells @CNET.com. www.cnet.com/tech/servic...
cnet.com
No, Your iPhone Isn't Listening to You. Here's What's Really Happening
There are lots of reasons an ad pops up on your phone, but none involve a microphone listening.
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Robert Reich @rbreich.bsky.social · 03/09/2025
The 100 lowest-paying US corporations spent $644B on stock buybacks from 2019 to 2024. Buybacks artificially boost share prices and inflate CEO pay. The typical worker at these companies earned $35k last year. Meanwhile, the average CEO was paid $17.2M See the problem?
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Ryan Marino, MD @ryanmarino.bsky.social · 03/09/2025
Vinay Prasad, a former adult oncologist, has moved to disrupt the childhood vaccine schedule by asserting - against all evidence - that administering multiple vaccines at the same time “could blunt their efficacy.” The added burden/delay of separating shots would sharply reduce US vaccination rates.
biocentury.com
FDA quietly positions itself to disrupt childhood vaccine schedule
While CDC turmoil grabbed the media spotlight, a quieter but potentially more consequential drama unfolded last week at FDA. The agency has positioned itse...
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Electronic Frontier Foundation @eff.org · 01/09/2025
Digital Rights Bytes is a place for you to get clear answers to the frequently asked questions that bug you about technology in short, easily digestible bites. www.digitalrightsbytes.org/
digitalrightsbytes.org
Welcome to Digital Rights Bytes
Digital Rights Bytes
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Red Blob Games @redblobgames.com · 01/09/2025
Weekend project: writing a simple search engine. Part 2 is about document ranking: www.redblobgames.com/blog/2025-08...
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Misty De Méo @cdrom.ca · 02/09/2025
Blaft with the true cure for modern malaise www.blaft.com/blogs/news/a...
"WHAT SHOULD I DO ABOUT MY CRIPPLING EXISTENTIAL DREAD AND FEAR OF THE FUTURE?"

Buy weird art!
Eat balanced meals!
Start a riot after lunch!
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Techdirt @techdirt.com · 29/08/2025
House Republicans Want To Doxx Wikipedia Editors Over Bogus ‘Bias’ Complaints Congress has absolutely zero constitutional authority to investigate a private website for its editorial decisions. Zero. None. This is First Amendment 101. Yet House Oversight Committee Chairman James Comer and…
techdirt.com
House Republicans Want To Doxx Wikipedia Editors Over Bogus ‘Bias’ Complaints
Congress has absolutely zero constitutional authority to investigate a private website for its editorial decisions. Zero. None. This is First Amendment 101. Yet House Oversight Committee Chairman James Comer and Cybersecurity Subcommittee Chairwoman Nancy Mace have decided otherwise. In a letter to Wikimedia Foundation CEO Maryana Iskander, these two Republicans are demanding that Wikipedia hand over editor identities, internal communications, and arbitration records because some studies suggest there might be bias in Wikipedia articles about Israel-Palestine issues.
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Dr Farbod @emergencybod.medsky.social · 30/08/2025
The best marketing "Socialism" ever had.
A meme made of two stacked social media posts.

Top post: A user named sigsauer1814 shares a Fox Business screenshot showing survey results titled “GEN Z HOLDING ‘FAVORABLE VIEW’ (Survey of Americans aged 18–29)”. The chart reports 62% Socialism and 34% Communism. Their caption reads: “18-39. Ok. Who's teaching this to our kids?”

Bottom post: A reply from themattylee says:
“You are. When people said, ‘Maybe people shouldn’t have to take on astronomical debt to get medical treatment’ you said ‘That’s socialism.’ When people said, ‘We shouldn’t be burdening young adults who want to get an education with predatory loans’ you cried ‘Socialism!’
You’re the best marketing Socialism ever had.”
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PKs Powerfromspace1 🚀 Last Angry Bernie Brother cast adrift 😒 @powerfromspace1.bsky.social · 31/08/2025
REFINERY BUSTER: Ukraine's ship-killing R-360 Neptune has been modified into the 'Long Neptune' for use as a Tactical Land Attack Missile (TLAM). With a 1000 Km (600 mi) range the Long Neptune can deliver precision strikes in adverse Electronic Warfare (EW) environments. x.com/chuckpfarrer...
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caspy7.bsky.social @caspy7.bsky.social · 31/08/2025
A cradle-to-grave analysis from the University of Michigan has shown that battery electric vehicles have lower lifetime greenhouse gas emissions than internal combustion engine vehicles, hybrids and plug-in hybrids in every county in the contiguous U.S. news.umich.edu/evs-reduce-c...
news.umich.edu
EVs reduce climate pollution, but by how much? New U-M research has the answer
Choosing a more electrified vehicle will reduce drivers' greenhouse gas emissions, regardless of where they live in the contiguous United States, according to a new study from the University of Michig...
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Rob Patro @robp.bsky.social · 30/08/2025
Without our own users, I have no idea when I would have learned about this extremely subtle limitation of the minimap2 serialized index github.com/COMBINE-lab/... (reference names > 255 bytes don't roundtrip). Users push your software in ways you might not even think to!
github.com
Indexing issue · Issue #46 · COMBINE-lab/oarfish
Hi Rob and team, This is Khi Pin from PacBio. I was testing oarfish recently and I tried creating an index with a FASTA file that had custom header: oarfish --only-index --annotated problematic.fas...
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Dan Johnson will design games for food @coil.bsky.social · 28/08/2025
While defending the luddite argument in Discord, I stumbled into this IMO succinct explanation for opposing generative AI: At every step in the process, it impoverishes us.
AI impoverishes us at every step of the process: 
- data centers pollute our environment
- energy use drives up costs
- content theft robs creators of income
- the actual output is used to displace workers and depress wages
- using it harms our mental health and impairs our competence
- the flood of AI slop is damaging our sociopolitical landscape

All in service of making a worse product - and world - to enrich a handful of already spectacularly wealthy people
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Jan Rosenow @janrosenow.bsky.social · 30/08/2025
There’s a persistent myth that new solar farms don’t really help tackle climate change because panels are “made with coal” and “never pay back” their carbon debt. This is simply false. - UN: solar ~8x cleaner than gas, ~19x than coal per kWh - panels repay CO2 in 4 months; save 57x over life
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DWink @d-winker.bsky.social · 30/08/2025
You hit the nail on the head! There's actually a paper on this: "ChatGPT is bullshit." link.springer.com/article/10.1...
link.springer.com
ChatGPT is bullshit - Ethics and Information Technology
Recently, there has been considerable interest in large language models: machine learning systems which produce human-like text and dialogue. Applications of these systems have been plagued by persist...
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GcL @grosscol.bsky.social · 19/08/2025
Finally implemented the pre-signed time limited links to the public VCFs of BRAVO bravo.sph.umich.edu/vcfs.html. Had to threading the needle of different dependencies handling AWS IAM credentials in their own "helpful" way.
bravo.sph.umich.edu
Bravo:VCFs
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Neil Renic @ncrenic.bsky.social · 14/05/2025
This is bleak reading
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IEEE Spectrum @spectrum.ieee.org · 10/05/2025
“Engineers and computer scientists, please defend humanities research just as loudly as you might defend research in STEM fields.” With thousands of funding cuts across the humanities, it’s vitally important that engineers stand up to support the humanities.
spectrum.ieee.org
Engineering and the Humanities: It's Complicated
As an electrical engineer turned historian who now studies engineers of the past, I have a good sense of how the engineering profession evolved. And what I've learned is this: Engineers have long…
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GcL @grosscol.bsky.social · 13/05/2025
How does one run a merge update on a collection of nearly 900 million records? Slowly
Output from top showing nearly 600 minutes of runtime by a mongod process.
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Johan Duchêne @johanduchene.bsky.social · 08/05/2025
Non-specific #antibodies still plague #reproducibility in biomedical research. @YCharOS1 tackles this by testing commercial antibodies in knockout cell lines—and sharing the data openly. Learn more in their online seminar: May 29, 2025 | 4pm–5pm CEST tinyurl.com/YCharOs-Semi...
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GcL @grosscol.bsky.social · 06/05/2025
Cautiously optimistic about the Ladybird Browser project. A non-google ad funded browser. For info: www.youtube.com/watch?v=9YM7... For devs: github.com/LadybirdBrow... Looks promising and has a code base that's tractable for the hobbyist hacker to contribute to.
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GcL @grosscol.bsky.social · 02/04/2025
Finally pushed to production a version of BRAVO that shows eQTL data. bravo.sph.umich.edu
bravo.sph.umich.edu
Bravo:Home
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