Gregor lab @gregorlab.bsky.social · 21/07/2026Live-cell imaging of a mature primary neuron (rat embryonic cortical origin). The morphology is illuminated through the precise intracellular microinjection of GFP, providing detailed look at the mature structural complexity of an individual neural cell." 000
Gregor lab @gregorlab.bsky.social · 21/07/2026“Illuminating the Architecture of Thought” by our Postdoc @GemperleJakub (@imgprague) has won the Prague @EuroBioImaging Node Picture of the Month. Congrats jakub! @imgprague imcf.natur.cuni.cz/IMCF/picture-o… #neuron #Live-cell imaging of a mature primary neuron through microinjected GFP 110
Gregor lab @gregorlab.bsky.social · 21/05/2026Cross-section of mouse diaphragm labeled for different muscle types: slow MHC type I (yellow), fast MHC IIa (cyan) and MHC IIx (magenta), leaving MHC IIb unstained (white). Outline of individual muscle fibers visualized by laminin staining (black). Leica DM6000 microscope & ImageJ. 010
Gregor lab @gregorlab.bsky.social · 21/05/2026“The Aquarelle of Motion” by our PhD student Vera Getmanchuk-Zaporoshchenko (@imgprague) has won the Prague @EuroBioImaging Node Picture of the Month. Congrats Vera! imcf.natur.cuni.cz/IMCF/picture... 210
Gregor lab @gregorlab.bsky.social · 05/05/2026@Gregor_lab #labretreat 2026: two days of exploring new angles of our projects, hiking, enjoying great food, and sharing lots of laughter in the beautiful scenery of Český ráj. Thanks to Vera, Káča, and Černá Louže for making it happen this year! 010
Gregor lab @gregorlab.bsky.social · 30/04/2026Happy to be part of this story: Jan Famera and Lea M. Skultéty from Gymnázium Karla Čapka in Dobříš advanced to the next round of Students’ Professional Activities, Czech national high-school research competition, with work on muscular dystrophy performed in our lab. Huge congratulations! 000
Gregor lab @gregorlab.bsky.social · 20/03/2026Great @imgprague seminar by our PhD student Srikant Ojha @sojha148 on hepatic stellate cell #mechanosignaling and its potential for new therapeutic approaches in liver #fibrosis. Lab of Integrative Biology @Gregor_lab is leveling up 🚀 010
Reposted by Gregor labInstitute of Molecular Genetics @imgprague.bsky.social · 19/01/2026🚀Open PhD position! Lab of Integrative Biology @gregorlab.bsky.social is seeking a new talent. 💪Ultimate goal: Develop AAV-compatible mini-plectins to treat muscular dystrophy and cardiomyopathy 👉Profile: MSc, interest in biology, motivation, independence 🧡APPLY: img.cas.cz/phd 002
Gregor lab @gregorlab.bsky.social · 31/12/2025Our paper on the anti-cancer effects of the first-in-class plectin inhibitor plecstatin is out in @MolOncology! Great work by @OutlaZuzana & @Kosla_Jan. Collaborations with @Selma_OsMyers (@MedUniWien), Sam Meier (@univienna) & Lukas Frick (@UZH). Check at pubmed.ncbi.nlm.nih.gov/41467448/ 030
Gregor lab @gregorlab.bsky.social · 22/12/2025It’s been an eventful year for all of us! Our Christmas party was a great reminder of the team spirit behind the science & we’re excited to take on the challenges of 2026. Merry Christmas & Happy New Year from the Laboratory of Integrative Biology! 040
Gregor lab @gregorlab.bsky.social · 09/10/2025At #WMS2025 in Vienna? Check out our PhD student Vera Getmanchuk-Zaporoshchenko’s poster on phenotyping a preclinical model of plectin-related LGMD. #LGMD #MuscularDystrophy" 010
Gregor lab @gregorlab.bsky.social · 23/09/2025Huge congrats to our PhD student, Piyush Bisht, for presenting his work on Flipper-TR probe applied to Circulating Tumor Cells at #Czechbioimaging's Imaging Principles of Life 2025 conference in Brno! He had amazing discussions and valuable feedback. Way to go, Piyush!" @imgprague.bsky.social 011
Gregor lab @gregorlab.bsky.social · 08/09/2025tn.nova.cz/zpravodajstv...tn.nova.czUnikátní výzkum českých vědců. Testují metodu, která by mohla zastavit šíření rakoviny | TN.czČeští vědci testují novou metodu, která by mohla zpomalit, nebo dokonce zastavit šíření rakoviny. Pomocí unikátního postupu dokážou ovlivňovat chování živých nádorových buněk. Výzkum probíhá zatím v l... 000
Gregor lab @gregorlab.bsky.social · 03/09/2025Two hours of tough work to make 2 minutes of science sparkle ✨ Today we helped popularize our #magnetogenetics manuscript by Gemperle Jakub for NUVR_CZ. Tune in to TV NOVA evening news! 120
Gregor lab @gregorlab.bsky.social · 20/08/2025“Cellfie: A triple-stained portrait of HeLa’s senescence” by Spoorthi Suresh Hiremath (@imgprague.bsky.social; @gregorlab.bsky.social) has won the Prague @eurobioimaging.bsky.social Node Picture of the Month. Congrats Spoorthi! 051
Gregor lab @gregorlab.bsky.social · 09/07/2025Our paper is getting 🔥attention on Instagram👍 www.instagram.com/reel/DL3O9AA...instagram.comLogin • InstagramWelcome back to Instagram. Sign in to check out what your friends, family & interests have been capturing & sharing around the world. 010
Gregor lab @gregorlab.bsky.social · 07/07/2025Congratulations to Jakub Gemperle for driving this research from start to finish! 100
Gregor lab @gregorlab.bsky.social · 07/07/2025Gamechanger for vesicle Control! We present an approach to remotely control endosomal distribution in living cells (even in #3Dmatrix) with high precision. 100
Gregor lab @gregorlab.bsky.social · 07/07/2025"It's official 🎉: Our remote magnetic control of #endosomes, driving invasive protrusions in living cells, has landed in #ScienceAdvances! #Magnetogenetics meets #Rabs! The journey was wild, but it works! 🔥 www.science.org/doi/full/10.... @imgprague.bsky.social #3Dmatrix #CellBiology @science.orgscience.orgLive-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migrationRepositioning of Rab25 vesicles containing formin and integrin cargos to the cell periphery promotes protrusion formation. 1188
Gregor lab @gregorlab.bsky.social · 25/06/2025Huge congratulations to our PhD student Srikant Ojha for winning the Microscopic Picture of the Year 2024/2025 award! Well deserved! 000
Gregor lab @gregorlab.bsky.social · 29/04/202530th Cytoskeletal Club was opened in Liblice on Monday, 28 April. The first day is complete - great keynote by Martijn Gloerich (@GloerichLab) from @UMCUtrecht on Mechanical control of epithelial cell division. More to come! 033
Gregor lab @gregorlab.bsky.social · 27/04/2025Great 2 days at MedUni Vienna hosted by @Selma_OsMyers from Institute of Medical Chemistry and Pathobiochemistry. Giving a seminar on our concept of targeting mechanical homeostasis in cancer. Great meeting the Lilli Winter and Osmanagic-Myers Labs. Evening with our mentor Gerhard Wiche. 030
Gregor lab @gregorlab.bsky.social · 11/04/2025Excited to share our new @elife.bsky.social in collaboration with @Schiller lab.: Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis doi.org/10.7554/eLif... #ECMatrix #chaperone #Clusterin #ECMresearch #Collagen #Integrin #AFM #Proteomics 061
Gregor lab @gregorlab.bsky.social · 24/03/2025"A microscopic cage: The image has 2 channels: black, phalloidin (actin) and color, alpha smooth muscle actin. The structure shows an architectural masterpiece of actin-bundle caging the nucleus in activated primary hepatic stellate cells isolated from mice." 000
Gregor lab @gregorlab.bsky.social · 24/03/2025Happy Monday... Happy to share the picture of our colleague Srikant Ojha winning EuBI Node Picture of the Month 2024/25 competition! (imcf.natur.cuni.cz/IMCF/picture...) 130
Gregor lab @gregorlab.bsky.social · 21/03/2025Huge thanks to all the co-authors including L. Frick, S.M. Meier-Menches, Mathias Heikenwälder, D. Jirak and their teams and involved funding agencies! @NUVR_cz @imgprague.bsky.social 000
Gregor lab @gregorlab.bsky.social · 21/03/2025💊 Plectin targeting: Our novel plectin inhibitor, plecstatin, effectively blocks HCC progression in vivo. Targeting plectin could open new doors for HCC therapy—much needed, as novel modes of action in the HCC pipeline are highly sought after! 100
Gregor lab @gregorlab.bsky.social · 21/03/2025🐭 In vivo HCC models: Knocking out or inhibiting plectin in preclinical liver cancer models significantly reduced tumor growth & metastasis—supporting its crucial role in disease progression. 100
Gregor lab @gregorlab.bsky.social · 21/03/2025🔬 In vitro experiments: We found that plectin enhances colony formation, invasion, and mechanosignaling, making tumor cells more aggressive. Disrupting plectin weakens cytoskeletal integrity and reduces the ability of cancer cells to spread. 100
Gregor lab @gregorlab.bsky.social · 21/03/2025📊 HCC patient meta-analysis: Our data show that plectin is upregulated in HCC tumors, advanced TNM stages and correlates with poor patient prognosis. This suggests plectin is not just a bystander but a key player in liver cancer progression. 100
Gregor lab @gregorlab.bsky.social · 21/03/2025Excited to share our new @elife.bsky.social paper! We show that plectin fuels the growth & metastasis of hepatocellular carcinoma (HCC). Targeting plectin could be promising in HCC therapy, as we show using a novel plectin inhibitor, plecstatin! elifesciences.org/articles/102... #plectin #HCCelifesciences.orgPlectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasisPlectin drives hepatocellular carcinoma progression and metastasis through cytoskeletal reorganization and oncogenic signaling, making it a promising therapeutic target for overcoming therapy resistan... 122
Gregor lab @gregorlab.bsky.social · 13/03/2025Hello! The Martin Gregor lab @imgprague is now on Bluesky! We will tweet about our #mechanobiology work, pretty microscopy images and videos and more. FOLLOW us! 010