Reposted by GoffinetLabGreg Folkers @gregfolkers.bsky.social · 10/07/2026Lancet: Ending HIV: a reality check bit.ly/4vRGVTj 0109
GoffinetLab @goffinetlab.bsky.social · 15/04/2026@arbovmom.bsky.social discussed how comes some arboviruses aren't transmitted by certain mosquito species and whether or not these barriers are set in stone 🦟 #BEACON 030
GoffinetLab @goffinetlab.bsky.social · 15/04/2026Daan elucidated how treatment with the HIV-1 capsid inhibitor Lenacapavir, in addition to serve as a "miracle" drug for #HIV prevention and therapy, might make infected cells more visible to the immune system, potentially aiding #HIVcure efforts ✨️ #AcademyofMedicalSciences 130
GoffinetLab @goffinetlab.bsky.social · 15/04/2026Saskia presented how SARS-CoV-2 escapes from neutralisation via anti-spike antibodies and inhibition via ISGs by spreading via direct cell-cell contacts, indicating another clever strategy of the virus 😎 to evade our immune system #COVID-19 120
GoffinetLab @goffinetlab.bsky.social · 15/04/2026Dom introduced our first efforts to establish a platform to study #Oroupouche virus entry for rapid risk analysis and functional characterisation of new emerging strains at CL2 level 📢 @hpruezi.bsky.social 121
GoffinetLab @goffinetlab.bsky.social · 15/04/2026@lstmnews.bsky.social 👾 Virology on top! With 1 poster and 4 talks, the team had a blast at this year's @microbiologysociety.org MicroSoc event in Belfast. 152
GoffinetLab @goffinetlab.bsky.social · 15/04/2026@lstmnews.bsky.social goes #MicroSoc! Phase separation between bacteriologists and virologists is an artifact just for the picture 😊 @microbiologysociety.org 173
GoffinetLab @goffinetlab.bsky.social · 10/01/2026Heading home after a rich day full of science at @institutpasteur.bsky.social. Warm thanks to @julianbuchrieser.bsky.social and Olivier Schwartz for the kind invite! 040
GoffinetLab @goffinetlab.bsky.social · 23/12/2025www.biorxiv.org/content/10.1...biorxiv.orgSynergistic latency reversal by the SMAC mimetic AZD5582 and iBET JQ1, combined with Nef ablation, facilitates immune-mediated elimination of latently HIV-1-infected T-cellsRecent breakdowns in the supply chains of antiretroviral therapy (ART) to lower income countries, where they are needed most, underpin the pressing need for an accessible and scalable HIV cure that wo... 010
GoffinetLab @goffinetlab.bsky.social · 23/12/2025www.biorxiv.org/content/10.1...biorxiv.orgType I interferons sensitise HIV-1-reactivating T-cells for NK cell-mediated elimination despite HDACi-imposed dysregulation of innate immunityShock-and-kill is one of the most advanced, yet unrealized, concepts towards establishment of HIV-1 cure. Treatment with latency-reversing agents (LRAs), including histone deacetylase inhibitors (HDAC... 110
GoffinetLab @goffinetlab.bsky.social · 23/12/20253/ in "shock-and-kill" approaches, as we found (link to studies below). Indeed, the authors don't seem to generate evidence for detectable reduction of the reservoir size, and (temporal) virus control seems to be achieved predominantly by T-cell responses. #HIVCure is not around the corner! 111
GoffinetLab @goffinetlab.bsky.social · 23/12/20252/ special profile from start on which may potentially have facilitated things). I really do wonder if the chosen LRA, the TLR9 agonist lefitolimod, modulates cell surface Env presentation (important for ADCC), and/or apoptosis. Many (but not all!) LRAs do, and paradoxically impede "kill" 111
GoffinetLab @goffinetlab.bsky.social · 23/12/20251/ I agree that (even functional) #HIVCure will probably need a multi-component and staged strategy, and is not close. This multi-pronged approach shows, 18 months post ATI, a delay of viral rebound in 6/9 participants, and remission in 1/9 participants (though the latter seems to display a 111
GoffinetLab @goffinetlab.bsky.social · 23/12/2025Definitely exciting and even more puzzling. Note that the patient himself was heterozygous for CCR5delta32. So either there is a dosage effect of truncated CCR5, and/or (more provocative) the CCR5 genotype is less relevant than we all anticipated and the allo-SCT per se does large part of the trick? 121
GoffinetLab @goffinetlab.bsky.social · 23/12/2025Last month, my team had the great pleasure of hosting a fantastic guest PhD student, Bridget Fisher, from Sharon Lewin's lab at The Peter Doherty Institute for Infection and Immunity, for our collaborative work on #HIVCure. Looking fwd to continuing this exciting joint study. Very well done Bridget! 151
GoffinetLab @goffinetlab.bsky.social · 10/12/2025Absolutely privileged to have met Michel Sidibé, AU Envoy for African Medicines Agency, former @unaids.org Director & Mali Health Minister. Our chat spanned topics ranging from #HIVcure development to implementation. Should a cure be discovered, do we have systems to ensure equitable access? 030
Reposted by GoffinetLabDylan Postmus @dylanpostmus.bsky.social · 19/10/2025Had an excellent time at this year’s #RetroPATH2025 meeting in Tübingen, Germany, talking about my work on #HIVcure. Many thanks to @agschindler.bsky.social and Daniel Sauter for hosting. Especially interesting was the variety of talks on #HERVs @goffinetlab.bsky.social @lstmnews.bsky.social 142
Reposted by GoffinetLabBaldauf_Lab @baldauflab.bsky.social · 17/09/2025I am very pleased to be hosting @goffinetlab.bsky.social from @lstmnews.bsky.social tomorrow, sponsored by @infect-net.bsky.social 📣: Feodor-Lynen lecture hall @genecenter-lmu.bsky.social 🕙 18.9. 1:00 pm 041
GoffinetLab @goffinetlab.bsky.social · 08/09/2025Many thanks Prof Henry Mwandumba and Prof Kondwani Jambo & teams for the warm welcome and hospitality at Malawi Liverpool Wellcome Research Programme, Blantyre. We had fantastic discussions and developed prospects for collaboration on #HIVCure. A truly inspiring visit! 072
GoffinetLab @goffinetlab.bsky.social · 11/08/2025We had a great time hosting three college students - Sadie, Chloe and Isobel - as part of the In2STEM programme with Dr Kelly Johnston. With @dylanpostmus.bsky.social, they learned about our work in #HIVCure, drug development pipelines and assay design. Check out the programme here: in2scienceuk.org 021
Reposted by GoffinetLabThe Ott Lab @theottlab.bsky.social · 17/07/2025Congratulations to @juliaprigann.bsky.social for being awarded the 2025 CFAR Excellence in Basic/Translational Science Award! cfar.ucsf.edu/user/11703cfar.ucsf.eduJulia Prigann, PhD | UCSF-Bay Area Center for AIDS Research (CFAR) 021
GoffinetLab @goffinetlab.bsky.social · 23/04/2025En route pour Lyon. Je me réjouis de présenter quelques snapshots de notre recherche @lstmnews.bsky.social sur le Chikungunya virus #CHIKV et son interaction avec le système immunitaire inné! #JFV2025 041
GoffinetLab @goffinetlab.bsky.social · 10/04/2025An inspiring meeting #KSHIV25 in Durban ends. Great presentation by @dylanpostmus.bsky.social on why many LRAs for #HIVCure are imperfect. A pleasure meeting the next promising generation of African ECRs, speaking to old friends and making new ones. Plus the daily sunrise over Indian Ocean! 041
GoffinetLab @goffinetlab.bsky.social · 04/04/2025Shout-out to @dylanpostmus.bsky.social speaking at #MicroBio25. Just in time before heading to Keystone Symposium on #HIVCure keysym.us/KSHIV25 Stay tuned!keysym.usHIV Cure: Antiretroviral Therapy-Free Control of HIV Infection | Keystone SymposiaJoin us at the Keystone Symposia on HIV Cure: Antiretroviral Therapy-Free Control of HIV Infection, April 2025, in Durban, with field leaders! 050
GoffinetLab @goffinetlab.bsky.social · 25/03/2025Happy to be part of the EU consortium DEFENDER @horizoneu.bsky.social and contribute to discovery of novel entry factors of #CHIKV, laying the ground for development of antiviral therapies @lstmnews.bsky.social 041
GoffinetLab @goffinetlab.bsky.social · 08/03/2025#InternationalWomensDay2025 “When I’m sometimes asked 'When will there be enough?’ and I say ‘When there are nine,’ people are shocked. But there'd been nine men, and nobody's ever raised a question about that.” Ruth Bader Ginsburg 1933-2020 0124
GoffinetLab @goffinetlab.bsky.social · 07/03/2025It was a pleasure attending #GfV2025 in Hamburg today and chairing the Innate Immunity Plenary today together with @sparrerlab.bsky.social with fantastic keynotes by Adolfo García-Sastre, @scheellab.bsky.social and Michaela Muller-Trutwin. Thanks for coming! 0132
GoffinetLab @goffinetlab.bsky.social · 25/02/2025Due to high interest in the role, the ad will be kept live until March 9th: 000
GoffinetLab @goffinetlab.bsky.social · 13/02/2025Deadline for submission of applications for the role of Chair in Immunology at @lstmnews.bsky.social is March 2nd 👇 000
GoffinetLab @goffinetlab.bsky.social · 10/02/2025Join me at the LSTM in Conversation Webinar with Barry Atkinson @ukhsa.bsky.social and @gsrajahram.bsky.social in less than two days! Sign up via the link in the description 👇 054
GoffinetLab @goffinetlab.bsky.social · 29/01/2025Of course, costs for Skilled Worker VISA application and NHS surcharges will be covered by LSTM. 000
GoffinetLab @goffinetlab.bsky.social · 29/01/2025We @lstmnews.bsky.social are looking to appoint a Professor of Immunology with strong record in human pathogen and/or tropical disease research for translation of basic science into tangible solutions for the patients affected by global health challenges: app.vacancy-filler.co.uk/salescrm/Car...app.vacancy-filler.co.ukProfessor of Immunology | Liverpool School of Tropical MedicineProfessor of Immunology Based in Liverpool, with flexible working opportunities available Liverpool School of Tropical Medicine (LSTM) is a globally recognised centre of excellence for research and... 086
GoffinetLab @goffinetlab.bsky.social · 29/01/2025📢Post-Doctoral Research Associate Position (2.5 years with prospect of extension) on alphavirology at @lstmnews.bsky.social, Liverpool, UK - Characterisation of cellular entry inhibitors of #CHIKV within starting @horizoneu.bsky.social Consortium DEFENDER📢 app.vacancy-filler.co.uk/salescrm/Car...app.vacancy-filler.co.ukPost-Doctoral Research Associate (88593) | Liverpool School of Tropical MedicineFull-time, Fixed-term appointment to 30th September 2027 The Liverpool School of Tropical Medicine (LSTM) is a world-leading institution dedicated to improving health through research, education, a... 187
GoffinetLab @goffinetlab.bsky.social · 15/01/2025Happy to be part of the new Horizon EU consortium DEFENDER and to start characterising CHIKV-modulating cellular factors and their druggability! 030
GoffinetLab @goffinetlab.bsky.social · 05/12/2024@lstmnews.bsky.social is recruiting a Full Professor in Immunology. If you are interested in developing a competitive and impactfull research programme in the field of immune control of tropical diseases, in a vibrant scientific environment, please reach out! app.vacancy-filler.co.uk/salescrm/Car...app.vacancy-filler.co.ukProfessor of Immunology | Liverpool School of Tropical MedicineProfessor of Immunology Based in Liverpool, with flexible working opportunities available Liverpool School of Tropical Medicine (LSTM) is a globally recognised centre of excellence for research and... 000
GoffinetLab @goffinetlab.bsky.social · 19/10/2023Will make sure to provide support for VISA/IHS costs 000
GoffinetLab @goffinetlab.bsky.social · 19/10/2023💥 Postdoc position advert in the making (to be filled early 2024 Liverpool School of Tropical Medicine): if you are interested in investigating arthritogenic alphavirus infections in human cells and mosquitoes, with a focus of cell-intrinsic innate immunity, sensing and viral evasion, stay tuned 💥 111
GoffinetLab @goffinetlab.bsky.social · 14/10/2023Our lab is open to virology scientists displaced from their labs in Israel. Please reach out! 082
GoffinetLab @goffinetlab.bsky.social · 12/10/2023Our most recent SARS-CoV-2 study on virus-mediated subversion of the iBET-induced antiviral state: journals.plos.org/plospathogen...journals.plos.orgPharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated anti...Author summary The COVID-19 pandemic has sparked interest in the therapeutic potential of iBETs, which was already being pursued to inhibit proliferation of cancer cells and reactivate HIV-1 latency. ... 020