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I love that. . . got an issue, get some tissue 😀

Nephrology Journal Club @nephjc.bsky.social · 29/10/2025

Reposted by Tiff Caza

IgA Vasculitis A kidney biopsy is mandatory in patients with persistent proteinuria ≥0.5 g/day for more than 4 weeks, impaired kidney function, or suspicion of rapidly progressive glomerulonephritis (RPGN). #NephJC

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When hematuria is the predominant presentation, does anyone do a genetic workup first or straight to biopsy? #NephJC

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Could an increased frequency of IgA vasculitis in children be at play as they are more often proliferative? #NephJC

Nephrology Journal Club @nephjc.bsky.social · 29/10/2025

When there is segmental sclerosis in an IgA nephropathy, patients may never achieve less than 0.5 g proteinuria. How does this impact the course of therapy? #NephJC

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Reposted by Tiff Caza

The evidence of immunomodulatory effects of steroids and Nefecon comes from the following trials. High dose steroids treatment suffered from complications like infections. Nefecon, however, still showed similar systemic side-effects of other oral steroids. #NephJC

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Reposted by Tiff Caza

Nephrology Journal Club @nephjc.bsky.social · 29/10/2025

Treatment Approach: 💊 Novel therapies for IgAN have shifted the paradigm to a bi-pronged approach. a) Generic responses to HTN/proteinuria b) Fundamental drivers of nephron loss by reducing the formation of aberrant IgA molecules & the maladaptive mechanisms that contribute to CKD. #NephJC

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Nephrology Journal Club @nephjc.bsky.social · 29/10/2025

While it may not be validated for that purpose, is there any utility in post-transplant? #NephJC

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Reposted by Tiff Caza

Global Implementation of IgAN 2025 guidelines: #NephJC As we learn more and develop new treatments, it is important to try to make these available to a wide population of patients. Including low-income patients in future studies might allow for at least some access to cutting edge therapies.

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Nephrology Journal Club @nephjc.bsky.social · 29/10/2025

This seems like a low threshold, but interested what others think and do in their practice. #NephJC

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Reposted by Tiff Caza

First things first — where the story starts! Time to unpack the 4-hit hypothesis of IgA nephropathy — understanding each step opens doors to new treatments. #NephJC

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Reposted by Tiff Caza

Nephrology Journal Club @nephjc.bsky.social · 29/10/2025

🎨Beautiful visual abstract by Dr Natalia Nombera @roxnonna23.bsky.social #NephJC www.nephjc.com/news/...

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ASN Publications @asnpublications.bsky.social · 17/10/2025

Hi 👋. I'm Tiff Caza, a kidney pathologist and #NephJC fan! Looking forward to learning about IgA. No COI. Hoping to see some of you all at Kidney Week next week 🙂

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Reposted by Tiff Caza

There is a 13-year gap between the approval of new drugs for use in adults and their approval in children. Could extrapolation accelerate clinical trials in pediatric nephrology? Read more in #ASNKidneyNews kidney.pub/KN1710-10

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Tiff Caza @glombandit.bsky.social · 16/10/2025

I agree! Super cool. I learned about this at Kidney week in 2022 and signed up with the NKR after. It's a good insurance policy to have a voucher for yourself and great you can list family members too (my kiddos have vouchers🙂)

Arkana Labs @arkanalabs.bsky.social · 28/08/2025

Reposted by Tiff Caza

Did you know inadequate renal biopsies are on the rise? Recently, Dr. Shree Sharma and @glombandit.bsky.social sat down with Dr. Vandana Niyyar, @nephrowhitt.bsky.social, and @juancarlosqvelez.bsky.social to discuss renal biopsy adequacy and understand why it matters. Listen to the conversation:

open.spotify.com

Renal biopsy adequacy

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It's not just TB. . . I think this is still true for a lot of conditions, such as psychiatric diseases, epilepsy, HIV infection, etc #NephJC

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That is a crazy high number!?! #NephJC

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It takes a lot of money to bring drugs to market and anti-microbials may not get prioritized enough in drug development☹️ #NephJC

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Biology had no moral compass. It does not punish the evil and reward the good. #NephJC

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Has to be hard to be one of the first patients treated though and not knowing what to expect. I think about that for patients in trials all the time. #NephJC

Sad, but incredibly thoughtful. It's likely what she needed to keep hope. #NephJC

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I liked the dicotomy between Henry's mother and father who had two very different reactions to their son's condition #NephJC

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I thought he would and that the doctor (that Henry's father threatened) would tell the rest and the story and use Henry as an example humanize this disease (which happened anyway!) #NephJC

100%. Definitely a character you get attached to and feel for #NephJC

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He lost his adolescence in sanitoriums, seen his friends die, and people who he was close to become distant. I think he had incredible strength #NephJC

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The 'consumption' references. Shocking it was considered beauty while so sick 🫤 #NephJC

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I meant covenant of water ah. . Although had read both