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Statistical Genetics Unit at Pasteur Paris

@ggspasteur.bsky.social
70 followers 33 following 24 posts

Our team is part of the Computational Biology department of the Institut Pasteur in Paris. The main focus of our work is on statistical methodology and epidemiology.

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Reposted by Statistical Genetics Unit at Pasteur Paris
Institut Pasteur | 130 years of biomedical research @pasteur.fr · 30/09/2026
🍽️ Eating: One Behavior, Many Sciences! Join us Nov 9 at Institut Pasteur for an interdisciplinary exploration of how genes, brains, cultures & environments shape what we eat. Where nutrition meets neuroscience, genetics, anthropology & more. 🧬🧠🌍 📍Paris | 9:30–17:30 🔗 docs.google.com/forms/d/e/1F...
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Reposted by Statistical Genetics Unit at Pasteur Paris
Computational Biology Dpt at Pasteur @pasteur-dbc.bsky.social · 20/03/2026
Our Methods Primer seminar are resuming! Today, March the 20th, we will have Ernest Mordret who will talk about Fine-tuning Protein Language Models for functional classification and discovery.
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Statistical Genetics Unit at Pasteur Paris @ggspasteur.bsky.social · 16/01/2026
We are proud to share a recent preprint from our lab: Taxonomic-free metagenome GWAS to identify gut microbiome functions influencing host phenotypes doi.org/10.64898/202... which studies the potential of taxonomy-free GWAS approach of the human gut microbiome, using our implemented tool MOGS.
doi.org
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Reposted by Statistical Genetics Unit at Pasteur Paris
Hanna Julienne @hanna-julienne.bsky.social · 12/01/2026
🚀 Fully Funded PhD Opportunities in AI for Personalized Medicine 🚀 🔹 Applications are officially open for a fully funded PhD position in the MSCA Doctoral Network @mlcare.bsky.social (Machine Learning Computational Advancements for peRsonalized mEdicine)! mlcare.webs.tsc.uc3m.es/projects-and...
mlcare.webs.tsc.uc3m.es
DC7 – MLCARE
A special emphasis will be placed on sex-specific disease patterns, uncovering how these conditions affect individuals differently. This work will open new doors for personalized prevention and treatment in both respiratory and mental health.
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Reposted by Statistical Genetics Unit at Pasteur Paris
Computational Biology Dpt at Pasteur @pasteur-dbc.bsky.social · 05/12/2025
Our Methods Primer continue! Today, Dec 5th, we will have Hervé Perdy talking about assortative mating and vertical cultural transmission in genetic studies --discussing the polygenic model and how our estimation of the genetic component of traits is impacted by those two phenomena.
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Reposted by Statistical Genetics Unit at Pasteur Paris
Computational Biology Dpt at Pasteur @pasteur-dbc.bsky.social · 24/11/2025
The INCEPTION is organizing its Annual Symposium. This year is about GWAS & beyond! We're happy to have @bpasaniuc.bsky.social, @caina89.bsky.social, Iuliana Ionita-Laza , Sriram Sankararaman, and others, who will talk about tools for understanding the genetic determinants of complex diseases
research.pasteur.fr
INCEPTION Symposium 2025 - Research
INCEPTION symposium 2025 - Focus on GWAS: paving the way for the future of genetics.
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Reposted by Statistical Genetics Unit at Pasteur Paris
Communications Biology @commsbio.nature.com · 07/11/2025
Co-abundance analysis of 938 healthy individuals uncovers how host factors shape gut microbiome interactions, highlighting a core set of 200 impacted genera and additional factor-specific interactions. @ggspasteur.bsky.social www.nature.com/articles/s42...
nature.com
The influence of environment on bacterial co-abundance in the gut microbiomes of healthy human individuals - Communications Biology
Co-abundance analysis of 938 healthy individuals uncovers how host factors shape gut microbiome interactions, highlighting a core set of 200 impacted genera and additional factor-specific interactions...
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Statistical Genetics Unit at Pasteur Paris @ggspasteur.bsky.social · 10/11/2025
We are happy to share a new paper from our lab: The influence of environment on bacterial co-abundance in the gut microbiomes of healthy human individuals www.nature.com/articles/s42... which investigates environmental effects on microbiome interactions, using our previously published tool MANOCCA.
nature.com
The influence of environment on bacterial co-abundance in the gut microbiomes of healthy human individuals - Communications Biology
Co-abundance analysis of 938 healthy individuals uncovers how host factors shape gut microbiome interactions, highlighting a core set of 200 impacted genera and additional factor-specific interactions...
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Statistical Genetics Unit at Pasteur Paris @ggspasteur.bsky.social · 24/10/2025
🧬👩‍🏫 Today, in our Journal Club, we discussed this preprint about multi-trait GWAS finemapping by Matthew Stephens’ Lab Yuxin Zou et al. Fast and flexible joint fine-mapping of multiple traits via the Sum of Single Effects model
biorxiv.org
Fast and flexible joint fine-mapping of multiple traits via the Sum of Single Effects model
We introduce mvSuSiE, a multi-trait fine-mapping method for identifying putative causal variants from genetic association data (individual-level or summary data). mvSuSiE learns patterns of shared gen...
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Reposted by Statistical Genetics Unit at Pasteur Paris
Hanna Julienne @hanna-julienne.bsky.social · 10/10/2025
🧬 New multi-trait genetic paper on asthma heterogeneity from Emmanuelle Bouzigon's lab and lead by Raphaël Vernet in the Journal of Allergy and Clinical Immunology Unraveling shared genetics across asthma subtypes and 81 asthma-related traits 🔗 doi.org/10.1016/j.ja...
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Statistical Genetics Unit at Pasteur Paris @ggspasteur.bsky.social · 10/10/2025
A new collaborative work with our colleagues from HealthFex! Unraveling shared genetics across asthma subtypes and 81 asthma-related traits - www.jacionline.org/article/S009...
jacionline.org
Unraveling shared genetics across asthma subtypes and 81 asthma-related traits
Asthma is a complex and heterogeneous disease with a large spectrum of clinical and biological expressions reflecting the multiple underlying pathophysiologic mechanisms. It can be divided into subtyp...
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Statistical Genetics Unit at Pasteur Paris @ggspasteur.bsky.social · 07/10/2025
📰Journal club Our team discussed “Leveraging the local genetic structure for trans-ancestry association mapping” (Xiao et al., AJHG 2022), which introduces LOG-TRAM, a method that boosts statistical power in underrepresented populations by using local genetic architecture. doi.org/10.1016/j.aj...
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Reposted by Statistical Genetics Unit at Pasteur Paris
Jim Woodgett @jwoodgett.bsky.social · 26/06/2025
Peer review is not quite dead but it’s on life support and the current model of scientific publishing is a burning platform. healthydebate.ca/2025/06/topi...
healthydebate.ca
Is peer-review dead? A scientist’s plea to fix a broken system - Healthy Debate
Peer-review may not be over, but the era of exploitative, opaque and corporatized gatekeeping should be.
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Reposted by Statistical Genetics Unit at Pasteur Paris
Mike Inouye @mikeinouye.bsky.social · 05/06/2025
📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41... Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.
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Statistical Genetics Unit at Pasteur Paris @ggspasteur.bsky.social · 03/06/2025
This long-shot paper aimed to assess whether common GWAS pipelines are reaching their limits for prediction purposes. The review process was lengthy and painful. We're curious to see how it will fly! All comments are welcome! www.cell.com/hgg-advances...
cell.com
Polygenic risk score prediction accuracy convergence
Polygenic risk prediction has the potential to transform the diagnosis, treatment, and prevention of many common human diseases. However, the timescale and breadth of this transformation is partly unk...
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Reposted by Statistical Genetics Unit at Pasteur Paris
Sasha Gusev @sashagusevposts.bsky.social · 19/05/2025
Nice! Add a special relatedness matrix for cross-chromosome correlations to estimate the extra heritability due to assortative mating. Much larger contribution for educational attainment than for fluid IQ. www.nature.com/articles/s41...
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Statistical Genetics Unit at Pasteur Paris @ggspasteur.bsky.social · 16/05/2025
For today's journal club, we discussed the LHC-MR (Latent Heritable Confounder MR, rdcu.be/emhYv) paper from @zkutalik.bsky.social group. The study propose a new method to model concordant horizontal pleitropy thus accounting for confounding effect.
rdcu.be
Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics
Nature Communications - Mendelian Randomization approaches are being increasingly refined, but certain statistical limitations hinder their application to GWAS. Here, the authors propose a new...
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Reposted by Statistical Genetics Unit at Pasteur Paris
Bjarni Vilhjalmsson @bvilhjal.bsky.social · 11/03/2025
We're hiring Pioneer Fellow Postdocs!! Join us at the Pioneer Centre for SMARTbiomed to develop innovative methods in epidemiology, biostatistics, and statistical genetics, working with big biomedical data. international.au.dk/about/profil... #StatGen #Epi #Postdoc #SMARTbiomed
international.au.dk
Postdocs in Epidemiology or Statistical Genetics at The Pioneer Centre for SMARTbiomed - Vacancy at Aarhus University
Vacancy at Department of Public Health - NCRR - National Centre for Register-based Research, Aarhus University
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Statistical Genetics Unit at Pasteur Paris @ggspasteur.bsky.social · 25/02/2025
A new study from the lab in collaboration with Michael J Cho from BWH investigating COPD subtypes using multi-trait genetics! www.sciencedirect.com/science/arti...
sciencedirect.com
Identifying chronic obstructive pulmonary disease subtypes using multi-trait genetics
Chronic Obstructive Pulmonary Disease (COPD) has a broad spectrum of clinical characteristics. The aetiology of these differences is not well understo…
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Statistical Genetics Unit at Pasteur Paris @ggspasteur.bsky.social · 24/02/2025
Glad to be part of this collaborative piece investigating how genetic effect changes with age! iovs.arvojournals.org/article.aspx...
iovs.arvojournals.org
Does Age Modify the Relation Between Genetic Predisposition to Glaucoma and Various Glaucoma Traits in the UK Biobank? | IOVS | ARVO Journals
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Statistical Genetics Unit at Pasteur Paris @ggspasteur.bsky.social · 26/11/2024
Thanks to Les Treilles Fondation (www.fondationdestreilles.com) for hosting us for a wonderful retreat to discuss causal inference in genetics with Charles Assad, Brielin Brown, @judithabk6.bsky.social, Anne Rovsing, Matti Pirinen,Marie Verbanck,Xiang Zhou,Chiara Sabatti, and Sriram Sankararaman...
fondationdestreilles.com
La Fondation des Treilles, un lieu virgilien pour les arts et la pensée
Dans « un paysage du bout du monde » situé dans le Haut Var, la Fondation des Treilles est un lieu qui favorise le dialogue entre créateurs et chercheurs.
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Statistical Genetics Unit at Pasteur Paris @ggspasteur.bsky.social · 09/09/2024
📢Our unit is opening a postdoc position! All candidates interested in working in the field of Statistical Genetics in the thriving Institut Pasteur Paris campus are welcome to apply !!! For details please check here: research.pasteur.fr/en/job/postd...
research.pasteur.fr
Postdoctoral position in Statistical Genetics - Research
JOB DESCRIPTION Applications are invited for a postdoctoral position at the Institut Pasteur within the Statistical Genetics unit of the department of Computational Biology. Our unit addresses methodo...
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