iiinova — where your digital self keeps evolving

Reposted by George Samantsidis

Nicolas Buchon @nicobuchon.bsky.social · 31/07/2026

Interested in #mosquito immunity, blood feeding & vector competence? @georgesaman.bsky.social & I have a new review in @frontiersin.bsky.social on how the blood meal, microbiota & endocrine signals shape immune function and pathogen transmission. 🦟 #VectorBiology www.frontiersin.org/journals/imm...

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Reposted by George Samantsidis

Ryan Smith @vectorimmunity.bsky.social · 02/12/2025

Pleased to share our recent work in collaboration with the @perrimonlab.bsky.social in which we perform the first genome-wide CRISPR knockout screen in Anopheles to examine essential fitness genes and genes associated with clodronate liposome function www.nature.com/articles/s41...

nature.com

A genome-wide CRISPR screen in Anopheles mosquito cells identifies fitness and immune cell function-related genes

Nature Communications - Mosquitoes are major vectors for the transmission of many serious pathogens. This study uses genome-wide CRISPR screens in the mosquito, Anopheles gambiae, to reveal new...

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Reposted by George Samantsidis

Waggoner Lab @labwaggoner.bsky.social · 25/11/2025

A genome-wide CRISPR knockout in a major malaria vector identifies genes important for fitness & immune-related processes @natcomms.nature.com @perrimonlab.bsky.social @iowastateu.bsky.social @harvardmed.bsky.social @georgesaman.bsky.social @vectorimmunity.bsky.social www.nature.com/articles/s41...

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George Samantsidis @georgesaman.bsky.social · 24/11/2025

To the insect folks — does anyone have experience with the World Precision Instruments injectors? Our new Nanoject III stopped working after the third use, and we’re now exploring other options, such as this one www.wpi-europe.com/products/ani... If you know anything about it, please drop a comment!

wpi-europe.com

World Precision Instruments | Nanoliter 2020 Injector

Nanoliter 2020 Injector

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Reposted by George Samantsidis

Institut Pasteur | 130 years of biomedical research @pasteur.fr · 12/11/2025

🦟 Can we "pasteurize" mosquitoes to stop dengue & Zika? Sarah Merkling @merklinglab.bsky.social uses AI + CRISPR to analyze stomach cells and understand why some mosquitoes spread viruses while others don't. Goal: Make disease-carrying mosquitoes harmless. #Zika #Dengue

pasteur.fr

Sarah Merkling wants to "pasteurize" mosquitoes!

At the Institut Pasteur, Sarah Merkling's research focuses on a topic that is still largely unknown: interactions between mosquitoes and viruses. She boldly devises novel strategies based on state-of-...

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Reposted by George Samantsidis

SalehLab @salehlabparis.bsky.social · 07/11/2025

Tempted to uncover the secrets of mosquito microbiota? Join us! We're hiring! 👇

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Reposted by George Samantsidis

Olivia Goldman PhD @oliviagoldman.net · 30/10/2025

Excited to announce the final version of the Mosquito Cell Atlas is out now in @cellpress.bsky.social!! 🦟🩸 There is SO much left to find & investigate in this dataset (& the rich biology of the Aedes aegypti mosquito)! We hope this helps scientists in many fields! www.cell.com/cell/fulltex...

cell.com

A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito

A comprehensive single-nucleus RNA-seq atlas of >367,000 nuclei from male and female Aedes aegypti mosquitoes reveals sexual dimorphism in sensory systems and brain cell types and widespread co-expres...

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George Samantsidis @georgesaman.bsky.social · 31/10/2025

It was about time to leave the old platform and join this one! Excited to connect with old and new friends here 🧬✨ #vectorbiology #mosquitoes

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Reposted by George Samantsidis

Nicolas Buchon @nicobuchon.bsky.social · 19/09/2025

Our new study is out in Cell Reports! We show that the DNA repair pathway ATM-γH2Av is repurposed in the gut during infection, even without DNA breaks. Pathogens, not microbiota, trigger it via NOX to clear damaged cells and drive stem cell regeneration. www.cell.com/cell-reports...

cell.com

Infectious bacteria, but not the microbiota, induce a NOX-ATM-cytokine pathway that controls epithelial turnover

Nagy et al. identify a NOX-ATM-cytokine signaling axis in the Drosophila gut that is activated by infection independently of DNA damage. This pathway promotes enterocyte loss, cytokine production, and...

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Reposted by George Samantsidis

Ryan Smith @vectorimmunity.bsky.social · 05/07/2025

Celebrating the holiday weekend with another bang! Our work describing roles of TNF signaling on mosquito immune cell function and in limiting malaria parasite infection is now published. Big shout out to @georgesaman.bsky.social and others for their contributions! journals.plos.org/plospathogen...

journals.plos.org

TNF signaling mediates cellular immune function and promotes malaria parasite killing in the mosquito Anopheles gambiae

Author summary Mosquito innate immunity is a major determinant of vector competence with significant implications in malaria transmission. During infection with the Plasmodium parasite, mosquitoes mou...

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