Mark Schreiber, PhD @genometron.bsky.social · 29/08/2026A few years ago Coke made an experimental line of Coke Zero espresso. Not sure if that was the actual name or something else. It sounds disgusting but was actually really really good. This needs to come back! 000
Mark Schreiber, PhD @genometron.bsky.social · 20/06/2026Checking prices for a laptop for kids college. A Mac Neo is around $500 with edu discount. This is about the same price as a pair of new tires for my car. How is it possible that tires cost the same as this incredibly sophisticated piece of equipment?? 000
Reposted by Mark Schreiber, PhDMark Fortner @markfortner.bsky.social · 16/05/2026Researchers found 1,700 tiny protein-like molecules hiding in the human genome | #proteomicszmescience.comResearchers Found 1,700 Tiny Protein-Like Molecules Hiding in the Human GenomeThe "dark proteome" is much more exciting than we thought. 021
Mark Schreiber, PhD @genometron.bsky.social · 07/03/2026@jesszafarris.com is there a word for the category of words that are derived from people’s names? I recently discovered the first quisling was a Quisling and that Mr Masoc was fond of pain. This led to a deep nerd-hole of discovery. There might be enough of these for a Words Unravelled episode? 120
Reposted by Mark Schreiber, PhDMark Fortner @markfortner.bsky.social · 17/02/2026Scientists discover brain switches that clear Alzheimer's plaques | #Alzheimerssciencedaily.comScientists discover brain switches that clear Alzheimer’s plaquesResearchers have identified two brain receptors that help the brain clear away amyloid beta, a hallmark of Alzheimer’s disease. By stimulating these receptors in mice, scientists increased levels of a... 021
Mark Schreiber, PhD @genometron.bsky.social · 20/01/2026This week I’ll be messing with (Austin) Texas 000
Mark Schreiber, PhD @genometron.bsky.social · 05/01/2026Asynchronous I/O isn't just for responsive user interfaces and web servers. It can also provide substantial benefits for file processing and data pipelines and it can be surprisingly simple to build your applications using the patterns in the linked article. repost.aws/articles/ARz...repost.awsJava Async NIO for File Processing: Beyond the UIDemonstrates how Java async I/O operations can benefit file processing applications 010
Reposted by Mark Schreiber, PhDMark Fortner @markfortner.bsky.social · 03/01/2026Scientists discover why mental disorders so often overlap www.sciencedaily.com/releases/202...sciencedaily.comScientists discover why mental disorders so often overlapA massive global genetics study is reshaping how we understand mental illness—and why diagnoses so often pile up. By analyzing genetic data from more than six million people, researchers uncovered dee... 121
Mark Schreiber, PhD @genometron.bsky.social · 23/12/2025#rdma is getting some love because all is currently AI. I suspect it could also be a major win for database engineering. See also #genomics where we seem to need 128GiB of ram per core for some reason. 010
Reposted by Mark Schreiber, PhDMing Tommy Tang @tommytang.bsky.social · 25/09/20251/ Bioinformaticians, I’ll say it loud: Never blindly trust the data you're given. Not from collaborators. Not from vendors. Not even from “reliable” sources. Here’s why: 241
Reposted by Mark Schreiber, PhDMark Fortner @markfortner.bsky.social · 25/09/2025Apple develops a lightweight #AI for protein folding prediction| #biosky9to5mac.comApple develops a lightweight AI for protein folding prediction - 9to5MacApple developed an alternative AI model to predict the 3D structure of proteins, and it shows promise. Here are the details. 021
Mark Schreiber, PhD @genometron.bsky.social · 25/09/2025It’s often said that solar isn’t a reliable energy source. Yet it has reliably powered our entire ecosystem for several billion years.media.tenor.coma man in a suit and tie is standing next to a woman in a black dress .ALT: a man in a suit and tie is standing next to a woman in a black dress . 030
Mark Schreiber, PhD @genometron.bsky.social · 13/09/2025Do we need an excuse for firing lasers at things? 030
Mark Schreiber, PhD @genometron.bsky.social · 30/08/2025Top tip, cooking spray is a trap. It contains a protein based emulsifier to make it easier to spray. When heated it forms a glue like substance that sticks to everything including non stick pans. 🤨 010
Mark Schreiber, PhD @genometron.bsky.social · 29/08/2025🚀 This is big! AWS HealthOmics now supports ECR pull through caches and remaps image URIs. Now you can use workflows that use containers from public repos without having to change all the image URIs. And you get all the reliability and security benefits of using ECR! #genomics #wdl #cwl #nextflowaws.amazon.comWhat's New at AWS - Cloud Innovation & News 021
Mark Schreiber, PhD @genometron.bsky.social · 26/08/2025Incredible engineering youtu.be/h_zgURwr6nA?...youtu.beUnveiling High NA EUV | ASMLYouTube video by ASML 130
Mark Schreiber, PhD @genometron.bsky.social · 14/08/2025So true. In 2025, do everyone a favor and ask an LLM to update your README.md with comprehensive documentation. 020
Mark Schreiber, PhD @genometron.bsky.social · 11/08/2025Dear software developers. A useful error message contains: 1. The specific error, 2. The likely cause, 3. Potential actions a user can take to prevent the error. 110
Reposted by Mark Schreiber, PhDMing Tommy Tang @tommytang.bsky.social · 11/08/20251/ 8 Books for you to learn bioinformatics🧵 1183
Mark Schreiber, PhD @genometron.bsky.social · 09/08/2025The thing people seem to miss about gerrymandering is that it doesn’t just disenfranchise voters from one party it disenfranchises everyone in the district. By making a district uncompetitive the representative no longer needs to care about any of their constituents. All voters loose. The party wins 020
Mark Schreiber, PhD @genometron.bsky.social · 02/07/2025Definitely not how it looked in my biology textbooks. The reality is so much cooler! 020
Reposted by Mark Schreiber, PhDAngel Pizarro @angelp.bsky.social · 24/06/2025Boost your HPC performance and efficiency on AWS with the newly updated Well-Architected HPC Lens! The new guidance consolidates years of AWS expertise into structured best practices for running HPC workloads on AWS. Read more about it at aws.amazon.com/blogs/hpc/op...aws.amazon.comOptimize HPC Workloads with the Updated AWS Well-Architected Lens | Amazon Web ServicesToday, we're announcing an update to the AWS Well-Architected High Performance Computing (HPC) Lens, providing you with comprehensive architectural guidance in a single, authoritative resource. This n... 022
Reposted by Mark Schreiber, PhDDarryl Ruggles @darryl-ruggles.cloud · 22/06/2025dev.to/aws-builders... Many examples use hardcoded credentials. These should never really be used. The good news is that in almost all cases there is a better way. When working with services like GitHub Actions and workflows you can use Open ID Connect (OIDC) for auth to AWS. (1️⃣/3️⃣) 🧵dev.toStep-by-Step Guide to Setting OIDC With Terraform for GitHub Actions Workflows with AWSYour GitHub Actions Secrets Are the Weakest Link in Your AWS Security Chain Are you still using... 121
Mark Schreiber, PhD @genometron.bsky.social · 20/06/2025🧬🚀 Happy to announce linter rules for Nextflow v0.1.2. Featuring some fixes, improved testing, improved docs and better tooling. Also added the CICD friendly option to fail on lint violations. github.com/awslabs/lint...github.comRelease v0.1.2 · awslabs/linter-rules-for-nextflowRelease v0.1.2 Release Date: 2025-06-20 Changes chore: bump version to 0.1.2 (728467f) feat: add comprehensive release automation (59b94ce) Installation JAR Files linter-rules-0.1.2.jar ast-echo... 010
Mark Schreiber, PhD @genometron.bsky.social · 19/06/2025www.maginative.com/article/anth...maginative.comAnthropic Researchers Ask the Question: What If Models Are Conscious?Anthropic has launched a research initiative exploring whether AI systems like Claude might one day warrant moral consideration—if not now, then soon. 100
Mark Schreiber, PhD @genometron.bsky.social · 19/06/2025🇳🇿🇦🇺🇬🇧🇸🇪🇸🇬🇮🇩🇲🇾🇹🇭🇷🇺🇨🇺🇵🇭🇩🇪🇨🇭🇨🇳🇹🇼🇿🇦🇮🇹🇳🇱🇨🇿🇮🇳🇯🇵🇧🇷🇲🇽🇺🇸 What’s your flag count? 110
Mark Schreiber, PhD @genometron.bsky.social · 09/06/2025AWS HealthOmics Run Analyzer can help you optimize your resource allocations for production workflows. aws.amazon.com/blogs/indust...aws.amazon.comReduce Genomic Discovery Time and Costs with AWS HealthOmics Run Analyzer | Amazon Web ServicesBioinformatics researchers running production genomic workflows face a critical challenge: ensuring computational resources are properly allocated to maximize cost efficiency without sacrificing perfo... 010
Mark Schreiber, PhD @genometron.bsky.social · 05/06/202577F and humid at 9am. It’s gonna be scorchio! 🥵☀️ 010
Mark Schreiber, PhD @genometron.bsky.social · 24/05/2025This is cool and kind of weird. I think that’s the point? wayofcode.comwayofcode.comRick Rubin | The Way of Code: The Timeless Art of Vibe CodingRick Rubin brings ancient wisdom to the modern age in The Way of Code, a meditation on the art and science of vibe coding. With Claude by Anthropic, the Grammy-award winning producer and author of The... 140
Mark Schreiber, PhD @genometron.bsky.social · 16/05/2025In a new tutorial I explain how to use Amazon Q Developer CLI's natural language and agentic AI capabilities to rapidly create, run, debug and analyze genomics workflows in AWS HealthOmics. What used to take bioinformatics experts days can now be achieved by any scientist in under an hour.github.com 020
Mark Schreiber, PhD @genometron.bsky.social · 18/04/2025AWS HealthOmics now supports workflow versioning simplifying management of multiple versions of a workflow. #genomics #aws #bioinformatics #hpc aws.amazon.com/about-aws/wh...aws.amazon.comAWS HealthOmics announces workflow versioning support - AWSDiscover more about what's new at AWS with AWS HealthOmics announces workflow versioning support 041
Mark Schreiber, PhD @genometron.bsky.social · 03/04/2025So far all I have been liberated from is wealth. 000
Mark Schreiber, PhD @genometron.bsky.social · 21/03/2025Was re-watching Alien last night. What’s up with half the crew smoking on the bridge and in the mess hall!!? 100
Reposted by Mark Schreiber, PhDAlbert Vilella, PhD. @albertvilella.bsky.social · 10/03/2025Ultima Genomics AGBT25 updates, with the $80 genome, 25c per million reads and a new Solaris system with higher throughput that runs 50,000 genomes per year. open.substack.com/pub/albertvi...open.substack.comUltima Genomics AGBT25 updatesWhat does it mean for the NGS short-reads race with Illumina and Roche SBX? 0172
Mark Schreiber, PhD @genometron.bsky.social · 10/03/2025CLAIM: To train AI you need high quality, curated data. COUNTER CLAIM: ChatGPT was trained on the pile of hot garbage that is the internet and it’s performing quite nicely thanks. 000
Reposted by Mark Schreiber, PhDAngel Pizarro @angelp.bsky.social · 07/03/2025Unlock the potential of quantum computing with Amazon Braket and NVIDIA CUDA-Q. Our latest blog explores how to seamlessly integrate these technologies for your quantum development needs. aws.amazon.com/blogs/quantu...aws.amazon.comHow to run CUDA-Q programs on Amazon Braket notebook instances | Amazon Web ServicesAmazon Braket provides access to quantum computing resources and tools to develop quantum algorithms, test them on quantum circuit simulators, and run them on different quantum hardware technologies. ... 031
Reposted by Mark Schreiber, PhDAlbert Vilella, PhD. @albertvilella.bsky.social · 05/03/2025More insightful discussions on the Roche SBX #NextGenSequencing platform, which was properly unveiled a few weeks ago. Read length: I think the main inefficiency here might be the synthesis part, where if you start with a 5000bp molecule, only the first 500-1000bps are "expanded". 292
Mark Schreiber, PhD @genometron.bsky.social · 03/03/2025When you use AI to help generate code for an App that helps people generate code. Is this recursive inference??🌀 #code #ai 000
Reposted by Mark Schreiber, PhDDarryl Ruggles @darryl-ruggles.cloud · 24/02/2025aws.amazon.com/about-aws/wh... The new version of one of the most popular AI models (Anthropic's Claude 3.7 Sonnet) is now available to use with Bedrock on AWS. Really interested to try this out using Bedrock!aws.amazon.comAnthropic's Claude 3.7 Sonnet is now available in Amazon Bedrock - AWSDiscover more about what's new at AWS with Anthropic's Claude 3.7 Sonnet is now available in Amazon Bedrock 121
Mark Schreiber, PhD @genometron.bsky.social · 22/02/2025When the main plot stresses the urgency of saving the world and you’re presented with 103 side quests. 000
Reposted by Mark Schreiber, PhDdrmaligator.medsky.social @drmaligator.medsky.social · 11/02/2025#Maine reporting confirmed #birdflu in “four Canada geese, two red-tailed hawks and a great horned owl in recent weeks. The wild birds were collected from the towns of Kennebunk, Kittery, Ogunquit, South Berwick, South Portland and York” #H5N1 www.wmtw.com/article/main...wmtw.comMultiple bird flu cases reported in southern Maine, officials sayThe latest announcement from state officials comes more than two weeks after bird flu was found in a Canada goose that was admitted to the Center for Wildlife in Kennebunk. 062
Reposted by Mark Schreiber, PhDMark Fortner @markfortner.bsky.social · 01/02/2025An interesting article on how 3D folding of DNA in cells determines cell-specific gene expression patterns. #bioinformatics #GeneExpression #genomics news.mit.edu/2025/with-ge...news.mit.eduWith generative AI, MIT chemists quickly calculate 3D genomic structuresMIT chemists found a new way to determine 3D genome structures, using generative AI, that can predict thousands of genome structures in minutes, making it much speedier than existing methods for analy... 072
Reposted by Mark Schreiber, PhDRandall Munroe @xkcd.com · 30/01/2025Humidifier Review xkcd.com/3044 192237921821
