Multicellular organisms, as the name suggests, are composed of many cells that work together. Cells need to stick together to ensure efficient cell coordination. Cadherins, which are calcium-dependent...

Mutations in the autophagy protein EPG5 cause multisystem disease, including neurodegeneration. This study shows that impaired mitophagy drives mitochondrial Ca2+ overload with permeability transition...

Mitochondrial DNA (mtDNA) encodes genes essential for oxidative phosphorylation. The m.3243A>G mutation causes severe disease, including myopathy, lactic acidosis and stroke-like episodes (MELAS) a...