Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodev...

Mutations in the autophagy protein EPG5 cause multisystem disease, including neurodegeneration. This study shows that impaired mitophagy drives mitochondrial Ca2+ overload with permeability transition...

ATP-binding cassette B8 (ABCB8) is a mitochondrial iron exporter known to prevent iron-dependent oxidative stress in cardiomyocytes and endothelial ce…