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chihyao.bsky.social

@chihyao.bsky.social

13 followers 23 following 1 posts

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Olivia Gillham @neuroliv.bsky.social · 27/05/2026

Beautiful work into Vici Syndrome from @kritsh.bsky.social, investigating how pathogenic variants in EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation. @gabbov.bsky.social @chihyao.bsky.social @natcomms.nature.com www.nature.com/articles/s41...

Pathogenic variants in the autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation - Nature Communications

Mutations in the autophagy protein EPG5 cause multisystem disease, including neurodegeneration. This study shows that impaired mitophagy drives mitochondrial Ca2+ overload with permeability transition...

chihyao.bsky.social @chihyao.bsky.social · 18/12/2025

Happy to be invited to write a small piece of commentary on a recent published paper in Scienc, showing the USP30 inhibition restotes mitophagy during mouse embryonic development, reducing a pathogenic mtDNA mutation. authors.elsevier.com/c/1mIAf8jWWJ...

authors.elsevier.com

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Reposted by @chihyao.bsky.social

Hubrecht Institute @hubrechtinstitute.bsky.social · 10/07/2025

🧬 Looking for a PhD position in molecular or developmental biology? 🔬 ✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/

Reposted by @chihyao.bsky.social

#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 29/05/2025

Pathogenic variants in autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation #NeuroDegeneration 🧪🧠 www.biorxiv.org/content/10.1101/202…

Reposted by @chihyao.bsky.social

Gabriel Esteban Valdebenito @gabbov.bsky.social · 13/12/2024

Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function www.tandfonline.com/doi/full/10....

tandfonline.com

Inhibition of the PI3K-AKT-MTORC1 axis reduces the burden of the m.3243A>G mtDNA mutation by promoting mitophagy and improving mitochondrial function

Mitochondrial DNA (mtDNA) encodes genes essential for oxidative phosphorylation. The m.3243A>G mutation causes severe disease, including myopathy, lactic acidosis and stroke-like episodes (MELAS) a...