Anirudh Jakhmola @funnirudh.bsky.social · 23hAfter a collective 28 hours of GPU time, the exosome for MD simulations for our iGEM project is ready. Now to do this exact thing 4 more times for other exosomes. 021
Anirudh Jakhmola @funnirudh.bsky.social · 22/09/2026Working with M13 phages is so much fun because WHAT DO YOU MEAN THE PLAQUES TURN BLUE!?!? 2152
Anirudh Jakhmola @funnirudh.bsky.social · 16/09/2026End of 3rd year presentation really made me realise that job application season is coming towards me in the next few months. 020
Reposted by Anirudh JakhmolaMart Krupovic @mkrupovic.bsky.social · 11/09/2026Why did some #viruses evolve to be #giants while others did not? Our perspective piece on this topic with Eugene Koonin. www.pnas.org/doi/10.1073/...pnas.orgWhy did some viruses evolve to be giants while others did not? | PNASViruses are ubiquitous mobile genetic elements that are obligate symbionts of cellular life forms and replicate exclusively within host cells. The ... 09639
Reposted by Anirudh JakhmolaEllinor Alseth @ellinoralseth.bsky.social · 11/09/2026It's finally published! What a journey @brownlab.bsky.social and I have been on with this one (ask me about it over a pint 🍻). Super excited to be able to say that it's finally out in Trends (author gift link to follow)! 🦠🧫 #phagesky 14322
Anirudh Jakhmola @funnirudh.bsky.social · 03/09/2026Phage on a (failed) western blot membrane. PS It’s insane how smooth these membranes are, I’d recommend writing on them. 010
Anirudh Jakhmola @funnirudh.bsky.social · 19/08/2026I had seen water leak from the roof, but a squirrel leak is a first for me. The wonders of Firth Court. 020
Anirudh Jakhmola @funnirudh.bsky.social · 07/08/2026Some non-phage TEM today. It seems like our iGEM team has successfully managed to induce exosomes from HEK cells. Now to engineer its membrane and package our protein in it. #exosomes 021
Reposted by Anirudh JakhmolaCraig MacLean @craigmaclean.bsky.social · 27/06/2026New #microsky#AMR Perspective paper with @penamiller.bsky.social rdcu.be/fqBJo ANTIBIOTIC RESISTANCE (IE MIC) AND TOLERANCE ARE NOT BACTERIAL TRAITS! Please read on if you want an explanation for this provocative claim.rdcu.beBeyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cellsNature Communications - Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells 17635
Anirudh Jakhmola @funnirudh.bsky.social · 25/06/2026~£18,000 raised so far, with IDT and Vazyme sponsoring our reagents; we are making steady progress towards our goal of engineering exosomes that cross the blood brain barrier and deliver Dravet Syndrome therapeutics. #healthcare 130
Reposted by Anirudh JakhmolaPilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 01/06/2026🛠️💉It's time for engineering contractile injection systems! @chipericson.bsky.social & @davidschaumann.bsky.social introduce programmable CIS - PROCIS, combining tail length control, non-native cargo loading, and cell retargeting all in one system! www.biorxiv.org/content/10.6... 🧵 1/5 26429
Reposted by Anirudh JakhmolaEllinor Alseth @ellinoralseth.bsky.social · 13/05/2026When is an antiphage mechanism an evolved defence adaptation? This question has been on my mind for so long, because despite the field’s rapid progress there is currently no widely agreed framework in place to answer it. So @brownlab.bsky.social and I wrote this, and I'm happy to share the preprint!ecoevorxiv.orgThe bacterial immune system: identifying evolved defense adaptations 15326
Anirudh Jakhmola @funnirudh.bsky.social · 08/05/2026Pretty pink single colonies on my pack of soft cheese. I wish my actual plates were so lucky. If anyone know what this might be, please do tell. 020
Reposted by Anirudh JakhmolaStephen Turner @stephenturner.us · 03/05/2026Free and open-source images, icons, and tools for creating scientific illustrations doi.org/10.59350/5zt... 🧪doi.orgFree and open-source images, icons, and tools for creating scientific illustrationsPhylopic, NIH Bioart, Bioicons, Scidraw, Open Science Art, Health Icons, Servier Medical Art, Biodiversity Heritage Library, the Noun Project, Segment Anything, Excalidraw, draw.io, Biographics 6406227
Anirudh Jakhmola @funnirudh.bsky.social · 25/04/2026Bit late to the party but I presented our work at Microsoc 2026 in Belfast this year. It was great to see so many talks on such diverse topics but of course I was biased towards phages and eukaryotic viruses talks. 162
Anirudh Jakhmola @funnirudh.bsky.social · 20/02/2026Congratulations to everyone involved! Glad to have contributed to this work. 051
Anirudh Jakhmola @funnirudh.bsky.social · 24/01/2026Had the opportunity to present my work at Viruses of Microbes UK this year. Had a lot of fruitful discussions regarding the work and phage therapy. Looking forward to seeing everyone in Prague in July! 161
Reposted by Anirudh JakhmolaAioeux Medlow @axmedlow.bsky.social · 07/11/2025Thrilled to present the findings from my 2025 #SUREscheme project - 'Investigating the influence of latent bacteriophages on healthcare-associated C. difficile lysogens' - at the showcase yesterday evening. Huge thanks to @funnirudh.bsky.social and @robfagan.bsky.social for making this possible! 1104
Reposted by Anirudh JakhmolaRob Fagan @robfagan.bsky.social · 31/10/2025🚨 Fully funded PhD studentships 🚨 We have three fully funded PhD studentships available for Oct 26 start. Funded by the MRC DiMeN programme & the BBSRC Yorkshire Biosciences DTP. Details below as they are advertised. Contact me here or via email for more details or to discuss an applicationsites.google.comClostridial Cell Biology GroupWe are the Clostridial Cell Biology Group at the University of Sheffield. We study all aspects of cell biology, including the architecture and biogenesis of surface structures on both vegetative cells... 1912
Anirudh Jakhmola @funnirudh.bsky.social · 16/10/2025Look at this beautiful CsCl gradient. I’m lying, my gradient crashed. I lost my phages and I am going home. 040
Reposted by Anirudh Jakhmolac0nc0rdance @c0nc0rdance.bsky.social · 07/09/2025You know that antibiotic use can exert pressure on bacterial populations to evolve resistance. So are vaccines exerting similar pressure on viruses? Let's talk about how vaccines MIGHT make viruses evolve to be LESS harmful over time. Warning: I'm speaking broadly here & biology loves exceptions. 35417
Reposted by Anirudh JakhmolaRob Fagan @robfagan.bsky.social · 03/09/2025Lab on tour - the wonderful #ClostPath2025 organisers have arranged great walking tours. Guess where we are? 062
Reposted by Anirudh JakhmolabioRxiv Microbiology @biorxiv-microbiol.bsky.social · 22/08/2025A novel two-component system controls vancomycin resistance in epidemic Clostridioides difficile www.biorxiv.org/content/10.1101/202… 021
Anirudh Jakhmola @funnirudh.bsky.social · 25/07/2025Me seeing the price of booking the cryo-EM for 3 days. 030
Reposted by Anirudh JakhmolaJason Nomburg @jnoms.bsky.social · 12/06/2025Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post! 26952
Reposted by Anirudh JakhmolaWiep Klaas Smits (ExpBac/CMAT) @smitslab.bsky.social · 05/06/2025Now engineering phages with Anirudh Jakhmola from @robfagan.bsky.social lab at @sheffielduni.bsky.social #3cdf 074
Reposted by Anirudh JakhmolaProf Paula Salgado @pssalgado.bsky.social · 06/06/2025Thank you to all participants for making the 2nd #3CdF such a fantastic event! See you next year for the next one! #microsky 🧪 #Cdiff 064
Reposted by Anirudh Jakhmolaannadragos.bsky.social @annadragos.bsky.social · 30/05/2025Prophage induction - nice study, inducers other than MitC, but also that inducer concentration matters. Search for optimum needed to get highest titers ☝️ www.biorxiv.org/content/10.1...biorxiv.orgHigh-throughput screening reveals diverse lambdoid prophage inducersProphages; dormant bacteriophage genomes integrated within the bacterial chromosome, play pivotal roles in shaping microbial communities when awakened. Our current understanding of prophage activation... 02514
Anirudh Jakhmola @funnirudh.bsky.social · 11/05/2025Managed to nab a signed copy of Everything is Tuberculosis by @johngreensbluesky.bsky.social. Quite excited to read this. 030
Reposted by Anirudh JakhmolaElisabeth Bik @elisabethbik.bsky.social · 30/04/2025The do’s and don’ts of scientific image editing Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies. @sarareardon.bsky.social reports www.nature.com/articles/d41...nature.comThe do’s and don’ts of scientific image editingAcceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies. 418859
Reposted by Anirudh JakhmolaProf Paula Salgado @pssalgado.bsky.social · 30/04/2025Happy to announce 2nd #3CdF Cross-channel C. difficile Forum in Newcastle, June 4-5 for #Cdiff researchers from UK, France and Europe, w/ strong emphasis on ECRs! Thanks to @microbiologysociety.org support! event.fourwaves.com/3cdf-2025/pa... Registration & abstract submission still open! #MicroSkyevent.fourwaves.com3CdF 2025Fourwaves - 3CdF 2025 022
Anirudh Jakhmola @funnirudh.bsky.social · 25/04/2025Pip can be a physicist if that’s her thing. I bet she’ll be a good physicist. 010
Anirudh Jakhmola @funnirudh.bsky.social · 22/04/2025Screening some mutant phages and can’t help but feel bad about this guy who: 1. Had his head burst (Red selection is where the head was supposed to be) 2. Tail tube broke in half RIP unnamed phage. You will be missed. 050
Anirudh Jakhmola @funnirudh.bsky.social · 06/04/2025Presented my work in the Science Graduate Showcase at the University of Sheffield. A bit subtle in design compared to my past posters but there’s always tomorrow. #phage 162
Reposted by Anirudh JakhmolaRob Fagan @robfagan.bsky.social · 26/03/2025New paper alert 🚨 We've solved the complete structure of a C. difficile-infecting phage using cryo-EM, in both extended and contracted conformations - published today in Life Science Alliance www.life-science-alliance.org/content/8/6/...life-science-alliance.orgMolecular mechanism of bacteriophage contraction structure of an S-layer–penetrating bacteriophageThe molecular details of phage tail contraction and bacterial cell envelope penetration remain poorly understood and are completely unknown for phages infecting bacteria enveloped by proteinaceous S-l... 2309
Anirudh Jakhmola @funnirudh.bsky.social · 10/03/2025NCBI has the most sassy server I’ve ever come across. What do you mean that the error code is NO_ERROR? Real helpful NCBI. 000
Reposted by Anirudh JakhmolaRob Fagan @robfagan.bsky.social · 08/03/2025Introducing Pip! 4 weeks old and doing brilliantly 1181
Anirudh Jakhmola @funnirudh.bsky.social · 14/01/2025Spending the last few days at my home and I can never get used to this view. The himalayan range in the background steals the show. Pretty curious about the phage diversity here though. 130
Anirudh Jakhmola @funnirudh.bsky.social · 06/01/2025Back at NISER to catch up with my old lab and friends. One thing that always amazes me is the sand art. 010
Anirudh Jakhmola @funnirudh.bsky.social · 26/12/2024Being back in India has rejuvenated my hatred towards high beams and people driving with high beams in the middle of the night. I had forgotten how annoying those are. 000
Reposted by Anirudh JakhmolaAlphaFold Unofficial @alphafold.bsky.social · 25/12/2024An international team of scientists has launched 115TB of validated scientific data to enable AI breakthroughs across disciplines! Two huge open-source datasets across dozens of fields, from bacteria to supernova! The Well: github.com/PolymathicAI... Multimodal Universe: github.com/MultimodalUn... 0205
Reposted by Anirudh JakhmolaOnisillos @onisillos.bsky.social · 16/12/2024I can't see these names being adopted in the short to medium term. I certainly won't be insisting on their use. Just keep in mind that creation of new names doesn't formally ban old ones. So whatever facilitates clearest communication is best. www.science.org/content/arti...science.org‘Silly and pompous’: Official new names for viruses rile up researchersAn overhaul of viruses’ scientific naming system has incensed some virologists, but others are more accepting 5274
Anirudh Jakhmola @funnirudh.bsky.social · 11/12/2024You know you have a big dog when the bandana you got him from UK marked specifically for “large adult dogs” looks like this. Time to bust out the ol’ towel and make a bandana out of it. 010
Anirudh Jakhmola @funnirudh.bsky.social · 04/12/2024Successfully scaled the Win Hill in the Peak District while casually chatting about unkillable superbugs… ya’know… like normal people. 010