Xing et al. construct a comprehensive pan-cancer human brain metastasis (BrM) atlas at single-cell resolution, uncovering five major BrM ecotypes associated with distinct phenotypic characteristics. The study also identifies several novel cell states and subsets that are strongly enriched in BrM across different lineages, suggesting them as potential therapeutic targets for future investigations.

Women who work night shifts may have an increased risk for irregular periods and hormonal imbalances, according to a study being presented Monday at ENDO 2025, the Endocrine Society’s annual meeting i...

We unite, lead, and grow the global endocrine community to accelerate scientific breakthroughs and improve health worldwide. endocrine.org

Nature Reviews Endocrinology, Published online: 24 June 2025; doi:10.1038/s41574-025-01134-8This international Consensus Statement provides guidelines on the management of pituitary incidentalomas.

Newborns will have whole genome sequencing to enable personalised healthcare that predicts and prevents illness

In this issue of Cancer Cell, Knol et al. present the Pan-Cancer Proteome Atlas (TPCPA), a proteomic resource developed using single-shot data-independent acquisition mass spectrometry (DIA-MS). TPCPA provides proteome-scale quantifications of 999 tumors across 22 cancer types in a unified manner, for discovering tumor biology, biomarkers, and therapeutic targets.

Gene expression reveals that different types of human cell can work as a unit. These cellular modules, found in several tissues, change during disease.

Endurance exercise induces multi-system adaptations that improve performance and benefit health. Gene regulatory circuit responses within individual skeletal muscle cell types, which are key mediators...

Nature Communications - Pituitary gonadotrophs secrete LH and FSH, regulating gonadal function. Here authors show that in the mouse pituitary most gonadotrophs originate from postnatal stem cells,...

While contemporary short-read single cell RNA-sequencing allows to decipher tissue composition, discrimination between transcript isoforms remains challenging. Here, we propose single cell long-read i...

This work presents SUM-seq, an ultra-high-throughput method for co-profiling chromatin accessibility and gene expression in single nuclei across multiplexed samples, advancing the study of gene regula...

Pioneer factor PAX7 highjacks control of DNA methylation maintenance, leading to enhancer demethylation and epigenetic memory.

Nature Reviews Genetics, Published online: 21 May 2025; doi:10.1038/s41576-025-00846-xTechnological and computational advances in recent years, from cryo-electron microscopy to sequencing technologies and machine learning, have substantially deepened our understanding of RNA splicing. Nature Reviews Genetics and Nature Reviews Molecular Cell Biology present an online collection that showcases the novel biological insights facilitated by these advances.

Post-transcriptional splicing has emerged as a key layer of gene expression regulation but is challenging to differentiate from co-transcriptional splicing. The authors review methodologies to detect ...