iiinova — where your digital self keeps evolving

Paul Frankland @franklandlab.bsky.social · 01/09/2026

A football version of this Blackadder classic: youtu.be/OKuHYO9TM5A?...

Paul Frankland @franklandlab.bsky.social · 16/06/2026

One especially cool thing was Sangyoon’s use of machine learning-based analysis of ultrasonic vocalizations (based on this paper: pubmed.ncbi.nlm.nih.gov/28472651/). Exon 3 mice exhibited an impoverished vocal repertoire, reminiscent of the communication deficits observed in ASD.

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Paul Frankland @franklandlab.bsky.social · 16/06/2026

This distinction mattered. Ptchd1 exon 3 mice exhibited a broader autism-relevant phenotype, including social and communication deficits not observed in the exon 2 model (pubmed.ncbi.nlm.nih.gov/27007844/)

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Paul Frankland @franklandlab.bsky.social · 16/06/2026

We found that deleting exon 2 does not necessarily abolish PTCHD1 function because it triggers compensatory upregulation of the Ptchd1-C isoform. In contrast, targeting exon 3 disrupts both major brain isoforms (Ptchd1-A and Ptchd1-C), producing a more complete loss-of-function model.

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Paul Frankland @franklandlab.bsky.social · 16/06/2026

Human genetics provided the motivation. Pathogenic PTCHD1 mutations in patients are concentrated in exon 3, yet previous mouse models primarily targeted exon 2.

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Paul Frankland @franklandlab.bsky.social · 16/06/2026

New paper from the lab, led by Sangyoon Ko (and a long-term collaboration with John Vincent at CAMH). The study revisits a basic question in modeling PTCHD1-associated autism: which exon should be targeted to best capture the human disorder? 🧵 can01.safelinks.protection.outlook.com?url=https%3A...

can01.safelinks.protection.outlook.com

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Paul Frankland @franklandlab.bsky.social · 12/05/2026

Just a few tickets remaining-- grab them while you can: www.eventbrite.ca/e/neural-cir...

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Reposted by Paul Frankland

mark cembrowski @markcembrowski.bsky.social · 11/05/2026

Lineup, including trainee talks, is all set for this year's Neural Circuits and Behaviour Satellite at @canacn.bsky.social, co-hosted with @franklandlab.bsky.social . One week away, with a few tickets remaining for anyone interested! www.eventbrite.com/e/neural-cir...

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Paul Frankland @franklandlab.bsky.social · 17/04/2026

The trainee talks are invariably the highlight of the meeting. Sign up with the link below for consideration!

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Paul Frankland @franklandlab.bsky.social · 29/03/2026

Updated list: 1= Amadeus 1= Bricolage 3 Johnson family bakery 4 Blackbird 5 Jules 6 Nord Lyon 7 Brodflour (NEW!!) 8 Bomou 9 Pompette 10 Petite Thuet 11 Thobors

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Paul Frankland @franklandlab.bsky.social · 29/03/2026

But overall… a bit disappointing. Crust looks great, but bread too dense for my taste. Not great, not terrible. But cafe worth a visit.

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Paul Frankland @franklandlab.bsky.social · 29/03/2026

New baguette alert. Been wanting to try Liberty Village’s Brodflour for a while, and today I got the chance. First of all, extra points for cool cafe vibe. Busy inside, and lots of people gathered outside with coffee cups doubling as hand-warmers.

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Sarah Lempriere @sarahlempriere.bsky.social · 20/03/2026

I'm always amazed by the complexity and nuance of the neuroscience of pain. In this Perspective, @simonbeggslab.bsky.social and @franklandlab.bsky.social do a great job of explaining some important new findings on the role of time in the mechanisms of chronic pain www.science.org/doi/10.1126/...

science.org

Pain across time

Two brain circuits facilitate the interaction between chronic pain and time

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Reposted by Paul Frankland

Ciaran Murphy-Royal @murphyroyallab.org · 16/03/2026

This satellite is a highlight of the @canacn.bsky.social meeting. Looking like another excellent lineup!

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mark cembrowski @markcembrowski.bsky.social · 16/03/2026

Registration for the @canacn.bsky.social 2026 Neural Circuits and Behaviour satellite meeting is now live! Looking forward to hosting this event with @franklandlab.bsky.social again, and we're looking to have 4 trainee talks as part of the satellite. Register at www.eventbrite.com/e/1984146883...

eventbrite.com

Neural Circuits and Behaviour CAN 2026 Satellite Meeting

The third-annual CAN satellite event, bringing together Canadian neuroscientists studying circuits and behaviour.

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Wendy Xin @droligo.bsky.social · 13/03/2026

Super stoked to share that I’m starting my lab at UHN @dkjei-uhn.bsky.social / @kbi-uhn.bsky.social and the University of Toronto! If you’re interested in neuron-myelin interactions in circuit maturation and cognition, please reach out - we are hiring! www.oligodendrocyte.org 1/

oligodendrocyte.org

Xin Lab

Welcome! We study the cellular interactions between neurons and oligodendrocytes, which produce myelin in the central nervous system. Myelination - the process by which oligodendrocytes ensheath neuro...

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Paul Frankland @franklandlab.bsky.social · 01/03/2026

Ground hopping #3. In the posh seats at Fulham. Spurs always kicking off 😂

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mark cembrowski @markcembrowski.bsky.social · 26/01/2026

Save the date for the annual "Neural Circuits and Behaviour" satellite conference at the Canadian Association for Neuroscience annual meeting, cohosted by @franklandlab.bsky.social and myself on May 18, 2026. We have a great speaker lineup and will be selecting 4 trainees talks from our registrants!

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Paul Frankland @franklandlab.bsky.social · 15/01/2026

Same for me-- but work not gym (yet)

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Paul Frankland @franklandlab.bsky.social · 13/01/2026

Depends how west is west side… Bricolage is the most west (College and Dufferin). Need to explore further west at some point.

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Paul Frankland @franklandlab.bsky.social · 13/01/2026

Updated list: 1=. Amadeus 1=. Bricolage 3. Johnson family (NEW ENTRY) 4. Blackbird 5. Jules 6. Nord Lyon 7. Bomou 8. Pompette 9. Petite Thuet 10. Thobors

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Paul Frankland @franklandlab.bsky.social · 13/01/2026

This baguette is spot on. Airy, with near perfect crust. Delicious with some Wensleydale and some Branston! It’s up there with the best baguettes in the city (Bricolage and Amadeus). Need to do a side-by-side comparison.

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Paul Frankland @franklandlab.bsky.social · 13/01/2026

Excited to continue my exploration of Toronto’s best baguettes. Next up the Johnson family bakery’s baguette (from the brother of @jimjohnsonsci.bsky.social)

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Yuki Murai @yukimurai.bsky.social · 28/11/2025

Today was the final day of my three-month stay in Paul and Sheena’s lab. It was short, but filled with unforgettable moments. I love the lab, the people, and this city. I can’t put into words how grateful I am for everything. Thank you so much, @franklandlab.bsky.social and @sjo09.bsky.social

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Paul Frankland @franklandlab.bsky.social · 22/10/2025

These time-dependent shifts in sub-engram engagement indicate that systems consolidation involves reorganization _within_ (as well as across) brain regions.

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Paul Frankland @franklandlab.bsky.social · 22/10/2025

We provide evidence for projection-defined 'sub-engrams' that contribute differentially to memory expression at recent and remote delays.

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Paul Frankland @franklandlab.bsky.social · 22/10/2025

New paper from the lab 🚨 Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age: authors.elsevier.com/a/1lzT-3BtfH...

authors.elsevier.com

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Paul Frankland @franklandlab.bsky.social · 01/10/2025

This adds to an emerging picture that not only do new neurons influence encoding of new memories but they _shape_ and _remodel_ existing memories. These shifts in resolution may facilitate generalization of event based memories beyond the original situation.

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