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Filipe De Vadder @filipedevadder.bsky.social · 30/09/2026

And yet both end up paying in the same place. When we let them breed, the difficulty in both sexes is getting a pregnancy started. Once started, litters are normal. Two opposite strategies, the same wall at the end. For females, it lifts once food returns.

Dot plot of conception rate per mating cycle in males paired with hyperfertile females, control versus low-protein diet. Each dot is one male. The control mean sits at about 77% and the low-protein mean at about 47%, with wide error bars that do not overlap at the means. Odds ratio 3.76, 95% interval 1.24 to 11.38, p = 0.019.

Dot plot of conception rate per cycle in females, classified by the diet they were actually on at fertilisation. Each dot is one female. The control mean sits at about 65%, the low-protein mean at about 26%. Several low-protein females never conceived, shown as dots at 0%. Odds ratio 5.20, 95% interval 1.55 to 17.44, p = 0.008.

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Filipe De Vadder @filipedevadder.bsky.social · 30/09/2026

Females do the opposite. They protect their growth and postpone puberty instead, waiting until they reach the right body size. One sex keeps the timetable and pays elsewhere. The other keeps the body and pays in time.

Kaplan-Meier curve of puberty onset in females, cumulative percentage against age from day 21 to 56. The control curve (dark teal) rises steeply and reaches nearly 100% by day 35. The low-protein curve (pale teal) rises slowly and has only reached about 75% by day 56, the end of the study. Hazard ratio 0.11, 95% interval 0.05 to 0.28, p < 0.001. A table below gives the number still at risk in each group.

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Filipe De Vadder @filipedevadder.bsky.social · 30/09/2026

Reproduction goes the other way, and this is where the two sexes clearly part. Males reach puberty on schedule, but their chemical signalling, the scent proteins they put in their urine, goes nearly silent. They mature on time and advertise much less.

Horizontal bar chart titled "Mup cluster", showing eleven major urinary protein genes. Every bar points left, meaning lower expression on the low-protein diet, ranging from about a 1.3 to a 7 on a log2 scale, that is roughly two-fold to over a hundred-fold. All bars carry one to three asterisks.

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Filipe De Vadder @filipedevadder.bsky.social · 30/09/2026

Is this just testosterone disappearing? We removed the testes at weaning to find out. Part of the liver change does depend on male hormones. The growth and metabolic collapse does not. It happens just the same without testes.

Two side-by-side line charts of body length from day 21 to 56 in males only: sham-operated on the left, castrated at weaning on the right. In both panels the control-diet curve rises well above the low-protein curve, and the two gaps are the same size. Asterisks mark the diet difference at every age from day 28 in both panels. Subtitle: diet by surgery by time interaction, p = 0.66.

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Filipe De Vadder @filipedevadder.bsky.social · 30/09/2026

And in the liver, one of the most sex-specific organs in the body, with hundreds of genes read differently in males and females. Under low protein, the male liver drifts toward the female profile. The female liver barely moves.

Box plot of a liver "feminization score" in four groups, where 0 is the typical control male liver and 1 the typical control female liver. Control males sit at 0. Low-protein males rise to about 0.75, crossing the halfway line. Control and low-protein females both sit at about 1 and are indistinguishable. Sex-by-diet interaction p < 0.001; the female diet comparison gives p = 0.902.

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Filipe De Vadder @filipedevadder.bsky.social · 30/09/2026

The same thing happens for metabolism: how much energy they burn, how they handle sugar, what they store in the liver. Put all of it together and the male and female profiles, normally far apart, end up nearly on top of one another.

Scatter plot titled "Somatic sexual dimorphism compression". Each dot is one mouse, positioned by a discriminant analysis of five growth and metabolic traits; ellipses show each group's 95% region and diamonds their centres. The control-diet male ellipse sits alone on the right. The three other groups overlap on the left. A long arrow labelled D = 4.72 spans the male-to-female distance on the control diet; a short arrow labelled D = 1.28 spans it on the low-protein diet. Footnote: 73% compression, permutation p = 0.0001.

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Filipe De Vadder @filipedevadder.bsky.social · 30/09/2026

On a normal diet, males and females separate as they grow. Males end up longer, heavier, with longer bones. On the low-protein diet, the two curves lie on top of each other. The difference between the sexes did not shrink. It never appeared.

Line chart of body length in centimetres from postnatal day 21 to 56, four groups. On the control diet, the male curve (dark gold) climbs above the female curve (dark teal) from day 28 onward and the gap keeps widening to day 56. On the low-protein diet, the male and female curves (pale gold and pale teal, dashed) run together as a single line for the whole period. Asterisks mark within-sex diet differences, hash marks a significant sex-by-diet interaction from day 35.

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Filipe De Vadder @filipedevadder.bsky.social · 19/11/2025

Look at Fig. 3. The same taxa reported as ↑, ↓, or “no change” across autism–microbiome papers. If you can call all of that “dysbiosis”, you do not have a disease signature. You have noise with good PR.

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Filipe De Vadder @filipedevadder.bsky.social · 21/10/2025

@mads100tist.bsky.social you will love this one. “Hey, give all your ideas to Springer-Nature, we’re totally cool with that. We already did it when we bought Research Squire and protocols.io but hey, keep feeding us please!”

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Filipe De Vadder @filipedevadder.bsky.social · 10/10/2025

#ProudPI 🎓 Thrilled to share that @ameliejoly.bsky.social received the thesis prize of the @sneuroendo.bsky.social, huge congratulations! 👏 And @lucasrebiffe.bsky.social is presenting the follow-up of the project in a great poster. Exciting to see the team’s work shining! 💪 #SNE25

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Filipe De Vadder @filipedevadder.bsky.social · 06/10/2025

La science est formelle: le prochain gouvernement aura une durée négative

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Filipe De Vadder @filipedevadder.bsky.social · 16/09/2025

Tomas “Tompa” Lindberg 16 October 1972 – 16 September 2025 Death and the labyrinth Swallowed by Earth itself Rest in power legend of Gothenburg metal

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Filipe De Vadder @filipedevadder.bsky.social · 22/07/2025

See you in hell, Prince of Darkness 🤘

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Filipe De Vadder @filipedevadder.bsky.social · 12/07/2025

We then identified a key mediator: FGF21, a liver-derived hormone. Under protein restriction, it rises in both sexes, but only delays growth and puberty in females.

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Filipe De Vadder @filipedevadder.bsky.social · 12/07/2025

Males entered puberty on time, despite stunting. Females, in contrast, showed delayed vaginal opening and estrus onset. Same stress, different developmental trajectories. The timing of puberty is more sensitive in females.

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Filipe De Vadder @filipedevadder.bsky.social · 12/07/2025

Males: severe and persistent stunting. Females: transient early impairment, but mostly recovered by adolescence. Same diet, different outcomes. The biological response to protein restriction is profoundly sex-specific.

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Filipe De Vadder @filipedevadder.bsky.social · 08/04/2025

I really wonder how in 2025, with the tons of computational tools we have, the non-parametric fits like LOESS and GAM, the possibility to plot residuals, etc. we can still see regressions like panels c and d, and assume that this is biologically meaningful just because p<0.05.

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Filipe De Vadder @filipedevadder.bsky.social · 21/03/2025

#ProudPI Once again @lucasrebiffe.bsky.social did an incredible presentation at the CECED yearly meeting and got the best presentation award. Incredibly proud of such a talented PhD candidate!

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Filipe De Vadder @filipedevadder.bsky.social · 16/03/2025

Not sure that “cum probability” for a paper about female reproduction is the best abbreviation 😅 (Besides that the paper is absolutely awesome) www.cell.com/neuron/abstr...

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Filipe De Vadder @filipedevadder.bsky.social · 14/03/2025

I was feeling skeptical about a setlist which was 90% of the three latest albums. Feeling they they were not as heavy as they used to be. Boy, was I wrong! That was absolutely insane. Best concert of 2025 so far. #Architects

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Filipe De Vadder @filipedevadder.bsky.social · 23/02/2025

Le Point, c’était pas ceux qui avaient demandé la parole d’expert à un certain Didier Raoult pour dédouaner Assad des crimes qu’il commettait? Ou peut-être c’est Wikipedia, je ne sais plus.

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Filipe De Vadder @filipedevadder.bsky.social · 07/01/2025

Y’en a qui ne se cachent même plus 💩💩💩💩

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Filipe De Vadder @filipedevadder.bsky.social · 27/12/2024

After 4+ amazing years, it’s time to say goodbye to @ameliejoly.bsky.social. You’ve been an inspiring scientist and an incredible colleague. Wishing you all the best for your postdoc with @irenemiguel-aliaga.bsky.social. The lab won’t be the same without you!

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Filipe De Vadder @filipedevadder.bsky.social · 09/12/2024

How can you be a metalhead and be happy at this? Come on, this has really become Disneyland.

Hellfest lineup 2025, available at www.hellfest.fr

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Filipe De Vadder @filipedevadder.bsky.social · 19/11/2024

@francoisleulier.bsky.social présente le cadre de la recherche lors de la journée Déclics pour des élèves de STL au lycée La Martinière Diderot.

François Leulier présente le travail de l’équipe lors des journées Déclics

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Filipe De Vadder @filipedevadder.bsky.social · 18/11/2024

En utilisant deux modèles animaux (la souris et la drosophile), l'équipe cherche à comprendre comment l'environnement microbien façonne la réponse physiologique à un stress nutritionnel: la carence en protéines pendant la période juvénile. 📷: Vincent Moncorgé

Image d'une souris sur un tube de mouches drosophiles, à côté d'une plaque de Petri contenant une culture bactérienne.

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