iiinova — where your digital self keeps evolving

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The Age's mad headline on its lead story, about education fairness, makes it about a possible fall in housing prices mentioned in passing in the 19th paragraph. #obsession

'How increasing private school funding could improve Melbourne house prices'

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The Onion @theonion.com · 4h

Friend Being Cagey About What She’s Going To Order theonion.com/friend-being-cagey-abo…

Friend Being Cagey About What She’s Going To Order
Apparently It’s Some Kind Of Really Private Matter For Her, Dining Companions Say

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Randall Munroe @xkcd.com · 4h

Dogcatcher xkcd.com/3309/

Comic. [Three people seated at table.] PERSON 1 with ponytail: Once we break this story, he won’t be able to get elected *dogcatcher*. PERSON 2: Why do people always use “dogcatcher” as the example of a worthless office? Animal control officers are valued professionals. It just seems unnecessarily insulting. PERSON 3 with shoulder-length hair: Well, their job *is* catching strays.

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Edward Nirenberg @enirenberg.bsky.social · 4h

I am shocked and deeply saddened by the loss of Helen Branswell. I tried to read everything she published because of her mastery in distilling complexity without sacrificing accuracy. She always asked the best questions and I learned a great deal from her work. May her memory be a blessing.

statnews.com

Helen Branswell, whose reporting on infectious diseases and public health drew acclaim, dies at 69

Helen Branswell, STAT's infectious disease reporter who earned the respect of experts and public health officials with her accessible, prescient dispatches, has died at age 69.

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Eliot Higgins @eliothiggins.bsky.social · 10h

We can't fact-check our way out of people feeling like institutional actors aren't responsive and consequences are a matter of power rather then evidence.

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Eliot Higgins @eliothiggins.bsky.social · 10h

Again, framing this primarly as a supply issue rather than one of demand sets our responses up for failure - MI5 chief Ken McCallum confirms Russia did interfere in Brexit referendum but says it had little impact – UK politics live www.theguardian.com/politics/liv...

theguardian.com

MI5 chief Ken McCallum confirms Russia did interfere in Brexit referendum but says it had little impact – UK politics live

He argued there was no evidence to suggest the result of the Brexit vote had been swayed as a result of the effort

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Doctors Without Borders / Médecins Sans Frontières (MSF) @msf.ca · 9h

Stopping #Ebola disease outbreak takes more than treating patients. Watch Monique Pereboom, our Epidemiology Advisor, share how our teams in #DRC are working to help stop the spread of Ebola disease for good:

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Alice Roberts @profaliceroberts.bsky.social · 7h

Constantine’s mum, Helena, was said to have discovered the “true cross” in an excavation at Golgotha. She sent the nails “from the crucifixion” back to the emperor Constantine, who had them incorporated into a military helmet and bridle, the better to subjugate barbarians with! 2/2

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Alice Roberts @profaliceroberts.bsky.social · 7h

For those saying Christian Nationalism isn’t very… Christian (including on Thought for the Day, OF COURSE) - Christianity has been nationalistic/imperialistic since the 4th century. Bishops actively sought more engagement with and buy-in from the Roman Empire, and supported its military efforts… 1/2

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The Onion @theonion.com · 12/10/2026

Dad Apparently At Age Where Tooth Can Fall Out And It Not That Big A Deal

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The Kyiv Independent @kyivindependent.com · 12/10/2026

⚡️ Russian assets are only leverage if Europe uses them, says Ukraine's FM Sybiha. "Europe can no longer stay immobilized on Russia's immobilized assets. The leverage is not in holding the money, but in using it for defense," Foreign Minister Andrii Sybiha said.

kyivindependent.com

Russian assets are only leverage if Europe uses them, says Ukraine's FM Sybiha

"Europe can no longer stay immobilized on Russia's immobilized assets. The leverage is not in holding the money, but in using it for defense," Foreign Minister Andrii Sybiha said.

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Humanists UK @humanists.uk · 12/10/2026

He became a regular contributor to Stanton Coit’s paper, the Ethical World, chaired several important congresses of the Union of Ethical Societies (today’s Humanists UK), and advocated for secular education in schools.

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Humanists UK @humanists.uk · 12/10/2026

A socialist, MacDonald believed in putting reason and compassion to work for reform, seeking equal opportunity and a fairer society. He dismissed doctrinal religion, finding a home in the early humanist movement which emphasised an applied ethical system, without reference to supernatural ideals.

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Humanists UK @humanists.uk · 12/10/2026

James Ramsay MacDonald was the first Labour Prime Minister of Great Britain, and an early, and active, member of the Ethical movement which would later become Humanists UK. He was born #OnThisDay 1866. #HumanistHeritage 🧵 heritage.humanists.uk/james-ramsay...

‘The moral value of a belief in eternal life is a doubtful matter. But this is certain, that where rest is to be found, it is for those who have earned it, not by prayer and fasting, but by work… Our work is a work of love, not a task for reward.’

James Ramsay MacDonald, Politician and humanist

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Eliot Higgins @eliothiggins.bsky.social · 12/10/2026

And it's understandable why people would think what's the point of doing that if it won't change the minds of Farage supporters, but it's a demonstration of principles led by evidence and revisability, not identity and loyalty.

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Eliot Higgins @eliothiggins.bsky.social · 12/10/2026

This also would demonstrate the difference between the two sides in the argument (if a difference exists), that for one evidence precedes opinions, and for the other identity precedes opinions.

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Eliot Higgins @eliothiggins.bsky.social · 12/10/2026

The correct response to this would be to make all the evidence used to draw the conclusion public, then challenge Farage to respond, otherwise people will just pick their opinions on the matter based purely on who they trust.

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Prof Gavin Yamey MD MPH @gavinyamey.bsky.social · 12/10/2026

Happening now, open to all, examining trust in science worldwide. It's the World Health Summit in Berlin, so the production values are rather good, lol! Femi Oke (British TV presenter) is moderating www.worldhealthsummit.org/sessions/e94...

worldhealthsummit.org

Does Science have a Trust Problem? New Findings from the Wellcome Global Monitor 2026

Do people around the world trust science? Do levels of trust differ across countries and communities? And what does this mean for global health?

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Prof Gavin Yamey MD MPH @gavinyamey.bsky.social · 12/10/2026

Not surprisingly, trust in science is correlated with trust in public health and medical systems And trust in science is lowest among those who are the most financially insecure

People with highe confidence in health systems have more trust in science

Trust in science is lowest among those who feel the are struggling to get by

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Prof Gavin Yamey MD MPH @gavinyamey.bsky.social · 12/10/2026

7 out of 10 people worlwide say they trust science, which is heartening, but it has fallen since 2020 There are regional variations Western Europe has by far the highest trust in science Data are from The Wellcome Global Monitor 2026 (surveys public attitudes towards science and health globally)

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Humanists UK @humanists.uk · 12/10/2026

The word 'evolved' only appears once in the 1859 first edition of On the Origin of Species, and this is it. Perhaps the most important words ever written. To humanists, evolution is basis of very understanding of existence, and our place in nature. #Hwotobeahappyhuman

Charles Darwin. Naturalist and humanist. 'From so simple a beginning endless forms most beautiful and most wonderful have been, and are being, evolved.

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TRAstonDrs @castltrastondrs.medsky.network · 09/10/2026

🧬Its remarkably strong baseline ACE2 receptor-binding capability acts as a structural buffer. This mirrors the early evolutionary path of the BA.2.86 lineage before it acquired the L455S mutation to become the globally dominant JN.1 strain

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TRAstonDrs @castltrastondrs.medsky.network · 09/10/2026

While PJ.2.1 does not demonstrate an immediate, definitive transmission advantage via #immuneevasion, its evolutionary strategy poses a significant #publichealth risk

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TRAstonDrs @castltrastondrs.medsky.network · 09/10/2026

🧬The virological profile of PJ.2.1 is characterized by an exceptional binding strength to host cell receptors coupled with a unique structural vulnerability to antibodies

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TRAstonDrs @castltrastondrs.medsky.network · 09/10/2026

Genomic surveillance tracks its evolutionary origin as a descendant of the MC.10.1 lineage (specifically derived from the KP.3.1.1 sublineage within the broader JN.1 family), carrying over 25 additional spike mutations vs to its parental backbone

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TRAstonDrs @castltrastondrs.medsky.network · 09/10/2026

#Medsky🧪 #IDsky #publichealth #Vaccinesmatter The emerging #COVID sub-variant PJ.2.1 is a highly mutated strain first detected in May 2026 that has achieved rapid intercontinental spread.

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TRAstonDrs @castltrastondrs.medsky.network · 09/10/2026

Because its baseline binding strength is so high, PJ.2.1 can comfortably acquire future immune-evasive mutations that typically compromise receptor affinity. 🦠 the study monitoring the variant note that if PJ.2.1 picks up common immune-evading substitutions like A475V, N487D, or D420N,

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bioRxivpreprint @biorxivpreprint.bsky.social · 09/10/2026

Epidemiology and virological characteristics of the emerging SARS-CoV-2 variant PJ.2.1 www.biorxiv.org/content/10.64898/20…

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Dr Noor Bari @njbbari3.bsky.social · 12/10/2026

I wonder why abc news didn’t mention chronic infections and never getting better while selling the Danish model of infect everyone to a well protected Australian public… A rhetorical question. 🙄

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Dr Noor Bari @njbbari3.bsky.social · 12/10/2026

Lucky we are taking infections in immunocompromised people and chronic infections seriously so that we can detect and treat these excellent variants before they travel the whole world… No?

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Dr Noor Bari @njbbari3.bsky.social · 12/10/2026

Oh well done everybody. /s Slow clap. (Excludes people that can’t wear a respie or are wearing a respie.)

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Humanists UK @humanists.uk · 12/10/2026

The report, Beyond ‘Christian nationalism’, argues that Christian nationalism is driven more by culture and identity than by Christian faith. But the report’s own figures, and recent events in the UK, point to a different conclusion: Christian nationalism cannot be separated from Christianity.

humanists.uk

We can’t tackle Christian nationalism by pretending it isn’t Christian

New research from the think tank Theos shows that the most religiously active group in the UK is also among the most supportive of Christian nationalist ideas. The report, Beyond ‘Christian…

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Humanists UK @humanists.uk · 12/10/2026

New research from the think tank Theos shows that the most religiously active group in the UK is also among the most supportive of Christian nationalist ideas.

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Dr Noor Bari @njbbari3.bsky.social · 12/10/2026

I think I would prefer to be led by donkeys. For the most part, animals don’t try to kill me.

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David Gorski, MD, PhD @gorskon.bsky.social · 12/10/2026

Last week, RFK Jr. and his minions opened a “vaccine injury clinic” at the NIH. With no budget, structure, or leadership announced, the program appears to be a sham in service of RFK Jr.’s war on vaccines. sciencebasedmedicine.org/rfk-jr-is-de...

sciencebasedmedicine.org

RFK Jr. is definitely coming for your vaccines (part 12): The new NIH vaccine injury clinic is likely a sham

Last week, RFK Jr. and his minions opened a "vaccine injury clinic" at the NIH. With no budget, structure, or leadership announced, the program appears to be a sham in service of RFK Jr.'s war on vacc

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The Onion @theonion.com · 12/10/2026

Nation’s Indigenous People Confirm They Don’t Need Special Holiday, Just Large Swaths Of Land Returned Immediately theonion.com/nation-s-indigenous-pe…

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Chise @sailorrooscout.bsky.social · 12/10/2026

The study has been published in Nature Cancer. YES, it is PEER-REVIEWED. • www.nature.com/articles/s43... 🧪🧵⬇️

Key Takeaways
• An adjuvant personalized DNA vaccine caused no serious adverse events and extended overall survival in nine patients in a phase I study compared with historical outcomes.
• Median overall survival was 16.3 months and the survival rate at 24 months was 33%, including one long-term survivor who was still alive 4 years from the time of initial surgery.
•Only about 10% to 15% of patients with this type of brain cancer survive up to 2 years.

Abstract
Glioblastoma is a fatal disease with a median prognosis of 12-18 months. Recent studies have shown encouraging results using neoantigen-based vaccines to stimulate glioblastoma-directed immune responses, but overall immunogenicity has been low.
Here, we report the results of an open-label, single-arm, phase 1 clinical trial (GT-20) to evaluate the satety and feasibility (primary endpoints) as well as immunogenicity and preliminary clinical activity (secondary endpoints) of GNOS-PV01 monotherapy, a DNA-based personalized therapeutic cancer vaccine administered following surgical resection and radiation for patients with MGMT unmethylated glioblastoma.
The GT-20 study vaccinated nine patients, using up to 40 neoantigens per patient (range, 17-40) without causing any serious adverse events, unexpected toxicities or dose-limiting toxicities.
The vaccine induced activation and expansion of circulating peripheral T cells in all evaluated patients, except one who was being treated with dexamethasone.
The secondary endpoint was to evaluate 6 month progression-free survival and 12 month overall survival; each observed in 66.7% of patients. Median progression-free survival was 8.5 months, median overall survival was 16.3 months and survival at 24 months was 33%, including one long-term survivor still alive 4 years from the time of initial surgery.
This study met the pre-specified endpoints and supports the use of GNOS-PV01 as a potentially impactful component of glioblastoma immunotherapy.
ClinicalTrials.gov: NCT04015700.

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Chise @sailorrooscout.bsky.social · 12/10/2026

The vaccine caused NO serious side effects AND prolonged patients’ overall survival compared to historical outcomes after standard-of-care surgery and chemo-radiotherapy. One long-term survivor remains recurrence-FREE nearly FIVE YEARS LATER. • www.insideprecisionmedicine.com/topics/oncol...

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The Kyiv Independent @kyivindependent.com · 12/10/2026

"The Kremlin must see that continued aggression will deepen its isolation. I ask you to take these proposals forward as an urgent priority," writes Finnish Foreign Minister Elina Valtonen in a letter seen by the Kyiv Independent.

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Eliot Higgins @eliothiggins.bsky.social · 12/10/2026

For all this talk of Russian bots being defeated by the Yandex strikes I'm still getting the usual Matryoshka emails with the same fake news posts and purchased bot engagement. Seems more like wishful thinking based on misinterpreted data than reality.

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Kaz Cooke @kazcooke.bsky.social · 12/10/2026

Good tram ride home chatting to stranger in wild clothes while a mean lady rolled eyes & harrumphily moved away. Stranger & I talked archaic hobbies (think: painting miniatures) & philosophy & thoughts on DV. As I got off, stranger & new person started chatting. Score: mean lady 0 vs Strangers 3.

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Dr Noor Bari @njbbari3.bsky.social · 12/10/2026

As you know I was really quite unwell recently… and I have mostly recovered… except I now have a nasty habit of ordering food online +++ Time to make my own sandwich!

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Wear ≥Filip Filipovich Preobrazhensky 2 respirator Do Not Follow @ff-preobrazhensky.bsky.social · 12/10/2026

Any country that continues to indulge in retaining capital punishment on it's books cannot call itself civilised ... any in this context means all (countries). Since I left school (1966) I've always refused to go to any country with it on their books, they can do without my custom/knowledge/skills.

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Dr Noor Bari @njbbari3.bsky.social · 12/10/2026

I stand against executions in general, and public ones in particular. Public executions will do nothing to stop people that believe in martyrdom, and will teach us to become as cruel as the most heinous murderer.

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