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Fern Koay

@fernery.bsky.social
174 followers 95 following 9 posts

👩🏼‍🔬🇲🇾🇦🇺🇺🇲🔬 T(ea) cells & bad banter.

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Reposted by Fern Koay
l-beattie.bsky.social @l-beattie.bsky.social · 02/02/2026
Ever wondered why gamma delta T cells are required for immunity to liver-stage malaria? www.nature.com/articles/s41...
nature.com
γδ T cell-derived IL-4 initiates CD8+ T cell immunity - Nature Immunology
The authors show how Vγ1+ γδ T cells produce IL-4 to drive early CD8+ T cell and dendritic cell responses to malaria infection in mice.
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Reposted by Fern Koay
γδ T cell Forum @forum-gd.bsky.social · 31/01/2026
γδ T cell-derived IL-4 initiates CD8+ T cell immunity #gdTcells @natimmunol.nature.com
nature.com
γδ T cell-derived IL-4 initiates CD8+ T cell immunity - Nature Immunology
The authors show how Vγ1+ γδ T cells produce IL-4 to drive early CD8+ T cell and dendritic cell responses to malaria infection in mice.
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Reposted by Fern Koay
Lydia Lynch @lydialynch.bsky.social · 28/07/2025
This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥 www.nature.com/articles/s42...
nature.com
The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism
This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
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Reposted by Fern Koay
CD1-MR1 Immunology @cd1mr1.bsky.social · 19/05/2025
Our third webinar from the AUS/APAC region, will feature Nick Gherardin and Sho Yamasaki. Thursday, June 12th at 17:00 AEST (8:00 London, 16:00 Tokyo). If you'd like to keep up to date, sign up to the mailing list here: cd1mr1.com/cd1-mr1-soci...
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Reposted by Fern Koay
Waggoner Lab @labwaggoner.bsky.social · 09/12/2024
Role for γδ T cell-derived IL-4 in initiating CD8 T cell immunity to Plasmodium doi.org/10.1101/2024...
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Fern Koay @fernery.bsky.social · 03/12/2024
😲🤩 Has a name yet??
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Reposted by Fern Koay
CD1-MR1 Immunology @cd1mr1.bsky.social · 30/11/2024
SAVE THE DATES - Join us for CD1-MR1 2025, September 9-12 in Portland, Oregon! Updates are on the website www.cd1mr1.com including Program at a Glance, Location and Venue details.
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Fern Koay @fernery.bsky.social · 21/11/2024
Thank u & great to connect again here Cliona! Indeed we've wondered then sifted through still-quite-conflicting lit on CD1dKOs, pre vs post activated NKT cells in hepatectomy. Also maybe functional subsets/lineages can compensate & muddle the phenotype, we could knock more of'em out simultaneously..
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Fern Koay @fernery.bsky.social · 21/11/2024
Many thanks to our collaborators across Unimelb MDHS, The Florey Institute, University of Queensland, Austin Health for providing tools, resources and discussion towards this study!
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Fern Koay @fernery.bsky.social · 21/11/2024
Conceptually, non-peer review'd diagram here: Within T cells at least, integrating thoughts posed by labs of P.Brennan, B.Jabri, perhaps the extent of tissue damage sensitivity could be a hallmark of the ‘T cell-innateness’ theory. tinyurl.com/ycy6dv24 tinyurl.com/bd6kxekk
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Fern Koay @fernery.bsky.social · 21/11/2024
Overall, these have implications to how we should (in certain contexts) move away from studying our T cell lineages in isolation, and the role of T cell IL-4 production that is now getting resurged attention.
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Fern Koay @fernery.bsky.social · 21/11/2024
Towards discussion, this sensing of damage metabolites may act to prevent excessive tissue inflammation and injury as a way to maintain tissue homeostasis from the explosive cytokine production from these innate-T cells, UNTIL there is cognate antigen for them involved.
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Fern Koay @fernery.bsky.social · 21/11/2024
Our data indicates that upon insult, release of tissue damage metabolites drives this P2RX7-mediated depletion of T-bet+ innate-T cells. Blocking this also uncovered more numbers & subsets (CD4 innate-like IFNg/IL-4++ anyone?) than we thought originally exists. Also raising the q of 'why them'?
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Fern Koay @fernery.bsky.social · 21/11/2024
This all started in the quest of trying to recover enough numbers of NKT/MAIT/gdT cells ex vivo, why do (some) of them die so easily?? We followed the literature & the correlation of P2RX7 (not other P2RX's) expression on innate-like T cells was a key, in both mice and humans.
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Fern Koay @fernery.bsky.social · 21/11/2024
Thanks for sharing our latest work @jexpmed.bsky.social ! We've uncovered that P2RX7 regulates unconventional T cells selectively, particularly subsets that co-produce IFN-γ & IL-4. Hoping this helps more discoveries in the role of these innate-like cells using inhibitors from the P2RX7/ARTC2 field.
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