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Fergal Waldron

@fergalwaldron.bsky.social
109 followers 154 following 7 posts

Advanced Research Fellow, University of Aberdeen | ALS/MND/FTD | Early diagnosis & precision-prevention | Biomarkers | Disease Heterogeneity | Non-motor symptoms

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Fergal Waldron @fergalwaldron.bsky.social · 11/07/2026
Context of use matters: interpreting extracellular vesicle TDP-43 as a biomarker in ALS link.springer.com/article/10.1...
link.springer.com
Context of use matters: interpreting extracellular vesicle TDP-43 as a biomarker in ALS - Acta Neuropathologica Communications
Acta Neuropathologica Communications -
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Fergal Waldron @fergalwaldron.bsky.social · 23/04/2026
🚨Our new paper: Protein misfolding enteropathy predicts and prognosticates neurodegenerative disease years before symptom onset - Gastroenterology www.gastrojournal.org/article/S001...
gastrojournal.org
Protein misfolding enteropathy predicts and prognosticates neurodegenerative disease years before symptom onset
Neurodegenerative disorders are characterized by progressive, irreversible neuronal loss that often advances silently for years before symptoms appear. Disease-modifying therapies are generally less e...
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Reposted by Fergal Waldron
#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 16/10/2025
Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset #NeuroDegeneration 🧪🧠 medrxiv.org/cgi/content/short/2025.…
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Fergal Waldron @fergalwaldron.bsky.social · 16/10/2025
🧠New preprint: Neurodegeneration-associated proteinopathies are not confined to the brain, they can be detected in routine GI biopsies, years before symptom onset. www.medrxiv.org/content/10.1...
medrxiv.org
Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset
Background : Disease-modifying therapies for neurodegenerative disorders are unlikely to succeed once symptoms emerge, as significant neuronal loss has already occurred. Accessible biomarkers that pre...
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Reposted by Fergal Waldron
medRxivpreprint @medrxivpreprint.bsky.social · 16/10/2025
Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset www.medrxiv.org/content/10.1101/202…
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Reposted by Fergal Waldron
TRAstonDrs @castltrastondrs.medsky.network · 16/10/2025
#Medsky🧪 #neurosky #immunosky Studies are investigating a link between #proteinmisfolding in GIT & the development of #neurodegenerativediseases like #Parkinson & #Alzheimer often years before symptoms appear.
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Reposted by Fergal Waldron
bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 04/10/2025
Brain Iron as a Surrogate Biomarker of Pathological TDP-43 Identifies Brain Region-Specific Signatures in Ageing, Alzheimer's Disease and Amyotrophic Lateral Sclerosis www.biorxiv.org/content/10.1101/202…
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Fergal Waldron @fergalwaldron.bsky.social · 14/03/2025
At LifeArc's recent 1st ever Translational Science Summit on MND & Rare Dementias, Clinical Prof. Jenna Gregory from @uniofaberdeen.bsky.social set out a vision for early diagnosis & prevention in #MND #ALS through learning from cancer, early detection tools, & a focus on prevention 🧵1/3
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Reposted by Fergal Waldron
Jack Humphrey @jack-humphrey.bsky.social · 04/03/2025
Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in @naturegenet.bsky.social with @trajnp.bsky.social and @panosroussos.bsky.social @sinaibrain.bsky.social www.nature.com/articles/s41...
nature.com
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics
This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...
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Reposted by Fergal Waldron
Andras Lakatos @LakatosLab @lakatoslab.bsky.social · 17/12/2024
Many thanks for the post - I am also recruiting for a postdoctoral Research Associate post in complex Human Organoid-based ALS disease modelling: www.jobs.cam.ac.uk/job/49564/
jobs.cam.ac.uk
Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Associate (Fixed Term) in the Department of Clinical Neurosciences at the University of Cambridge.
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