Lay Summary. Accurately differentiating actual tumor progression from treatment-related changes, such as pseudoprogression or radiation-induced injury, rem

In a phase 1/2a umbrella trial in patients with glioblastoma matching targeted therapies according to tumor molecular profiling, temsirolimus plus radiotherapy improved PFS compared to standard of car...

A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabili...

Stunning results in mice herald gene-editing advances for neurological diseases.

YouTube video by Ludwig Boltzmann Gesellschaft

Gliomas classified as CNS WHO grade 3 and 4 (herein referred to as HGG) are aggressive, fast-growing tumors with a poor prognosis and limited therapeutic o

The World Federation of Neurology represents 125 member societies globally and aims to foster brain health and quality neurology worldwide. The term brain health has become an acknowledged term of cru...

PURPOSEStereotactic radiation (SRS/SRT) as opposed to whole-brain radiation (WBRT) represents the standard of care for patients with a limited number of brain metastases given the relatively favorable...

Nature Medicine - The Response Assessment in Neuro-Oncology (RANO) group defines a standardized framework for amino acid PET imaging of brain metastases for use in clinical trials and eventually in...

Elp1 heterozygous LOF mutations in Sonic hedgehog medulloblastoma (MB) elevate transformation risk in granule neuron precursors through stalled differentiation, DNA replication stress, genomic instabi...

Supervised machine learning models were designed and externally validated to predict glioma therapeutic clinical trial enrollment.

Beck et al. conducted single-cell and spatial profiling of embryonal tumors with multilayered rosettes, finding that malignant cellular hierarchies are driven by developmental programs and specific me...

AbstractBackground. Astrocytoma, isocitrate dehydrogenase-mutant, WHO grade 4 (Astro4), is a new tumor type in the 2021 WHO classification of central nervo

Purpose Positron emission tomography (PET) is increasingly used in neuro-oncology. However, little is known about its application across European institutions and reasons for variable implementation. ...

AbstractBackground. Advances in our technological capacity to interrogate CNS tumor biology have led to the ever increasing use of genomic sequencing in di

Advice on finding a supportive academic environment, building inclusivity in science, tackling scientific problems with an open mind, and more from Dr. Joyce.

AbstractBackground. Glioblastoma (GB), particularly IDH-wildtype, is the most aggressive brain malignancy with a dismal prognosis. Despite advances in mole

We are looking to support our rapidly growing team as soon as possible:

This cohort study examines chromosomal copy number alterations that could be used to improve the current World Health Organization grading of meningioma

Young patients under 40 years of age with grade 3 oligodendroglioma show distinct molecular profiles, including fewer CDKN2A deletions and specific chromosomal abnormalities, compared to those over 4....

Nature Medicine - Multi-omic single-cell and spatial analyses of lung cancer brain metastases from multiple cohorts identify high levels of chromosomal instability and a neural-like profile in...

The goal of this study was to conduct an external, independent validation of an O -(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET) PET automatic segmentation network on a cohort of patients with glioblasto...

Central nervous system malignancies include primary tumors and brain metastases (BrMs) originating from extracranial cancers. Bejarano et al. examine primary and metastatic brain tumors and find disti...

MethyLYZR, an epigenetic classifier of brain tumors, provides clinically relevant cancer classification results within 15 min of sequencing, with potential applications for neurosurgical intraoperativ...

Previously, OLIG2-expressing stems cells have been identified as having a role in medulloblastoma recurrence. Here, the authors investigate the effects of targeting this OLIG2+ stem cell population in...