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Matthias Guckenberger

@mguckenberger.bsky.social
367 followers 17 following 23 posts

Passionate Radiation Oncologist Chairman University Hospital Zurich Professor University of Zurich President of ESTRO

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Matthias Guckenberger @mguckenberger.bsky.social · 25/05/2025
Fresh from #ASCO2025 meetings.asco.org/abstracts-pr... SBRT vs microwave ablation (MWA) in pts with CRC liver oligo-mets ➡️ n=100, n=92 treated (39 SBRT, 53 MWA) ➡️ 18/92 pts (20%) reported side effects ➡️ n=3 G3-4 pain; n=2 infections after open MWA, n=1 bowelperforation after percutaneous MWA
meetings.asco.org
Program Guide – ASCO Meeting Program Guide
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Matthias Guckenberger @mguckenberger.bsky.social · 25/05/2025
Neoadjuvant chemo-IO for Borderline Resectable & Unresectable Stage III NSCLC Conclusion of authors: "high rates of surgical resectability" Pts with completed surgery: III A: 65/79 - 82% III B: 16/27 - 59% III C: 3/6 - 50% -> careful interpretation needed jamanetwork.com/journals/jam...
jamanetwork.com
PD-1 and PD-L1 Blockade With Chemotherapy for Borderline Resectable and Unresectable Stage III Non–Small Cell Lung Cancer
This cohort study evaluates the efficacy of neoadjuvant programmed cell death 1 protein (PD-1) or programmed cell death 1 ligand 1 (PD-L1) blockade combined with chemotherapy in enhancing surgical out...
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Matthias Guckenberger @mguckenberger.bsky.social · 27/01/2025
🔥 SAVE THE DATE 🔥 ❓ What is the population-health effect of novel anti-cancer drugs ❓ How do anti-cancer drugs compare to other drugs and health services ❓ How to improve sustainability of cancer care and medicine in the future Virtual Grand Rounds in Radiation Oncology www.usz.ch/veranstaltun...
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Matthias Guckenberger @mguckenberger.bsky.social · 05/01/2025
Thought provoking ! Population-health impact of new drugs recommended by NICE in England during 2000–20 - quality-adjusted life-years and incremental cost-effectiveness ratio used for analysis 👉 overall NEGATIVE (!) cumulative impact 👉 data for #radonc ? www.thelancet.com/journals/lan...
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Matthias Guckenberger @mguckenberger.bsky.social · 05/01/2025
Retrospective multicenter study of SBRT for pulmonary oligometastatic HNSCC - 16 centers, 178 pts, 284 pulmonary mets - 1a local failure rate 5.5% - no grade 4/5 toxicities 👉 supporting prospective evaluation, in preparation by EORTC & P Balermpas www.redjournal.org/article/S036...
redjournal.org
DEFINE_ME
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Matthias Guckenberger @mguckenberger.bsky.social · 02/01/2025
Aiming to refine your #radonc in 2025 ! Offer RT for low-volume metastatic PC, only ? What benefit of RT is to be communicated to pts & colleagues ? How about SBRT or surgery ? Virtual Grand Rounds in Radiation Oncology Jan 8th / 17:00 - 17:30 CET Dr Alberto Bossi 👇 www.usz.ch/veranstaltun...
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Matthias Guckenberger @mguckenberger.bsky.social · 24/12/2024
Virtual Grand Rounds in Radiation Oncology Let`s start 2025 with another highly-important lecture Jan 8th 2025 - 17:00 - 17:30 Dr. Alberto Bossi Radiotherapy of the primary in metastatic prostate cancer - insights from PEACE-1 Link 👇 www.usz.ch/veranstaltun...
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Matthias Guckenberger @mguckenberger.bsky.social · 23/12/2024
Season's Greetings
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Matthias Guckenberger @mguckenberger.bsky.social · 19/12/2024
Safe practice of spine SBRT requires high-quality data about SC dose tolerance - Cohort study 2051 pts - 30 cases of RM, 19 of which G3 to G4 - 2a rate of G1-4 RM 1.8% - cord dose D0.1cc of 19.1Gy / Dmax of 20.8Gy = 1.0% risk of G3 to G4 RM at 2 years jamanetwork.com/journals/jam...
jamanetwork.com
Radiation Myelitis After Hypofractionated Spine Stereotactic Body Radiation Therapy
This cohort study characterizes the risk of radiation myelitis after spine stereotactic body radiation therapy to update the current dosimetric constraints.
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Matthias Guckenberger @mguckenberger.bsky.social · 19/12/2024
Todas is HCC day! - RTOG 1112 - HCC unsuitable for or refractory to local-regional Tx (n=177) - SBRT & Sorafenib vs Sorafenib - After adjustment for stratification factors, improved OS after SBRT (HR 0.72) - Median PFS improved from 5.5 to 9.2 mo (HR 0.55) jamanetwork.com/journals/jam...
jamanetwork.com
Stereotactic Body Radiotherapy vs Sorafenib Alone in Hepatocellular Carcinoma
This phase 3 randomized clinical trial evaluates whether stereotactic body radiation therapy improves outcomes in patients with locally advanced hepatocellular carcinoma compared with sorafenib alone.
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Matthias Guckenberger @mguckenberger.bsky.social · 19/12/2024
And yet another prospective trial confirming excellent efficacy of SBRT for localized HCC - n=36 pts - median tumor size 2.3 cm - median FU 49 mo - 3-year local control rate 93% - Grade 3 AE 11% www.redjournal.org/article/S036...
redjournal.org
DEFINE_ME
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Matthias Guckenberger @mguckenberger.bsky.social · 19/12/2024
Randomized comparison of SBRT vs RFA for recurrent small HCC (n=166 pts) 👆 Freedom from local progression significantly improved after SBRT: 2a 92.7% vs 75.8%, HR=0.45 ! 👉 No difference in PFS (median 37.6 vs 27.6mo) and OS (2a 97.6% vs 93.9%) 👍 ascopubs.org/doi/10.1200/...
ascopubs.org
Radiofrequency Ablation Versus Stereotactic Body Radiotherapy for Recurrent Small Hepatocellular Carcinoma: A Randomized, Open-Label, Controlled Trial
PURPOSETo assess the efficacy and safety of radiofrequency ablation (RFA) versus stereotactic body radiotherapy (SBRT) in treating recurrent small hepatocellular carcinoma (HCC).METHODSIn this trial, ...
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Matthias Guckenberger @mguckenberger.bsky.social · 15/12/2024
Remember the misleading press about "brutal" #radonc after PROSPECT ? This is what modern RT can achieve for elderly breast cancer patients ! 👉 "Endocrine Tx was associated with a greater reduction in HRQOL compared with RT at 24 mo" 👉 oncological data awaited www.thelancet.com/journals/lan...
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Matthias Guckenberger @mguckenberger.bsky.social · 15/12/2024
ESTRO power team ! Anna Kirby and Barbara Jereczek-Fossa as past-president and president-elect Thanks you so much for your 💪 collaboration, friendship and dedication, to 👉 advance multidisciplinary cancer care 👉 elevate radiation oncology 👉 develop ESTRO society
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Matthias Guckenberger @mguckenberger.bsky.social · 07/12/2024
Radiation Oncology is characterized by rapid innovation Dissemination & implementation are important aspects to bring this progress to our cancer patients in daily practice Well written review by Erin Gillespie and colleagues 👇 www.redjournal.org/article/S036...
redjournal.org
DEFINE_ME
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Matthias Guckenberger @mguckenberger.bsky.social · 05/12/2024
In case you may have missed any of the Virtual Grand Rounds in Radiation Oncology lectures Recordings are 👇 youtube.com/playlist?lis... Endorsed by: ESTRO DEGRO SASRO
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Matthias Guckenberger @mguckenberger.bsky.social · 28/11/2024
Virtual Grand Rounds in Radiation Oncology „Revving Up Gastric Cancer Care: Insights from the TOPGEAR Trial” Presented by Prof. Karin Haustermans December 4th 17:00 – 17:30 Link to online meeting 👇 www.usz.ch/veranstaltun... Endorsed by: ESTRO DEGRO SASRO
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Matthias Guckenberger @mguckenberger.bsky.social · 27/11/2024
ESTRO Scientific Council Meeting in Brussels Hopefully in brighter colors than todays sky …
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Matthias Guckenberger @mguckenberger.bsky.social · 26/11/2024
ETH Zürich Polyball Zwischen Göttern und Menschen Preparations almost finished
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Reposted by Matthias Guckenberger
Chris Parker @ccparker.bsky.social · 25/11/2024
PEACE-1 trial of prostate radiotherapy in mHSPC. Improvement in rPFS when used in addition to ADT and abiraterone. Medsky. Oncsky.
PEACE-1: rPFS for low volume mHSPC
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Matthias Guckenberger @mguckenberger.bsky.social · 26/11/2024
PEACE-1 published Radiotherapy of the prostate in metastatic pts prevents serious GU complications, in pts with low and high tumor burden How to select patients? - all ? - based on live expectancy ? - response to systemic Tx ? - prostate volume ? www.thelancet.com/journals/lan...
thelancet.com
Efficacy and safety of prostate radiotherapy in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design
Combining radiotherapy with standard of care plus abiraterone improves radiographic progression-free survival and castration resistance-free survival, but not overall survival in patients with low-vol...
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Matthias Guckenberger @mguckenberger.bsky.social · 26/11/2024
Curious about #RadiationOncology on BlueSky Warm welcome to all colleagues and friends !
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