Benign adrenal tumours, found in 1–7% of adults, can be non-functioning (NFAT) or show mild autonomous cortisol secretion (MACS), i.e., biochemical co…

Nature Reviews Endocrinology, Published online: 28 July 2025; doi:10.1038/s41574-025-01160-6Rapid weight loss with GLP1 receptor agonists can come at the cost of skeletal muscle, potentially undermining metabolic and functional outcomes. This Comment highlights emerging evidence and advocates for clinical strategies that prioritize muscle preservation to ensure the long-term success and safety of pharmacological weight management.

Nature Reviews Endocrinology, Published online: 04 August 2025; doi:10.1038/s41574-025-01157-1Inpatient hyperglycaemia is found in the settings of known diabetes mellitus, previously undiagnosed diabetes mellitus and stress hyperglycaemia, and is associated with poor outcomes. Current approaches to managing inpatient hyperglycaemia and diabetes mellitus are outlined in this Review.

Nature Reviews Endocrinology, Published online: 24 June 2025; doi:10.1038/s41574-025-01134-8This international Consensus Statement provides guidelines on the management of pituitary incidentalomas.

Nature Reviews Endocrinology, Published online: 24 June 2025; doi:10.1038/s41574-025-01147-3Unpicking the effects of FGF21 on longevity

YouTube video by European Society of Endocrinology

Nature Reviews Endocrinology, Published online: 04 June 2025; doi:10.1038/s41574-025-01132-wIn this Review, the authors discuss different methods for assessing polygenic risk of diabetes mellitus and the utility of polygenic risk scores in classifying and screening for diabetes mellitus. The current limitations of these scores and ways of overcoming these limitations are also covered.

Nature Reviews Endocrinology, Published online: 22 May 2025; doi:10.1038/s41574-025-01131-xThis article outlines evidence pointing to an important contribution of endocrine-disrupting chemicals to increasing rates of female reproductive disorders such as abnormal puberty, impaired fertility, premature menopause or polycystic ovarian syndrome reported over the past half a century.

AbstractBackground. Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with high recurrence rates and poor prognosis. Current prognostic model

Nature Reviews Endocrinology, Published online: 11 February 2025; doi:10.1038/s41574-025-01089-wThe first CRFR1 antagonist (crinecerfont) to be used for the treatment of congenital adrenal hyperplasia recently received FDA approval. This Clinical Outlook…

Nature Reviews Endocrinology, Published online: 29 January 2025; doi:10.1038/s41574-025-01087-yExercise exacerbates cardiac damage from high-fat, high-calorie feeding in mice