Our latest preprint shows what prolonged glucocorticoid exposure can do to the immune system: HIF1⬇️🐁->GC⬆️(+Receptor)-HSPC->Immune❄️☀️ www.biorxiv.org/content/10.1... CRC-TRR 205 @adrenal-research.bsky.social ! #hypoxia #glucocorticoids #HIF #HSC #Immunology
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Hypoxia Inducible Factor 1α-driven steroidogenesis impacts systemic hematopoiesis
Glucocorticoids regulate hematopoiesis, but how chronic elevation of endogenous glucocorticoid production affects hematopoietic stem cell (HSC) function and immune cell development remains incompletel...