Simulating the complete cell cycle of the minimal cell provides a platform to understand the progression of complete states over time. The spatial heterogeneity of the intracellular environment can strongly affect biochemical reactions that control phenotypes.

Cell Symposia: Decoding Cellular Complexity: Single Cell Biology in the Era of AI

Protein function is dynamically modulated by post-translational modifications (PTMs). Many different types of PTMs can nowadays be identified and quantified at a large scale using mass spectrometry. ...

To get more out of genome sequences, the effects of variants need to be quantified

Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...

Single-cell transcriptomic analysis reveals the hepatocyte metabolic plasticity during pregnancy and lactation, highlighting a hepatic “pregnancy clock” that coordinates maternal metabolic adaptation across pregnancy and postpartum recovery.

Biophysicist and organoid researcher Andreas Bausch takes over the endowed professorship of the Heinz Nixdorf Foundation at the TUM.

TUM researchers receive funding from Google.org for the ‘AIdvice’ project. Medical expertise is to be translated into understandable answers.

Mass spectrometry data mining tools enabled the creation of an MS/MS spectral library containing hundreds of N-acyl lipids, including conjugates with short-chain fatty acids. This resource enabled the discovery of associations between microbially derived N-acyl lipids and several phenotypes, including HIV status and cognitive impairment.

Although acute inflammatory responses are critical for survival, chronic inflammation is a leading cause of disease and mortality worldwide. Nevertheless, our mechanistic understanding of pathogenesis...