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Arlin Stoltzfus

@evolarlin.bsky.social
396 followers 40 following 68 posts

Mutation samples from the possible, selection from the actual #evobio #popgen #mutation book: bit.ly/3QNudjQ blog: molevol.org youtube: bit.ly/3aytCms

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Reposted by Arlin Stoltzfus
Jeffrey Ross-Ibarra @jrossibarra.bsky.social · 14/09/2026
I have released my most powerful & high-yielding corn yet. It has already escaped my field & invaded three soybean farms. I fear it will soon kill all humans. But rather than quit corn & work to stop the apocalypse, I'm releasing even better corn in 3 months. Meanwhile, please use corn responsibly.
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Reposted by Arlin Stoltzfus
Nature Communications @natcomms.nature.com · 02/08/2026
#Adaptation is assumed to proceed by survival of the fittest. The study shows that #mutation bias can drive adaptation via survival of the likeliest, steering bacteria along divergent paths to resistance with major consequences for control strategies. www.nature.com/articles/s41...
nature.com
Mutation-biased adaptation is consequential even in large bacterial populations - Nature Communications
Adaptation is assumed to proceed by survival of the fittest. The study shows that mutation bias can drive adaptation via survival of the likeliest, steering bacteria along divergent paths to resistanc...
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Arlin Stoltzfus @evolarlin.bsky.social · 17/08/2026
Arrival bias - plays a quantitatively important role in adaptation - addresses a long-standing gap in "Modern Synthesis" thinking - provides a formal basis to explore the intuition that evolution tends to do what is easy or accessible Tomorrow I'll talk about how to teach it to students
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Arlin Stoltzfus @evolarlin.bsky.social · 11/08/2026
At our next evol-mut-circle seminar (18 August, 15:00 UTC), I will give a presentation on how to teach arrival bias to #evolution students. My slides and other materials will be available for anyone to use Please share. DM me to join or get connection info www.molevol.org/evol-mut-circle
molevol.org
evol-mut-circle
evol-mut-circle is an international group of scientists, philosophers, and historians interested in research on the role of mutation in evolution, particularly as a dispositional factor. The group …
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Reposted by Arlin Stoltzfus
Jake Barber @jakenbarber.bsky.social · 20/07/2026
New paper from myself and Alejandro Couce out now in Nature Communications! We wanted to test the idea that mutation biased adaptation - aka arrival bias / arrival of the fittest - is only of importance in small population sizes... www.nature.com/articles/s41... (thread below)
nature.com
Mutation-biased adaptation is consequential even in large bacterial populations - Nature Communications
Adaptation is assumed to proceed by survival of the fittest. The study shows that mutation bias can drive adaptation via survival of the likeliest, steering bacteria along divergent paths to resistanc...
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Arlin Stoltzfus @evolarlin.bsky.social · 20/07/2026
Our monthly evol-mut-circle seminar for July is coming up tomorrow (21 July, 15:00 UTC). Alex Palazzo will present "How non-adaptive evolution shapes the 5'ends of human protein-coding genes" DM me to join or get connection info www.molevol.org/evol-mut-cir... #evolution
doi.org
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Alex Palazzo @ribonucleicacids.bsky.social · 19/07/2026
Tuesday I will be talking about our work on how non-adaptive evolution shapes the 5'ends of human protein-coding genes as part of the evol-mut-circle online seminar series (@evolarlin.bsky.social should be posting details in the next day or so)
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Arlin Stoltzfus @evolarlin.bsky.social · 15/06/2026
Our monthly evol-mut-circle seminar for June is coming up tomorrow (16 June, 15:00 UTC). Matthew Jago will present "The role of extended sequence context in shaping mutational bias" (doi.org/10.1073/pnas...) DM me to join or get connection info www.molevol.org/evol-mut-cir... #evolution
molevol.org
evol-mut-circle
evol-mut-circle is an international group of scientists, philosophers, and historians interested in research on the role of mutation in evolution, particularly as a dispositional factor. The group …
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Reposted by Arlin Stoltzfus
Haoran Cai @haorancai.bsky.social · 18/05/2026
I’m looking forward to presenting my project on the puzzles of fly wings evolution at the Evol-Mut-Circle seminar Tuesday, May 19th at 11:00 AM EDT/3:00 PM UTC molevol.org/2025/12/08/e... DM me for the Zoom info, or reach out to Arlin Stoltzfus (evolarlin@gmail.com) to sign up for the email list!
molevol.org
evol-mut-circle
evol-mut-circle is an international group of scientists, philosophers, and historians interested in research on the role of mutation in evolution, particularly as a dispositional factor. The group …
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Arlin Stoltzfus @evolarlin.bsky.social · 16/03/2026
The evol-mut-circle seminar tomorrow at 15:00 UTC (11:00 EDT) features Donate Weghorn (CRG Barcelona), "Transcription start sites experience a high influx of heritable variants fueled by early development", following www.nature.com/articles/s41... DM me to join the list & get full info
nature.com
Transcription start sites experience a high influx of heritable variants fueled by early development - Nature Communications
The impact of transcription on germline mutagenesis remains poorly understood. Here, the authors identify a mutational hotspot at transcription start sites in the human germline that is significantly ...
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Arlin Stoltzfus @evolarlin.bsky.social · 16/02/2026
Coming up tomorrow in the evol-mut-circle seminar series
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Arlin Stoltzfus @evolarlin.bsky.social · 11/02/2026
The next evol-mut-circle meeting happens Tues, 17 Feb, 15:00 UTC (8:30 pm India, 10 am EST). Marwan Tuffaha (York) will present her work on cancer drivers and mutation bias reversals academic.oup.com/mbe/article/... DM me to join the list for meeting info
academic.oup.com
Genome Biology and Evolution | Oxford Academic
The official journal of the Society for Molecular Biology and Evolution. Publishes original research on the evolutionary advances at the forefront of genomics, embracing genome-wide evolutionary inves...
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Arlin Stoltzfus @evolarlin.bsky.social · 17/01/2026
the first evol-mut-circle meeting of 2026 happens Tuesday, 20 Jan, 15:00 UTC (8:30 pm India, 10 am EST). Madeleine Oman will present "How Sequence Context-Dependent Mutability Drives Mutation Rate Variation in the Genome" academic.oup.com/gbe/article/... DM me to join the list for meeting info
academic.oup.com
How Sequence Context-Dependent Mutability Drives Mutation Rate Variation in the Genome
Abstract. The rate of mutations varies >100-fold across the genome, altering the rate of evolution, and susceptibility to genetic diseases. The stronges
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Arlin Stoltzfus @evolarlin.bsky.social · 14/10/2025
our next evol-mut-circle seminar (21 Oct, 15:00 UTC) features Timothy Fuqua on "De novo promoters emerge more readily from random DNA than genomic DNA" www.biorxiv.org/content/10.1... DM me to join the email list. Full schedule: www.molevol.org/evol-mut-cir... #popgen, #mutation, #evobio
biorxiv.org
De-novo promoters emerge more readily from random DNA than from genomic DNA
Promoters are DNA sequences that help to initiate transcription. Point mutations can create de-novo promoters, which can consequently transcribe inactive genes or create novel transcripts. We know lit...
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Arlin Stoltzfus @evolarlin.bsky.social · 15/05/2025
Next Tuesday (20 May), evol-mut-circle hosts a discussion on hypotheses to account for targeted hypomutation We'll have a panel of experts to help with the discussion, including some with key roles in this issue Message me to join the email list www.molevol.org/distinguishi...
molevol.org
Distinguishing hypotheses for the appearance of targeted hypomutation | Stoltzfus Research Group at IBBR
March 18, 2025 / Arlin Stoltzfus / 0 Comments
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Reposted by Arlin Stoltzfus
Andrea Love, PhD | Biomedical Scientist @drandrealove.bsky.social · 01/04/2025
The CDC has literally been gutted today. There’s no need for “April Fools” when reality is a nightmare for every human on this planet. Thousand of scientists fired. Entire departments erased. 1/
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Arlin Stoltzfus @evolarlin.bsky.social · 03/04/2025
Monroe, et al 2022 argued that mutation in Arabidopsis evolved adaptively to be lower in genes than non-genes That stimulated a lot of debate over whether the pattern is real What about the evo model? A model of gene-targeted hyper-repair (to avoid damage)... www.molevol.org/distinguishi...
molevol.org
Distinguishing hypotheses for the appearance of targeted hypomutation | Stoltzfus Research Group at IBBR
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Prof Christina Pagel @chrischirp.bsky.social · 23/03/2025
It's 5 yrs today since lockdown started in England, but "We must never have lockdown again" is the wrong lesson. Lockdowns are terrible but so are deadly pandemics. Our choices 5 years ago were limited - we can & must do better in the future. Do read my post. open.substack.com/pub/christin...
open.substack.com
We are learning the wrong lessons from lockdown
And unless we learn the right ones, we risk making the same mistakes in a new pandemic
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Arlin Stoltzfus @evolarlin.bsky.social · 14/03/2025
Great opportunity in a beautiful city
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Arlin Stoltzfus @evolarlin.bsky.social · 14/03/2025
Coming up next Tuesday @kelleyharris.bsky.social "What causes mutation rates to vary among populations, species, and cell lineages?" DM to join the email list
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Ragothaman Yennamalli @structbioinfo.bsky.social · 11/03/2025
Today is the 100th bday of Margaret Dayhoff! She is the mother of bioinformatics. In her honor, some are celebrating it as Bioinformatics Day or Bioinformaticians' Day. H/T to Farzana! www.nature.com/articles/s43... Happy bioinformatics day to all!
nature.com
Celebrating a pioneer in bioinformatics - Nature Computational Science
In honor of the 100th birthday of Margaret Dayhoff, we spotlight her footprint in the field of bioinformatics.
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Reposted by Arlin Stoltzfus
Don Moynihan @donmoyn.bsky.social · 09/03/2025
New, from me: you were told that the threats to free speech came from wokeness. Some compared it to Maoist China. Now we are witnessing government power being used to silence dissent and censor ideas. Now we know what real society-wide chilling effects look like. 🧵 open.substack.com/pub/donmoyni...
open.substack.com
Real chilling effects
A extraordinary pattern of government censorship and threats to speech
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Reposted by Arlin Stoltzfus
Alex Wild @alexwild.bsky.social · 08/03/2025
Really wish people would stop talking about the problem with Science under Trump as “budget cuts”. No. Budgets are set deliberatively by elected members of congress. Budgets haven’t been cut. What’s happening are *purges* and *censorship*.
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David Shiffman, Ph.D. 🦈 @whysharksmatter.bsky.social · 06/03/2025
Exploring New Niches - Superorganism | a guide to nature jobs in the private sector for anyone who recently lost a government science or nature job
buff.ly
Exploring New Niches
With US federal layoffs, we share a Cliffs Notes for some private sector opportunities. And Superorganism is hiring!
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Arlin Stoltzfus @evolarlin.bsky.social · 06/03/2025
These are some resources I found useful to understand the administrative coup taking place here. The 2-part series by Robert Evans (with guest Ed Helms) is a bit repetitive but worth 2 hrs IMHO www.thenerdreich.com/reboot-elon-... medium.com/@alysion42/d... www.podchaser.com/podcasts/beh...
thenerdreich.com
'Reboot' Revealed: Elon Musk's CEO-Dictator Playbook
In 2022, one of Peter Thiel's favorite thinkers envisioned a second Trump Administration in which the federal government would be run by a “CEO”
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Arlin Stoltzfus @evolarlin.bsky.social · 27/02/2025
In the most recent evol-mut-circle seminar, @bryangitschlag.bsky.social (of @davidmccandlish.bsky.social lab) presented his latest work: Graduated effects of mutation bias in adaptation The recorded talk plus Q-and-A is free here for 6 months: umd.zoom.us/rec/share/b-... Passcode: g3PH=?9v
umd.zoom.us
Video Conferencing, Web Conferencing, Webinars, Screen Sharing
Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ...
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Arlin Stoltzfus @evolarlin.bsky.social · 07/02/2025
This new book is going on my reading list. I'm particularly interested in how the development of evolutionary thinking was shaped by highly engaged non-scientist intellectuals who wrote about evolution early in the 20th century press.uchicago.edu/ucp/books/bo...
press.uchicago.edu
The Arrival of the Fittest
In the early twentieth century, varied audiences took biology out of the hands of specialists and transformed it into mass culture, transforming our understanding of heredity in the process.   In the ...
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Arlin Stoltzfus @evolarlin.bsky.social · 28/01/2025
Also, late last year I gave evol-mut-circle an overview of how the mutation spectrum can shape evo, in 3 modes (each with its own theory and empirical results) * deleterious mut pressure * ultimate source of raw materials * introduction of novelty www.youtube.com/watch?v=n8Tb...
youtube.com
The role of the mutation spectrum in evolution (theory)
YouTube video by Mutation, Randomness and Evolution
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Arlin Stoltzfus @evolarlin.bsky.social · 28/01/2025
Latest video in the series: James Horton @jameshearsawho shares ongoing work combining genetic dissection of a GGGGT hotspot in P. fluorescens with an analysis of Salmonella genomes, exploring the basis of a 1000X enhancement of T-to-G mutation rate umd.zoom.us/rec/share/-G... Passcode: ?3H+M@Ph
umd.zoom.us
Video Conferencing, Web Conferencing, Webinars, Screen Sharing
Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ...
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Arlin Stoltzfus @evolarlin.bsky.social · 24/01/2025
Thanks for the synopsis! With regard to your final comment about specialized mutation systems, I also find these systems fascinating. Some day, one hopes, their existence will be integrated into mainstream evolutionary thinking, along with the importance of arrival bias
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Reposted by Arlin Stoltzfus
Jess McLaughlin, PhD (they/them) @jfmclaughlin92.bsky.social · 20/11/2024
cis folks: one thing to know is that while there are orgs helping trans folks, the needs rn HUGELY exceed the funding they have available. want to help trans people? a real material thing you can do is donate to these orgs, especially the smaller orgs
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Arlin Stoltzfus @evolarlin.bsky.social · 22/11/2024
Potential post-docs: are you interested the role of mutation in evolution? Please consider applying for a competitive NRC post-doc fellowship (2 yrs, generous salary and benefits, open to US citizens) Contact me if you are interested www.nist.gov/iaao/academi...
nist.gov
Postdoctoral Students (NRC Postdocs)
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Arlin Stoltzfus @evolarlin.bsky.social · 05/11/2024
The next evol-mut-circle seminar is Nov 19 (15:00 UTC) by Nora Martin, "Non-Poissonian Bursts in the Arrival of Phenotypic Variation and their Effect on Adaptation"(reading: doi.org/10.1093/molb...) DM me to join. Schedule and info here: www.molevol.org/evol-mut-cir...
doi.org
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Arlin Stoltzfus @evolarlin.bsky.social · 17/09/2024
Another excellent evol-mut-circle seminar today by Rose Novick with her insightful and broad account of structuralism and functionalism in evo bio Zoom recording is linked below (Passcode: W0u!^sig) DM me with your email to join the email list for regular seminars umd.zoom.us/rec/share/iQ...
umd.zoom.us
Video Conferencing, Web Conferencing, Webinars, Screen Sharing
Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ...
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Arlin Stoltzfus @evolarlin.bsky.social · 21/08/2024
The recording of the latest evol-mut-circle talk from @peteralind.bsky.social (role of mut bias in experimental adaptation) is now available online. See the full list of upcoming and past talks, with recordings, here: molevol.org/evol-mut-cir...
molevol.org
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Arlin Stoltzfus @evolarlin.bsky.social · 20/06/2024
The evol-mut-circle talk by @DeepaAgashe is available (pw = #?HS2x&$) Planned talks: Alex Klug (role of rare muts in adaptation), Peter Lind (experimental evo under mut bias) and Rose Novick (structuralism and functionalism) DM me to join #popgen #evolution #mutation umd.zoom.us/rec/share/_n...
umd.zoom.us
Video Conferencing, Web Conferencing, Webinars, Screen Sharing
Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ...
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Joanna Masel @joannamasel.bsky.social · 12/06/2024
I'm hiring a postdoc, for bioinformatics work on amino acid substitution models. I think they are key for understanding biophysics of selection on proteins, mutation patterns, and ancient life, as well as improving phylogenetic methods. evol.mcmaster.ca/brian/evoldi...
evol.mcmaster.ca
https://evol.mcmaster.ca/brian/evoldir/PostDocs//UArizona.AminoAcidSubstitutionModels
Postdoc position: amino acid substitution models A postdoc position is available with PI Joanna Masel (https://www.masellab.org/) at the University of Arizona in Tucson. Tucson is a vibrant city of n...
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Arlin Stoltzfus @evolarlin.bsky.social · 24/05/2024
The evol-mut-circle seminar series opened Tuesday with a talk by Grey Monroe. The recorded version of the talk and discussion is now available (passcode y=Rtc**0) Highlight from the auto-generated transcript: "Calamity de Monis, the algal model system" umd.zoom.us/rec/share/FO...
umd.zoom.us
Video Conferencing, Web Conferencing, Webinars, Screen Sharing
Zoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ...
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Reposted by Arlin Stoltzfus
Tiffany Taylor @taylorlabgroup.bsky.social · 10/11/2023
From James Horton (not here). James and myself have recently penned ✍️ a review article for Microbiology titled Mutation Bias and Adaptation in Bacteria: www.microbiologyresearch.org/content/jour... A short 🧵 on why we should care about mutation bias below (1/7)
microbiologyresearch.org
Mutation bias and adaptation in bacteria
Genetic mutation, which provides the raw material for evolutionary adaptation, is largely a stochastic force. However, there is ample evidence showing that mutations can also exhibit strong biases, wi...
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Arlin Stoltzfus @evolarlin.bsky.social · 16/04/2024
I’m starting a special interest group with monthly seminars + discussion focused on the role of mutation in evolution covering #evobio #popgen #histsci #philsci Upcoming speakers: @PeterALind, @DeepaAgashe, Grey Monroe, Rose Novick, Alex Klug To join, email <myfirstname>@umd.edu Please repost
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bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 27/03/2024
Mutation bias alters the distribution of fitness effects of mutations www.biorxiv.org/content/10.1101/202…
biorxiv.org
Mutation bias alters the distribution of fitness effects of mutations https://www.biorxiv.org/content/10.1101/2024.03.24.586369v1
Mutation bias is an important factor determining the diversity of genetic variants available for sel
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Arlin Stoltzfus @evolarlin.bsky.social · 29/03/2024
This is the latest in a string of important pieces establishing the algorithmic and pop-gen basis of evolutionary *self-organization* qua findability of intrinsically likely forms (gallons of ink have been spilled on this in the philosophy-of-evolution literature) journals.plos.org/ploscompbiol...
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David Shiffman, Ph.D. 🦈 @whysharksmatter.bsky.social · 15/03/2024
My latest for American Scientist the Sigma Xi, The Scientific Research Honor Society magazine: Did you see news coverage of a newborn great white shark a few weeks ago? Lots of the stories you read were wrong about several key issues related to shark science and conservation! 🦑🧪🦈🌎🐡
americanscientist.org
Baby Shark Sighting Misrepresented in Media Coverage
A photograph of a small great white shark made headlines, but for the wrong reasons. The coolest aspect of the study was missed.
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Julia Kreiner @jmkreiner.bsky.social · 29/02/2024
The Kreiner and Carley Labs at @UChicago E&E are co-hiring a Lab Manager/Research Technician position in Plant Evolutionary Ecology & Genomics! Please see the link for more details and instructions on how to apply: bit.ly/UChiPlantTec...
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Bertrand Servin @bertrandservin.bsky.social · 26/02/2024
Job position is now online ! jobs.inrae.fr/concours/con... Deadline is near. Don't hesitate to contact me to know more.
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David Shiffman, Ph.D. 🦈 @whysharksmatter.bsky.social · 16/02/2024
Hypothesis: more people will care about this important news story if it is presented as a Baby Yoda meme www.southernfriedscience.com/noaa-confirm...
Baby yoda with text about right whales getting killed by lobster fishing gear
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Eryn McFarlane @erynmcfarlane.bsky.social · 24/01/2024
I'm Eryn and I will be adding Ecologists and Evolutionary Biologists to the science feed. Please respond below with evidence that you are an Eco/Evol scientist to be added to the feed. This moderation will be done in the same way as the general science feed 🧪. bsky.app/profile/did:...
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Vaughn Cooper @vscooper.micropopbio.org · 07/02/2024
And microbiome wide, here's a slide I show frequently, with the punchline: "you are your own evolving community"
Your microbiome generates approximately 38 billion mutations per day
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