Reposted by Arlin StoltzfusJeffrey Ross-Ibarra @jrossibarra.bsky.social · 14/09/2026I have released my most powerful & high-yielding corn yet. It has already escaped my field & invaded three soybean farms. I fear it will soon kill all humans. But rather than quit corn & work to stop the apocalypse, I'm releasing even better corn in 3 months. Meanwhile, please use corn responsibly. 69520
Reposted by Arlin StoltzfusNature Communications @natcomms.nature.com · 02/08/2026#Adaptation is assumed to proceed by survival of the fittest. The study shows that #mutation bias can drive adaptation via survival of the likeliest, steering bacteria along divergent paths to resistance with major consequences for control strategies. www.nature.com/articles/s41...nature.comMutation-biased adaptation is consequential even in large bacterial populations - Nature CommunicationsAdaptation is assumed to proceed by survival of the fittest. The study shows that mutation bias can drive adaptation via survival of the likeliest, steering bacteria along divergent paths to resistanc... 0259
Arlin Stoltzfus @evolarlin.bsky.social · 17/08/2026Arrival bias - plays a quantitatively important role in adaptation - addresses a long-standing gap in "Modern Synthesis" thinking - provides a formal basis to explore the intuition that evolution tends to do what is easy or accessible Tomorrow I'll talk about how to teach it to students 021
Arlin Stoltzfus @evolarlin.bsky.social · 11/08/2026At our next evol-mut-circle seminar (18 August, 15:00 UTC), I will give a presentation on how to teach arrival bias to #evolution students. My slides and other materials will be available for anyone to use Please share. DM me to join or get connection info www.molevol.org/evol-mut-circlemolevol.orgevol-mut-circleevol-mut-circle is an international group of scientists, philosophers, and historians interested in research on the role of mutation in evolution, particularly as a dispositional factor. The group … 000
Reposted by Arlin StoltzfusJake Barber @jakenbarber.bsky.social · 20/07/2026New paper from myself and Alejandro Couce out now in Nature Communications! We wanted to test the idea that mutation biased adaptation - aka arrival bias / arrival of the fittest - is only of importance in small population sizes... www.nature.com/articles/s41... (thread below)nature.comMutation-biased adaptation is consequential even in large bacterial populations - Nature CommunicationsAdaptation is assumed to proceed by survival of the fittest. The study shows that mutation bias can drive adaptation via survival of the likeliest, steering bacteria along divergent paths to resistanc... 161
Arlin Stoltzfus @evolarlin.bsky.social · 20/07/2026Our monthly evol-mut-circle seminar for July is coming up tomorrow (21 July, 15:00 UTC). Alex Palazzo will present "How non-adaptive evolution shapes the 5'ends of human protein-coding genes" DM me to join or get connection info www.molevol.org/evol-mut-cir... #evolutiondoi.org 010
Reposted by Arlin StoltzfusAlex Palazzo @ribonucleicacids.bsky.social · 19/07/2026Tuesday I will be talking about our work on how non-adaptive evolution shapes the 5'ends of human protein-coding genes as part of the evol-mut-circle online seminar series (@evolarlin.bsky.social should be posting details in the next day or so) 221
Arlin Stoltzfus @evolarlin.bsky.social · 15/06/2026Our monthly evol-mut-circle seminar for June is coming up tomorrow (16 June, 15:00 UTC). Matthew Jago will present "The role of extended sequence context in shaping mutational bias" (doi.org/10.1073/pnas...) DM me to join or get connection info www.molevol.org/evol-mut-cir... #evolutionmolevol.orgevol-mut-circleevol-mut-circle is an international group of scientists, philosophers, and historians interested in research on the role of mutation in evolution, particularly as a dispositional factor. The group … 000
Reposted by Arlin StoltzfusHaoran Cai @haorancai.bsky.social · 18/05/2026I’m looking forward to presenting my project on the puzzles of fly wings evolution at the Evol-Mut-Circle seminar Tuesday, May 19th at 11:00 AM EDT/3:00 PM UTC molevol.org/2025/12/08/e... DM me for the Zoom info, or reach out to Arlin Stoltzfus (evolarlin@gmail.com) to sign up for the email list!molevol.orgevol-mut-circleevol-mut-circle is an international group of scientists, philosophers, and historians interested in research on the role of mutation in evolution, particularly as a dispositional factor. The group … 033
Arlin Stoltzfus @evolarlin.bsky.social · 16/03/2026The evol-mut-circle seminar tomorrow at 15:00 UTC (11:00 EDT) features Donate Weghorn (CRG Barcelona), "Transcription start sites experience a high influx of heritable variants fueled by early development", following www.nature.com/articles/s41... DM me to join the list & get full infonature.comTranscription start sites experience a high influx of heritable variants fueled by early development - Nature CommunicationsThe impact of transcription on germline mutagenesis remains poorly understood. Here, the authors identify a mutational hotspot at transcription start sites in the human germline that is significantly ... 233
Arlin Stoltzfus @evolarlin.bsky.social · 16/02/2026Coming up tomorrow in the evol-mut-circle seminar series 000
Arlin Stoltzfus @evolarlin.bsky.social · 11/02/2026The next evol-mut-circle meeting happens Tues, 17 Feb, 15:00 UTC (8:30 pm India, 10 am EST). Marwan Tuffaha (York) will present her work on cancer drivers and mutation bias reversals academic.oup.com/mbe/article/... DM me to join the list for meeting infoacademic.oup.comGenome Biology and Evolution | Oxford AcademicThe official journal of the Society for Molecular Biology and Evolution. Publishes original research on the evolutionary advances at the forefront of genomics, embracing genome-wide evolutionary inves... 020
Arlin Stoltzfus @evolarlin.bsky.social · 17/01/2026the first evol-mut-circle meeting of 2026 happens Tuesday, 20 Jan, 15:00 UTC (8:30 pm India, 10 am EST). Madeleine Oman will present "How Sequence Context-Dependent Mutability Drives Mutation Rate Variation in the Genome" academic.oup.com/gbe/article/... DM me to join the list for meeting infoacademic.oup.comHow Sequence Context-Dependent Mutability Drives Mutation Rate Variation in the GenomeAbstract. The rate of mutations varies >100-fold across the genome, altering the rate of evolution, and susceptibility to genetic diseases. The stronges 062
Arlin Stoltzfus @evolarlin.bsky.social · 14/10/2025our next evol-mut-circle seminar (21 Oct, 15:00 UTC) features Timothy Fuqua on "De novo promoters emerge more readily from random DNA than genomic DNA" www.biorxiv.org/content/10.1... DM me to join the email list. Full schedule: www.molevol.org/evol-mut-cir... #popgen, #mutation, #evobiobiorxiv.orgDe-novo promoters emerge more readily from random DNA than from genomic DNAPromoters are DNA sequences that help to initiate transcription. Point mutations can create de-novo promoters, which can consequently transcribe inactive genes or create novel transcripts. We know lit... 072
Arlin Stoltzfus @evolarlin.bsky.social · 15/05/2025Next Tuesday (20 May), evol-mut-circle hosts a discussion on hypotheses to account for targeted hypomutation We'll have a panel of experts to help with the discussion, including some with key roles in this issue Message me to join the email list www.molevol.org/distinguishi...molevol.orgDistinguishing hypotheses for the appearance of targeted hypomutation | Stoltzfus Research Group at IBBRMarch 18, 2025 / Arlin Stoltzfus / 0 Comments 020
Reposted by Arlin StoltzfusAndrea Love, PhD | Biomedical Scientist @drandrealove.bsky.social · 01/04/2025The CDC has literally been gutted today. There’s no need for “April Fools” when reality is a nightmare for every human on this planet. Thousand of scientists fired. Entire departments erased. 1/ 502151514970
Arlin Stoltzfus @evolarlin.bsky.social · 03/04/2025Monroe, et al 2022 argued that mutation in Arabidopsis evolved adaptively to be lower in genes than non-genes That stimulated a lot of debate over whether the pattern is real What about the evo model? A model of gene-targeted hyper-repair (to avoid damage)... www.molevol.org/distinguishi...molevol.orgDistinguishing hypotheses for the appearance of targeted hypomutation | Stoltzfus Research Group at IBBR 152
Reposted by Arlin StoltzfusProf Christina Pagel @chrischirp.bsky.social · 23/03/2025It's 5 yrs today since lockdown started in England, but "We must never have lockdown again" is the wrong lesson. Lockdowns are terrible but so are deadly pandemics. Our choices 5 years ago were limited - we can & must do better in the future. Do read my post. open.substack.com/pub/christin...open.substack.comWe are learning the wrong lessons from lockdownAnd unless we learn the right ones, we risk making the same mistakes in a new pandemic 1192818702
Arlin Stoltzfus @evolarlin.bsky.social · 14/03/2025Coming up next Tuesday @kelleyharris.bsky.social "What causes mutation rates to vary among populations, species, and cell lineages?" DM to join the email list 122
Reposted by Arlin StoltzfusRagothaman Yennamalli @structbioinfo.bsky.social · 11/03/2025Today is the 100th bday of Margaret Dayhoff! She is the mother of bioinformatics. In her honor, some are celebrating it as Bioinformatics Day or Bioinformaticians' Day. H/T to Farzana! www.nature.com/articles/s43... Happy bioinformatics day to all!nature.comCelebrating a pioneer in bioinformatics - Nature Computational ScienceIn honor of the 100th birthday of Margaret Dayhoff, we spotlight her footprint in the field of bioinformatics. 02713
Reposted by Arlin StoltzfusDon Moynihan @donmoyn.bsky.social · 09/03/2025New, from me: you were told that the threats to free speech came from wokeness. Some compared it to Maoist China. Now we are witnessing government power being used to silence dissent and censor ideas. Now we know what real society-wide chilling effects look like. 🧵 open.substack.com/pub/donmoyni...open.substack.comReal chilling effectsA extraordinary pattern of government censorship and threats to speech 11042941696
Reposted by Arlin StoltzfusAlex Wild @alexwild.bsky.social · 08/03/2025Really wish people would stop talking about the problem with Science under Trump as “budget cuts”. No. Budgets are set deliberatively by elected members of congress. Budgets haven’t been cut. What’s happening are *purges* and *censorship*. 222747929
Reposted by Arlin StoltzfusDavid Shiffman, Ph.D. 🦈 @whysharksmatter.bsky.social · 06/03/2025Exploring New Niches - Superorganism | a guide to nature jobs in the private sector for anyone who recently lost a government science or nature jobbuff.lyExploring New NichesWith US federal layoffs, we share a Cliffs Notes for some private sector opportunities. And Superorganism is hiring! 0179
Arlin Stoltzfus @evolarlin.bsky.social · 06/03/2025These are some resources I found useful to understand the administrative coup taking place here. The 2-part series by Robert Evans (with guest Ed Helms) is a bit repetitive but worth 2 hrs IMHO www.thenerdreich.com/reboot-elon-... medium.com/@alysion42/d... www.podchaser.com/podcasts/beh...thenerdreich.com'Reboot' Revealed: Elon Musk's CEO-Dictator PlaybookIn 2022, one of Peter Thiel's favorite thinkers envisioned a second Trump Administration in which the federal government would be run by a “CEO” 001
Arlin Stoltzfus @evolarlin.bsky.social · 27/02/2025In the most recent evol-mut-circle seminar, @bryangitschlag.bsky.social (of @davidmccandlish.bsky.social lab) presented his latest work: Graduated effects of mutation bias in adaptation The recorded talk plus Q-and-A is free here for 6 months: umd.zoom.us/rec/share/b-... Passcode: g3PH=?9vumd.zoom.usVideo Conferencing, Web Conferencing, Webinars, Screen SharingZoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ... 020
Arlin Stoltzfus @evolarlin.bsky.social · 07/02/2025This new book is going on my reading list. I'm particularly interested in how the development of evolutionary thinking was shaped by highly engaged non-scientist intellectuals who wrote about evolution early in the 20th century press.uchicago.edu/ucp/books/bo...press.uchicago.eduThe Arrival of the FittestIn the early twentieth century, varied audiences took biology out of the hands of specialists and transformed it into mass culture, transforming our understanding of heredity in the process. In the ... 020
Arlin Stoltzfus @evolarlin.bsky.social · 28/01/2025Also, late last year I gave evol-mut-circle an overview of how the mutation spectrum can shape evo, in 3 modes (each with its own theory and empirical results) * deleterious mut pressure * ultimate source of raw materials * introduction of novelty www.youtube.com/watch?v=n8Tb...youtube.comThe role of the mutation spectrum in evolution (theory)YouTube video by Mutation, Randomness and Evolution 121
Arlin Stoltzfus @evolarlin.bsky.social · 28/01/2025Latest video in the series: James Horton @jameshearsawho shares ongoing work combining genetic dissection of a GGGGT hotspot in P. fluorescens with an analysis of Salmonella genomes, exploring the basis of a 1000X enhancement of T-to-G mutation rate umd.zoom.us/rec/share/-G... Passcode: ?3H+M@Phumd.zoom.usVideo Conferencing, Web Conferencing, Webinars, Screen SharingZoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ... 001
Arlin Stoltzfus @evolarlin.bsky.social · 24/01/2025Thanks for the synopsis! With regard to your final comment about specialized mutation systems, I also find these systems fascinating. Some day, one hopes, their existence will be integrated into mainstream evolutionary thinking, along with the importance of arrival bias 020
Reposted by Arlin StoltzfusJess McLaughlin, PhD (they/them) @jfmclaughlin92.bsky.social · 20/11/2024cis folks: one thing to know is that while there are orgs helping trans folks, the needs rn HUGELY exceed the funding they have available. want to help trans people? a real material thing you can do is donate to these orgs, especially the smaller orgs 28658
Arlin Stoltzfus @evolarlin.bsky.social · 22/11/2024Potential post-docs: are you interested the role of mutation in evolution? Please consider applying for a competitive NRC post-doc fellowship (2 yrs, generous salary and benefits, open to US citizens) Contact me if you are interested www.nist.gov/iaao/academi...nist.govPostdoctoral Students (NRC Postdocs) 031
Arlin Stoltzfus @evolarlin.bsky.social · 05/11/2024The next evol-mut-circle seminar is Nov 19 (15:00 UTC) by Nora Martin, "Non-Poissonian Bursts in the Arrival of Phenotypic Variation and their Effect on Adaptation"(reading: doi.org/10.1093/molb...) DM me to join. Schedule and info here: www.molevol.org/evol-mut-cir...doi.org 000
Arlin Stoltzfus @evolarlin.bsky.social · 17/09/2024Another excellent evol-mut-circle seminar today by Rose Novick with her insightful and broad account of structuralism and functionalism in evo bio Zoom recording is linked below (Passcode: W0u!^sig) DM me with your email to join the email list for regular seminars umd.zoom.us/rec/share/iQ...umd.zoom.usVideo Conferencing, Web Conferencing, Webinars, Screen SharingZoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ... 101
Arlin Stoltzfus @evolarlin.bsky.social · 21/08/2024The recording of the latest evol-mut-circle talk from @peteralind.bsky.social (role of mut bias in experimental adaptation) is now available online. See the full list of upcoming and past talks, with recordings, here: molevol.org/evol-mut-cir...molevol.org 011
Arlin Stoltzfus @evolarlin.bsky.social · 20/06/2024The evol-mut-circle talk by @DeepaAgashe is available (pw = #?HS2x&$) Planned talks: Alex Klug (role of rare muts in adaptation), Peter Lind (experimental evo under mut bias) and Rose Novick (structuralism and functionalism) DM me to join #popgen #evolution #mutation umd.zoom.us/rec/share/_n...umd.zoom.usVideo Conferencing, Web Conferencing, Webinars, Screen SharingZoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ... 020
Reposted by Arlin StoltzfusJoanna Masel @joannamasel.bsky.social · 12/06/2024I'm hiring a postdoc, for bioinformatics work on amino acid substitution models. I think they are key for understanding biophysics of selection on proteins, mutation patterns, and ancient life, as well as improving phylogenetic methods. evol.mcmaster.ca/brian/evoldi...evol.mcmaster.cahttps://evol.mcmaster.ca/brian/evoldir/PostDocs//UArizona.AminoAcidSubstitutionModelsPostdoc position: amino acid substitution models A postdoc position is available with PI Joanna Masel (https://www.masellab.org/) at the University of Arizona in Tucson. Tucson is a vibrant city of n... 01929
Arlin Stoltzfus @evolarlin.bsky.social · 24/05/2024The evol-mut-circle seminar series opened Tuesday with a talk by Grey Monroe. The recorded version of the talk and discussion is now available (passcode y=Rtc**0) Highlight from the auto-generated transcript: "Calamity de Monis, the algal model system" umd.zoom.us/rec/share/FO...umd.zoom.usVideo Conferencing, Web Conferencing, Webinars, Screen SharingZoom is the leader in modern enterprise video communications, with an easy, reliable cloud platform for video and audio conferencing, chat, and webinars across mobile, desktop, and room systems. Zoom ... 010
Reposted by Arlin StoltzfusTiffany Taylor @taylorlabgroup.bsky.social · 10/11/2023From James Horton (not here). James and myself have recently penned ✍️ a review article for Microbiology titled Mutation Bias and Adaptation in Bacteria: www.microbiologyresearch.org/content/jour... A short 🧵 on why we should care about mutation bias below (1/7)microbiologyresearch.orgMutation bias and adaptation in bacteriaGenetic mutation, which provides the raw material for evolutionary adaptation, is largely a stochastic force. However, there is ample evidence showing that mutations can also exhibit strong biases, wi... 11111
Arlin Stoltzfus @evolarlin.bsky.social · 16/04/2024I’m starting a special interest group with monthly seminars + discussion focused on the role of mutation in evolution covering #evobio #popgen #histsci #philsci Upcoming speakers: @PeterALind, @DeepaAgashe, Grey Monroe, Rose Novick, Alex Klug To join, email <myfirstname>@umd.edu Please repost 01518
Reposted by Arlin StoltzfusbioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 27/03/2024Mutation bias alters the distribution of fitness effects of mutations www.biorxiv.org/content/10.1101/202… biorxiv.orgMutation bias alters the distribution of fitness effects of mutations https://www.biorxiv.org/content/10.1101/2024.03.24.586369v1 Mutation bias is an important factor determining the diversity of genetic variants available for sel 022
Arlin Stoltzfus @evolarlin.bsky.social · 29/03/2024This is the latest in a string of important pieces establishing the algorithmic and pop-gen basis of evolutionary *self-organization* qua findability of intrinsically likely forms (gallons of ink have been spilled on this in the philosophy-of-evolution literature) journals.plos.org/ploscompbiol... 001
Reposted by Arlin StoltzfusDavid Shiffman, Ph.D. 🦈 @whysharksmatter.bsky.social · 15/03/2024My latest for American Scientist the Sigma Xi, The Scientific Research Honor Society magazine: Did you see news coverage of a newborn great white shark a few weeks ago? Lots of the stories you read were wrong about several key issues related to shark science and conservation! 🦑🧪🦈🌎🐡americanscientist.orgBaby Shark Sighting Misrepresented in Media CoverageA photograph of a small great white shark made headlines, but for the wrong reasons. The coolest aspect of the study was missed. 13215
Reposted by Arlin StoltzfusJulia Kreiner @jmkreiner.bsky.social · 29/02/2024The Kreiner and Carley Labs at @UChicago E&E are co-hiring a Lab Manager/Research Technician position in Plant Evolutionary Ecology & Genomics! Please see the link for more details and instructions on how to apply: bit.ly/UChiPlantTec... 02735
Reposted by Arlin StoltzfusBertrand Servin @bertrandservin.bsky.social · 26/02/2024Job position is now online ! jobs.inrae.fr/concours/con... Deadline is near. Don't hesitate to contact me to know more. 014
Reposted by Arlin StoltzfusDavid Shiffman, Ph.D. 🦈 @whysharksmatter.bsky.social · 16/02/2024Hypothesis: more people will care about this important news story if it is presented as a Baby Yoda meme www.southernfriedscience.com/noaa-confirm... 48916
Reposted by Arlin StoltzfusEryn McFarlane @erynmcfarlane.bsky.social · 24/01/2024I'm Eryn and I will be adding Ecologists and Evolutionary Biologists to the science feed. Please respond below with evidence that you are an Eco/Evol scientist to be added to the feed. This moderation will be done in the same way as the general science feed 🧪. bsky.app/profile/did:... 28512746
Reposted by Arlin StoltzfusVaughn Cooper @vscooper.micropopbio.org · 07/02/2024And microbiome wide, here's a slide I show frequently, with the punchline: "you are your own evolving community" 061