iiinova — where your digital self keeps evolving

Reposted by Evan Newell

David R. Glass, PhD @dr-glass.bsky.social · 20/04/2026

This work was co-led by my wife, Marla Glass! Thanks to everyone who contributed to this work, including my PI @evnewell.bsky.social, and our institutes, the @alleninstitute.org and the @fredhutch.org!

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Reposted by Evan Newell

Fred Hutch @fredhutch.org · 07/07/2025

A study from the lab of @evnewell.bsky.social looks at the immune response to multiple myeloma. It turned out the most interesting thing was what they didn’t find: T cells that had already recognized and tried to fight off tumor cells. Read more: pubmed.ncbi.nlm.nih.gov/40163891/

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Reposted by Evan Newell

Fred Hutch Innovation Lab @hutchinnovation.bsky.social · 23/05/2025

Excited to share work from our team, released today. Check out how it compares to other methods on multiple platform's datasets. Would love to hear how it performs on your data. www.nature.com/articles/s41...

nature.com

Cell simulation as cell segmentation - Nature Methods

Proseg is a segmentation approach for single-cell spatially resolved transcriptomics data that uses unsupervised probabilistic modeling of the spatial distribution of transcripts to accurately segment...

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Reposted by Evan Newell

Koen De Gelas @kdegelas.bsky.social · 25/05/2025

New independent single cell benchmarking study by the @fredhutch.bsky.social innovation lab. Check it out! www.biorxiv.org/content/10.1...

biorxiv.org

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Reposted by Evan Newell

Waggoner Lab @labwaggoner.bsky.social · 08/05/2025

Phenotype and function of IL-10–producing NK cells in individuals with malaria experience @jci-insight.bsky.social insight.jci.org/articles/vie...

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Reposted by Evan Newell

Fred Hutch Innovation Lab @hutchinnovation.bsky.social · 24/04/2025

FHIL loves working with the Srivastava Lab! Their work explores factors enabling CAR-T response to checkpoint blockade in solid tumors. Infiltration of CAR-Ts was assessed spatially with a Xenium custom panel including probes targeting the construct and lung tumor. www.biorxiv.org/content/10.1...

biorxiv.org

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Reposted by Evan Newell

Jane Yinghui Huang @janehuang.bsky.social · 28/03/2025

Excited to share my graduate work from the @ejohnwherry.bsky.social lab on the molecular mechanisms locking in the differentiation fate of exhausted CD8 T cells (Tex), published earlier this month in @science.org immunology. Main findings below! www.science.org/doi/10.1126/...

science.org

Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate

TOX safeguards exhaustion biology in established Tex cells and restrains fate conversion to Teff cells.

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Reposted by Evan Newell

Puneet Rawat, PhD @puneet021192.bsky.social · 14/12/2024

Happy to share our new collaborative work! 🚨 We analyzed 2250 TCR repertoires to uncover how HLA risk alleles shape immune autoreactivity in T1D. T1D-specific HLA-motifs were also validated in pancreatic lymph nodes (pLN) & spleen. 🧬🧵 #T1D #Immunology #TCR 1/9

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Reposted by Evan Newell

Alison Feder @alisonfeder.bsky.social · 19/11/2024

Sharing again for new followers - check out this fully-funded postdoc to work with any Fred Hutch comp bio faculty members! Pre-apps due Dec 20 to start next year! www.fredhutch.org/en/research/...

fredhutch.org

Mahan Fellowship

Fred Hutch is dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. As part of that goal, we offer the Mahan postdoctoral fellow...

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Reposted by Evan Newell

Fred Hutch @fredhutch.org · 06/12/2024

Please join us in welcoming Madhav Dhodapkar, MBBS, as the new leader of Fred Hutch’s #Myeloma Program. Dr. Dhodapkar, a board-certified hematologist and oncologist, is a renowned expert in the treatment of multiple myeloma and other hematologic malignancies. #ASH24 1/3

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Reposted by Evan Newell

Dominic Grün @dominicgrun.bsky.social · 06/12/2024

NiCo is out! Our new algorithm for spatial transcriptomics data analysis predicts the crosstalk of cell types co-localized in tissue niches and sheds light on signalling mediators and downstream effects of cell-cell interactions by inferring covarying gene programs. www.nature.com/articles/s41...

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