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EvE Bio @evebio.bsky.social · 30/04/2026

We are excited to be included on the new Hugging Science site from @hf.co! Scientific datasets and models deserve a dedicated space. You can find our drug-target interaction dataset on Hugging Face here: huggingface.co/datasets/eve...

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EvE Bio @evebio.bsky.social · 08/04/2026

EvE Bio is partnering with The OpenAI Foundation on their AI for Alzheimer's initiative! Allosteric modulators hold promise as Alzheimer's drugs, but designing them is hard. AI models could help...if they had the right data. That's where we come in. evebio.org/eve-bio-part...

evebio.org

EvE Bio partners with OpenAI Foundation on "AI for Alzheimer's" : EvE Bio

EvE Bio is partnering with the OpenAI Foundation. Can AI help us design drugs for Alzheimer's? Not without the right data. EvE generates it.

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EvE Bio @evebio.bsky.social · 25/02/2026

We're busy here at EvE Bio generating drug-target interaction data for GPCR, NR, and kinase targets. Meanwhile, we're expanding our compounds and we want your input! Our current library has 1,300 approved small molecule and peptide drugs. The next will include 6 categories: 🧵

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EvE Bio @evebio.bsky.social · 11/12/2025

New data is live!! With 25 new kinases, we have a total of 420,497 drug-target interaction results! There are multiple ways to access the dataset 🧵

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EvE Bio @evebio.bsky.social · 10/12/2025

It's the final day of our data release preview -- data will be posted tomorrow! The last five new targets to preview are metabolic and regulatory kinases: YES, FER, FES, PASK1, and CCK2

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EvE Bio @evebio.bsky.social · 09/12/2025

Day 5 of our kinase preview for our imminent data release: Emerging Oncology Targets We're adding four kinases gaining traction in cancer drug discovery: PVK2, SVK, TBK1, and CGK2.

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EvE Bio @evebio.bsky.social · 08/12/2025

It's data release week at EvE! Continuing with day 4 of our preview of the 25 kinases we'll release later this week, today's focus is on stress and survival pathways. We're adding four kinases involved in cellular stress responses: MST2, MSK1, DAPK1, and ROS.

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EvE Bio @evebio.bsky.social · 07/12/2025

For the day 3 preview of EvE's kinase data release, the theme is calcium. We're adding three "calcium decoders" to our dataset: CaMK2a, CaMKK2, and MLK1.

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EvE Bio @evebio.bsky.social · 05/12/2025

Day 2 preview of EvE's kinase data release: The RSK Family We're adding 5 ribosomal S6 kinases to our dataset: RSK1, RSK2, RSK3, RSK4, and p70S6K. These kinases are key effectors of the MAPK signaling pathway, and are important targets in cancer research.

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EvE Bio @evebio.bsky.social · 05/12/2025

At EvE, we release data regularly, and our next release is coming up next week! We're adding 25 more kinases to our public drug-target interaction dataset. Over the next 6 days, we'll preview what's coming. Day 1: The PKC Family

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EvE Bio @evebio.bsky.social · 18/11/2025

We're excited to share several new developments. Our pharmome mapping dataset is now more accessible and integrated than ever, and the use cases we imagined are coming to life! 🧪 evebio.org/pharmome-dat... Here's what's new: 🧵

evebio.org

Putting Pharmome Data in Researchers' Hands : EvE Bio

We've been busy at EvE Bio these last two years establishing the largest available pharmome mapping dataset. Now it’s making its way into the world to drive real discoveries.

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Andrew Payne @andrewcpayne.bsky.social · 01/10/2025

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. Read more: e11.bio/blog/prism

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EvE Bio @evebio.bsky.social · 22/07/2025

Each of our bimonthly HTS data releases reveals previously unknown drug/off-target interactions, but some, like this snippet from last week's Release 5, showing that capsaicin is a highly selective agonist for the orphan nuclear receptor, ESRRB, deserves special note. 🧵 1/4 🧪

Tiny snippet from a much larger heatmap of EvE Bio's HTS screening results for 1,397 FDA-approved drugs versus hundreds (and growing to thousands) of human gene products to identify drugs' off-targets (what we call mapping the pharmome). Highlighted in red is the cell reporting the previously unsuspected agonist activity of capsaicin, the pungent chemical of hot peppers, on the orphan nuclear receptor estrogen-related receptor beta (ESRRB) with sub-micromolar pXC50.

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EvE Bio @evebio.bsky.social · 18/07/2025

🧪Excited to learn that EvE Bio's unique pharmome-mapping data has been adopted by yet another biomedical reasoning model, Stanford's Biomni (biomni.stanford.edu). Awareness of and appreciation for our efforts is really snowballing. We're grateful to be of service to the community.

Screenshot of a *weet from the Other Place announcing the adoption of EvE Bio's data by the biomedical reasoning engine, Biomni.

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EvE Bio @evebio.bsky.social · 14/07/2025

🧪EvE will soon make our 1st announcement re: a potential drug repurposing opportunity open for licensing by orgs resourced to bring such things to the clinic. If your org would like early notice of such opptys, drop us a DM (or email list.signup@evebio.org) w/ name, org name, & business email.

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EvE Bio @evebio.bsky.social · 14/07/2025

🧪 Thank-you to Abhi Mahajan for his long essay on EvE's efforts to map the pharmome. He did a good job of explaining a pretty arcane topic. "EvE really exemplifies the thesis [that] smart people in biology should do more boring things." 🤠 www.owlposting.com/p/mapping-th...

owlposting.com

Mapping the off-target effects of every FDA-approved drug in existence (EvE Bio)

6.2k words, 29 minutes reading time

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EvE Bio @evebio.bsky.social · 06/06/2025

🧪 New toy! It's a robotic -20C freezer that can store 17,000 sample tubes, and upon command can spit out a rack containing just the tubes you've requested, in whatever pattern you want them. Everything is barcoded so the right sample always ends up in the right place. Or that's what they tell me.

Front view of the Hamilton Versa robotic freezer, with its keyboard and LCD screen. Hard to see here, the airlock through which racks of tubes enter/exit is a deep blue glow between the keyboard and the LCD.

Peeking through the freezer's narrow inspection window at the rows and rows of sample tubes within. In normal operation the only way in or out of the freezer is through the airlock (see other photo), and the freezer chamber is supplied with dry air at positive pressure, so frost never builds up.

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EvE Bio @evebio.bsky.social · 05/06/2025

🧪 Exciting to see EvE Bio's ever-expanding pharmome mapping dataset (data.evebio.org) cited as a source of training/test data for @futurehousesf.bsky.social's ether0 LLM, a new scientific reasoning model for chemistry. Preprint: storage.googleapis.com/aviary-publi...

data.evebio.org

Eve Bio: Pharmome Data

Browse/download data for 1,400 FDA drugs' actions on an ever-growing collection of gene products.

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EvE Bio @evebio.bsky.social · 19/05/2025

🧪 EvE Bio's biggest public data release (#4) yet! 1.4k Rx drugs screened for 24 new potential off-targets including adrenergic, apelin, muscarinic, dopamine, gastrin-releasing, orexin, 5-HT, neuromedin, opioid, prostaglandin, sphingosine, somatostatin & neuromedin receptors. evebio.org/data

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IMPRINT @imprintlabs.bsky.social · 15/05/2025

🧵 Today, IMPRINT, a pioneering new nonprofit initiative, is announcing $15 million in philanthropic funding to advance our work to decode the body's immune memory and uncover the causes of chronic diseases. #Immunology #Biotech #BiotechResearch

imprint.org

Press Release May 2025 — Imprint FRO

Imprint FRO launches with $15M in funding

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EvE Bio @evebio.bsky.social · 18/05/2025

Wake up, babe. EvE Bio's data release #4 just dropped. 1.4k Rx drugs, 85 targets & counting: 237,490 combinations screened (mode/target/compound) 8 median agonists per target (potency < 1 uM) 31 median antagonists per target (potency < 1uM) 🧪Browse or DL (for non-commercial use) at evebio.org/data

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EvE Bio @evebio.bsky.social · 05/05/2025

Come work with us at EvE Bio in Durham, NC! EvE's Assay Dev team is looking for a pharmacology scientist to develop new cell-based screening assays. While this is a temporary position (filling in for a scientist on family leave) it has potential to become permanent. jobs.lever.co/convergentre...

jobs.lever.co

Convergent Research - Temporary Scientist, Receptor Pharmacologist in Cell-Based Assay Development

Durham NC’s EvE Bio is looking for a receptor biochemist/pharmacologist to join its assay development group at the scientist level. This is a temporary position (5 months) that has the potential to tr...

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EvE Bio @evebio.bsky.social · 01/04/2025

Our data release #3, now live at data.evebio.org, adds 7 new nuclear receptors + 14 new 7TMs to our ever-growing list of human gene products screened against 1.4K FDA-approved drugs to ID off-targets, train AIs, repurpose drugs, and more. Enjoy! 🧪

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EvE Bio @evebio.bsky.social · 13/02/2025

Work with us! We seek a data scientist in the Research Triangle w/ great R & Shiny experience, comfort making technical decisions, and some scientific bkgd. This is a hybrid position requiring 2d/wk in our Durham office. 🧪https://jobs.lever.co/convergentresearch/ab999aec-2298-438a-bc54-d368b51cc6f4

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EvE Bio @evebio.bsky.social · 10/02/2025

EvE Data Release 2 now live! 1.4K drugs screened vs 21 7TMs: ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1, DRD2, GAL1, GAL2 GHSR, HRH1, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1F, HTR2A, HTR5, HTR6, and PTH1R in ag & antag modes. data.evebio.org For data drop announcements via email sign up at evebio.org

data.evebio.org

Eve Bio: Pharmome Data

Browse/download data for 1,400 FDA drugs' actions on an ever-growing collection of gene products. Data Release 1 now live.

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EvE Bio @evebio.bsky.social · 08/12/2024

Thank you Schmidt Initiative For Long Covid for moving the needle on clinical trials in search of therapeutics for LC. Repurposing Evusheld for LC is an interesting long-shot. 🤞 youtu.be/Nihzqamt5xY?...

youtu.be

Are Monoclonal Antibodies a Possible Treatment for Long COVID? (E23) ft Prof Nancy Kilmas

YouTube video by Long Covid The Answers

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Brittany Trang @brittanytrang.com · 20/11/2024

Farid's hot takes contradict many dogmas in the AI #drugdesign industry: That attaching the workhorse of the wet lab to the #AI cart will make it go; that designing small molecule drugs with AI will work at all; that all of the startups purporting to use AI are actually telling the truth. 🩺🖥️🧪💊

statnews.com

AI in drug discovery is ‘nonsense,’ but call Schrödinger ‘AI’ if you want, says CEO

Ramy Farid of Schrödinger maintains that AI drug discovery won't work unless physics-based calculations are part of the picture.

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Andrew Payne @andrewcpayne.bsky.social · 03/12/2024

🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. Read more: e11.bio/news/roadmap

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Michael Kevin Spencer @aisupremacy.bsky.social · 03/12/2024

It's a very weird moment geopolitically. I'm worried for China, South Korea, France and Germany. Signs of major political instability. President Yoon Suk Yeol invoked emergency powers and declared martial law, raising fear of instability in the world’s 13th-largest economy.

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algobaker @algobaker.bsky.social · 03/12/2024

Hyped about the work these guys are doing. Hopefully someone joins that can continue accelerating it. We need data!

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EvE Bio @evebio.bsky.social · 02/12/2024

Come work with us in Durham, NC! Are you a molecular or synthetic biologist, with mol-bio & mammalian cell culture skills, living in NC's Research Triangle region (extra points if you're experienced in drug development/discovery in academia or industry)? Let's talk! 🧪 jobs.lever.co/convergentre...

jobs.lever.co

Convergent Research - SCIENTIST (Molecular/Synthetic Biologist in Cell-Based Assay Development)

Job Description: Durham NC's EvE Bio is looking for a molecular/synthetic biologist to join its assay development group at the Scientist level. This position is responsible for developing a novel cell...

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EvE Bio @evebio.bsky.social · 29/11/2024

Celebrating a year of amazing efforts: by the upcoming end of its first year, EvE Bio's assay development team will have produced a whopping 200 validated HTS- and profiling-grade target actvity assays for nuclear hormone receptors (biochemical assay) and 7TM receptors (cell-based assay). Wow 😍 🧪

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EvE Bio @evebio.bsky.social · 26/11/2024

🧪Participants who received a single dose had a 78% lower risk of symptomatic COVID-19 infection in the first month compared to placebo. That compares quite favorably with the efficacy of approved COVID vaccines, which has been reported to be 52% at four weeks. apnews.com/press-releas...

apnews.com

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EvE Bio @evebio.bsky.social · 23/11/2024

🧪 We asked ChatGPT4o Mini: "Does [compound X] have partial agonist activity at [gene name Y], the [receptor common name] receptor?" No one but us knows the answer to this. Like a sociopath, ChatGPT lied with a virtual grin, giving an unqualified "yes!" backed up w/ nonexistent citations. 🧵 1/3

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EvE Bio @evebio.bsky.social · 23/11/2024

🧪 By "the pharmome" we mean the union of all drugs, all gene products, & all the functionally relevant actions of the former on the latter. When we say "mapping the pharmome," here's what we mean, and why. We're working to make it much more than just a pipe dream. evebio.org/why-map-the-...

evebio.org

Why map the pharmome? (Part 1) : EvE Bio

Pharmaceuticals' off-target side effects are familiar yet poorly understood. EvE Bio and pharmome mapping aim to uncover their mechanisms.

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EvE Bio @evebio.bsky.social · 23/11/2024

🧪 Why? Because you can't have a rational discussion in a Skinner box.

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EvE Bio @evebio.bsky.social · 22/11/2024

🧪 Not an EvE Bio production, but uses our recent Data Release 1 data. Very cool to gain a peek into how others' minds approach dataviz surrounding our work. Open data unleashes enormous creativity. longitudinal.blog/2024/11/20/f...

longitudinal.blog

First look at first micro-drop of EvE Bio data

dropped a first bit of pharm-ome mapping data today, with 1397 compounds against 19 nuclear receptor targets. This is just a tracer bullet and taste of what is to come. I made a little Colab notebo…

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Andrew White 🐦‍⬛ @andrew.diffuse.one · 22/11/2024

Here's a little drawing of some of the 1400 compounds released in @evebio.bsky.social's first data dump.

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EvE Bio @evebio.bsky.social · 21/11/2024

Test tube tagged to include this in the Science feed. 🧪

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Adam Marblestone @adammarblestone.bsky.social · 21/11/2024

Smart Young Folks, Hope you can make better visualizations than this notebook I whipped up colab.research.google.com/gist/adam-ma... It makes a heat-map and clusters compounds and targets (currently set to agonist mode only). (Not an official & vetted FRO work product, just me munging around.)

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Elaine Houskeeper @ehouskee.bsky.social · 21/11/2024

I have been working from a hypothesis that so far seems to be correct but I’d love to get some constructive input especially from #duckdb folks Hypothesis: Using JavaScript and DuckDB-wasm allows for the public deployment of data apps with minimal server costs and ongoing maintenance. Caveats in 🧵

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EvE Bio @evebio.bsky.social · 20/11/2024

We're honored to find EvE Bio's efforts cited alongside heavy hitters like Protein Data Bank and Align to Innovate in renaissancephilanthropy.org 's new playbook on philanthropic support for mid-scale science efforts in open datasets and benchmarks. Thank you!

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Dani cRabaiotti 🦀 @danirabaiotti.bsky.social · 10/02/2024

Welcome to the Science feed! Please read our FAQs for instructions for how to be added as a contributor: bossett.io/science-feed/ Mod introductory posts linked below⬇️ Use the test tube emoji on posts you want to appear in the feed🧪 Please like the feed and make sure you follow our feed rules:

Science Feed Rules:
🧪 No misinformation
🧪 Keep posts relevant to science
🧪 Use alt text
🧪 Credit images
🧪 Give context to links to external sites
🧪 Have fun!

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EvE Bio @evebio.bsky.social · 20/11/2024

🧪 Back when we were collecting voice-of-customer for EvE Bio, some of the best advice we received was "just put all your data on the web & smart young people will instantly start analyzing the bejeebers out of it." Just released our first dataset and bejeeber #1 has already dropped! (alas, on x)

Screenshots of the logic flow of a data analysis and chatbot output of the 4 nuclear hormone receptors that interact with the poster's prescribed drugs, according to EvE Bio data.

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EvE Bio @evebio.bsky.social · 19/11/2024

🧪 Now live: Data Release 1 of data revealing functional interactions of 1.4K small-molecule drugs with an ultimately vast # of human gene products. This 1st release is a shake-down cruise, so limited to select nuclear receptors. More to come at regular intervals. Browse, DL, enjoy! data.evebio.org

data.evebio.org

Eve Bio: Pharmome Data

Browse/download data for 1,400 FDA drugs' actions on an ever-growing collection of gene products. Data Release 1 now live.

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