EvE Bio @evebio.bsky.social · 30/04/2026Last week's release brings the dataset to over 500,000 drug-target interaction measurements, covering 228 human protein targets. As always, this data is collected systematically with well documented assays and consistent methods. Every drug in our library, measured at Every released target: EvE! 010
EvE Bio @evebio.bsky.social · 30/04/2026We are excited to be included on the new Hugging Science site from @hf.co! Scientific datasets and models deserve a dedicated space. You can find our drug-target interaction dataset on Hugging Face here: huggingface.co/datasets/eve... 142
EvE Bio @evebio.bsky.social · 08/04/2026Generating open pharmacology datasets is what we do! Check out our existing work: huggingface.co/blog/hugging...huggingface.coThe Pharmome Map: a comprehensive public dataset for drug-target interaction modelingA Blog post by Hugging Science on Hugging Face 010
EvE Bio @evebio.bsky.social · 08/04/2026EvE Bio is partnering with The OpenAI Foundation on their AI for Alzheimer's initiative! Allosteric modulators hold promise as Alzheimer's drugs, but designing them is hard. AI models could help...if they had the right data. That's where we come in. evebio.org/eve-bio-part...evebio.orgEvE Bio partners with OpenAI Foundation on "AI for Alzheimer's" : EvE BioEvE Bio is partnering with the OpenAI Foundation. Can AI help us design drugs for Alzheimer's? Not without the right data. EvE generates it. 131
EvE Bio @evebio.bsky.social · 25/02/20266) Compounds in widespread human use, even if not FDA approved 120
EvE Bio @evebio.bsky.social · 25/02/20261) Recently approved drugs not in our first compound library 110
EvE Bio @evebio.bsky.social · 25/02/2026We're busy here at EvE Bio generating drug-target interaction data for GPCR, NR, and kinase targets. Meanwhile, we're expanding our compounds and we want your input! Our current library has 1,300 approved small molecule and peptide drugs. The next will include 6 categories: 🧵 131
EvE Bio @evebio.bsky.social · 11/12/2025Academic users of DrugBank can also check our integration there: go.drugbank.com/evebiogo.drugbank.comDrugBank OnlineEvE Bio is now integrated into DrugBank, creating the largest public resource of drug–protein interactions and making off-target biology searchable, connected, and actionable for the first time. 020
EvE Bio @evebio.bsky.social · 11/12/2025Download data files by filling out the form here 🔗 data.evebio.org Multiple versions are available depending on your use case, from viewing summary results in a spreadsheet to building ML models.data.evebio.orgEve Bio: Pharmome DataExplore/download data for 1,400 FDA drugs' actions on an ever-growing collection of gene products. 120
EvE Bio @evebio.bsky.social · 11/12/2025For programmatic access, find us on @hf.co : huggingface.co/datasets/eve...huggingface.coeve-bio/drug-target-activity · Datasets at Hugging FaceWe’re on a journey to advance and democratize artificial intelligence through open source and open science. 110
EvE Bio @evebio.bsky.social · 11/12/2025For interactive exploration, go directly to tinyurl.com/eve-resultstinyurl.comRedirecting to EvE Bio Data Browser...Redirecting to EvE Bio Data Browser... 110
EvE Bio @evebio.bsky.social · 11/12/2025New data is live!! With 25 new kinases, we have a total of 420,497 drug-target interaction results! There are multiple ways to access the dataset 🧵 152
EvE Bio @evebio.bsky.social · 10/12/2025To be sure you know about each new data release, subscribe to our "latest news" email list at 🔗 data.evebio.orgdata.evebio.orgEve Bio: Pharmome DataExplore/download data for 1,400 FDA drugs' actions on an ever-growing collection of gene products. 021
EvE Bio @evebio.bsky.social · 10/12/2025The 25 new kinases added tomorrow will bring EvE's dataset to 67 total kinases, in addition to 85 7-transmembrane receptors and 32 nuclear receptors. All of these have activity measurements (or confirmed inactivity) for our 1,400 compound small molecule drug library.data.evebio.orgEve Bio: Pharmome DataExplore/download data for 1,400 FDA drugs' actions on an ever-growing collection of gene products. 121
EvE Bio @evebio.bsky.social · 10/12/2025It's the final day of our data release preview -- data will be posted tomorrow! The last five new targets to preview are metabolic and regulatory kinases: YES, FER, FES, PASK1, and CCK2 142
EvE Bio @evebio.bsky.social · 09/12/2025These less-characterized kinases represent the expanding frontier of cancer target space. Meanwhile, our previous release already includes well-established oncology targets like EGFR, BTK, and Aurora kinases -- along with EGFR and BTK mutants. Explore those results: 🔗 data.evebio.org 121
EvE Bio @evebio.bsky.social · 09/12/2025Day 5 of our kinase preview for our imminent data release: Emerging Oncology Targets We're adding four kinases gaining traction in cancer drug discovery: PVK2, SVK, TBK1, and CGK2. 132
EvE Bio @evebio.bsky.social · 08/12/2025These kinases help cells decide their fate under stress - whether to survive, adapt, or undergo apoptosis. Understanding how drugs modulate these stress-response kinases is crucial for cancer therapy, where the goal is often to tip stressed tumor cells toward death rather than survival. 010
EvE Bio @evebio.bsky.social · 08/12/2025It's data release week at EvE! Continuing with day 4 of our preview of the 25 kinases we'll release later this week, today's focus is on stress and survival pathways. We're adding four kinases involved in cellular stress responses: MST2, MSK1, DAPK1, and ROS. 131
EvE Bio @evebio.bsky.social · 07/12/2025...or go directly to our methods page: tinyurl.com/eve-methods 020
EvE Bio @evebio.bsky.social · 07/12/2025As we release data at EvE, we also provide methods details about our assays, our quantitative screening and profiling approach, and our data processing. Access this in our interactive data explorer, download a pdf or use our chatbot on our download site... 120
EvE Bio @evebio.bsky.social · 07/12/2025These kinases translate calcium spikes into cellular decisions. CaMK2 plays important roles in cardiac function and neuronal signaling, while CaMKK2 has emerged as a metabolic drug target, with inhibitors explored for obesity and diabetes. 120
EvE Bio @evebio.bsky.social · 07/12/2025For the day 3 preview of EvE's kinase data release, the theme is calcium. We're adding three "calcium decoders" to our dataset: CaMK2a, CaMKK2, and MLK1. 142
EvE Bio @evebio.bsky.social · 05/12/2025If you'd like to explore our released data, in addition to downloads and programmatic access, we have an interactive data exploration app. Follow the Explore Data link here: 🔗 data.evebio.org 021
EvE Bio @evebio.bsky.social · 05/12/2025Day 2 preview of EvE's kinase data release: The RSK Family We're adding 5 ribosomal S6 kinases to our dataset: RSK1, RSK2, RSK3, RSK4, and p70S6K. These kinases are key effectors of the MAPK signaling pathway, and are important targets in cancer research. 152
EvE Bio @evebio.bsky.social · 05/12/2025You can also access our data on Hugging Face 🔗 huggingface.co/datasets/eve... 021
EvE Bio @evebio.bsky.social · 05/12/2025Stay tuned for Day 2! In the meantime, explore our existing dataset: 159 targets × 1,397 small molecule drugs. 🔗 data.evebio.org 121
EvE Bio @evebio.bsky.social · 05/12/2025 We're starting with some classics: PKCα, PKCγ, PKCθ, and PKN1 - protein kinase C isoforms that have been cancer drug targets for decades. 111
EvE Bio @evebio.bsky.social · 05/12/2025At EvE, we release data regularly, and our next release is coming up next week! We're adding 25 more kinases to our public drug-target interaction dataset. Over the next 6 days, we'll preview what's coming. Day 1: The PKC Family 132
EvE Bio @evebio.bsky.social · 18/11/2025As we continue EvE's mission, we're excited to see our work impact the drug development, ML, and AI communities. More to come! 011
EvE Bio @evebio.bsky.social · 18/11/2025👥 Leadership news: @ehouskee.bsky.social steps into the CEO role, leading us into our next phase, while founding CEO William Busa continues as EvE's Chief Scientific Officer. 131
EvE Bio @evebio.bsky.social · 18/11/2025🤖 @futurehousesf.bsky.social used our data in the development of the ether0 chemistry reasoning model, showing the value of experimental group truth data for scientific AI models. 121
EvE Bio @evebio.bsky.social · 18/11/2025💻 Our pharmome mapping data is now accessible to ML developers on @hf.co, making our purpose-built drug-target interaction data easily accessible for model development. huggingface.co/blog/hugging...huggingface.coThe Pharmome Map: a comprehensive public dataset for drug-target interaction modelingA Blog post by Hugging Science on Hugging Face 192
EvE Bio @evebio.bsky.social · 18/11/2025🤝 We're partnering with DrugBank to integrate our drug-target interaction data into their drug intelligence platform, bringing it directly to the drug development community with rich context and annotation. go.drugbank.com/evebiogo.drugbank.comEve Bio and DrugBankEvE Bio is now integrated into DrugBank, creating the largest public resource of drug–protein interactions and making off-target biology searchable, connected, and actionable for the first time. 121
EvE Bio @evebio.bsky.social · 18/11/2025We're excited to share several new developments. Our pharmome mapping dataset is now more accessible and integrated than ever, and the use cases we imagined are coming to life! 🧪 evebio.org/pharmome-dat... Here's what's new: 🧵evebio.orgPutting Pharmome Data in Researchers' Hands : EvE BioWe've been busy at EvE Bio these last two years establishing the largest available pharmome mapping dataset. Now it’s making its way into the world to drive real discoveries. 172
Reposted by EvE BioAndrew Payne @andrewcpayne.bsky.social · 01/10/2025E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. Read more: e11.bio/blog/prism 16030
EvE Bio @evebio.bsky.social · 22/07/2025We've confirmed the capsaicin data w/ orthogonal assays, are diving deeper into it for a report, and have filed a provisional patent app to help preserve this indication's business oppty for any pharma willing to look into its clinical potential. Ping us if that's you. 4/4🧪 040
EvE Bio @evebio.bsky.social · 22/07/2025Further, in light of research implicating reduced ESRRB expression in certain breast cancers' progression, our capsaicin data might suggest an interesting drug repurposing opportunity for this FDA-approved, off-patent drug with a sterling safety record. 3/4 🧪 120
EvE Bio @evebio.bsky.social · 22/07/2025Capsaicin's agonistic action at the orphan receptor, estrogen-related receptor β, is of some interest because it is the first ESRRB agonist with perfect specificity for this family member versus closely related ESRRA and ESRRG. 2/4 🧪 110
EvE Bio @evebio.bsky.social · 22/07/2025Each of our bimonthly HTS data releases reveals previously unknown drug/off-target interactions, but some, like this snippet from last week's Release 5, showing that capsaicin is a highly selective agonist for the orphan nuclear receptor, ESRRB, deserves special note. 🧵 1/4 🧪 161
EvE Bio @evebio.bsky.social · 18/07/2025🧪Excited to learn that EvE Bio's unique pharmome-mapping data has been adopted by yet another biomedical reasoning model, Stanford's Biomni (biomni.stanford.edu). Awareness of and appreciation for our efforts is really snowballing. We're grateful to be of service to the community. 020
EvE Bio @evebio.bsky.social · 14/07/2025🧪EvE will soon make our 1st announcement re: a potential drug repurposing opportunity open for licensing by orgs resourced to bring such things to the clinic. If your org would like early notice of such opptys, drop us a DM (or email list.signup@evebio.org) w/ name, org name, & business email. 031
EvE Bio @evebio.bsky.social · 14/07/2025🧪 Thank-you to Abhi Mahajan for his long essay on EvE's efforts to map the pharmome. He did a good job of explaining a pretty arcane topic. "EvE really exemplifies the thesis [that] smart people in biology should do more boring things." 🤠 www.owlposting.com/p/mapping-th...owlposting.comMapping the off-target effects of every FDA-approved drug in existence (EvE Bio)6.2k words, 29 minutes reading time 043