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EvE Bio

@evebio.bsky.social
226 followers 176 following 86 posts

EvE Bio is a nonprofit biomed research institute in Durham NC. We're a Focused Research Org on a 5-year mission to create the discipline of "pharmome mapping." What that means: evebio.org. Watch here for job & data drop announcements

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EvE Bio @evebio.bsky.social · 30/04/2026
Last week's release brings the dataset to over 500,000 drug-target interaction measurements, covering 228 human protein targets. As always, this data is collected systematically with well documented assays and consistent methods. Every drug in our library, measured at Every released target: EvE!
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EvE Bio @evebio.bsky.social · 30/04/2026
We are excited to be included on the new Hugging Science site from @hf.co! Scientific datasets and models deserve a dedicated space. You can find our drug-target interaction dataset on Hugging Face here: huggingface.co/datasets/eve...
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EvE Bio @evebio.bsky.social · 08/04/2026
Generating open pharmacology datasets is what we do! Check out our existing work: huggingface.co/blog/hugging...
huggingface.co
The Pharmome Map: a comprehensive public dataset for drug-target interaction modeling
A Blog post by Hugging Science on Hugging Face
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EvE Bio @evebio.bsky.social · 08/04/2026
EvE Bio is partnering with The OpenAI Foundation on their AI for Alzheimer's initiative! Allosteric modulators hold promise as Alzheimer's drugs, but designing them is hard. AI models could help...if they had the right data. That's where we come in. evebio.org/eve-bio-part...
evebio.org
EvE Bio partners with OpenAI Foundation on "AI for Alzheimer's" : EvE Bio
EvE Bio is partnering with the OpenAI Foundation. Can AI help us design drugs for Alzheimer's? Not without the right data. EvE generates it.
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EvE Bio @evebio.bsky.social · 25/02/2026
What would you like to see us include?
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EvE Bio @evebio.bsky.social · 25/02/2026
6) Compounds in widespread human use, even if not FDA approved
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EvE Bio @evebio.bsky.social · 25/02/2026
5) Drug metabolites
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EvE Bio @evebio.bsky.social · 25/02/2026
4) Drugs currently in later stage clinical trials
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EvE Bio @evebio.bsky.social · 25/02/2026
3) Failed clinical candidates
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EvE Bio @evebio.bsky.social · 25/02/2026
2) Scheduled approved drugs (controlled substances)
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EvE Bio @evebio.bsky.social · 25/02/2026
1) Recently approved drugs not in our first compound library
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EvE Bio @evebio.bsky.social · 25/02/2026
We're busy here at EvE Bio generating drug-target interaction data for GPCR, NR, and kinase targets. Meanwhile, we're expanding our compounds and we want your input! Our current library has 1,300 approved small molecule and peptide drugs. The next will include 6 categories: 🧵
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EvE Bio @evebio.bsky.social · 11/12/2025
Academic users of DrugBank can also check our integration there: go.drugbank.com/evebio
go.drugbank.com
DrugBank Online
EvE Bio is now integrated into DrugBank, creating the largest public resource of drug–protein interactions and making off-target biology searchable, connected, and actionable for the first time.
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EvE Bio @evebio.bsky.social · 11/12/2025
Download data files by filling out the form here 🔗 data.evebio.org Multiple versions are available depending on your use case, from viewing summary results in a spreadsheet to building ML models.
data.evebio.org
Eve Bio: Pharmome Data
Explore/download data for 1,400 FDA drugs' actions on an ever-growing collection of gene products.
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EvE Bio @evebio.bsky.social · 11/12/2025
For programmatic access, find us on @hf.co : huggingface.co/datasets/eve...
huggingface.co
eve-bio/drug-target-activity · Datasets at Hugging Face
We’re on a journey to advance and democratize artificial intelligence through open source and open science.
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EvE Bio @evebio.bsky.social · 11/12/2025
For interactive exploration, go directly to tinyurl.com/eve-results
tinyurl.com
Redirecting to EvE Bio Data Browser...
Redirecting to EvE Bio Data Browser...
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EvE Bio @evebio.bsky.social · 11/12/2025
New data is live!! With 25 new kinases, we have a total of 420,497 drug-target interaction results! There are multiple ways to access the dataset 🧵
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EvE Bio @evebio.bsky.social · 10/12/2025
To be sure you know about each new data release, subscribe to our "latest news" email list at 🔗 data.evebio.org
data.evebio.org
Eve Bio: Pharmome Data
Explore/download data for 1,400 FDA drugs' actions on an ever-growing collection of gene products.
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EvE Bio @evebio.bsky.social · 10/12/2025
The 25 new kinases added tomorrow will bring EvE's dataset to 67 total kinases, in addition to 85 7-transmembrane receptors and 32 nuclear receptors. All of these have activity measurements (or confirmed inactivity) for our 1,400 compound small molecule drug library.
data.evebio.org
Eve Bio: Pharmome Data
Explore/download data for 1,400 FDA drugs' actions on an ever-growing collection of gene products.
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EvE Bio @evebio.bsky.social · 10/12/2025
It's the final day of our data release preview -- data will be posted tomorrow! The last five new targets to preview are metabolic and regulatory kinases: YES, FER, FES, PASK1, and CCK2
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EvE Bio @evebio.bsky.social · 09/12/2025
We'll finish up the preview tomorrow!
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EvE Bio @evebio.bsky.social · 09/12/2025
These less-characterized kinases represent the expanding frontier of cancer target space. Meanwhile, our previous release already includes well-established oncology targets like EGFR, BTK, and Aurora kinases -- along with EGFR and BTK mutants. Explore those results: 🔗 data.evebio.org
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EvE Bio @evebio.bsky.social · 09/12/2025
Day 5 of our kinase preview for our imminent data release: Emerging Oncology Targets We're adding four kinases gaining traction in cancer drug discovery: PVK2, SVK, TBK1, and CGK2.
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EvE Bio @evebio.bsky.social · 08/12/2025
These kinases help cells decide their fate under stress - whether to survive, adapt, or undergo apoptosis. Understanding how drugs modulate these stress-response kinases is crucial for cancer therapy, where the goal is often to tip stressed tumor cells toward death rather than survival.
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EvE Bio @evebio.bsky.social · 08/12/2025
It's data release week at EvE! Continuing with day 4 of our preview of the 25 kinases we'll release later this week, today's focus is on stress and survival pathways. We're adding four kinases involved in cellular stress responses: MST2, MSK1, DAPK1, and ROS.
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EvE Bio @evebio.bsky.social · 07/12/2025
...or go directly to our methods page: tinyurl.com/eve-methods
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EvE Bio @evebio.bsky.social · 07/12/2025
As we release data at EvE, we also provide methods details about our assays, our quantitative screening and profiling approach, and our data processing. Access this in our interactive data explorer, download a pdf or use our chatbot on our download site...
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EvE Bio @evebio.bsky.social · 07/12/2025
These kinases translate calcium spikes into cellular decisions. CaMK2 plays important roles in cardiac function and neuronal signaling, while CaMKK2 has emerged as a metabolic drug target, with inhibitors explored for obesity and diabetes.
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EvE Bio @evebio.bsky.social · 07/12/2025
For the day 3 preview of EvE's kinase data release, the theme is calcium. We're adding three "calcium decoders" to our dataset: CaMK2a, CaMKK2, and MLK1.
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EvE Bio @evebio.bsky.social · 05/12/2025
If you'd like to explore our released data, in addition to downloads and programmatic access, we have an interactive data exploration app. Follow the Explore Data link here: 🔗 data.evebio.org
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EvE Bio @evebio.bsky.social · 05/12/2025
Day 2 preview of EvE's kinase data release: The RSK Family We're adding 5 ribosomal S6 kinases to our dataset: RSK1, RSK2, RSK3, RSK4, and p70S6K. These kinases are key effectors of the MAPK signaling pathway, and are important targets in cancer research.
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EvE Bio @evebio.bsky.social · 05/12/2025
You can also access our data on Hugging Face 🔗 huggingface.co/datasets/eve...
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EvE Bio @evebio.bsky.social · 05/12/2025
Stay tuned for Day 2! In the meantime, explore our existing dataset: 159 targets × 1,397 small molecule drugs. 🔗 data.evebio.org
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EvE Bio @evebio.bsky.social · 05/12/2025
We're starting with some classics: PKCα, PKCγ, PKCθ, and PKN1 - protein kinase C isoforms that have been cancer drug targets for decades.
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EvE Bio @evebio.bsky.social · 05/12/2025
At EvE, we release data regularly, and our next release is coming up next week! We're adding 25 more kinases to our public drug-target interaction dataset. Over the next 6 days, we'll preview what's coming. Day 1: The PKC Family
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EvE Bio @evebio.bsky.social · 18/11/2025
As we continue EvE's mission, we're excited to see our work impact the drug development, ML, and AI communities. More to come!
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EvE Bio @evebio.bsky.social · 18/11/2025
👥 Leadership news: @ehouskee.bsky.social steps into the CEO role, leading us into our next phase, while founding CEO William Busa continues as EvE's Chief Scientific Officer.
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EvE Bio @evebio.bsky.social · 18/11/2025
🤖 @futurehousesf.bsky.social used our data in the development of the ether0 chemistry reasoning model, showing the value of experimental group truth data for scientific AI models.
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EvE Bio @evebio.bsky.social · 18/11/2025
💻 Our pharmome mapping data is now accessible to ML developers on @hf.co, making our purpose-built drug-target interaction data easily accessible for model development. huggingface.co/blog/hugging...
huggingface.co
The Pharmome Map: a comprehensive public dataset for drug-target interaction modeling
A Blog post by Hugging Science on Hugging Face
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EvE Bio @evebio.bsky.social · 18/11/2025
🤝 We're partnering with DrugBank to integrate our drug-target interaction data into their drug intelligence platform, bringing it directly to the drug development community with rich context and annotation. go.drugbank.com/evebio
go.drugbank.com
Eve Bio and DrugBank
EvE Bio is now integrated into DrugBank, creating the largest public resource of drug–protein interactions and making off-target biology searchable, connected, and actionable for the first time.
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EvE Bio @evebio.bsky.social · 18/11/2025
We're excited to share several new developments. Our pharmome mapping dataset is now more accessible and integrated than ever, and the use cases we imagined are coming to life! 🧪 evebio.org/pharmome-dat... Here's what's new: 🧵
evebio.org
Putting Pharmome Data in Researchers' Hands : EvE Bio
We've been busy at EvE Bio these last two years establishing the largest available pharmome mapping dataset. Now it’s making its way into the world to drive real discoveries.
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Reposted by EvE Bio
Andrew Payne @andrewcpayne.bsky.social · 01/10/2025
E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. Read more: e11.bio/blog/prism
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EvE Bio @evebio.bsky.social · 29/07/2025
Yikes.
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EvE Bio @evebio.bsky.social · 22/07/2025
We've confirmed the capsaicin data w/ orthogonal assays, are diving deeper into it for a report, and have filed a provisional patent app to help preserve this indication's business oppty for any pharma willing to look into its clinical potential. Ping us if that's you. 4/4🧪
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EvE Bio @evebio.bsky.social · 22/07/2025
Further, in light of research implicating reduced ESRRB expression in certain breast cancers' progression, our capsaicin data might suggest an interesting drug repurposing opportunity for this FDA-approved, off-patent drug with a sterling safety record. 3/4 🧪
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EvE Bio @evebio.bsky.social · 22/07/2025
Capsaicin's agonistic action at the orphan receptor, estrogen-related receptor β, is of some interest because it is the first ESRRB agonist with perfect specificity for this family member versus closely related ESRRA and ESRRG. 2/4 🧪
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EvE Bio @evebio.bsky.social · 22/07/2025
Each of our bimonthly HTS data releases reveals previously unknown drug/off-target interactions, but some, like this snippet from last week's Release 5, showing that capsaicin is a highly selective agonist for the orphan nuclear receptor, ESRRB, deserves special note. 🧵 1/4 🧪
Tiny snippet from a much larger heatmap of EvE Bio's HTS screening results for 1,397 FDA-approved drugs versus hundreds (and growing to thousands) of human gene products to identify drugs' off-targets (what we call mapping the pharmome). Highlighted in red is the cell reporting the previously unsuspected agonist activity of capsaicin, the pungent chemical of hot peppers, on the orphan nuclear receptor estrogen-related receptor beta (ESRRB) with sub-micromolar pXC50.
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EvE Bio @evebio.bsky.social · 18/07/2025
🧪Excited to learn that EvE Bio's unique pharmome-mapping data has been adopted by yet another biomedical reasoning model, Stanford's Biomni (biomni.stanford.edu). Awareness of and appreciation for our efforts is really snowballing. We're grateful to be of service to the community.
Screenshot of a *weet from the Other Place announcing the adoption of EvE Bio's data by the biomedical reasoning engine, Biomni.
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EvE Bio @evebio.bsky.social · 14/07/2025
🧪EvE will soon make our 1st announcement re: a potential drug repurposing opportunity open for licensing by orgs resourced to bring such things to the clinic. If your org would like early notice of such opptys, drop us a DM (or email list.signup@evebio.org) w/ name, org name, & business email.
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EvE Bio @evebio.bsky.social · 14/07/2025
🧪 Thank-you to Abhi Mahajan for his long essay on EvE's efforts to map the pharmome. He did a good job of explaining a pretty arcane topic. "EvE really exemplifies the thesis [that] smart people in biology should do more boring things." 🤠 www.owlposting.com/p/mapping-th...
owlposting.com
Mapping the off-target effects of every FDA-approved drug in existence (EvE Bio)
6.2k words, 29 minutes reading time
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