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Esther van Kleef @esthervk.bsky.social · 08/10/2026

At the same time identifying key drivers of community-level AMR exposure, and generating causal evidence on what works, for whom, and under what conditions. (4/4)

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Esther van Kleef @esthervk.bsky.social · 08/10/2026

Taking a One Health perspective, we’ll co-design and test animal-sensitive and climate-resilient WASH solutions that address interconnected human–animal–water systems, while remaining contextualised, yet scalable, low-cost and sustainable. (3/4)

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Esther van Kleef @esthervk.bsky.social · 08/10/2026

Aiming to be genuinly transdisciplinary, we’ll go beyond ‘traditional’ Water, Sanitation and Hygiene (WASH) approaches which focus largely on human faecal–oral transmission and individual behavioural change. (2/4)

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Esther van Kleef @esthervk.bsky.social · 08/10/2026

Really excited and grateful to get started together with co-lead Zvitambo, and others, on tackling environmental AMR pathways in rural, sub-Saharan settings through our recently funded UKRI CLEAN-AMR study tinyurl.com/2jvtyhuw within this scheme www.ukri.org/opportunity/.... (1/4)

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Centre for Tropical Medicine and Global Health @tropicalmedicine.ox.ac.uk · 07/07/2026

#ResearchHighlight from Cherry Lim @cghr.ox.ac.uk The burden of antimicrobial-resistant bacterial infections: a causal perspective Read more 👉 ndm.ac/tropmed-res-hi Full publication 👉 www.nature.com/articles/s41...

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Esther van Kleef @esthervk.bsky.social · 10/08/2026

Another huge thanks to colleagues at CRUN / URCN, @ox.ac.uk, @itmantwerp.bsky.social @uantwerpen.be, and many dedicated field, lab, and community partners.

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Esther van Kleef @esthervk.bsky.social · 10/08/2026

Perhaps more importantly, strong seasonality and links with sanitation suggested that the mitigation of AMR burden in low-resource sSA settings will have to involve targeting #environmental transmission pathways alongside #antibiotic use.

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Esther van Kleef @esthervk.bsky.social · 10/08/2026

Most stewardship interventions stop there....With repeated stool sampling, we went further, quantifying whether the intervention also changed acquisition of resistant bacteria within households and communities. Our findings support a beneficial effect on ESBL E. coli acquisition in the short term.

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Esther van Kleef @esthervk.bsky.social · 10/08/2026

Our low-cost, co-created intervention targeted #antibiotic use and #WASH across communities and formal and informal medicine providers. The earlier companion paper published in @thelancetinfdis.bsky.social showed clear intervention effects on antibiotic dispensing (listen here shorturl.at/lGDud).

shorturl.at

Brecht Ingelbeen and Daniel Valia on a community-based antimicrobial stewardship intervention in Burkina Faso and DRC

Podcast Episode · The Lancet Infectious Diseases in conversation with · June 15 · 27m

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Esther van Kleef @esthervk.bsky.social · 10/08/2026

We found high levels of ESBL-producing E. coli carriage and acquisition among ~1200 community members - providing rare longitudinal data on community and household AMR dynamics in a high-burden sub-Saharan African setting.

shorturl.at

Brecht Ingelbeen and Daniel Valia on a community-based antimicrobial stewardship intervention in Burkina Faso and DRC

Podcast Episode · The Lancet Infectious Diseases in conversation with · June 15 · 27m

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Esther van Kleef @esthervk.bsky.social · 10/08/2026

Changing antibiotic dispensing of #AMR is one thing. But does it actually reduce the problem? Our new paper, part II of the CABU EICO study, is now out! #IDSky #ClinMicro #OpenAccess #OA @ndm.ox.ac.uk @itmantwerp.bsky.social @oxprimarycare.bsky.social

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Esther van Kleef @esthervk.bsky.social · 26/03/2026

Looking forward to work with great partners to share our results in the coming year! CRUN / URCN (Burkina Faso), @kemriwellcome.bsky.social (Kenya),@itmantwerp.bsky.social, @medsci.ox.ac.uk, @umcutrecht.bsky.social,Basel (UKBB).,@nstoesser.bsky.social @ingelbeen.bsky.social @bugwonk.bsky.social(3/3)

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Esther van Kleef @esthervk.bsky.social · 26/03/2026

...Combining metagenomic output from environmental and human reservoirs with modelling, we aim to develop sentinel surveillance that can: • Guide empiric prescribing where microbiology is absent; • Identify/monitor community-level AMR exposure risks in rural, low-resource settings. (2/3)

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Esther van Kleef @esthervk.bsky.social · 26/03/2026

tinyurl.com/yzjuadpu Our ALARUM protocol is now out #JPIAMR! How do we make metagenomics and One Health actionable - especially in LMICs, where microbiology and sewage surveillance are not straightforward? ALARUM aims to tackle this using innovative pooled metagenomic sequencing...(1/3)

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Esther van Kleef @esthervk.bsky.social · 19/03/2026

Using pooled-sampling, ALARUM aims to develop an affordable and scalable One Health metagenomics surveillance strategy that can: 1) Guide empiric prescribing where microbiology is absent 2) Identify and monitor community-level AMR exposure risks in rural, low-resource settings.

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gram-oxford.bsky.social @gram-oxford.bsky.social · 20/01/2026

AMR researchers and professionals, please join the #GRAMproject on 29th Jan to learn more about key tools and resources, including MICROBE, GLASS, the AMR R package, and the AMR data repository! Register below. Story: bit.ly/4pJuBAD

bit.ly

GRAM to host 29th January webinar on AMR tools and resources

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Esther van Kleef @esthervk.bsky.social · 25/12/2025

Missed the launch of the latest #WHO_GLASS report? Here a brief newsdesk summary @thelancetinfdis.bsky.social highlighting the progress made in GLASS participation, and why increased investment in AMR, incl. improved access to basic microbiology, remains pressing.. www.thelancet.com/journals/lan...

thelancet.com

WHO publishes update on global antibiotic resistance

A new report from WHO highlights the increasing threat of antibiotic resistance, particularly in regions with limited surveillance and access to antibiotics. Timothy Jesudason reports.

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Esther van Kleef @esthervk.bsky.social · 20/12/2025

I should add: many AMR/stewardship interventions don't measure microbiological outcomes such as we did. By measuring microbiological outcomes using longitudinal stool sampling, we provided rare insight into AMR transmission dynamics in rural sub-Saharan Africa #Episky #IDsky

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Esther van Kleef @esthervk.bsky.social · 20/12/2025

Huge thanks to an amazing collaborative team R. Aizouk, Y. Sibidou, D. Valia, @ingelbeen.bsky.social , L. Campbell, JS. Kouanda, A. Welgo, PM Diagne, B. Riems, L. Hardy, E.Wouters, M. Meudec, M. van der Sande, H. Tinto, @bugwonk.bsky.social, and the wider CABU-EICO study team!

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Esther van Kleef @esthervk.bsky.social · 20/12/2025

So: Low-cost, non-technology community interventions can reduce AMR. But..this also highlights that in high-burden rural AMR settings, in addition to antibiotic use, tackling environmental transmission is key!

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Esther van Kleef @esthervk.bsky.social · 20/12/2025

We found: 1️⃣ High baseline AMR (ESBL-E. coli) carriage (~50%) 2️⃣ >10 times higher household-transmission than in HIC 3️⃣Antibiotic dispensing fell by >50%, with low baseline healthcare seeking and ab use 4️⃣ ~20% reduction in ESBL-E acquisition after 6 months 5️⃣Seasonal acquisition, peaking in wet season

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Esther van Kleef @esthervk.bsky.social · 20/12/2025

New PREPRINT! tinyurl.com/yynzevrh Thanks to a true transdisciplinary collaboration, we developed and evaluated a low-cost community #AMR intervention set in rural Burkina Faso and DRCongo. Combining #WHO #AWaRe–based feedback/training (medicine providers) and AMR awareness campaigns (community).

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Esther van Kleef @esthervk.bsky.social · 27/10/2025

Alternative way of science communication: @worldpop-uos.bsky.social made a podcast of our recent work on modelling for pandemic decision making in @eurosurveillance.org! Click on the link below to listen 👇

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Esther van Kleef @esthervk.bsky.social · 23/10/2025

We should find sustainable mechanisms for these infrastructures and collaborations to stay, which may include funding models that bring together public, non-profit, and private-sector partners. More to read in the full text. Thanks to all collaborators and funders @ec.europa.eu

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Esther van Kleef @esthervk.bsky.social · 23/10/2025

@chpoletto.bsky.social @sdellicour.bsky.social @mariusgilbert.bsky.social @lauradidomenico.bsky.social @eonore.bsky.social Wim V. Bortel, Elena Arsevska, Vittoria Colizza, L. Busani, Shengjie Lai, P. Lemey, S. Merler, Z. Milosavljevic, A Rizzoli, D. Simic, Andy Tatem, M. Teisseire, William Wint

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Esther van Kleef @esthervk.bsky.social · 23/10/2025

Intending to move beyond our “prepare-for-the-previous-pandemic” bias, this work highlights, among other findings, how the collaborative platforms and research consortia that emerged during COVID-19 laid the groundwork for new data and modelling ecosystems.

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Esther van Kleef @esthervk.bsky.social · 23/10/2025

However, systematic, quantitative analyses remain rare; for COVID-19 but also for previous PH threats. These reflections are easy to set aside once urgency fades and fatigue sets in, especially in an academic world that rewards moving on quickly and governments driven by short political cycles.

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Esther van Kleef @esthervk.bsky.social · 23/10/2025

Our main aim with this publication was to help preserve a collective memory of how data were generated, shared, and interpreted through modelling during the COVID-19 pandemic. Many opinions and reflections have been written.

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Esther van Kleef @esthervk.bsky.social · 23/10/2025

Really great to see that our paper is now officially published in the latest #Eurosurveillance. As it was accepted with only minor edits, this earlier post still captures the key messages: tiny.cc/036u001.

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Emily Moin @emilymoin.com · 10/10/2025

I am open to the idea that there are people who don't have and don't want to gain the skills to engage directly with their data but every single day that I do I learn the answer to a question you'd never even think to ask unless you were personally staring into the abyss of an uncleaned dataset.

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Esther van Kleef @esthervk.bsky.social · 09/10/2025

This has been a huge undertaking and a great leap forward in reporting global AMR surveillance data. For the first time, country, and regional-level data are supported my Bayesian modelling that allow for better comparison of resistance rates between countries/ regions and trends over time @who.int

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Esther van Kleef @esthervk.bsky.social · 09/10/2025

Coming Monday 13 October, WHO will launch the latest Global antibiotic resistance surveillance report. Don't miss it, register here! www.who.int/news-room/ev...

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Gwen Knight @gmknght.bsky.social · 10/06/2025

Very excited for this event on the 9th July! It's part of our #AMR short course but open to everyone as it's online. Do join in and here what the amazing Prof Dame Sally Davies has to stay on the current status of global action on #AMR! @lshtmamrcentre.bsky.social

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Quentin Leclerc @quentinlclrc.bsky.social · 19/06/2025

We're recruiting a postdoc in our lab @mesurs-cnam.bsky.social (Paris) to work on epidemic modelling over healthcare networks, as part of the EU project ARCANE ! 💻🦠 Start date between 09/25-01/26, 2y contract Interested in AMR, healthcare-related research & mathematical modelling? Find out more! ⬇️

iddjobs.org

IDDjobs — Postdoctoral position in epidemic modelling over healthcare networks — Conservatoire national des Arts et Métiers

Find infectious disease dynamics modelling jobs, studentships, and fellowships.

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Esther van Kleef @esthervk.bsky.social · 11/06/2025

Great ID modelling opportunity to aim for real impact on mitigating and monitoring AMR in sub-Saharan Africa. You'll work closely with us @ox.ac.uk, and Oxford’s Modernising Medical Microbiology group, as well as collaborators at CRUN (Burkina Faso) and KWRTP-KEMRI (Kenya). tinyurl.com/mry25kxe

tinyurl.com

Epidemiologist

Epidemiologist for modelling AMR transmission in LMICMore than 500 staff members at the Institute of Tropical Medicine (ITM) contribute e...

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Esther van Kleef @esthervk.bsky.social · 04/05/2025

Certainly! And sharing the knowledge here in England whenever I can now stroopwafels are almost as much an export product as Gouda cheese…

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Esther van Kleef @esthervk.bsky.social · 29/04/2025

The first preview was also presented at ESCMID global see tinyurl.com/4sh5v3hf. Combined these reports provide valuable new insights to enhance country-level use of GLASS data to help inform local, national, and regional AMR strategies World Health Organization #UNGA.

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Esther van Kleef @esthervk.bsky.social · 29/04/2025

The GLASS report on antimicrobial resistance (AMR) will be published separately later this year. The 2025 GLASS AMR report will expand on previous editions by presenting regional- CTA-level AMR estimates and trends across 93 pathogen-antibiotic combinations from CTAs enrolled by the end of 2024.

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Esther van Kleef @esthervk.bsky.social · 29/04/2025

The latest Global Antimicrobial Resistance and Use Surveillance System (GLASS) report on antimicrobial use is now out, reporting on 2022 national AMU surveillance data globally tinyurl.com/3muyp2pu @who.int .

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Esther van Kleef @esthervk.bsky.social · 15/04/2025

Emphasising the relevance of such information is something I feel we should target, among others by working on direct ways (eg good dashboards) of feeding back national and local AMR/isolate data. Until then, we are limited to reporting AMR prevalence.

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Esther van Kleef @esthervk.bsky.social · 15/04/2025

On another note: WHO GLASS has moved to individual isolate reporting since 2023. This is great and will provide a first possibility to move beyond reporting prevalences only. But countries to date struggle even to report much needed denominators for incidence.

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Esther van Kleef @esthervk.bsky.social · 15/04/2025

In addition, national surveillance guidance is underway, aiming to inform national action, not global estimates as a stand alone. Discussion are ongoing. For an early version of the survey guidance, see here www.who.int/publications.... Of note: both ACORN I and II and these surveys are intensive.

who.int

GLASS method for estimating attributable mortality of antimicrobial resistant bloodstream infections

Global Antimicrobial Resistance Surveillance System (GLASS)

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Esther van Kleef @esthervk.bsky.social · 15/04/2025

Good news is that WHO and ACORN collaborators have been working on this in tandem, I.e currently piloted WHO surveys on estimating burden, incl. all indicators presented by ACORN are developed in close consultation with/borrowing from similar protocols for places where MML access is challenging

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