npj Dementia - A Phase IIa clinical trial to evaluate the effects of anti-retroviral therapy in Alzheimer’s disease (ART-AD)

Molecular Psychiatry - Effects of sleep on the glymphatic functioning and multimodal human brain network affecting memory in older adults

Nature Aging - Exposing the exposome in aging

Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive remodeling ...

The Human Microbiome Compendium is a unified database of publicly available human gut microbiome 16S samples, built with the integrated data from hundreds of independent projects. The compendium is us...

Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive remodeling ...

Histone mark age predictors will complement cytosine methylation-based clocks in aging and rejuvenation studies.

Inter-organ communication (IOC) is a complex mechanism involved in maintaining metabolic homeostasis and healthy aging. Dysregulation of distinct forms of IOC is linked to metabolic derangements and age-related pathologies, implicating these processes as a potential target for therapeutic intervention to promote healthy aging. In this review, we delve into IOC mediated by hormonal signaling, circulating factors, organelle signaling, and neuronal networks and examine their roles in regulating metabolism and aging. Given the role of the hypothalamus as a high-order control center for aging and longevity, we particularly emphasize the importance of its communication with peripheral organs and pave the way for a better understanding of this critical machinery in metabolism and aging.

Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.

Research on so-called mirror cells, which defy fundamental properties of living organisms, should be prohibited as too dangerous, biologists said.

RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.

Ketone bodies, known for their role in energy metabolism during fasting, have been shown to directly interact with damaged proteins in the brain, aiding their clearance through autophagy.

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