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Eric Topol

@erictopol.bsky.social
194K followers 309 following 3.4K posts

physician-scientist, author, editor www.scripps.edu/faculty/topol Ground Truths erictopol.substack.com SUPER AGERS www.simonandschuster.com/books/Supe…

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Eric Topol @erictopol.bsky.social · 09/10/2026
Healthy aging: the immune system's prominent links from 12 million single-cell RNA sequencing and proteomics in 8 cohorts www.cell.com/immunity/ful...
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Eric Topol @erictopol.bsky.social · 08/10/2026
Why do small dogs live longer than large dog species, and what is the biologic basis of differences in lifespan and healthspan? Epigenetics. There's a lot in the methylation pattern of dogs to explain this @science.org science.org/doi/10.1126/...
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Eric Topol @erictopol.bsky.social · 08/10/2026
New @science.org A breakthrough in understanding why do we get fever and an inflammation response to vaccines. The gut microbiome chronic production of flagellin Paves the way to potentially prevent these acute phase side-effects in the future www.science.org/doi/10.1126/...
science.org
The human gut microbiome primes fever after vaccination
Fever is a common adverse reaction to vaccination, contributing to vaccine hesitancy and reduced uptake. To understand variation in fever risk, we longitudinally profiled fecal microbiota, oral temper...
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Eric Topol @erictopol.bsky.social · 07/10/2026
Who do you think was responsible, for Francis's firing, Jeremy?
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Jeremy Berg @jeremymberg.bsky.social · 07/10/2026
@erictopol.bsky.social Podcast with Michael Lewis about Blockers including an extensive discussion of the Francis Collins chapter. erictopol.substack.com/p/michael-le...
erictopol.substack.com
Michael Lewis: The NIH “Murder Mystery,” DOGE, and Our Government Immune System
Our conversation on his new book BLOCKERS
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Eric Topol @erictopol.bsky.social · 07/10/2026
Semaglutide (Ozempic) consistently reduced proteomic organ age 2-4 years for the heart, artery, and kidney clocks across 5 placebo-controlled trials researchsquare.com/article/rs-1...
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Eric Topol @erictopol.bsky.social · 06/10/2026
He spoke to the DOGE team members to get the plan of attacks
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Eric Topol @erictopol.bsky.social · 06/10/2026
Published today, there's a lot in Michael Lewis's new book we didn't know about. Including the NIH, unbridled assertion of power, cruelty, and many civil servant heroes (the "blockers") erictopol.substack.com/p/michael-le...
erictopol.substack.com
Michael Lewis: The NIH “Murder Mystery,” DOGE, and Our Government Immune System
Our conversation on his new book BORDERS
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Eric Topol @erictopol.bsky.social · 05/10/2026
A "normal" mammogram interpreted by AI can accurately forecast high-risk of breast cancer in the next 5 years. Approved by FDA, now becoming available. But it should be free and part of every mammogram readout. Front page @nytimes.com today, www.nytimes.com/2026/10/01/w...
nytimes.com
Women Can Now Assess Their Breast Cancer Risk With the Help of A.I. (Gift Article)
Clairity Breast, an A.I. tool that can predict five-year risk of developing breast cancer, is rolling out nationwide. Here’s what experts want you to know.
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Eric Topol @erictopol.bsky.social · 03/10/2026
Can we prevent the process and these diseases? erictopol.substack.com/p/loss-of-ce...
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Eric Topol @erictopol.bsky.social · 02/10/2026
The list of reported benefits of the GLP-1 drug family that are weight-loss independent continues to grow. My tally with citations
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Eric Topol @erictopol.bsky.social · 01/10/2026
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Eric Topol @erictopol.bsky.social · 01/10/2026
In the new @science.org special issue on women's health, a 5★ review of menopause hormone therapy to promote healthy aging science.org/doi/10.1126/...
science.org
Reframing menopause and menopause hormone therapy as opportunities for healthy aging
Menopause is an important biological transition with up to 72 symptoms that shapes aging trajectories across organs and encompasses ~40% of the female lifespan. Although menopause awareness is increas...
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Eric Topol @erictopol.bsky.social · 30/09/2026
Why do our cells age? It's not just wear and tear, accumulated damage. Loss of cell identity takes center stage. A new Nature paper and connection with prior work that substantially advances the science of aging. In the new Ground Truths. erictopol.substack.com/p/loss-of-ce...
erictopol.substack.com
Loss of Cell Identity Drives Human Aging
That’s What Biological (Epigenetic) Aging Clocks Are Measuring
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Eric Topol @erictopol.bsky.social · 30/09/2026
Exercise slowed epigenetic aging again. This time in a randomized controlled trial among breast cancer survivors. academic.oup.com/jnci/advance...
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Eric Topol @erictopol.bsky.social · 28/09/2026
Measles: What is likely going to happen in Florida (and much of the US) as MMR vaccination has dropped below the threshold needed to prevent outbreaks? Hundreds of deaths in the next 5 years projected throughout the US. www.pnas.org/doi/full/10....
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Eric Topol @erictopol.bsky.social · 27/09/2026
The word of the day: Zombified www.nytimes.com/2026/09/26/h...
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Eric Topol @erictopol.bsky.social · 22/09/2026
A partial list of factors that affect HRV
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Eric Topol @erictopol.bsky.social · 21/09/2026
How forever chemicals (PFAS) block our immune response to viruses www.pnas.org/doi/full/10....
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Eric Topol @erictopol.bsky.social · 20/09/2026
More on this, horrifying www.nytimes.com/2026/09/20/s...
nytimes.com
White House Moves to Take Control of N.I.H. Grants (Gift Article)
Federal officials are drafting an executive order that would place grants under review by an outside panel, the latest effort to redirect billions of dollars in research spending.
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Eric Topol @erictopol.bsky.social · 20/09/2026
thank you
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Eric Topol @erictopol.bsky.social · 20/09/2026
Link for the latter reuters.com/business/healthcare-pharmaceuticals/trump-seeks-bring-health-research-funding-under-his-control-politico-reports-2026-09-20/
reuters.com
Trump seeks to bring health-research funding under his control, Politico reports
U.S. President Donald Trump is seeking to bring ​a major part of national funding for health ‌research under the control of his political appointees, Politico reported on Saturday.
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Eric Topol @erictopol.bsky.social · 20/09/2026
The irony of it all Yesterday, @NEJM posted a new essay suggesting that the US government attacks on biomedical science will subside. www.nejm.org/doi/full/10.... On the same day, it was announced the President wants control of NIH funding
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Eric Topol @erictopol.bsky.social · 20/09/2026
intensive workouts can lower HRV for a prolonged period and it's unclear what that means....inadequate study of this issue
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Eric Topol @erictopol.bsky.social · 19/09/2026
Your wearable or mattress sensor is giving you your HRV and a "Readiness" score every day? What are these metrics and do they have value? erictopol.substack.com/p/the-big-ho...
erictopol.substack.com
The Big Holes in Wearable Heart Rate Variability And Readiness Scores
A Gaping Lack of Evidence for Health Benefits
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Eric Topol @erictopol.bsky.social · 17/09/2026
A brilliant new @nature.com synthesis of what we know about Alzheimer's disease pathogenesis, which is non-linear, with discrete phases (Figure), and notable inflection and transition points. Also helps to explain why symptoms do not correlate with underlying pathology. nature.com/articles/s41...
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Eric Topol @erictopol.bsky.social · 11/09/2026
Most supplements and vitamins have little or no proven benefit, and even some have potential of harm, but that hasn't held back ~80% Americans taking them, highest proportion ever www.nytimes.com/2026/09/11/w...
nytimes.com
Supplements Are More Popular Than Ever (Gift Article)
A new survey found that 8 in 10 Americans were taking vitamins, protein powders or other supplements. But experts said many offer little to no benefit.
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Eric Topol @erictopol.bsky.social · 11/09/2026
Here's your supplement and vitamin pairing for today! pewresearch.org/short-reads/... @pewresearch.org gift link @washingtonpost.com wapo.st/4A6QyjF
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Eric Topol @erictopol.bsky.social · 10/09/2026
Prior to cancer immunotherapy, vaccination of any kind, not only mRNA Covid (as previously reported), is associated with a small and transient (~6 months) benefit of improved survival www.nature.com/articles/s41...
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Eric Topol @erictopol.bsky.social · 09/09/2026
Marked benefit of Covid updated or booster vaccination in people with autoimmune conditions Real world evidence for over 60,000 individuals with major (40-70%) reduction of hospitalization acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
acrjournals.onlinelibrary.wiley.com
Updated <fc>COVID</fc>‐19 Vaccines and Health Outcomes in Patients With Autoimmune Rheumatic Conditions
Objective We aimed to assess the association between COVID-19 vaccination status and COVID-19-related hospital admissions, need for mechanical ventilation or extracorporeal membrane oxygenation (ECM...
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Eric Topol @erictopol.bsky.social · 07/09/2026
We have traditionally provided reassurance to patients with a borderline anemia. This new prospective data from >500,000 people challenges that lack of concern, indicating an increased risk of all-cause mortality www.acpjournals.org/doi/10.7326/... @annalsofim.bsky.social
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Eric Topol @erictopol.bsky.social · 07/09/2026
Sickening.
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Eric Topol @erictopol.bsky.social · 05/09/2026
And this nails it www.youtube.com/watch?v=kAX5...
youtube.com
Is the wellness industry selling you snake oil? #DailyShow #Wellness #DesiLydic
YouTube video by The Daily Show
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Eric Topol @erictopol.bsky.social · 05/09/2026
On the wellness industry BS. "I Need A Drip to Recover From My IV Drip" gift link nytimes.com/2026/09/02/m... Now a $3 billion market for IV drips!
nytimes.com
I Need an IV Drip to Recover From My IV Drip (Gift Article)
Wellness clinics are shooting people up with vitamins, but is the point to actually feel better — or the opposite?
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Eric Topol @erictopol.bsky.social · 05/09/2026
Why did 2 large, pivotal clinical trials [vs interleukin-6 and Lp(a)] fail to lower heart attacks, strokes and cardiovascular deaths? erictopol.substack.com/p/the-corona...
erictopol.substack.com
The Coronary Artery Inflammation Controversy
How Two Large Outcome Trials Based on Surrogate Metrics Failed
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Eric Topol @erictopol.bsky.social · 04/09/2026
Why have antioxidant supplements not helped reduce the incidence of cancer and in some trials shown an increase? Suppression of T cell immune response to cancer @ScienceMagazine science.org/doi/10.1126/... science.org/doi/10.1126/...
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Eric Topol @erictopol.bsky.social · 03/09/2026
This new report questions the previous one that found a survival benefit specifically conferred to mRNA Covid vaccine before cancer immunotherapy. Similar benefit was also seen with the J&J adenovirus Covid and flu vaccines www.pnas.org/doi/epdf/10....
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Eric Topol @erictopol.bsky.social · 02/09/2026
What is being done vs #LongCovid and other post-viral serious chronic illness? Not enough. www.nature.com/articles/d41...
nature.com
When do infections lead to long COVID? Scientists close in on triggers and treatments for post-viral syndromes
Hundreds of millions of people have long-term conditions as a result of an infection. Researchers are working out how to help them.
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Eric Topol @erictopol.bsky.social · 01/09/2026
Ovarian aging and the "leaky gut" "These findings provide the strongest evidence to date that menopause may promote gut barrier dysfunction and microbial translocation in otherwise-healthy women." jci.org/articles/vie...
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PLOS Medicine @plosmedicine.org · 01/09/2026
In this Perspective, Anja Schmidt and colleagues (@erictopol.bsky.social) discuss how #openaccess options for publishing commercially-funded research are often restricted, examine the consequences of this inequity, and argue for funder-neutral #publishing policies🧪📑🔐 #MedSky plos.io/4ioSRbB
plos.io
Enabling equitable open access to commercially funded research publications
In this Perspective, Christopher Winchester and colleagues discuss how open access options for publishing commercially-funded research are often restricted, examine the consequences of this inequity, ...
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Eric Topol @erictopol.bsky.social · 31/08/2026
On #LongCovid and profiling my colleague @julialmv.bsky.social @smithsonianmag.bsky.social www.smithsonianmag.com/innovation/m...
smithsonianmag.com
For Many Americans, Covid Is Still a Chronic, Disabling Disease. These Scientists Are Working Tirelessly to Bring Them Relief
Long Covid saps the strength and vitality of patients, who have little recourse to fight it. A team of specialists—including an afflicted researcher working mostly from her bed—is looking for answers
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Eric Topol @erictopol.bsky.social · 31/08/2026
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Paula Dunn @kenaiseasky.bsky.social · 31/08/2026
substack.com/profile/1280...
substack.com
Julia Belk (@juliabelk)
here are the papers! https://www.nature.com/articles/s41586-026-10939-0 https://www.science.org/doi/10.1126/science.adt8307
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Eric Topol @erictopol.bsky.social · 31/08/2026
One of the most important discoveries about our brain in many years! erictopol.substack.com/p/two-landma...
erictopol.substack.com
Two Landmark Studies Challenge Dogma About our Brain Immune Cells and Aging
Lead Authors Julia Belk and Nathan Zemke Discuss and Translate their Findings
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Eric Topol @erictopol.bsky.social · 28/08/2026
We need to rev it up. Cancer vaccines. nature.com/articles/d41... @nature.com
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Eric Topol @erictopol.bsky.social · 28/08/2026
Self-directed antibodies are found in people with #LongCovid. A key source of these was identified, and these autoantibodies and cell origin are also seen in lupus. @cp-immunity.bsky.social www.cell.com/immunity/ful...
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Eric Topol @erictopol.bsky.social · 27/08/2026
Good news www.nytimes.com/2026/08/27/w...
nytimes.com
What to Know About New Covid Vaccines for Fall 2026
The shots have been approved for people 65 and older, and for younger people with underlying conditions. Others may be able to get them off label.
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Eric Topol @erictopol.bsky.social · 26/08/2026
New insights for vaccinology, a field that is accelerating our understanding of the human immune system, with the help of AI. Reviewed @nature.com nature.com/articles/s41...
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Eric Topol @erictopol.bsky.social · 26/08/2026
The US, a Nation of Needles Some of these injections are well validated; others, such as unregulated peptides (some promoting longevity) have no meaningful human data but pushed through to unbanned status by RFK Jr Front page @nytimes.com today gift link nytimes.com/2026/08/17/w...
nytimes.com
Welcome to Needle Nation (Gift Article)
Weight-loss drugs, peptides, I.V.F. As sharps migrate out of doctors’ offices, even needle-phobics are willing to embrace shots.
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Eric Topol @erictopol.bsky.social · 26/08/2026
Calcium scans of the heart arteries, one of the most frequently ordered tests by primary care physicians and cardiologists, have little incremental value compared with well-established clinical risk scores. t.co/l6MwSpd0OB
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